细胞信号和蛋白质组学研究中心是郑州大学医学科学院的七大中心之一，中心主要围绕肿瘤信号转导、蛋白质组学和抗体研发等方面为重点展开工作，中心将基础研究与临床研究相结合，针对我国和我省多发肿瘤的特点，大力开展转化医学的研究，服务于人民和社会，为提高国民健康的水平作出贡献。主要研究内容为：（1）肿瘤信号转导相关通路在肿瘤发生发展、新的血管形成和治疗耐受中的作用及其分子机制研究；（2）重金属在肿瘤发生和新的血管生成中的作用和机制研究；（3）与临床研究人员密切合作，开发专门治疗肺癌和食管癌的药物；（4）发现肺癌和食管癌新的生物标记物，用于肺癌和食管癌的早期检测、治疗、耐药性治疗和精准医疗。
细胞信号转导和蛋白质组学研究中心依托医学科学院转化中心平台，自2017年4月初成立以来，针对我省高发肿瘤的特点，组建团队，搭建平台，开展科学研究，现有工作人员20余人，有博士学位的专职科研人员9人，主要针对肿瘤发生发展和新的血管生成分子机制展开研究。
核心骨干林李家宓教授
林李家宓教授，博士生导师，中心资深PI，先后任职于美国Vanderbilt大学、宾州州立大学、美国国立卫生研究院（NIH），参与百时美施贵宝（Bristal-Myers Squibb）公司癌症、心血管降脂药物的开发研究。多年来在功能基因组学、基因治疗，化学生物学和药物发现等领域开展了多项卓有成效的研究工作，在癌症研究、肠胃病学、肝脏病学等国际权威杂志上发表论著200余篇，H指数为37，申请获得了美国专利6项。
核心骨干王琳副教授
王琳博士，硕士生导师，直聘副教授，毕业于南京医科大学，主要从事肿瘤发生发展以及信号转导的分子机制研究；主持国家自然科学基金项目1项；主要研究成果发表在Toxicol Appl Pharmacol、Front Pharmacol、Oncogene和Sci Rep等期刊。
核心骨干张帆副教授
张帆博士，直聘副教授，毕业于西安交通大学；主要研究方向为纳米生物光谱传感技术；主持郑州大学青年教师（拔尖博士）启动基金1项；主要研究结果发表在APL, J. Mater. Chem. C和Sens. Actuat. B Chem.等国际权威期刊。
核心骨干姚亚婷副教授
姚亚婷博士，直聘副教授，毕业于中国科学院大连化学物理研究所；主要从事蛋白质组分析新技术和新方法的研究；主要研究结果发表在Analytical Chemistry、Journal of Chromatography A和Journal of Proteome Research等期刊。
核心骨干邱建阁副教授
邱建阁博士，直聘副教授，毕业于暨南大学；主要从事肿瘤发生发展及耐药机制研究和小分子抗肿瘤药物研究；主持国家自然科学基金1项和中国博士后基金面上项目1项；主要研究结果发表在Br J Pharmacol、Front Pharmacol、Pharmacol Sci和Drug Discov Today等期刊。
中心主要的科研进展：
Ø重金属在肿瘤发生和新的血管生成中的作用和机制研究
Ø与临床研究人员密切合作，开发专门治疗肺癌和食管癌的药物
Ø发现肺癌和食管癌新的生物标记物，用于肺癌和食管癌的早期检测、治疗、耐药性治疗和精准医疗
中心承担的主要项目（共计216.5万）：
Ø国家自然科学基金面上项目2项
Ø国家自然科学基金委-河南联合基金重点项目1项
Ø国家自然科学基金青年项目2项
Ø中国博士后科学基金面上项目1项
Ø河南省博士后科研启动经费1项
中心承担的合作项目
Ø中原人群多组学参比数据库项目，共计1000万
中心的代表性论著：
1.PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y,Jiang BH, Jiang T, Li H, Lu Z.Mol Cell.2019Aug 22.
2. Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis. Qian YC, Xie YX, Wang CS, Shi ZM, Jiang CF, Tang YY, Qian X, Wang L,Jiang BH. Asian J Androl.2019 Sep 6.
