新乡医学院药学院导师教师简介-高庆贺

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高庆贺，男，1983 年 6 月出生，2016 年 6 月毕业于华中师范大学，获博士学位。新乡医学院太行青年学者。主持厅级科研课题 1 项，作为主要成员参与国家自然基

金等项目 2 项；申请国家发明专利 5 项，已授权 2 项。目前以第一作者和通讯作者在 Organic Letters、Advanced Synthesis & Catalysis、Organic Chemistry Frontiers、Journal of Organic Chemistry 等国内外期刊上发表论文 19 篇，他引次数千余次。其中 2 篇论文入选 ESI 高被引论文，2 篇论文被 Synfacts 作为亮点文章进行评价，1 篇论文被 X-MOL 学术网站做亮点介绍，6 篇论文被Nature Index 所收录。形成了具有鲜明特色的碘的金属性催化行为和三级胺的远程活化的研究方向，同时基于此产生新颖的合成设计策略和探索新型合成方法学，并由此探索药物分子高效简捷的合成新方法。指导大学生参与河南省创新课题重点项目 1 项。

联系方式

新乡医学院南校区老实验楼药学院药物化学教研室 309 电话：**927

E-mail: gao_qinghe@xxmu.edu.cn; gao_qinghe@163.com

研究方向

ü 有机合成方法学：主要基于碘的金属性催化行为和三级胺的远程活化，建立新颖的合成设计策略，探索新型合成方法高效构筑嘧啶类杂环化合物。

ü 药物合成工艺的开发：主要进行嘧啶类小分子药物的分子高效简捷的合成和工艺开发。

招生方向

ü 学术学位硕士（学硕）：药物化学

ü 专业学位硕士（专硕）：药物研发与转化

教育经历

ü 2010/09-2016/06，华中师范大学，有机化学专业，理学博士（硕博连读）

ü 2006/09-2010/06，河南师范大学，化学专业，理学学士

工作经历

ü 2016/06-2020/04, 新乡医学院，药学院，讲师

ü 2020/04-至今，新乡医学院，药学院，副教授

承担项目

ü 国家自然科学基金委员会，NSFC-河南联合基金，U**，特异性靶向 LSD1 小分子降解剂的设计、合成及抗肿瘤活性研究，2018-01 至 2020-12，51 万元，在研，参加。

ü 国家自然科学基金委员会，面上项目，**，基于新型氧杂七元环的重排反应构建芳环骨架结构体及相关开环产物的研究，2015-01 至 2018-12，95 万元，已结题，参加。

ü 河南省科技厅，河南省科技攻关项目，**0616，双载药位点姜黄素纳米粒缓释制剂研究， 2017-01 至 2018-12，已结题，参加。

ü 河南省教育厅，河南省高等学校重点科研项目， 19A350010，基于碘诱导酮肟酯产生亚胺自由基构建氮杂环化合物合成的研究，2019-01 至 2020-12，3 万，在研，主持。

代表性论文

ü Qinghe Gao,* Manman Wu, Ke Zhang, Ning Yang, Mengting Liu, Juan Li, Lizhen Fang, Suping Bai, and Yongtao Xu.* I₂-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines. Org. Lett. 2020, 22, 5645−5649.

ü Qinghe Gao,* Xinya Han, Peiyuan Tong, Zhiang Zhang, Haotian Shen, Yanrong Guo, and Suping Bai. Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N Bond Cleavage of Triethylamine: Difunctional Ammonium Iodide Enabling the Regioselective Synthesis of 4- Arylpyrimido[1,2-b]indazoles. Org. Lett. 2019, 21, 6074−6078.

ü Qinghe Gao,* Zhaomin Liu, Yakun Wang, Xia Wu, Jixia Zhang, and Anxin Wu.* I₂-Triggered Reductive Generation of N-Centered Iminyl Radicals: An Isatin-to-Quinoline Strategy for the Introduction of Primary Amides. Adv. Synth. Catal. 2018, 360, 1364–1369.

ü Qinghe Gao,* Shuang He, Xia Wu, Jingjing Zhang, Suping Bai, Yandong Wu, and Anxin Wu.* Selective access to dipyrazolo-fused pyridines via formal [3 + 2 + 1] heteroannulation of methyl ketones with pyrazol-5-amines. Org. Chem. Front. 2018, 5, 765–768.

ü Qinghe Gao,* Huijuan Yan, Manman Wu, Jiajia Sun, Xiqing Yan, and Anxin Wu. Direct synthesis of 2-methylpyridines via I₂-triggered [3 + 2 + 1] annulation of aryl methyl ketoxime acetates with triethylamine as the carbon source. Org. Biomol. Chem. 2018, 16, 2342–2348.

ü Qinghe Gao,* Yakun Wang, Qianqian Wang, Yanping Zhu, Zhaomin Liu, and Jixia Zhang. I₂- Triggered N-O cleavage of ketoxime acetates for the synthesis of 3-(4-pyridyl)indoles. Org. Biomol. Chem. 2018, 16, 9030–9037.

