姓名

蓝宇

性别

男

出生年月

1981.1

职称

教授

民族

汉族

籍 贯

河北丰南

电子邮箱

Lanyu@zzu.edu.cn

最终学位

理学博士

学术头衔/兼职

2017年河南省特聘教授

2018年国家优秀青年基金

研究方向

理论有机化学、计算有机化学、金属有机化学

主要学习、科研和工作经历

2018至今 郑州大学 博士生导师/教授

2012~2018 重庆大学 博士生导师/特聘研究员/教授

2009~2012 Univ. of California, Los Angeles 博士后（导师K. N. Houk教授）

2003~2008 北京大学 博士研究生 （导师吴云东教授）

1999~2003 北京大学 本科

代表性

教学成果与荣誉

代表性

科研成果

一、科研项目

(1) 2019~2021 自然科学基金优秀青年基金项目 《理论有机化学》130万，基金号**（主持）

(2) 2018~2021 自然科学基金面上项目 《铜催化偶联反应中Cu(III)中间体生成机制的理论研究》64万，基金号**（主持）

(3) 2014~2017 自然科学基金面上项目 《铑催化碳-硅键、碳-碳键断裂生成机理的理论研究》80万，基金号**（主持）

(4) 2014~2016 自然科学基金青年项目 《单层石墨烯化学方法修饰的理论研究》25万，基金号**（主持）

二、论文论著

(56) “A unified approach for divergent synthesis of contiguous stereodiads employing a small boronyl group” Zhan, M.; Ding, Z.; Du, S.; Chen, H.; Feng, C.; Xu, M.; Liu, Z.; Zhang, M.; Wu, C.; Lan, Y.*; Li, P.* Nat. Commun. 2020, 11, 792. (DOI: 10.1038/s41467-020-14592-7)

(55) “Nucleophilicity versus Brønsted basicity controlled chemoselectivity: mechanistic insight into silver- or scandium-catalyzed diazo functionalization” Liu, F.; Zhu, L.; Zhang, T.; Zhong, K.; Xiong, Q.; Shen, B.; Liu, S.; Lan, Y.*; Bai, R.* ACS Catal. 2020, 10, 1256-1263. (DOI: 10.1021/acscatal.9b02040)

(54) “Reaction Scope and Mechanistic Insights of Nickel-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling” Li, Y.; Luo, Y.; Peng, L.; Li, Y.; Zhao, B.; Wang, W.; Pang, H.; Deng, Y.; Bai, R.; Lan, Y.*; Yin, G.* Nat. Commun. 2020, 11, 147. (DOI: 10.1038/s41467-019-14016-1)

(53) “Highly Selective and Catalytic Generation of Acyclic Quaternary Carbon Stereocenters via Functionalization of 1,3-Dienes with CO₂” Chen, X.-W.; Zhu, L.; Gui, Y.-Y.; Jing, K.; Jiang, Y.-X.; Bo, Z.-Y.; Lan, Y.*, Li, J.; Yu, D.-G.* J. Am. Chem. Soc. 2019, 141, 18825-18835. (DOI: 10.1021/jacs.9b09721)

(52) “Unveiling How Intramolecular Stacking Modes of Covalently Linked Dimers Dictate Photoswitching Properties” Lu, R.-Q.; Yan, X.-Y.; Zhu, L.; Yang, L.-L.; Qu, H.; Wang, X.-C.*; Luo, M.; Wang, Y.; Chen, R.; Wang, X.-Y.; Lan, Y.*; Pei, J.; Weng, W.; Xia, H.; Cao, X.-Y.* Nat. Commun. 2019, 10, 5480. (DOI: 10.1038/s41467-019-13428-3)

(51) “Enantiodivergence by Minimal Modification of an Acyclic Chiral Secondary Aminocatalyst” Dai, J.; Wang, Z.; Deng, Y.; Zhu, L.; Peng, F.; Lan, Y.*; Shao, Z.* Nat. Commun. 2019, 10, 5182. (DOI: 10.1038/s41467-019-13183-5)

(50) “Oxidative Addition Promoted C−C Bond Cleavage in Rh-Mediated Cyclopropenone Activation: A DFT Study” Luo, Y.; Shan, C.; Liu, S.; Zhang, T.; Zhu, L.; Zhong, K.; Bai, R.*; Lan, Y.* ACS Catal. 2019, 9, 10876-10886. (DOI: 10.1021/acscatal.9b03361)