3. Adverse Effects Profile of Dicycloplatin (DCP) Offers Chemotherapeutic Advantage Over Cisplatin and Carboplatin. Yu JJ, Hogan T, Morley C, Crigger C, Jiao S, Williams DJ, Salkini MW, Yang X, Liang X, Yan B, Cecil C, Winn AC, Zheng J, Guo YI,Jiang BH, Washington IM.Anticancer Res.2019 Aug;39(8):4455-4462.
4. Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation. He J, Liu W, Ge X, Wang GC, Desai V, Wang S, Mu W, Bhardwaj V, Seifert E, Liu LZ, Bhushan A, Peiper SC,Jiang BH.Toxicol Appl Pharmacol.2019 Sep 1;378:114606.
5.Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth. Wang L, Qiu JG, He J, Liu WJ, Ge X, Zhou FM, Huang YX,Jiang BH, Liu LZ.Toxicol Appl Pharmacol. 2019 Sep 1;378:114603.
6.Using recursive partitioning approach to select tumor-associated antigens in immunodiagnosis of gastric adenocarcinoma. Qin J, S Wang, J Shi, Y Ma, K Wang, H Ye, X Zhang, P Wang, X Wang, C Song, L Dai, K Wang,BH Jiang, and J Zhang.Cancer Sci. 2019 Jun;110(6):1829-1841.
7. Apigenin inhibits IL-6 transcription and suppresses esophageal carcinogenesis, Jian-Ge Qiu, Lin Wang, Wen-Jing Liu, Ju-Feng Wang, Er-Jiang Zhao, Feng-Mei Zhou, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Wei Wang, Marie Chia-mi Lin, Ling-Zhi Liu, Ying-Xue Huang,Bing-Hua Jiang.Front Pharmacol.2019Sep 11;10:1002. doi: 10.3389/fphar.2019.01002.
8.Suppressor gene GRHL1 is associated with prognosis in patients with oesophageal squamous cell carcinoma.Li M, Li Z, Guan X,Qin Y.Oncol Lett. 2019 May;17(5):4313-4320.
9. Positive PD-L1 expression is predictive for patients with advanced EGFR wild-type non-small cell lung cancer treated with gemcitabine and cisplatin.Qiu Y, Jiang J, Zhang M,Qin Y.Oncol Lett. 2019 Jul;18(1):161-168.
10. Clinical efficacy and survival analysis of apatinib combined with docetaxel in advancedesophageal cancer.Li J, Jia Y, Gao Y, Chang Z, Han H, Yan J,Qin Y.Onco Targets Ther. 2019 Apr 8;12:2577-2583.
11. Endoscopic Mediastinal Lymph Node Identification and Resection Using Carbon Nanoparticles in a Porcine Model.Liu BR, Ahmed MR, He D, Zhao L, Yang W, Zhang X, Shi Y, Zhou Y, Zhang D, Chen Y, Cao Z, He D, Yuan Y, Li D. Gastroenterology. 2019 Apr;156(5):1250-1252.
12. Endoscopic full-thickness resection and endoscopic lymphadenectomy for advanced colonic cancer in an inoperable patient: first human clinical experience.Liu BR, Liu D, Ullah S, Zhao L, Zheng Q, Ullah R.Gastrointest Endosc. 2019 Sep 11.
13. Endoscopic gastroplasty as therapy for postoperative gastric distortion and stenosis.Liu BR, Liu D, Zhao LX, Ullah S, Zhou YY, Zhang JY, Ling-Jian K.Endoscopy. 2019 May;51(5):E105-E107.
14. Mucosal loss as a critical factor in esophageal stricture formation after mucosal resection: a pilot experiment in a porcine model.Liu BR, Liu D, Yang W, Ullah S, Cao Z, He D, Zhang X, Shi Y, Zhou Y, Chen Y, He D, Zhao L, Yuan Y, Li D.Surg Endosc. 2019 Apr 12.
15.Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.Liu S,Liu B.Med Sci Monit.2018 Mar 9;24:1424-1433.
16.Endoscopic submucosal dissection for gastric ectopic pancreas: a single-center experience. Zhou Y, Zhou S, Shi Y, Zheng S,Liu B.World J Surg Oncol. 2019 Apr 16;17(1):69.
