李海涛
性别：男
学历：博士
职称：教授
其他：硕士生导师
李海涛，教授，博士, 硕士生导师。南开大学国家吸附分离功能材料重点实验室高分子化学与物理专业毕业，获理学博士学位；多年来，一直从事有机合成和高分子合成领域的研究工作，在吸附分离功能材料、精细催化合成等研究领域有多年的研究工作经历和系列研究成果。近年来，主攻新型探针分子、功能材料的研制，在聚合物吸附剂表面结构、吸附机制、吸附过程热力学、分子识别材料的制备等方面获得了一些新的认识，先后在React. Func. Polym., J. Coll. Inter. Sci.. Polymer, Biosensor and Bioelectronics, Talanta, New Journal of Chemistry, Analyst等重要学术期刊上发表论文50多篇。先后主持了国家自然科学基金课题、湖南省自然科学基金项目“OPEs分子导线的研制及其在电场中的光电行为研究”等多项课题研究，参加过973项目及多项国家自然科学基金课题的研究工作。

一、近年来主持和参与的科研项目：

1.国家自然科学基金项目：多功能亲水性链珠结构分子导线合成、电子传输机理以及在免疫分析中的应用研究 (2011.01-2013.12, 项目主持人)

2.湖南省自然科学基金：OPEs分子导线的研制及其在电场中的光电行为研究已顺利完成。 （2007.01-2010.12，项目主持人）

3.生物传感与计量学国家重点实验室开放基金资助项目：光电敏感树状聚合物的光电响应机制及其超分子识别作用的研究（2008.01-2010.12，项目主持人）

4.国家自然科学基金项目：基于纳米颗粒编码的DNA单碱基突变检测技术研究 （2007.01-2009.12，主要研究人员）

5.湖南省自然科学基金项目，基于亲水性核壳结构分子导线的生物传感器研究 （2009.01-2011.12，主要研究人员）
二、近年来发表的部分论文
1. Qiujun Lu, Jianhui Deng, Yuxin Hou, Haiyan Wang, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Hydroxyl-rich C-dots synthesized by a one-pot method and their application in the preparation of noble metal nanoparticles, Chem. Commun., 2015, DOI: 10.1039/C5CC01771H

2. Jianhui Deng, Qiujun Lu, Haitao Li, Youyu Zhang,* and Shouzhuo Yao, Large scale preparation of graphene quantum dots from graphite oxide in pure water via one-step electrochemical tailoring, RSC Advances, 2015, 5, 29704-29707.

3. Jianhui Deng, Qiujun Lu, Yuxin Hou, Meiling Liu*, Haitao Li, Youyu Zhang* and Shouzhuo Yao, Nanosensor Composed of N-doped Carbon Dots and Au Nanoparticles for High Selective Detection of Cysteine with Multiple Signals, Anal. Chem., 2015, 87, 2195-2203.

4. Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Upconversion nanoparticle-based fluorescence resonance energytransfer assay for organophosphorus pesticide, Biosensor and Bioelectronics,2015, 68, 168-174.

5. Yuxin Hou, Qiujun Lu, Jianhui Deng, Haitao Li, Youyu Zhang*, Shouzhuo Yao, One-pot electrochemical synthesis of functionalized fluorescent carbon dots and their selectivity sensing for mercury ions, Anal. Chim. Acta, 2015, 866, 69-74.

6. Xue Peng, Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, “Turn on-off” fluorescent sensor for protamine and heparin based on label-free silicon quantum dots coupled with gold nanoparticles, Sensors and Actuators B: Chemical, 2015, 213, 131-138.

7. Biao Gu, Naxiu Mi, Youyu Zhang, Peng Yin, Haitao Li*, Shouzhuo Yao,A tetraphenylimidazole-based fluorescent probe for the detection of hydrogen sulfide and its application in living cells, Anal. Chim. Acta, 2015, DOI: 10.1016/j.aca.2015.03.017

8. Qiongqiong Wu, Qian Long, Haitao Li, Youyu Zhang*, Shouzhuo Yao, An upconversion fluorescence resonance energy transfer nanosensor for one step detection of melamine in raw milk, Talanta, 2015, 136, 47-53.

