邓磊
教授，博士生导师
E-mail: ldeng@hnu.edu.cn







基本信息
邓磊，2015年于比利时根特大学 – 弗拉芒生物技术研究所（VIB）获得博士学位，现湖南大学生物学院教授。主要研究方向为研制多种广谱抗流感疫苗，包括口服、注射、滴鼻或皮肤免疫型蛋白亚单位或纳米颗粒广谱抗流感疫苗。


招聘信息：
课题组招募博士后研究员和实验室管理员。课题组将提供优厚待遇和良好实验条件。有意向者请将个人简历发送至ldeng@hnu.edu.cn。
教育背景
2011年11月至2015年12月，比利时根特大学-弗拉芒生物技术研究所（VIB），生物化学与生物技术专业博士研究生。

2008年9月至2011年7月，华东理工大学-生物反应器工程国家重点实验室，微生物学专业硕士研究生；
2002年9月至 2006年7月，武汉工程大学，生物工程专业本科生；
工作履历
2018年12月至今，湖南大学生物学院，教授、博士生导师
2016年5月至2018年12月，佐治亚州立大学生物医学研究所，博士后研究员、助理研究员
2016年2月至2016年5月，埃默里大学医学院，博士后研究员

2007年2月至2008年7月，湖北省宜昌人福药业有限责任公司，QA岗位
学术兼职
Belgian Virology Association (BELVIR) 比利时病毒学学会会员
American Society for Microbiology (ASM) 美国微生物学会会员
International Society of Vaccines (ISV)国际疫苗学会会员
研究领域
利用多学科交叉手段设计并研制口服、注射、滴鼻或皮肤免疫型蛋白亚单位或纳米颗粒广谱抗流感疫苗。主要突破性学术成果是成功研制了微针皮肤免疫肽段纳米颗粒广谱抗流感疫苗、双层蛋白质纳米颗粒广谱抗流感疫苗和口服肠道菌载体广谱抗流感疫苗，并初步研究了疫苗保护作用机制和长效免疫应答机制。
研究兴趣：1，设计甲、乙型流感疫苗广谱抗原；2，研制广谱抗流感病毒抗体治疗剂；3，研究纳米颗粒剂型与疫苗递送系统。
科研项目
主持国家自然科学基金面上项目（2020.01-2023.12）
主持国家自然科学基金青年项目（2020.01-2022.12）
主持湖南省自然科学基金面上项目（2020.01-2022.12）
主持湖南大学科研启动经费
学术成果
文献：
Lei Deng, Teena Mohan, Timothy Z. Chang, Gilbert X. Gonzalez, Ye Wang, Young-Man Kwon, Sang-Moo Kang, Richard W. Compans, Julie A. Champion, Bao-Zhong Wang*.Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses.Nature Communications. Jan 2018, 9:359. doi:10.1038/s41467-017-02725-4.
Lei Deng, Timothy Z. Chang, Ye Wang, Song Li, Shelly Wang, Shingo Matsuyama, Richard W. Compans, Jian-Dong Li, Mark R. Prausnitz, Julie A. Champion, Bao-Zhong Wang*. Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice.Proceedings of the National Academy of Sciences of US. July 2018, https://doi.org/10.1073/pnas..

Lei Deng, Kenny Roose, Emma R. Job, Riet De Rycke, Evelien Van Hamme, Amanda Goncalves, Eef Parthoens, Laetitia Cicchelero, Niek Sanders, Walter Fiers, Xavier Saelens*. Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus.Journal of Controlled Release, 2017, Oct 28;264:55-65.
Lei Dengand Bao-Zhong Wang*. A perspective of nanoparticle universal influenza vaccines.ACS Infectious Diseases, November 2018, DOI: 10.1021/acsinfecdis.8b00206.

Lei Deng, Jong R. Kim, Timothy Z. Chang, Han Zhang, Teena Mohan, Julie A. Champion, Bao-Zhong Wang*. Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge.Virology, February 2017, 509:82-89.

Lei Deng, Ki joon Cho, Walter Fiers and Xavier Saelens*. M2e-Based Universal Influenza A Vaccines.Vaccines, 2015, 3(1): 105-136.
Lei Deng, Lorena Itatí Iba?ez, Veronique Van den Bossche, Kenny Roose, Walter Fiers, Xavier Saelens*. Protection against influenza A virus challenge with M2e-displaying filamentous E. coli phages.PLoS ONE, 2015, 10(5):e**.

