姓 名：谭丽君
学 科： 生理学
研究方向： 骨质疏松的分子与统计遗传
电话/传真：
电子邮件： lijuntan2005@aliyun.com
通讯地址： 湖南师范大学生命科学学院


学习经历


1）2003年毕业于南华大学医学院，获医学学士学位。
2）2008年毕业于湖南师范大学生命科学学院，获理学博士学位。
3）2008年8月至今，湖南师范大学生命科学学院工作。
4) 2010年7月--2011年8月,美国Tulane University公共卫生与热带医学院,博士后研究.



工作经历


承担本科生《人体组织解剖学》理论课和实验课教学，研究生《分子遗传学》和《数量遗传学》课程教学。



承担科研课题


1) 国家自然科学基金青年科学基金项目（**）骨质疏松性骨折重要候选基因的关联研究，20010.1-2012.12，20万（主持）
2) 国家自然科学基金面上项目（**），骨质疏松症相关基因STAT1的功能调控研究，2008.1-2010.12，300,000RMB（副主持）
3) 国家自然科学基金面上项目STAT1基因变异及转录结合与人类骨质疏松的关联和在斑马鱼骨骼发育中的功能研究（**）2013.1-2016.12,85万（副主持）
4) 国家自然科学基金面上项目 miRNA靶位点遗传多态性调控骨质疏松症机理研究（**）国家自然科学基金面上项目2011.1-2013.12，36 万（副主持）