9. Qian Long, Jiangna Zhao, Bangda Yin, Haitao Li, Youyu Zhang*, Shouzhuo Yao，A novel label-free upconversion fluorescence resonance energy transfer-nanosensor for ultrasensitive detection of protamine and heparin，Analytical Biochemistry, 2015, DOI: 10.1016/j.ab.2015.02.017
2014

10. Qiong Chen, Meiling Liu, Jiangna Zhao, Xue Peng, Xiaojiao Chen, Naxiu Mi, Bangda Yin, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Water-Dispersible Silicon Dots as Peroxidase Mimetics for the Highly-Sensitive Colorimetric Detection of Glucose, Chem. Commun., 2014, 50, 6771-6774.

11. Jianhui Deng, Qiujun Lu, Naxiu Mi, Haitao Li, Meiling Liu, Mancai Xu, Liang Tan, Qingji Xie, Youyu Zhang*, Shouzuo Yao, Electrochemical Synthesis of Carbon Nanodots directly from Alcohols, Chem. Eur. J, 2014, 20, 4993-4999.

12. Meiling Liu, Liping Wang, Yue Meng, Youyu Zhang*, Haitao Li, Shouzhuo Yao, (4-ferrocenylethyne) phenylamine Functionalized Graphene Oxide Modified for Sensitive Nitrite Sensing, Electrochim Acta, 2014, 116, 504-511.

13. Jiangna Zhao, Jianhui Deng, Yinhui Yi, Haitai Li, Youyu Zhang*, Shouzhuo Yao, Label-free Si quantum dots as fluorescent probe for selective and sensitive detection of copper ions, Talanta, 2014, 125, 372-377.

14. Chang Liu, Youming Shen, Peng Yin, Lidong Li, Youyu Zhang, Haitao Li*, and Shouzhuo Yao, Sensitive detection of acetylcholine based on a novel boronate intramolecular charge transfer fluorescence probe, Analytical Biochemistry, 2014, 465, 172-178.

15. Youming Shen, Youyu Zhang*, Xiangyang Zhang, Chunxiang Zhang, Linli Zhang, Junling Jin, Haitao Li, Shouzhuo Yao, A new turn-on fluorescent sensor based on NBD for highly selective detection of Hg²⁺ in aqueous media and imaging in live cells, Anal. Method, 2014, 6, 4797-4802.

2013及以前

16. Yinhui Yi, Gangbing Zhu, Chang Liu,Yan Huang, Youyu Zhang*, Haitao Li, Jiangna Zhao, Shouzhuo Yao, A Label-free Silicon Quantum Dots-Based Photoluminescence Sensor for Ultrasensitive Detection of Pesticides, Anal. Chem., 2013, 85, 11464–11470.

17. Yinhui Yi, Jianhui Deng, Youyu Zhang*, Haitao Li, Shouzhuo Yao, Label-free Si Quantum Dots as Photoluminescence Probe for Glucose Detection, Chem. Commun., 2013, 49, 612-614.

18. Meiling Liu, Qiong Chen,Cailang Lai, Youyu Zhang,Jianhui Deng, Haitao Li^*,Shouzhuo Yao, A double signal amplification platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a nanocomposite of ferrocene thiolate stabilized Fe₃O₄@Au nanoparticles with graphene sheet , Biosensor and Bioelectronics, 2013, 48, 75-81.

19. Meiling Liu,Jianhui Deng, Qiong Chen, Yan Huang, Linping Wang,Yan Zhao, Youyu Zhang^*,Haitao Li, Shouzhuo Yao^*, Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes, Biosensor and Bioelectronics, 2013, 41, 275-281.

20. Jie Zhao, Youyu Zhang*, Haitao Li, Yanqing Wen, Xiaoyu Fan, Fanbo Lin, Liang Tan, Shouzhuo Yao, Ultrasensitive electrochemical aptasensor for thrombin based on the amplification of aptamer-AuNPs-HRP conjugates, Biosensor and Bioelectronics, 2011, 26, 2297-2303.

21. Min Ye, Youyu Zhang*, Haitao Li, Yuqin Zhang, Ping Tan, Hao Tang, Shouzhuo Yao, A novel method for the detection of point mutation in DNA using single-base-coded CdS nanoprobes, Biosensors and Bioelectronics, 2009, 24, 2339-2345.