(49) “Unmasking the Ligand Effect in Manganese-Catalyzed Hydrogenations: Mechanistic Insight and Catalytic Application” Wang, Y.; Zhu, L.; Shao, Z.; Li, G.; Lan, Y.*; Liu, Q.* J. Am. Chem. Soc. 2019, 141, 17337-17349. (DOI: 10.1021/jacs.9b09038)

(48) “Origin of Regiochemical Control in Rh(III)/Rh(V)-Catalyzed Reactions of Unsaturated Oximes and Alkenes to Form Pyrdines” Li, Y.; Chen, H.; Qu, L.-B.; Houk, K. N.*; Lan, Y.* ACS Catal. 2019, 9, 7154-7165. (DOI: 10.1021/acscatal.9b02085)

(47) “Mechanism of Rhodium Catalyzed Desymmetrization by Hydroacylation: A DFT Study” Luo, X.; Peng, J.; Liu, S.; Zhong, K.; Zhang, T.; Chen, R.; Lan, Y.* Sci. Sin. Chem. 2019, 49, 1094-1103. (DOI: 10.1360/SSC-2019-0051)

(46) “Inverse Electron-Demand, Pd-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding” Wang, Y.-N.; Xiong, Q.; Lu, L.-Q.*; Zhang, Q.-L.; Wang, Y.; Lan, Y.*; Xiao, W.-J.* Angew. Chem. Int. Ed. 2019, 58, 11013-11017. (DOI: 10.1002/anie.**3)

(45) “S₈-Catalyzed Triple Cleavage of Bromodifluoro Compounds for the Assembly of N-containing Heterocycles” Deng, S.; Chen, H.; Ma, X.; Zhou, Y.; Yang, K.; Lan, Y.*; Song, Q.* Chem. Sci. 2019, 10, 6828-6833. (DOI: 10.1039/c9sc01333d)

(44) “Key Intermediate in Copper-Mediated Arene Trifluoromethylation [nBu₄N][Cu(Ar)(CF₃)₃]: Synthesis, Characterization and C(sp²)-CF₃ Reductive Elimination” Lu, Z.; Liu, H.; Liu, S.; Leng, X.; Lan, Y.*; Shen, Q.* Angew. Chem. Int. Ed. 2019, 58, 8510-8514. (DOI: 10.1002/anie.**1)

(43) “Theoretical Study of the Addition of Cu–Carbenes to Acetylenes to Form Chiral Allenes” Zhong, K.; Shan, C.; Zhu, L.; Liu, S.; Zhang, T.; Liu, F.; Shen, B.; Lan, Y.*; Bai, R.* J. Am. Chem. Soc. 2019, 141, 5227-5280. (DOI: 10.1021/jacs.8b13055)

(42) “Enantioselective Synthesis of Biaryl Atropisomers via Pd‐Catalyzed C–H Olefination using Chiral Spiro Phosphoric Acid Ligands” Luo, J.; Zhang, T.; Wang, L.; Liao, G.; Yao, Q.-J.; Wu, Y.-J.; Zhan, B.-B.; Lan, Y.*; Lin, X.-F.*; Shi, B.-F.* Angew. Chem. Int. Ed. 2019, 58, 6708-6712. (DOI: 10.1002/anie.**6)

(41) “Asymmetric Propargylic Radical Cyanation Enabled by Dual Organophotoredox and Copper Catalysis” Lu, F.-D.; Liu, D.; Zhu, L.; Lu, L.-Q.*; Yang, Q.; Zhou, Q.-Q.; Wei, Y.; Lan, Y.*; Xiao, W.-J.* J. Am. Chem. Soc. 2019, 141, 6167-6172. (DOI: 10.1021/jacs.9b02338)

(40) “Kinetic Resolution of Allylic Alcohol with Chiral BINOL-based Alkoxides: A Combination of Experimental and Theoretical Studies” Liu, Y.; Liu, S.; Li, D.; Zhang, N.; Peng, L.; Ao, J.; Eui, C.; Lan, Y.*; Yan, H. J. Am. Chem. Soc. 2019, 141, 1150-1159. (DOI: 10.1021/jacs.8b12796)

