张英杰
副教授
Tel:**
E-mail:yingjiezhang@hnu.edu.cn







基本信息
张英杰，河南郑州人，1983年生。2011年于华南师范大学激光生命科学教育部重点实验室获得生物物理博士学位，并于同年赴美国纽约大学医学院细胞生物学系进行博士后研究。2013年起在明尼苏达大学荷美尔医学研究所任荷美尔研究员，2015年受聘于湖南大学生物学院，现为副教授，硕士生导师。主要研究方向为肿瘤遗传,新型靶向性小分子药物/抑制剂的筛选和分子机制，以及活细胞实时单分子成像。近年来一直关注于细胞死亡和自噬的平衡关系，及其在肿瘤治疗中的应用。主持及参与国家自然科学基金3项，湖南省自然科学基金1项，深圳市科创委基础研究项目1项。在Cell Rep, Theranostics, Cell Death & Dis等多个著名国际期刊上发表论文20余篇，总影响因子超过100，他引总次数超过600。主讲课程《细胞工程》入选湖南省一流课程，荣获2019年湖南省高校教师课堂教学竞赛二等奖，2018年湖南大学讲课比赛一等奖。
教育背景
2006-2011华南师范大学生物光子学研究院，激光生命科学教育部重点实验室，生物物理专业，博士
2011-2013纽约大学医学院，细胞生物学系，博士后
工作履历
2013-2015 明尼苏达大学，荷美尔研究所，荷美尔研究员
2015-2019 湖南大学，生物学院，助理教授
2019-至今 湖南大学，生物学院，副教授


研究领域
1. 肿瘤遗传，免疫及转化医学；
2. 鉴定新的肿瘤治疗靶点并进行药物筛选；
3. 细胞死亡，自噬的分子机制和信号转导通路；
4. 利用活细胞实时单分子成像和FRET研究蛋白的激活，时空转位及相互作用；