22. Mingjie Wei, Peng Yin, Youming Shen, Lingli Zhang, Jianhui Deng, Shanyan Xue, Haitao Li, Bin Guo, Youyu Zhang*, Shouzhuo Yao, A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells, Chem. Commun., 2013, 49, 4640-4642.

23. Meiling Liu,linping Wang,Jianhui Deng,Qiong Chen, Yuzhen Li, Youyu Zhang,Haitao Li^*, Shouzhuo Yao^*, Highly sensitive and selective dopamine biosensor based on a phenylethynyl ferrocene/graphene nanocomposite modified electrode, Analyst, 2012, 137, 4577-4583.

24. Bangda Yin, Jianhui Deng, Xue Peng, Qian Long, Jiangna Zhao, Qiujun Lu, Qiong Chen, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Green Synthesis of Carbon Dots with Down- and Up-conversion Fluorescent Properties for Sensitive Detection of Hypochlorite with Dual-Readout Assay. Analyst, 2013, 138 (21), 6551 - 6557.

25. Linping Wang, Yue Meng, Qiong Chen, Jianhui Deng, Youyu Zhang*, Haitao Li*, Shouzhuo Yao, Simultaneous electrochemical determination of dihydroxybenzene isomers based on the hydrophilic carbon nanoparticles and ferrocene-derivative mediator dual sensitized graphene composite, Electrochim. Acta, 2013, 92, 216-225.

26. Jie Zhao, Meiling Liu, Youyu Zhang*, Haitao Li, Yuehe Lin*, Shouzhuo Yao, Apoferritin Protein Nanoparticles Dually labeled with Aptamer and Horseradish Peroxidase as A Sensing Probe for Thrombin Detection, Anal. Chim. Acta, 2013, 759, 53-60.

27. Jie Zhao, Fanbo Lin, Yinhui Yi, Yan Huang, Haitao Li, Youyu Zhang*, Shouzhuo Yao, Dual Amplification Strategy of Highly Sensitive Thrombin Amperometric Aptasensor Based on Chitosan-Au Nanocomposites, Analyst, 2012, 137, 3488-3495.

28. Jiao Luo, Mingnan Dong, Fanbo Lin, Meiling Liu Haitao Li, Hao Tang, Youyu Zhang*, Shouzhuo Yao, Three-dimensional Network Polyamidoamine Dendrimer-Au Nanocomposites for the Construction of a Mediator-free Horseradish Peroxidase Biosensors, Analyst, 2011, 136, 4500-4506.

29. Jiangna Zhao, Yinhui Yi, Naxiu Mi, Bangda Yin, Mingjie Wei, Qiong Chen, Haitao Li, Youyu Zhang*, Shouzhuo Yao,Gold nanoparticle coupled with fluorophore for ultrasensitive detection of protamine and heparin, Talanta, 2013, 116, 951-957.

30. Yinhui Yi, Yan Huang, Gangbing Zhu, Fanbo Lin, Lingli Zhang, Haitao Li, Youyu Zhang*, .Shouzhuo Yao,A Colorimetric and Fluorescence Sensing Platform for Two Analytes in Homogenous Solution Based on Aptamer-Modified Gold Nanoparticles, Anal. Method, 2013, 5, 2477-2484.

31. Yuqin Zhang, Fanbo Lin, Youyu Zhang*, Haitao Li*, Yue Zeng, Hao Tang, Shouzhuo Yao, Quartz Crystal Microbalance Detection of DNA Single-base Mutation Based on Monobase-coded Cadmium Tellurium Nanoprobe, Anal. Sci., 2011, 27, 1229-1235.

32. Fanbo Lin, Bangda Yin, Chengzhi Li, Jianhui Deng, Xiaoyu Fan, Yinhui Yi, Chang Liu, Haitao Li*, Youyu Zhang*, Shouzhuo Yao, Fluorescence Resonance Energy Transfer Aptasensor for Platelet-derived Growth Factor Detection Based on Upconversion Nanoparticles in 30% Blood Serum, Anal. Method, 2013, 5, 699-704.

33. Haitao Li, Yuan Zhi, Fuxin Chen, Bin Liu, Bin Shen, Binglin He, Preparation and Adsorption Properties of PAM Based Adsorbents for Plasma Lipoproteins, Chin. Chem. Lett., 2004, 15, 449.

