王磊，博士，硕士生导师，河南省优秀硕士论文指导教师
办公室：生物楼413
实验室：生物楼313
联系方式：wangleibio@126.com

◆教育背景
2002/09-2006/07，信阳师范学院，本科
2006/09-2009/06 信阳师范学院，硕士 （导师：袁红雨 教授 & 刘彦明 教授）
2011/09-2014/06 复旦大学生命科学学院，博士（导师：马 红 教授）
◆工作经历
2009/09- 2011/06 复旦大学植物科学研究所， 科研助理
2014/07- 至今 信阳师范学院生命科学学院， 讲师
2016/12- 2019/12中科院生物物理研究所， 博士后 （合作导师：薛愿超 研究员）
◆研究方向
动植物基因家族的功能性进化研究
利用生物信息学手段并结合多组学测序技术，深入开展RNA结合蛋白和非编码RNA在人类疾病中的功能研究
利用先进基因编辑技术CRISPR-Cas9和单细胞测序技术开展肿瘤异质性和耐药性研究
◆研究项目（主持和主要参加）
利用转录组学解析大豆亲本和子代减数分裂细胞的差异（**7），河南省科技厅项目2016.1-2019.12，8万元，主持
Pri-miRNA加工机器的筛选及功能机制研究(**),国家自然科学基金青年项目，26万元，主持
◆获得奖励
2016 信阳师范学院青年骨干教师
2017 信阳师范学院优秀教师
2018 信阳师范学院优秀硕士研究生指导教师
2018 河南省优秀硕士研究生指导教师
2019 首届信阳师范学院研究生十佳导师
◆代表性文章(*Corresponding author, #Equal contributors)
Zhaokui Cai#, Changchang Cao#, Lei Ji#, Rong Ye, Di Wang, Cong Xia, Sui Wang, Zongchang Du, Naijing Hu, Xiaohua Yu, Juan Chen, Lei Wang, Xianguang Yang, Shunmin He & Yuanchao Xue*. (2020). Ric-seq for global in situ profiling of rna–rna spatial interactions. Nature, 1-6.(SCI IF: 43.0)
Lian, Shuaibin#*, Li, Liansheng#, Zhou, Yongjie, Liu, Zixiao, and Wang, Lei* (2019). The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers. PeerJ 7, e7696. .( SCI IF: 1.8)
Zhang, Pengpeng, Chao, Zhe, Zhang, Rui, Ding, Ruoqi, Wang, Yaling, Wu, Wei, Han, Qiu, Li, Cencen, Xu, Haixia, Wang, Lei* and Yongjie Xu* (2019). Circular RNA Regulation of Myogenesis. Cells 8, 885.( SCI IF: 5.7)
Wang, Lei#, Shi, Yan#, Chang, Xiaojun#, Jing, Shengli, Zhang, Qunjie, You, Chenjiang, Yuan, Hongyu*, and Wang, Haifeng* (2019). DNA methylome analysis provides evidence that the expansion of the tea genome is linked to TE bursts. Plant biotechnology journal 17, 826-835(SCI IF: 6.5)
Chen, Juan#, Cai, Zhaokui#, Bai, Meizhu#, Yu, Xiaohua#, Zhang, Chao#, Cao, Changchang, Hu, Xihao, Wang, Lei, Su, Ruibao, and Wang, Di (2018). The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell research 28, 981. (SCI IF: 17.8)
Zhang, Zaibao#, Ke, Danxia#, Hu, Menghui, Zhang, Chi, Deng, Lijun, Li, Yuting, Li, Jiuli, Zhao, Hai, Cheng, Lin, and Wang, Lei* and Hongyu Yuan* (2019). Quantitative phosphoproteomic analyses provide evidence for extensive phosphorylation of regulatory proteins in the rhizobia–legume symbiosis. Plant molecular biology 100, 265-283.( SCI IF: 2.9)
Han, Yapeng, Li, Xiangyong, Cheng, Lin, Liu, Yanchun, Wang, Hui, Ke, Danxia, Yuan, Hongyu, Zhang, Liangsheng, and Wang, Lei* (2016). Genome-wide analysis of soybean JmjC domain-containing proteins suggests evolutionary conservation following whole-genome duplication. Frontiers in plant science 7, 1800. ( SCI IF: 4.4)
Ke, Danxia*, Li, Xiangyong, Han, Yapeng, Cheng, Lin, Yuan, Hongyu, and Wang, Lei* (2016). ROP6 is involved in root hair deformation induced by Nod factors in Lotus japonicus. Plant Physiology and Biochemistry 108, 488-498. ( SCI IF: 2.7)
