王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职



研究方向
[1].天然药物化学、微生物学、质谱学、计算化学

个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.


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王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

论文成果

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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---

王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

科研项目

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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---

王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

著作成果

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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---

王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

专利成果

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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---

王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

教学成果

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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---

王文宣 学位：博士学位
职称：特聘副教授
所在单位：湘雅药学院

特聘副教授
入职时间：2016-09-01
所在单位：湘雅药学院
学历：博士研究生毕业
性别：男
联系方式： 电子邮箱：wenxuanwang@tom.com
学位：博士学位
在职信息：在职

获奖信息

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个人简介
主要从事微生物天然药物的生物活性成分研究，利用质谱、核磁共振、计算化学、计算机辅助药物设计等多学科的技术交叉融合，研究开发抗肿瘤、抗微生物、免疫抑制等创新药物。在科研上对各学科的新兴技术有浓厚兴趣，积极探索药物开发的新思路新方法。目前已经发表SCI论文数十篇，其中在天然药物化学顶级期刊Organic Letters、Journal of Natural Product、Organic Biomolecular Chemistry上发表论文6篇。
代表论文
1. Curtachalasans, immunosuppressive agents from endophytic fungus Xylaria cf. curta. Wen-Xuan Wang; Gui-Guang Cheng; Zheng-Hui Li; Hong-Lian Ai; Juan He; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic & Biomolecular Chemistry, 2019, 17: 7985-7994.
2. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans. Wen-Xuan Wang; Xinxiang Lei; Hong-Lian Ai*; Xue Bai; Jing Li; Juan He; Zheng-Hui Li; Yong-Sheng Zheng; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21: 1108-1111.
3. Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Wen-Xuan Wang; Xinxiang Lei; Yan-Ling Yang; Zheng-Hui Li; Hong-Lian Ai; Jing Li*; Tao Feng*; Ji-Kai Liu*. Organic letters, 2019, 21(17): 6957-6960.
4. Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10. Wen-Xuan Wang; Zheng-Hui Li; Tao Feng; Jing Li; Huan Sun; Rong Huang; Qing-Xia Yuan; Hong-Lian Ai*; Ji-Kai Liu*. Organic Letters, 2018, 20(24): 7758-7761.
5. Xylaridines C and D, Unusual Thiopyranodipyridine Alkaloids from the Fungus Xylaria longipes. Jing Li; Wen-Xuan Wang*; Zheng-Hui Li; Juan He; Rong Huang; Yong-Sheng Zheng; Lan-Qing Li; Xian Wang; Tao Feng*; Ji-Kai Liu*. Organic Letters, 2019, 21(15): 6145-6148.



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