5. 利用新型纳米/高分子材料进行肿瘤的靶向治疗；


学术成果
1. Jing Liu, Shuaiyu Long, Huanan Wang, Nannan Liu, Chuchu Zhang, Lingling Zhang and Yingjie Zhang*. “Blocking AMPK/ULK1?dependent autophagy promoted apoptosis and suppressed colon cancer growth”. Cancer Cell International 2019; doi: 10.1186/s12935-019-1054-0.
2. Yuan Huang, Nannan Liu, Jing Liu, Yeying Liu, Chuchu Zhang, Shuaiyu Long, Guang Luo, Lingling Zhang and Yingjie Zhang*. “Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA”. Cell Cycle 2019; 14: 1-14.
3. Huanan Wang, Yeying Liu, Jie Ding, Yuan Huang, Jing Liu, Nannan Liu, Yue Ao, Yi Hong, Lefeng Wang, Lingling Zhang, Jiangang Wang and Yingjie Zhang*. “Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF-4E/PUMA pathway”. Cancer Gene Therapy 2019; doi: 10.1038/s41417-019-0117-7.
4. Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang and Yingjie Zhang*. “Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy”. Cancer Cell International 2019; 9(19): 124.
5. Yingjie Zhang, Liming Nie, Keqian Xu, Yang Fu, Juchang Zhong, Kongzhen, Gu, Lingling Zhang. “SIRT6, A Novel Direct Transcriptional Target of FoxO3a, Mediates Colon Cancer Therapy”. Theranostics 2019; 9(8) 2380-2394.
6. Jingfei Chen, Juchang Zhong, Yeying Liu, Yuan Huang, Fei Luo, Yingjun Zhou, Xi Pan, Shousong, Cao, Lingling Zhang, Yingjie Zhang*, Jiangang Wang*. “Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer”. Cancer Medicine 2018; 7(12): 6158-6169.
7. Juchang Zhong^#, Yingjie Zhang^#, Jingfei Chen, Ruiying Huang, Yikun Yang, Haoxiang Chen, Yuan Huang, Weihong Tan, and Zhikai Tan. “In Vitro Study of Colon Cancer Cell Migration Using E-Jet 3D Printed Cell Culture Platforms”. Macromol Biosci 2018; 18(11): e**.
8. Li Sun, Yuan Huang, Yeying Liu, Yujie Zhao, Xiaoxiao He, Lingling Zhang, Feng Wang and Yingjie Zhang*. “Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis”. Cell Death Dis 2018; 9(9): 911.
9. Xianwang Wang, Xiaochun Peng, Xueqing Zhang, Hanyi Xu, Chengbiao Lu, Lian Liu, Jiaxing Song, Yingjie Zhang*. “The Emerging Roles of CIB1 in Cancer”. Cell Physi Biochemi 2017; 43: 1413-1424.
10. Zhikai Tan, Yikun Yang, Shurui Liao, Juchang Zhong, Yingjie Zhang*, Weihong Tan. “3D printed scaffolds for tumor targeting and controlled drug release”. J Controlled Release 2017; 259: e5-e195.
11. Lingling Zhang, Huanan Wang, Wei Li, Juchang Zhong, Rongcheng Yu, Xinfeng Huang, Honghui Wang, Zhikai Tan, Jiangang Wang, Yingjie Zhang*. “Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis”. Oncotarget 2017; 8(2): 3289-3303.
12. Li Sun, Defeng Wang, Xiaotian Li, Lingling Zhang, Hui Zhang, Yingjie Zhang*. “Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway”. BIOMED PHARMACOTHER 2016; 81: 145-151.
13. Lei Wang, Ji Wang, Hua Xiong, Fengxia Wu, Tian Lan, Yingjie Zhang, Xiaolan Guo, Huanan Wang, Mohammad Saleem, Cheng Jiang, Junxuan Lu, Yibin Deng. “Co-Targeting Hexokinase 2-Mediated Warburg Effect and ULK1-Dependent Autophagy Suppresses Tumor Growth of PTEN- and TP53-Deficiency-Driven Castration-Resistant Prostate Cancer”. EBioMedicine 2016; 7: 50-61.
14. Huanan Wang, Lei Wang, Yingjie Zhang, Ji Wang, Yibin Deng, Degui Lin. “Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth” Cancer Cell Int. 2016; 16(16): 9.
15. Huanan Wang, Lingling Zhang, Xu Yang, Yipeng Jin, Shimin Pei, Di Zhang, Yingjie Zhang* and Degui Lin*. “PUMA Mediates the Combinational Therapy of 5-FU and NVP-BEZ235 in Colon Cancer” Oncotarget 2015; 6(16): 14385-98.
16. Lei Wang, Hua Xiong, Fengxia Wu, Yingjie Zhang, Ji Wang, Liyan Zhao, Xiaolan Guo, Li-Ju Chang, Yong Zhang, M. James You, Shahriar Koochekpour, Mohammad Saleem, Haojie Huang, Junxuan Lu and Yibin Deng. “Hexokinase 2-Mediated Warburg Effect Is Required for PTEN and p53 Deficiency-Driven Prostate Cancer Growth”. Cell Rep 2014; 8: 1-14.
17. Jie Feng, Yingjie Zhang and Da Xing. “Low-power laser irradiation (LPLI) promotes VEGF expression and vascular endothelial cell proliferation through the activation of ERK/Sp1 pathway”. Cellular Signalling. 2012; 24: 1116-1125 (Cited: 57).
18. Yingjie Zhang and DaXing. “PUMA Promotes Bax Activation in a FOXO3a-dependent Manner in STS-induced Apoptosis”. J Innov Opt Health Sci 2010; 3: 31-38.
19. Lingling Zhang, Yingjie Zhang and Da Xing. “LPLI Inhibits Apoptosis Upstream of Bax Translocation via a GSK-3β-Inactivation Mechanism”. J. Cell. Physiol. 2010; 224(1): 218-228 (Cover Story, Cited: 40).
20. Yingjie Zhang, Da Xing and Lei Liu. “PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X_L during UV-induced apoptosis”. Mol. Biol. Cell. 2009; 20: 3077-3087 (Cited: 67).
21. Yingjie Zhang, Da Xing and Lei Liu. “The molecular imaging study of PUMA and Bcl-2 family members in UV-induced apoptosis”. Chinese Journal of Lasers 2009; 36 (10): 2609-2613.
22. Yingjie Zhang* and Qun Chen. “PUMA Promotes Bax Translocation in FOXO3a-dependent Pathway during STS-induced Apoptosis”. Proc. of SPIE. 2009; 7519: 75191A1-9.
23. Lei Liu, Yingjie Zhang and Xianwang Wang. “Using FRET Technique to Investigate The Apoptotic Mechanism Induced by Cisplatin in Living Cells”. Progress in Biochemistry and Biophysics 2009; 36 (9): 1172-1179 (Cited: 37).
24. Lei Liu, Yingjie Zhang and Xianwang Wang. “Involvement of Caspase-dependent and –independent apoptotic pathways in cisplatin-induced apoptosis”. Proc. of SPIE. 2009; 7178: 71780N1-8.
25. Yingjie Zhang, Da Xing, Yinyuan Wu and Lei Liu. “PUMA promotes Bax translocation by competitive binding to Bcl-Xl during UV-induced apoptosis”. Proc. of SPIE. 2008; 6857: 68570N1-10.


奖励与荣誉
1. 主讲课程《细胞工程》入选湖南省一流课程；
2. 湖南省2019年普通高校教师课堂教学竞赛二等奖；
3. 湖南大学2018年讲课比赛一等奖；
4. 湖南大学2018年本科毕业设计（论文）优秀指导教师。