Xiaolong Fang#, Lei Wang#, Xiaojuan Deng, Peng Wang, Qibin Ma, Hai Nian, Yingxiang Wang*, Cunyi Yang*. Genome-wide characterization of soybean P1B-ATPases gene family provides functional implications in cadmium responses.BMC Genomics,2016, 17, 376. (SCI IF: 3.8)
Cheng Lin, Hong-Yu Yuan, Ren Ren, Shi-Qi Zhao, Ya-peng Han, Qi-Ying Zhou, Dan-Xia Ke, Ying-xiang Wang*, Wang Lei*. Genome-wide identification, classification and expression analysis of amino acid transporter gene family in Glycine max. Frontiers in Plant Science, 2016, 7: 00515. (SCI IF: 4.4)
Hongxing Yang?, Fang Chang*,?, Chenjiang You, Jie Cui, Genfeng Zhu, Lei Wang, Yu Zheng, Ji Qi*, Hong Ma*. Whole-genome DNA methylation patterns and complex associations with gene structure and expression during flower development in Arabidopsis. Plant Journal, 2015，81: 268–281. (SCI IF: 6.5)
Liangsheng Zhang, Lei Wang, Yulin Yang, Jie Cui, Fang Chang, Yingxiang Wang3*, Hong Ma*. Analysis of Arabidopsis floral transcriptome: detection of new florally expressed genes and expansion of Brassicaceae-specific gene families. Frontiers in Plant Science, 2015, 5:00802. (SCI IF: 4.4)
Lei Wang?, Chenlong Cao?, Qibin Ma, Qiaoying Zeng, Haifeng Wang, Zhihao Cheng, Genfeng Zhu, Ji Qi, Hong Ma, Hai Nian*, Yingxiang Wang*. RNA-seq analyses of multiple meristems of soybean: novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biology, 2014, 14:169. (SCI IF: 4.7)
Haifeng Wang1,2?, Chenjiang You?, Fang Chang, Yingxiang Wang, Lei Wang, Ji Qi*, Hong Ma*. Alternative splicing during Arabidopsis flower development results in constitutive and stage-regulated isoforms. Frontiers in Genetics, 2014, 5:00025. (SCI IF: 3.5)
Hongxing Yang, Yan Zhou, Jianlei Gu, Shuying Xie, Yao Xu, Genfeng Zhu, Lei Wang, Jiyue Huang, Hong Ma*, Jihua Yao*. Deep mRNA Sequencing Analysis to Capture the Transcriptome Landscape of Zebrafish Embryos and Larvae. PLoS ONE, 2013, 8(5), e64058. (SCI IF: 3.0)
Huimin Yang, Suxia Xie, Lei Wang, Shengli Jing, Xiaopei Zhu, Xianwen Li, Wei Zeng, Hongyu Yuan*, Identification of up-regulated genes in tea leaves under mild infestation of green leafhopper, Scientia Horticulturae, 2011, 130(2): 476-481. (SCI IF: 1.5)
Lei Wang, Xianwen Li, Qin Zhao, Shengli Jing, Shifeng Chen, Hongyu Yuan*. Identification of Genes Induced in Response to Low-Temperature Treatment in Tea Leaves. Plant Molecular Biology Reporter, 2009, 27(3): 257-265. (SCI IF: 2.3)
参加会议
第十七届全国植物基因组学大会（Plant Genomic in China），2016年8月19－22日，中国 福州
2016全国植物生物学大会(National Congress of Plant Biology)， 2016年10月9日－12日，中国 武汉
2016世界生命科学大会 (WORLD LIFE SCIENCE CONFERENCE,WLSC2016)，2016年11月1日-3日，中国 北京
颠覆性技术国际研讨会（International workshop on Disruptive Technologies—Disruptive Technologies in Biology and Crossing Fields），2016年11月23日-25日，中国 北京
河南省遗传学会2018年学术年会大会报告，河南 驻马店
2019 Keystone Symposia in Daejeon (Small Regulatory RNAs) 大会报告，韩国 大田