张朋朋
男
博士
讲师


教育经历

2012-2014 美国普渡大学 动物科学系 博士生联合培养
2009-2015 华中农业大学 动物遗传育种与繁殖专业 博士
2005-2009 华中农业大学 动物科学专业 学士



教学情况：

本科生：生物技术导论、生物专业英语
研究生：表观遗传学、分子生物学


研究领域：

1骨骼肌卫星细胞及肌肉生长发育的调控
在动物机体组成中，肌肉占动物体重的 40%以上，是动物主要的运动和代谢器官。骨骼肌的生长发育和再生主要依赖于骨骼肌干细胞（卫星细胞）的增殖和分化。常见的肌肉生长发育异常包括:肌肉营养不良、肌肉减少症、肌肉萎缩症、肌肉恶病质等，探索控制骨骼肌卫星细胞行为的关键基因的功能和信号调控通路将有助于提高动物生产性能及人类的生活质量。
2 动物脂肪沉积的调控
脂肪组织是机体能量的主要储存场所，体内过多的白色脂肪沉积会引发肥胖以及糖尿病，心脏病等疾病的发生。与白色脂肪不同的是，米色脂肪与棕色脂肪以产热的形式消耗大量能量，可以降低白色脂肪的沉积，提高米色脂肪与棕色脂肪的沉积成为解决肥胖相关疾病的重要途径。探索不同脂肪的干细胞来源以及基因基因表达差异，将为解决肥胖问题提供理论依据。



获资助项目：

主持国家自然科学基金青年基金、河南省科技厅基金、河南省教育厅基金


代表性论文和著作：

* 表示通讯作者
1. Shan, T., P. Zhang, Q. Jiang, Y. Xiong, Y. Wang and S. Kuang (2016). Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin
resistance in mice. Diabetologia 59(9): 1995-2004.（并列第一）
2. Shan, T., Y. Xiong, P. Zhang, Z. Li, Q. Jiang, P. Bi, F. Yue, G. Yang, Y. Wang and X. Liu (2016). Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nature Communications（online）.
3. Shan, T., P. Zhang, Y. Xiong, Y. Wang and S. Kuang (2016). Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts. The international journal of biochemistry & cell biology 76: 31-38.
4. P. Zhang, X. Liang, T. Shan, Q. Jiang, C. Deng, R. Zheng, S. Kuang, mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration. Biochemicaland Biophysical Research Communications 463 (2015) 102-108.
5. P. Zhang, T. Shan, X. Liang, C. Deng, S. Kuang, Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice, Biochemical and Biophysical Research Communications 452 (2014) 53-59.
6. T. Shan, P. Zhang, P. Bi, S. Kuang, Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles, Journal of Cellular Physiology 230(2015): 1033-41. （并列第一）
7. T. Shan, P. Zhang, X. Liang, P. Bi, F. Yue, S. Kuang, Lkb1 is indispensable for skeletal muscle development, regeneration and satellite cell homeostasis, Stem Cells 32(2014): 2893-907
8. T.Z. Shan, X.R. Liang, P.P. Bi, P.P. Zhang, W.Y. Liu, S.H. Kuang, Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues,Journal of Lipid Research 54 (2013) 2214-24.
9. W.Y. Liu, T.Z. Shan, X. Yang, S. Liang, P.P. Zhang, Y.Q. Liu, X.Q. Liu, S.H. Kuang, A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes, Journal of Cell Science 126 (2013) 3527-32.
10. Q. Xiong J. Chai, P. P. Zhang, J. Wu, S. W. Jiang, R. Zheng and C. Y. Deng, MyoD control of SKIP expression during pig skeletal muscle development. Molecular Biology Reports, 2011. 38(1): p. 267-4.
11. Mu Qiao, Hua-Yu Wu, Ling Guo, Shu-Qi Mei, Peng-Peng Zhang, Feng-E Li, Rong Zheng and Chang-Yan Deng. Imprinting analysis of porcine DIO3 gene in two fetal stages and association analysis with carcass and meat quality traits. Molecular Biology Reports, 39（2012）2329-35 .
12. Jin Chai, Qi Xiong, Pengpeng Zhang, Rong Zheng, Jian Peng and Siwen Jiang. Induction of Ca2+ signal mediated apoptosis and alteration of IP3R1 and SERCA1 expression levels by stress hormone in differentiating C2C12 myoblasts. General and Comparative Endocrinology, 2010. 166(2): p. 241-9.
13. J. Chai, Q. Xiong, P. P. Zhang, Y. Y. Shang, R. Zheng, J. Peng and S. W. Jiang. Evidence for a new allele at the SERCA1 locus affecting pork meat quality in part through the imbalance of Ca2+ homeostasis. Molecular Biology Reports, 2010. 37(1): p. 613-9.
Email：ppzhang15@163.com