(39) “Computational Advances Aiding Mechanistic Understanding of Silver-Catalyzed Carbene/Nitrene/Silylene Transfer Reactions” Zhang, J.; Shan, C.; Zhang, T.; Liu, T.*; Song, J.*; Lan, Y.* Coor. Chem. Rev. 2019, 382, 69-84. (DOI: 10.1016/j.ccr.2018.12.009)

(38) “Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study” Xiong, Y.; Du, Z.; Chen, H.; Yang, Z.; Tan, Q.; Zhang, C.; Zhu, L.; Lan, Y.*; Zhang, M.* J. Am. Chem. Soc. 2019, 141, 961-971. (DOI: 10.1021/jacs.8b10939)

(37) “Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of Ethylene” Li, J.; Luo, Y.; Cheo, H. W.; Lan, Y.*; Wu, J.* Chem 2019, 5, 192-203. (DOI: 10.1016/j.chempr.2018.10.006)

(36) “Mechanistic View of Ru-Catalyzed C–H Bond Activation and Functionalization: Computational Advances” Shan, C.; Zhu, L.; Qu, L.-B.; Bai, R.*; Lan, Y.* Chem. Soc. Rev. 2018, 47, 7552-7576. (DOI: 10.1039/c8cs00036k)

(35) “Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C−H/C−H Coupling of Phenols with Aromatic Amides Using Air as Oxidant: Scope, Synthetic Applications and Mechanistic Insights” Zhang, L.; Zhu, L.; Zhang, Y.; Yang, Y.; Wu, Y.; Ma, W.; Lan, Y.*; You, J.* ACS Catal. 2018, 8, 8324-8335. (DOI: 10.1021/acscatal.8b02816)

(34) “Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2” Yan, S.-S.; Zhu, L.; Ye, J.-H.; Zhang, Z.; Huang, H.; Zeng, H.; Li, C.-J.*; Lan, Y.*; Yu, D.-G.* Chem. Sci. 2018, 9, 4873-4878. (DOI: 10.1039/c8sc01299g)

(33) “Author Profile” Lan, Yu* Angew. Chem. Int. Ed. 2018, 57, 11852. (DOI: 10.1002/anie.**5)

(32) “Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives” Yuan, C.; Zhu, L.; Chen, C.; Chen, X.; Yang, Y.; Lan, Y.*; Zhao, Y.* Nat. Commun. 2018, 9, 1189. (DOI: 10.1038/s41467-018-03341-6)

(31) “Regioselective Palladium-Catalyzed C‑H Bond Trifluoroethylation of Indoles: Exploration and Mechanistic Insight” Zhang, H.; Wang, H.-Y.; Luo, Y.; Chen, C.; Cao, Y.; Chen, P.; Guo, Y.-L.; Lan, Y.*; Liu, G.* ACS Catal. 2018, 8, 2173-2180. (DOI: 10.1021/acscatal.7b03220)

(30) “Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF₃O^- Palladation Initiated by Pd(IV)” Chen, C.; Luo, Y.; Fu, L.; Chen, P.; Lan, Y.*; Liu, G.* J. Am. Chem. Soc. 2018, 140, 1207-1210. (DOI: 10.1021/jacs.7b11470)

(29) “Ruthenium(II)-catalyzed C-H Difluoromethylation of Ketoxime: Tuning the Regioselectivity from meta to para Position” Yuan, C.; Zhu, L.; Zeng, R.; Lan, Y.*; Zhao, Y.* Angew. Chem. Int. Ed. 2018, 57, 1277-1281. (DOI: 10.1002/anie.**1)

(28) “Mechanism of Rhodium-Catalyzed C−H Functionalization: Advances in Theoretical Investigation” Qi, X.; Li, Y.; Bai, R.; Lan, Y.* Acc. Chem. Res. 2017, 50, 2799-2808. (DOI: 10.1021/acs.accounts.7b00400)

(27) “Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO₂” Ye. J.-H.; Zhu, L.; Yan, S.-S.; Miao, M.; Zhang, X.-C.; Zhou, W.-J.; Li, J.; Lan, Y.*; Yu, D.-G.* ACS Catal. 2017, 7, 8324-8330. (DOI: 10.1021/acscatal.7b02533)