Lei Deng, Bingyang Shi, Yingping Zhuang, Ju Chu, Xiaolin Shi and Siliang Zhang, Meijin Guo*. Performance and mechanism of neuroleukin in the growth and survival of sertoli cell-induced neurons in a coculture system.Cell Transplantation, 2014, 23(3): 381-394.

Lei Deng, Florencia Linero and Xavier Saelens*. Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes. Protocol, Vaccine Design, Volume 1404 of the seriesMethods in Molecular Biologypp 483-495. Springer Press. 14, April, 2016. (Linkage:http://link.springer.com/protocol/10.1007%2F978-1-4939-3389-1_31)

Ye Wang, Lei Deng, Gilbert X. Gonzalez, Latika Luthra, Chunhong Dong, Yao Ma, Jun Zou, Sang-Moo Kang and Bao-Zhong Wang*.Double-layered M2e-NA protein nanoparticle immunization induces broad cross-protection against different influenza viruses in mice. Advanced Healthcare Materials, 2019, DOI: 10.1002/adhm..

Dubravka Grdic Eliasson, Ajibola Omokanye, Karin Sch?n, Alexander Wenzel, Valentina Bernasconi, Mats Bemark, Karim El Bakkouri, Tine Ysenbaert,Lei Deng, Walter Fiers, Xavier Saelens and Nils Lycke*. M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection.Mucosal Immunology, March 2017, doi: 10.1038/mi.2017.14.
Ye Wang,Lei Deng, Sang-Moo Kang, Bao-Zhong Wang. Universal influenza vaccines: From viruses to nanoparticles.Expert review of vaccines, November 2018. 17(11): 967-976.

Timothy Z. Chang,Lei Deng, Bao-Zhong Wang, Julie A. Champion*. H7 Hemagglutinin nanoparticles retain immunogenicity after >3 months of 25°C storage. PLoS ONE. Aug 2018. 13(8): e**.

Yuan Luo, Teena Mohan, Wandi Zhu, Chao Wang,Lei Deng, and Bao-Zhong Wang*. Sequential Immunizations with heterosubtypic virus-like particles elicit cross protection against divergent influenza A viruses in mice.Scientific reports. March 2018. 8(1): 4577.

Teena Mohan,Lei Deng, Bao-Zhong Wang*. CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.Int Immunopharmacol. August 2017, 24(51):165-170.

Silvie Van den Hoecke, Katrin Ehrhardt, Annasaheb Kolpe, Karim El Bakkouri,Lei Deng, Hendrik Grootaert, Steve Schoonooghe, Anouk Smet, Mostafa Bentahir, Kenny Roose, Michael Schotsaert, Bert Schepens, Nico Callewaert, Falk Nimmerjahn, Peter Staeheli, Hartmut Hengel and Xavier Saelens*. Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies.Journal of Virology, February, 2017, 91(3).

Ki Joon Cho, Bert Schepens, Kristof Moonens,Lei Deng, Walter Fiers, Han Remaut and Xavier Saelens*. Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody.Journal of Virology, January, 2016, 90(1): 611-615.(Epitopes described in ‘Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody’. Reference ID: **; Linkage:www.iedb.org/assayld/**).

Bingyang Shi,Lei Deng, Xiaolin Shi, Sheng Dai, Hu Zhang, Yonghong Wang, Jingxiu Bi* and Meijin Guo*. The enhancement of neural stem cell survival and growth by coculturing with expanded Sertoli cells in vitro.Biotechnology Progress, 2012, 28(1): 196-205.

Suwen Hu,Lei Deng, Huamao Wang, Yingping Zhuang*, Ju Chu, Siliang Zhang, Zhonghai Li and Meijin Guo*. Bioprocess Development for the Production of Mouse-human Chimeric Anti-Epidermal growth factor receptor vIII Antibody C12 by Suspension Culture of Recombinant Chinese Hamster Ovary Cells.Cytotechnology, 2011, 63(3): 247-258.

专利：
Baozhong Wang,Lei Deng. Headless Hemagglutin influenza vaccine.[Patent](Provisional Patent Applicant, Georgia State University; Application No. **) Filed Date: 2017, Oct.
Meijin Guo,Lei Deng, Siliang Zhang, Ju Chu and Yingping Zhuang. A Neuroleukin Obtaining Method.[Patent](Patent Applicant, East China University of Science and Technology; Publication No., CNA) 2013, May. [State Intellectual Property Office of the P.R.C]


奖励与荣誉