湖南大学化学化工学院教授，博士生导师
生物传感与计量学国家重点实验室
分子科学与生物医学实验室（mbl.hnu.edu.cn）
研究方向：生物传感

邮箱：zlzhao@hnu.edu.cn





基本信息
2009年于中国科学院化学研究所获得物理化学博士学位。2010年1月-2016年12月先后在美国佛罗里达大学和湖南大学谭蔚泓教授课题组从事博士后研究。2017年1月加入湖南大学化学化工学院。主要研究方向为化学生物学和纳米生物学。已在JACS、Angew. Chem. Int. Ed.等国际期刊发表学术论文50余篇。




教育背景
2006.09 - 2009.06，中国科学院化学研究所，博士（物理化学）
2003.09 - 2006.06，湖南师范大学，硕士（分析化学）
1999.09 - 2003.06，湖南师范大学，学士
工作履历
2021.01至今，湖南大学化学化工学院，教授
2017.01 - 2020,12，湖南大学化学化工学院，副教授
2018.09 - 2019.09，美国犹他大学，访问****
2013.12 - 2016.12，湖南大学生物学院，副研究员

2011.11 - 2013.11，湖南大学，博士后
2010.01 - 2011.01，美国佛罗里达大学，博士后
研究领域
化学生物学、纳米生物学
科研项目
1、国家自然科学基金青年基金，特异性识别胰导管腺癌核酸适配体的筛选及其诊治应用的初步研究（**），2015.01-2017.12，25万元，主持

2、国家自然科学基金国家重大科研仪器研制项目，基于核酸适配体识别的肿瘤细胞新型标志物高效筛选仪的研制子课题（**），2016.01-2020.12，214万元，主持
3、国家自然科学基金面上项目，精准识别肿瘤细胞条件性核酸适体的构建及其活体成像应用研究（**），2020.01-2023.12，65万，主持




学术成果
（# Co-first author，* Corresponding author)：
[21] ...


[20]New Insights from Chemical Biology: Molecular Basis of Transmission, Diagnosis, and Therapy of SARS-CoV-2, CCS Chemistry, 2020, 2, 1501-1528.
ZilongZhao#,Yaling Wang#,Liping Qiu#,Ting Fu,Yu Yang,Ruizi Peng,Mengyu Guo,Lichun Mao,Chunying Chen*,YuliangZhao,Weihong Tan*


[19]MicroRNA-Initiated and Intracellular Na⁺-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer, Anal. Chem., 2020, 92, 7404-7408.

Kun Chen#, Qin Huang#, Ting Fu, Guoliang Ke, Zilong Zhao*, Xiaobing Zhang*, Weihong Tan


[18]Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity,J. Am. Chem. Soc.2019, 141, 18421-18427.

Fang Zhou, Ting Fu, Qin Huang, Hailan Kuai, Liuting Mo, Honglin Liu, Qianqian Wang, Yongbo Peng, Dongmei Han,Zilong Zhao*, Xiaohong Fang*, Weihong Tan*


[17]Molecular Engineering-Based Aptamer-Drug Conjugates withAccurate Tunability of Drug Ratios for Drug Combination TargetedCancer Therapy,Angew. Chem. Int. Ed.,2019, 58, 11661-11665.
Fang Zhou^#, Peng Wang^#, Yongbo Peng, Pengge Zhang, Qin Huang, Weidi Sun, Nongyue He,Ting Fu,Zilong Zhao*, Xiaohong Fang*,Weihong Tan



[16]DNA-Supramolecule Conjugates in Theranostics,Theranostics, 2019, 9, 3262-3279.
Kun Chen^#, Ting Fu^#, Weidi Sun, Qin Huang, Pengge Zhang,Zilong Zhao*, Xiaobing Zhang*,Weihong Tan*


[15]Tumor Extracellular pH-Driven Cancer-Selective Artificial Receptor-Mediated Tumor-Targeted Fluorescence Imaging,Anal. Chem., 2019, 91, 13349-13354.
Qian Guo, Zhan Wu*, Yongbo Peng, Wenyi Peng, Qin Huang, Miao Peng, Ni Huang, Xiaoxiao Hu, Ting Fu,Zilong Zhao*, Weihong Tan*


[14]Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery,J. Am. Chem. Soc.,2018,140, 6780-6784.
Ying Jiang,Xiaoshu Pan,Jin Chang,Weijia Niu,Weijia Hou,Hailan Kuai,Zilong Zhao*,Ji Liu,Ming Wang*, Weihong Tan*


[13]Smart Human-Serum-Albumin-As₂O₃Nanodrug with Self-Amplified Folate Receptor-Targeting Ability for Chronic Myeloid Leukemia Treatment,Angew. Chem. Int. Ed.,2017, 56, 10845-10849.
Yongbo Peng^#,Zilong Zhao^#*, TengLiu^#, XiongLi, Xiaoxiao Hu, Xiaoping Wei, XiaobingZhang, WeihongTan*


[12]Nanocarrier Based on the Assembly of Protein and Antisense Oligonucleotide to Combat Multidrug Resistance in Tumor Cells,Science China Chemistry, 2017, 60, 1318-1323.
Xuan Yu, Liang Gong, Jing Zhang,Zilong Zhao*, Xiaobing Zhang*, Weihong Tan*