(26) “Rhodium/Copper Cocatalyzed Highly trans-Selective 1,2- Diheteroarylation of Alkynes with Azoles via C−H Addition/Oxidative Cross-Coupling: A Combined Experimental and Theoretical Study” Tan, G.; Zhu, L.; Liao, X.; Lan, Y.*; You, J.* J. Am. Chem. Soc. 2017, 139, 15724-15737. (DOI: 10.1021/jacs.7b07242)

(25) “Nine-Membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.; Yang, L.-C.; Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.*; Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (DOI: 10.1021/jacs.7b09161)

(24) “Cp*CoIII-Catalyzed Branch-Selective Hydroarylation of Alkynes via C−H Activation: Efficient Access to α-gem-Vinylindoles” Zhou, X.; Luo, Y.; Kong, L.; Xu, Y.; Zheng, G.; Lan, Y.*; Li, X.* ACS Catal. 2017, 7, 7296-7304. (DOI: 10.1021/acscatal.7b02248)

(23) “Catalyst-controlled regioselectivity in phosphine catalysis: the synthesis of spirocyclic benzofuranones via regiodivergent [3+2] annulations of aurones and an allenoate” Ni, H.; Yu, Z.; Yao, W.; Lan, Y.*; Ullah, N.*; Lu, Y.* Chem. Sci. 2017, 8, 5699-5704. (DOI: 10.1039/c7sc02176c)

(22) “Chiral phosphine-mediated intramolecular [3+2] annulation: enhanced enantioselectivity by achiral Brønsted acid” Yao, W.; Yu, Z.; Wen, S.; Ni, H.; Ullah, N.*; Lan, Y.*; Lu, Y.* Chem. Sci. 2017, 8, 5196-5200. (DOI: 10.1039/c7sc00952f)

(21) “Bioinspired Total Synthesis of Homodimericin A” Huang, J.; Gu, Y.; Guo, K.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 7890-7894. ( DOI: 10.1002/anie.**8)

(20) “Bioinspired Asymmetric Synthesis of Hispidanin A” Li, F.; Tu, Q.; Chen, S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 5844-5848. (DOI: 0.1002/anie.**8)

(19) “C−O Functionalization of α‑Oxyboronates: A Deoxygenative gemDiborylation and gem-Silylborylation of Aldehydes and Ketones” Wang, L.; Zhang, T.; Sun, W.; He, Z.; Xia, C.; Lan, Y.*; Liu, C.* J. Am. Chem. Soc. 2017, 139, 5257-5264. (DOI: 10.1021/jacs.7b02518)

(18) “Regioselective -Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins” Wu, B.; Yu, Z.; Gao, X.; Lan, Y.*; Zhou, Y.* Angew. Chem. Int. Ed. 2017, 56, 4006-4010. (DOI:10.1002/anie.**7)

(17) “Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A” Han, Y.; Jiang, Y.; Li, Y.; Yu, H.; Tong, B.; Niu, Z.; Zhou, S.; Liu, S.; Lan, Y.;* Chen, J.;* Yang, Z.;* Nat. Commun. 2017, 8, 14233. (DOI: 10.1038/ncomms14233)

(16) “Mild Acylation of C(sp3)−H and C(sp2)−H Bonds under Redox-Neutral Rh(III) Catalysis” Yu, S.; Li, Y.; Kong, L.; Zhou, X.; Tang, G.; Lan, Y.;* Li, X.* ACS Catal. 2016, 6, 7744-7748. (DOI: 10.1021/acscatal.6b02668)

(15) “Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity are Influenced by the Hydrogen Donor” Pan, H. J.; Zhang, Y.; Shan, C.; Yu, Z.; Lan, Y.;* Zhao, Y.* Angew. Chem. Int. Ed. 2016, 55, 9615-9619. (DOI:10.1002/anie.**5)

(14) “Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp³)-H and C(sp²)-H under Rhodium(III) Catalysis” Yu, S.; Tang, G.; Li, Y.; Zhou, X.; Lan, Y.;* Li, X.* Angew. Chem. Int. Ed. 2016, 55, 8696-8700. (DOI: 10.1002/anie.**4)

(13) “Rhodium(III)-Catalyzed Annulation between N‑Sulfinyl Ketoimines and Activated Olefins: C−H Activation Assisted by an Oxidizing N−S Bond” Wang, Q.; Li, Y.; Qi, Z.; Xie, F.; Lan, Y.*; Li, X.* ACS Catal. 2016, 6, 1971-1980. (DOI: 10.1021/acscatal.5b02297)

