周小山 教授


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周小山 教授，男，1974年出生，博士，硕士研究生导师。1998年毕业于河南医科大学获医学学士学位，2001年毕业于郑州大学获医学硕士学位，2004毕业于中国协和医科大学获得博士学位。2004年至2005年，作为讲师，工作于郑州大学公共卫生学院。2005年赴瑞典卡罗林斯卡大学线粒体疾病中心从事博士后工作。在此期间主要从事线粒体相关遗传性疾病的研究。2008年在卡罗林斯卡大学获得助理教授职位，2010年在卡罗林斯卡大学获得资深研究员职位。2015年获得河南省****职位。目前，主要研究方向为肿瘤细胞的代谢异常及其在肿瘤防治中的应用。
代表作一览：


Zhou X, Paredes JA, Krishnan S, Curbo S, Karlsson A. The mitochondrial carrier SLC25A10 regulates cancer cell growth. Oncotarget. 2015 Apr 20;6(11):9271-83.
Krishnan S, Paredes JA, Zhou X, Kuiper RV, Hultenby K, Curbo S, Karlsson A. Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances. J Biol Chem. 2014 Nov 21;289(47):32835-44.
Zhou X, Kannisto K, Curbo S, von D?beln U, Hultenby K, Isetun S, G?fvels M, Karlsson A. Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation. PLoS One. 2013;8(3):e58843.
Paredes JA, Zhou X, H?glund S, Karlsson A. Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells. PLoS One. 2013;8(1):e53698.
Krishnan S, Zhou X, Paredes JA, Kuiper RV, Curbo S, Karlsson A. Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency. J Biol Chem. 2013 Feb 15;288(7):5072-9.
Zhou X, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A. Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome. J Inherit Metab Dis. 2010 Jun;33(3):231-6.
Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P. Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. Hum Mol Genet. 2010 May 1;19(9):1669-77
Xiaoshan Zhou, Nicola Solaroli, Mia Bjerke, et al. Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice. Human Molecular Genetics, 2008, 17(15):2329-2335
Xiaoshan Zhou, Xinlai Qian Yuanzhi Lu, et al. Efficient expression of modified humanpapillomavirus 16 E6/E7 fusion protein and the anti-tumor efficacy in a mouse model. Biol Pharm Bull, 2004,27(3)：303-307
Ma Yewei, Zhou Xiaoshan, Zhao Qingzheng, et al. Inhibitory effect of a modified adenovirus type 5 E1A gene on the NF-?B activity in porcine aortic endothelial cells induced by TNF-α. Chinese Science Bulletin, 2003, 48 (1): 82~86.