[11]CD109 Is Identified as a Potential Nasopharyngeal Carcinoma Biomarker Using Aptamer Selected by Cell-SELEX, 2016,Oncotarget,2016, 7, 55328-55342.
Wenting Jia, Caiping Ren*, Lei Wang, Bin Zhu, Wei Jia, Menghui Gao, Fei Zeng, Liang Zeng, Xiaomeng Xia, Xiaobing Zhang, Ting Fu, Shasha Li, Can Du, Xingjun Jiang, Yuxiang Chen, Weihong Tan,Zilong Zhao*, Weidong Liu*


[10]Circular Bivalent Aptamers Enablein vivoStability and Recognition,J. Am. Chem. Soc.,2017, 139, 9128-9131.
Hailan Kuai^#,Zilong Zhao^#, Liuting Mo, Hui Liu, Xiaoxiao Hu, Ting Fu, Xiaobing Zhang, Weihong Tan*



[9]A Multi-Mitochondrial Anticancer Agent that Selectively Kills Cancer Cells and Overcomes Drug Resistance,ChemMedChem,2017, 12, 250-256.
Yongbo Peng^#,Zilong Zhao^#, Teng Liu^#, Guojian Xie, Cheng Jin, Tanggang Deng, Yang Sun, Xiong Li, Xiaoxiao Hu, Xiaobing Zhang, Mao Ye, Weihong Tan*


[8]A Smart Detection System Based on Specific Magnetic and Rolling Cycle Amplification Signal-Amplified Dual-Aptamers to Accurately Monitor Minimal Residual Diseases in Patients with T-ALL,J. Biomed. Nanotechnol.,2016, 12, 2151-2160.
Xia Li^#, Bo Zhou^#,Zilong Zhao^#, Zixi Hu, Sufang Zhou, Nuo Yang, Yong Huang, Zhenghua Zhang, Jing Su, Dan Lan, Xue Qin, Jinyu Meng, Duo Zheng, Jian He, Xianing Huang, Jing Zhao, Zhiyong Zhang, Weihong Tan*, Xiaoling Lu*, Yongxiang Zhao*


[7]A Smart DNAzyme-MnO₂Nanosystem for Efficient Gene Silencing,Angew. Chem. Int. Ed., 2015, 54, 4801-4805.
Huanhuan Fan^#,Zilong Zhao^#, Guobei Yan, Xiaobing Zhang, Chao Yang, Hongmin Meng, Zhuo Chen, Hui Liu, Weihong Tan*



[6]Study of the Function of G-Rich Aptamers Selected for Lung Adenocarcinoma,Chem. Asian J., 2015, 10, 1519-1525.
Jun Hu^#,Zilong Zhao^#, Qiaoling Liu, Mao Ye, Bingqiang Hu, Jing Wang, Weihong Tan*


[5]DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition,Theranostics,2015, 5, 985-994.
Xiaoqiu Wu^#,Zilong Zhao^#, Huarong Bai, Ting Fu, Chao Yang, Xiaoxiao Hu, Qiaoling Liu, Carole Champanhac, I-Ting Teng, Mao Ye*, Weihong Tan*


[4]Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO₂Nanosheet-Aptamer Nanoprobe,J. Am. Chem. Soc.,2014, 136, 11220-11223.（高被引论文）
Zilong Zhao^#, Huanhuan Fan^#, Gaofeng Zhou, Huarong Bai, Hao Liang, Ruowen Wang, Xiaobing Zhang, Weihong Tan*


[3]Gold Nanorod-Photosensitizer Conjugate with Extracellular pH-Driven Tumor Targeting Ability for Photothermal/Photodynamic Therapy,Nano Research,2014, 7, 1291-1301.
Nannan Wang^#,Zilong Zhao^#, Yifan Lv, Huanhuan Fan, Huarong Bai, Hongmin Meng, Yuqian Long, Ting Fu, Xiaobing Zhang, Weihong Tan*



[2]A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery,Angew. Chem. Int. Ed.,2013, 52, 7487-7491.
Zilong Zhao, Hongmin Meng, Nannan Wang, Micheal J Donovan, Ting Fu, Mingxu You, Zhuo Chen, Xiaobing Zhang*, Weihong Tan*


[1]Recognition of Subtype Non-Small Cell Lung Cancer by DNA Aptamers Selected from Living Cells,Analyst,2009, 134, 1808-1814.
Zilong Zhao, Li Xu, Xiaoli Shi, Weihong Tan, Xiaohong Fang*, Dihua Shangguan*
奖励与荣誉
1、脱氧核酶分子识别体系构建及生物分析应用, 中华人民共和国教育部, 自然科学, 省部一等奖, 2019.1.15，张晓兵; 谭蔚泓; 赵子龙; 袁荃；
2、高性能荧光探针构建与生物成像应用, 湖南省人民政府, 自然科学奖, 省部一等奖, 2019.02.27，张晓兵; 谭蔚泓; 陈卓; 赵子龙