34. Qing Yang, Youyu Zhang*, Haitao Li, Yuqin Zhang, Meiling Liu, Jiao Luo, Liang Tan, Hao Tang, Shouzhuo Yao, Electrochemical copolymerization study of o-toluidine and o-aminophenol by the simultaneous EQCM and in situ FTIR spectroelectrochemisty, Talanta, 2010, 81, 664-672.

35. Jiao Luo, Meiling Liu, Qiangqin Zhao, Jie Zhao, Youyu Zhang^*, Liang Tan, Hao Tang, Qingji Xie, Haitao Li^*, Shouzhuo Yao, A study on the electro-oxidation and electropolymerization of a new OPE linear molecule by EQCM and in situ FTIR spectroelectrochemistry, Electrochim. Acta, 2010, 56, 454-462.

36. Meiling Liu^,Jianhui Deng^, Cailang Lai^, Qiong Chen^, Qiangqing Zhao, Youyu Zhang, Haitao Li^*,Shouzhuo Yao^*, Synthesis, characterization of conjugated oligo-phenylene-ethynylenes and their supramolecular interaction with beta-cyclodextrin for salicylaldehyde detection, Talanta, 2012, 100, 229-238.

37. Lingli Zhang, Naxiu Mi, Youyu Zhang*, Mingjie Wei, Haitao Li, Shouzhuo Yao, Label-freeDNA sensor forPb²⁺ based on a duplex-quadruplex exchange, Anal. Method, 2013, 5, 6100-6105.

38. Lingli Zhang, Youyu Zhang*, Mingjie Wei, Yinhui Yi, Haitao Li, Shouzhuo Yao, A label-free ?uorescent molecular switch for Cu²⁺ based on metal ion-triggered DNA-cleaving DNAzyme and DNA intercalator, New J. Chem., 2013, 37, 1252-1257.

39. Xiaoyu Fan, Haitao Li*, Jie Zhao, Fanbo Lin, Lingli Zhang, Youyu Zhang*, Shouzhuo Yao, A novel label-free fluorescent sensor for the detection of potassium ions based on DNAzyme, Talanta, 2012, 89, 57-62.

40. Xiaoyu Fan, Fanbo Lin,Youyu Zhang*, Jiangna Zhao, Haitao Li, Shouzhuo Yao, A simple adenosine fluorescent aptasensor based on the quenching ability of guanine, New J. Chem., 2012, 36, 2260-2265.

41. Hongyu Wu, Cailang Lai, Haitao Li*, Youyu Zhang*,Structure Modulation of New Mesostructured Silica Vesicles, Chinese Journal of Inorganic Chemistry, 2012, 28, 257-262.

42. Linping Wang, Meiling Liu, Yue Meng, Yan zhao, Jianhui Deng, Youyu Zhang*, Haitao Li*, Shouzhuo Yao, (4-Ferrocenylethyne) phenylamine on Graphene as the Signal Amplificator to Determinate Dopamine and Acetaminophen Simultaneously, Chin. J. Chem., 2013, 31, 845-854.

43. Haitao Li, Yinchun Jiao, Mancai Xu, Zuoqing Shi, Binqlin He, Thermodynamics aspect of tannin sorption on polymeric adsorbents. Polymer, 2004, 45, 181.

44. Hait Li, Mancai Xu, Zhuoqin Shi, Binglin He, Isotherm analysis of phenol adsorption on polymeric adsorbent from non-aqueous solution. J. Coll. Inter. Sci., 2004, 271, 47.

45. Haitao Li, Yumei Zhang, Xinfu Chen, Keyu Shi, Zhi Yuan, Bin Liu, Bin Shen, Binglin He, Synthesis and adsorption aspect of crosslinked PVA-based blood compatible adsorbents for LDL aphaeresis. React. Func. Polym., 2004, 58, 53.

46. Haitao Li, Yuan Zhi, Fuxin Chen, Bin Liu, Bin Shen, Binglin He, Preparation and Adsorption Properties of PAM Based Adsorbents for Plasma Lipoproteins, Chin. Chem. Lett., 2004, 15, 449.

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