ü Yongtao Xu,* Zihao He, Min Yang, Yunlong Gao, Linfeng Jin, Meiting Wang, Yichao Zheng, Xiaoyuan Lu, Songjie Zhang, Chang Wang, Zongya Zhao, Junqiang Zhao, Qinghe Gao* and Yingchao Duan*. Investigating the Binding Mode of Reversible LSD1 Inhibitors Derived from Stilbene Derivatives by 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation. Molecules, 2019, 24, 4479.

ü Xia Wu, Jingjing Zhang, Shan Liu, Qinghe Gao,* and Anxin Wu.* An Efficient Synthesis of Polysubstituted Pyridines via Csp3-H Oxidation and C-S Cleavage of Dimethyl Sulfoxide. Adv. Synth. Catal. 2016, 358, 218–225.

ü Qinghe Gao, Shan Liu, Xia Wu, Jingjing Zhang, and Anxin Wu.* Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles via Oxidative C(CO)–C(methyl) Bond Cleavage of Methyl Ketones. Org. Lett. 2015, 17, 2960−2963.

ü Qinghe Gao, Jingjing Zhang, Xia Wu, Shan Liu,and Anxin Wu.* Direct Regioselective Oxidative Cross-Coupling of Indoles with Methyl Ketones: A NovelRoute to C3- Dicarbonylation of Indoles. Org. Lett. 2015, 17,134−137.

ü Qinghe Gao, Shan Liu, Xia Wu, JingjingZhang, and Anxin Wu.* CoproductPromoted Povarov Reaction: Synthesis of Substituted Quinolines from MethylKetones, Arylamines, and α- Ketoesters. J. Org. Chem. 2015, 80, 5984−5991.

ü Shan Liu, Hailing Xi, Jingjing Zhang,Xia Wu, Qinghe Gao,*and Anxin Wu.* Organopromoteddirect synthesis of 6-iodo-3-methylthioimidazo[1,2-a]pyridines via convergent integration of three self-sorting domino sequence. Org. Biomol. Chem. 2015,13, 8807–8811.

ü Qinghe Gao, Shan Liu, Xia Wu, and Anxin Wu.* Povarov-Type Reaction Using Methyl as NewInput: Direct Synthesis of Substituted Quinolines by I₂-Mediated Formal [3 + 2 + 1] Cycloaddition. Org. Lett. 2014, 16, 4582−4585.

ü Qinghe Gao, Xia Wu, Shan Liu, and Anxin Wu* I₂-PromotedSelective Oxidative Cross- Coupling/Annulationof 2-Naphthols with Methyl Ketones:A Strategy To BuildNaphtho[2,1- b]furan-1(2H)-ones with aQuaternary Center. Org. Lett. 2014, 16, 1732−1735.

ü Qinghe Gao, Xia Wu, Yuhong Li, Shan Liu, Xianggao Meng, and Anxin Wu.* Iodine-Promoted Sequential C(sp3)-H Functionalization Reaction:An Annulation Strategyfor the Construction of 3-Methylthio-4-Aryl-Maleimides. Adv. Synth.Catal. 2014, 356,2924–2930.

ü Qinghe Gao, Shan Liu, Xia Wu, and Anxin Wu.*Convergent integration of three self-sortingdomino sequences: three-component direct synthesis of 3-methylthio-4-aryl-maleimides from methyl ketoneswith acetonitrile and DMSO. Tetrahedron Lett. 2014, 55, 6403–6406.

ü Qinghe Gao, Xia Wu, Fengcheng Jia, Meicai Liu,Yanping Zhu, Qun Cai, and Anxin Wu.*Design and Synthesis of 2-Acylbenzothiazoles via In Situ Cross-TrappingStrategy from Benzothiazoles with Aryl Ketones. J. Org. Chem. 2013, 78, 2792−2797.

ü Qing-He Gao, Zhuan Fei, Yan-Ping Zhu, Mi Lian, Feng-Cheng Jia, Mei-Cai Liu, Neng-FangShe*, and An-Xin Wu.* Metal-free dual sp3 C-H functionalization: I₂-promoted dominooxidative cyclization to construct 2,5-disubstituted oxazoles. Tetrahedron 2013, 69, 22–28.

ü Qinghe Gao, Yanping Zhu, Mi Lian, Meicai Liu, Jingjing Yuan, GuodongYin,* and AnxinWu.* Unexpected C−C Bond Cleavage: A Route to 3,6-Diarylpyridazines and6-Arylpyridazin-3- ones from1,3-Dicarbonyl Compounds and Methyl Ketones. J. Org. Chem. 2012, 77, 9865−9870.

ü Jia-ChenXiang, Qing-He Gao, and An-Xin Wu,Solvents as Reagents in Organic Synthesis (Ed,: Xiao-Feng Wu), Wiley-VCH, 2017,pp 315-353. (专著专章)

已授权发明专利

ü 高庆贺，刘兴霞，刘兆敏，杨利敏，原焕，贺爽。一种喹啉-4-甲酰胺类化合物的合成方法，2020.06.05，中国，ZL**3302.2

ü 高庆贺，刘兴霞，原焕，王亚坤，仝培源，申昊天，张志昂，张伟荣，张积霞。一种3-(4-吡啶)吲哚类化合物的合成方法，2020.06.26，中国，ZL**3559.1