(12) “Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates” Wang, Q.; Qi, X.; Lu, L. Q.*; Li, T. R.; Yuan, Z. G.; Zhang, K.; Li, B. J.; Lan, Y.*; Xiao, W. J.* Angew. Chem. Int. Ed. 2016, 55, 2840-2844. (DOI: 10.1002/anie.**3)

(11) “Regiodivergent Enantioselective γ‑Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α‑Amino Acids and N,O‑Acetal Derivatives” Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.*; Lu, Y.* J. Am. Chem. Soc. 2016, 138, 265-271. (DOI: 10.1021/jacs.5b10524)

(10) “Silver Migration Facilitates Isocyanide-Alkyne [3+2] Cycloaddition Reactions: Combined Experimental and Theoretical Study” Qi, X.; Zhang, H.; Shao, A.; Zhu, L.; Xu, T.; Gao, M.*; Liu, C.*; Lan, Y.* ACS Catal. 2015, 5, 6640-6647. ( DOI: 10.1021/acscatal.5b02009)

(9) “Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction” Fu, J.; Gu, Y.; Yuan, H.; Luo, T.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2015, 6, 8617. (DOI: 10.1038/ncomms9617)

(8) “Highly enantioselective construction of tertiary thioethers and alcohols via phosphine-catalyzed asymmetric γ-addition reactions of 5H-thiazol-4-ones and 5H-oxazol-4-ones: scope and mechanistic understandings” Wang, T.; Yu, Z.; Hoon, D. L.; Huang, K.-W.; Lan, Y.*; Lu, Y.* Chem. Sci. 2015, 6, 4912-4922. (DOI: 10.1039/c5sc01614b)

(7) “Nickel-Catalyzed Selective Oxidative Radical Cross-Coupling: An Effective Strategy for Inert Csp³−H Functionalization” Liu, D.; Li, Y.; Qi, X.; Liu, C.; Lan, Y.*; Lei, A.* Org. Lett. 2015, 17, 998-1001. (DOI: 10.1021/acs.orglett.5b00104)

(6) “Transition-Metal-Free Formal Decarboxylative Coupling of a-Oxocarboxylates with a-Bromoketones under Neutral Conditions: A Simple Access to 1,3-Diketones” He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.*; Lan, Y.*; Wu, Y.; Lan, J.; You, J.* Angew. Chem. Int. Ed. 2015, 54, 855-859. (DOI: 10.1002/anie.**1)

(5) “Rhodium-Catalyzed C−H Activation of Phenacyl Ammonium Salts Assisted by an Oxidizing C−N Bond: A Combination of Experimental and Theoretical Studies” Yu, S.; Liu, S.; Lan, Y.*; Wan, B.*; Li, X.* J. Am. Chem. Soc. 2015, 137, 1623-1631. (DOI: 10.1021/ja511796h)

(4) “Chemoselective Carbophilic Addition of a-Diazoesters through Ligand-Controlled Gold Catalysis” Xi, Y.; Su, Y.; Yu, Z.; Dong, B.; McClain, E. J.; Lan, Y.*; Shi, X.* Angew. Chem. Int. Ed. 2014, 53, 9817-9821. (DOI: 10.1002/anie.**6)

(3) “Visible-Light-Mediated Decarboxylation/Oxidative Amidation of α-Keto Acids with Amines under Mild Reaction Conditions Using O₂” Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R.; Qi, X.; Lan, Y.*; Lei, A.* Angew. Chem. Int. Ed. 2014, 53, 502-506. (DOI: 10.1002/anie.**4)

(2) “Cu(II)−Cu(I) Synergistic Cooperation to Lead the Alkyne C−H Activation” Bai, R.; Zhang, G.; Yi, H.; Huang, Z.; Qi, X.; Liu, C.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lan, Y.*; Lei, A.* J. Am. Chem. Soc. 2014, 136, 16760-16763. (DOI: 10.1021/ja**)

(1) “Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition” Long, R.; Huang, J.; Shao, W.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2014, 5, 5707. (DOI: 10.1038/ncomms6707)

三、科技奖励

2019 ACP LECTURESHIP AWARD

2019年河南省高校科技创新人才

2019年中国青年化学家元素周期表（中国化学会）代言“钽”

2018年重庆市自然科学奖：一等奖 第一完成人

2016年中国化学会青年化学奖