丁劲松,1972年2月生
教授,博导
药剂学系主任
电话(0731)**
传真(0731)**
Email:dingjs0221@163.com
教育经历:
1990-1994华西医科大学药学院(现四川大学华西药学院)药学专业,获学士学位
1997-2000华西医科大学药学院(现四川大学华西药学院)药剂学专业,获硕士学位
2003-2007中南大学药学院药理学专业(生物药剂学方向),获博士学位
工作经历:
1994-1995湖南医科大学湘雅医院(现中南大学湘雅医院),进修
1995-1997湖南医科大学附三院(现中南大学湘雅三医院)
2000-2004中南大学湘雅二医院
2004-至今中南大学药学院药剂学系
课题组:
http://yxy.csu.edu.cn/info/1105/2191.htm
研究领域:
应用基础研究:核酸适配体介导药物及诊断试剂纳米粒靶向传递系统研究
应用研究:缓控释制剂、药物经皮肤传递系统的研究,药物新剂型的研究与开发
研究生规模:在读研究生约15人。每年招收硕士生2-4名,博士生1-2名。
主要业绩与社会兼职:
主持国家重大新药创制科技专项课题、省科技厅科技计划重点项目、市重点科技项目等科研项目6项,完成国家新药药学研究和临床研究项目共50余项,申请专利7项。近5年发表论文80余篇,参编专著2部、主编(副)/参编教材7部。《解放军医学杂志》、《中国医院药学杂志》、《中南药学》、《中国药剂学杂志》、《儿科药学杂志》等杂志(通讯)编委。中国药学会纳米药物专业委员会委员,湖南省药物安全评价协会理事,湖南省新药审评专家库成员,湖南省药用辅料战略联盟副秘书长。
在研课题:
1.国家十二五重大专项,2012ZX** -051,基于Procaspase-3激活的1.1类抗肺癌新药SM-1的成药性研究,起止年限:2012.1-2015.12,总经费:489万元,在研。主持。
2. 国家十二五重大专项,2012ZX**-001),感冒灵颗粒组方合理性研究课题组经费,起止年限:2012.1-2015.12,:主持子任务:药动学观点评价处方合理性,139万元,
3.深圳市重大产业技术攻关计划,SW**,难溶型药物胃肠道缓释递药系统产业化成型与评价的关键技术研究。起止年限:2012.1-2014.12 ,总经费700万元,第二主持人(联合申报)。
代表论文(IF值为最新数据):
[1]Wenhu Zhou, Jinsong Ding* and Juewen Liu*.Platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold. Chem Commun, 2015, DOI: 10.1039/C5CC04340A(IF=6.834)
[2] Zhou W, Chen Q, Huang PJ, Ding J*, Liu J*. DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum.Anal Chem,2015, Apr 7;87(7):4001-7(IF=5.636)
[3]Zhenbao Liu, Huanzhe Zhao, Lingyun He, Yanbin Zhou, Jianping Wu, Juewen Liu*and Jinsong Ding*. Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells.RSC Advances, 2015, 5(22), 16931-9(IF=3.840)
[4] Jing Tang, Zhenbao Liu, Yue Zhang, Ling Wang, Dai Li, Jinsong Ding*, Xuehua Jiang* .Fluorofenidone-loaded PLGA microspheres for targeted treatment of paraquat-induced acute lung injury in rats. RSC Advances, 2015, 5, 30153-30159(IF=3.840)
[5]Liu Z, Chen S, Liu B, Wu J, Zhou Y, He L, Ding J*andLiu J* .Intracellular Detection of ATP Using an Aptamer Beacon Covalently Linked to Graphene Oxide Resisting Nonspecific Probe Displacement,Anal Chem.2014, 86(24):12229-35(IF=5.636)
[6]Zhou W,Wang F,Ding J*and Liu J*.Tandem phosphorothioate modifications for DNA adsorption strength and polarity control on gold nanoparticles. ACS Appl Mater Interfaces. 2014, 6(17):14795-00.(IF=6.723)
[7]Zhou W, Huang PJ, Ding J*and Liu J*.Aptamer-based biosensors for biomedical diagnostics. Analyst,2014,139(11): 2627-2640. ( IF=4.107)
[8]Liu Z,Liu B,Ding Jand Liu J*.Fluorescent sensors using DNA-functionalized graphene oxide. Anal Bioanal Chem, 2014, 406(27):6885-902 (IF=3.436)
[9]Zhou W,Zhou Y,Wu J,Liu Z,Zhao H,Liu J*,Ding J*.Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells.J Drug Target, 2014, 22(1):57-66. (IF=2.741)
[10]Zhou W,He S,Yang Y,Jian D,Chen X* and Ding J*.Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma. Drug Dev Ind Pharm, 2014:1-11. (IF=2.101)
[11]Xu S,Peng J,Li Y,He L,Chen F,Zhang JandDing J*.Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats. JEthnopharmacol,2012, 139(2):395-400. (IF=2.998)
[12] Chen F,Li S,Li D and Ding JS*.Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo. Fitoterapia, 2012, 83(5):954-960. (IF=2.345)
[13]High-Performance Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Trospium Chloride in Human Plasma and Its Application in a Bioequivalence Study. Anal Lett,2011,44(4): 607-616.(IF=1.030)
[14]Ding JS, Gao R, Li D, Peng J, Ran LL, Li YJ. Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats. Biopharm Drug Dispos, 2008, 29(9):495-500. (IF=2.340)
[15] Quantification of Teprenone in Human Plasma by HPLC Coupled to Mass Spectrometry Application to a Bioequivalence Study. Chromatographia, 2007, 65(9-10): 533-538. (IF=1.411)