发表论文


1. Yang F, Lv JH, Lei SF, Chen XD, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, Yang YJ, Wang YB, Sun X, Xiao SM, Jiang C, Guo YF, Guo JJ, Li YN, Zhu XZ, Papasian CJ, Deng HW. 2006 Receiver-operating characteristic analyses of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in young adults in central south of China. Clin Nutr. 121:1030-1039.
2. Xiao SM*, Lei SF*, Chen XD*, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, YangYJ, Wang YB, Sun X, Jiang C, Guo YF, Guo JJ, Li YN, Jiang H, Zhu XZ, DengHW. 2006 Correlation and prediction of trunk fat mass with four anthropometric indices in Chinese males. British Journal of Nutrition. 96: 949–955.
3. Lei SF, Liu MY, Chen XD, Deng FY, Lv JH, Jian WX, Xu H, Tan LJ, Yang YJ, Wang YB, Xiao SM, Sun X, Jiang C, Guo YF, Guo JJ, Li YN, Liu YJ, Deng HW. 2006 Relationship of total body fatness and five anthropometric indices in Chinese aged 20-40 years: different effects of age and gender. Eur J Clin Nutr. 60:511-8.
4. Tan LJ, Lei SF, Chen XD, Liu MY, Guo YF, Xu H, Sun X, Jiang C, Xiao SM, Guo JJ, Yang YJ, Deng FY,Wang YB, Li YN, Zhu XZ, Deng HW. 2007 Establishment of Peak Bone Mineral Density in Southern Chinese Males and its Comparisons with other Males from Different Regions of China. J Bone Miner Metab. 25:114-121
5. Wu S, Lei SF, Chen XD, Tan LJ, Jian WX, Hong X, Deng FY, Sun X, Xiao SM, Jiang C, Guo YF, Zhu XZ, Deng HW. 2007 The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults. Ann Hum Biol. 34: 344-353.
6. Tang ZH, Xiao P, Lei SF, Deng FY, Zhao LJ, Deng HY, Tan LJ, Shen H, Xiong DH, Recker RR, Deng HW. 2007 A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. J Clin Endocr Metab. 92: 2751-2757.
7. Jiang C*, Lei SF*, Liu MY, Xiao SM, Chen XD, Deng FY, Xu H, Tan LJ, Yang YJ, Wang YB, Sun X, Guo YF, Guo JJ and Deng HW. 2007 Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years. Nutr Metab Cardiovasc Dis 17:676-83
8. Guo Y, Xiao P, Lei S, Deng F, Xiao GG, Liu Y, Chen X, Li L, Wu S, Chen Y, Jiang H, Tan L, Xie J, Zhu X, Liang S, Deng H. 2008 How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin, 40(5):426-36. （影响因子1.54）
9. Tan LJ, Liu YZ, Xiao P, Yang F, Tang ZH, Liu PY, Recker RR. Deng HW. 2008 Evidence for Major Pleiotropic effects on Bone Size Variation from Principal Component Analysis of 451 Caucasian Families. Acta Pharmacologica Sinica, 29:745-51. 5
10. Wang XL, Deng FY, Tan LJ, Deng HY, Liu YZ, Papasian CJ, Recker RR. Deng HW. 2008 Bivariate whole-genome linkage analyses for total body lean mass and bone mineral density. J Bone Miner Res. 23(3):447-52
11. Deng FY, Liu YZ, Li LM, Jiang C, Wu S, Chen Y, Jiang H, Yang F, Xiong JX, Xiao P, Xiao SM, Tan LJ, Sun X, Zhu XZ, Liu MY, Lei SF, Chen XD, Xie JY, Xiao GG, Liang SP, Deng HW. 2008 Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. Proteomics. 8(20):4259-4272
12. Li LM, Lei SF, Chen XD, Deng FY, Tan LJ, Zhu XZ, Deng HW. 2008 Anthropometric indices as the predictors of trunk obesity in Chinese young adults: receiver operating characteristic analyses.Ann Hum Biol. 35(3):342-8.
13. Chen XD, Xiao P, Lei SF, Liu YZ, Guo YF, Deng FY, Tan LJ, Zhu XZ, Chen FR, Recker RR, Deng HW. Gene Expression Profiling in Monocytes and SNP Association Suggest the Importance of STAT1 Gene for Osteoporosis in Both Chinese and Caucasians.J Bone Miner Res. 2010 Feb;25(2):339-55
14. Liu YZ, Guo YF, Wang L, Tan LJ, Liu XG, Pei YF, Yan H, Xiong DH, Deng FY, Yu N, Zhang YP, Zhang L, Lei SF, Chen XD, Liu HB, Zhu XZ, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. 2009 Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. PLoS Genet. 5(3):e**.
15. Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW. 2009 Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. Am J Hum Genet. 84(3):418-23.
16. Xiong DH, Liu XG, Guo YF, Tan LJ, Wang L, Sha BY, Tang ZH, Pan F, Yang TL, Chen XD, Lei SF, Yerges LM, Zhu XZ, Wheeler VW, Patrick AL, Bunker CH, Guo Y, Yan H, Pei YF, Zhang YP, Levy S, Papasian CJ, Xiao P, Lundberg YW, Recker RR, Liu YZ, Liu YJ, Zmuda JM, Deng HW.2009 Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet. 84(3):388-98.
17. Lei SF, Wu S, Li LM, Deng FY, Xiao SM, Jiang C, Chen Y, Jiang H, Yang F, Tan LJ, Sun X, Zhu XZ, Liu MY, Liu YZ, Chen XD, Deng HW.2009 An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone. 44(5):1010-4.
18. Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Jin TB, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW. 2009 Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet. 18(9):1661-9
19. Lei SF, Yang TL, Tan LJ, Chen XD, Guo Y, Guo YF, Zhang L, Liu XG, Yan H, Pan F, Zhang ZX, Peng YM, Zhou Q, He LN, Zhu XZ, Cheng J, Liu YZ, Papasian CJ, Deng HW. 2009 Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Hum Genet. 125(1):1-9.
20. Guo Y*, Tan LJ*, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. 2010 Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 8;6(1):e**.(*并列第一作者)
21. Zhang F*, Tan LJ*, Lei SF, Deng HW. 2010 The differences of femoral neck geometric parameters: effects of age, gender and race. Osteoporos Int.;21(7):1205-14 (*并列第一作者)
22. Tan LJ, Liu R, Lei S F, et al. 2010 A genome-wide association analysis implicates SOX6 as a candidate gene for wrist bone mass. Sci China Life Sci, 53: 1065–1072.
23. X Li*, L Tan*, X Liu, S Lei, T Yang, X Chen,H Deng. 2010 A genome wide association study between copy number variation (CNV) and human height in Chinese population. Jounal of Genetics and Genomics .37:778-785(*并列第一作者)
24. Sun L, Tan LJ, Lei SF, Chen XD, Li X, Pan R, Yin F, Liu QW, Yan XF, Papasian CJ, Deng HW. 2011 Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.PLoS One. 6(11):e27325
25. Deng FY, Lei SF, Chen XD, Tan LJ, Zhu XZ, Deng HW. 2011 An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese.J Bone Miner Res. 26(11):2695-701.
26. Hai R, Pei YF, Shen H, Zhang L, Liu XG, Lin Y, Ran S, Pan F, Tan LJ, Lei SF, Yang TL, Zhang Y, Zhu XZ, Zhao LJ, Deng HW. 2012 Genome-wide association study of copy number variation identified gremlin1 as a candidate gene for lean body mass. J Hum Genet. 57(1):33-7.
27. Tan LJ, Liu SL, Lei SF, Deng HW. 2012 Molecular Genetic Studies of Gene Identification for Sarcopenia. Hum Genet.131(1):1-31 （影响因子5.05）
28. 谭丽君, 刘荣, 雷署丰, 潘蓉, 杨铁林, 阎函, 培育芳, 杨芳, 张峰, 潘峰, 张银萍, LEVY Shawn, 邓红文，2010全基因组关联分析显示SOX6为影响腕部骨密度的候选基因。中国科学:生命科学 08：685-693,
29. 谭丽君, 杨铁林，刘拥军，邓红文，ZBTB40基因与中国汉族人群和美国高加索人群骨密度的关联研究，生命科学研究，2012，16（4）:324-328
30. 谭丽君, 杨铁林，刘拥军，邓红文，PHACTR3基因与中国汉族人群和美国高加索人群骨密度的关联研究，激光生物学报，2012;21（4）: 365-369
31. Zhong K, Lei SF, Yang F, Chen XD, Tan LJ, Zhu XZ, Tian Q, Deng HW. 2012 The differences of sarcopenia-related phenotypes: effects of gender and population. Eur Rev Aging Phys Act. 9(1):63-69

上一条：王斌
下一条：邱义兰