17.A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery. Du B, Fan YJ, Zhao LX, Geng XY, Li L, Wu XW, Zhang K,Liu BR. J Dig Dis. 2019 Aug;20(8):383-390.
18. Endoscopic Full-thickness Resection for Gastric Subepithelial Tumors Originating From
the Muscularis Propria: A 69-Case Series. Sun M, Song J, Song X,Liu B.Surg Laparosc Endosc Percutan Tech. 2018 Feb;28(1):e12-e17.
19.Effect of the Sphingosine Kinase 1 Selective Inhibitor, PF543 on Dextran Sodium Sulfate-Induced Colitis in Mice.Sun M, Zhou Y, Shi Y,Liu B.DNA Cell Biol. 2019 Aug 29.
20.Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis.Sun M, Du B, Shi Y, Lu Y, Zhou Y,Liu B.Med Sci Monit. 2019 May 5;25:3303-3315.
21.Effect of the Sphingosine Kinase 1 Selective Inhibitor, PF543 on Dextran Sodium Sulfate-Induced Colitis in Mice.Sun M, Zhou Y, Shi Y,Liu B.DNA Cell Biol. 2019 Aug 29.
22.Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis.Sun M, Du B, Shi Y, Lu Y, Zhou Y,Liu B.Med Sci Monit. 2019 May 5;25:3303-3315.
23.Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling. Yan J, Du P, Jia Y, Chang Z, Gan S, Xu X, Wang Y,Qin Y, Kan Q.Onco Targets Ther. 2018 Jun 6;11:3323-3333.
24.miR-143 Inhibits Cell Proliferation of Gastric Cancer Cells Through Targeting GATA6. Guoping M, Ran L,Yanru Q.Oncol Res. 2018 Aug 23;26(7):1023-1029.
25.Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. Yang LL, Xu W,Yan J, Su HL, Yuan C, Li C, Zhang X, Yu ZJ, Yan YH, Yu Y, Chen Q, Wang Z, Li L, Qian S, Li GB. Medchemcomm. 2018 Dec 7;10(1):164-168.
26.Discovery of a novel six-long non-coding RNA signature predicting survival of colorectal cancer patients. Fan Q,Liu B.J Cell Biochem. 2018 Apr;119(4):3574-3585.
27.Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer. Fan Q,Liu B.Onco Targets Ther. 2018 May 1;11:2453-2466.
28.Prognostic implications of MYBL2 in resected Chinese gastric adenocarcinoma patients.Jia Y, Gao Y, Li J, Chang Z, Yan J,Qin Y.Onco Targets Ther. 2019 Feb 11;12:1129-1135.
29.Estrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer. Jiang CF, Shi ZM, Li DM, Qian YC, Ren Y, Bai XM, Xie YX, Wang L, Ge X, Liu WT, Zhen LL, Liu LZ,Jiang BH.Mol Cancer. 2018Apr 23;17(1):83.）.
30.Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis. Xin Ge, Ming-Hong Pan, Lin Wang, Wei Li, Cheng-Fei Jiang, Jun He, Khaled Mohamad, Ling-zhi Liu, Zhu-Mei Shi, Bing-Hua Jiang,Cell Death Dis.2018 Nov 13;9(11):1128.
31.Plasma miR-124 is a Promising Candidate Biomarker for Human Intracerebral Hemorrhage Stroke. Wang Z, Lu G, Sze J, Liu Y, Lin S, Yao H, Zhang J, Xie D, Liu Q, Kung HF,Lin MC, Poon WS.Mol Neurobiol. 2018 Jul;55(7):5879-5888. doi: 10.1007/s12035-017-0808-8. Epub 2017 Nov 3.
32.A Phytochemical-Based Copolymer Derived from Coriolus versicolor Polysaccharopeptides for Gene Delivery. Lai WF,Lin MC, Tang G.Molecules.2018 Sep 6; 23(9). pii: E2273. doi: 10.3390/molecules23092273.
33.LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1. Chang ZW, Jia YX, Zhang WJ, Song LJ, Gao M, Li MJ, Zhao RH, Li J, Zhong YL, Sun QZ,Qin YR. J Exp Clin Cancer Res. 2018 Mar 12;37(1):56.
34.Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells. Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH4, Lin G, Wang X, Leung KS, Kung HF, Chen C,Lin MC.Sci Report. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.
