杨海杰，厦门大学博士，硕士生导师。从事神经保护和干细胞分化研究多年，目前主要从事亚低温应激及冷休克蛋白基因表达调控的研究。学术上担任中国研究型医院学会血液病精准诊疗专业委员会委员，白求恩精神研究会检验分会常务理事，中国医学装备协会现场快速检测装备技术专业委员会委员。主持国家自然科学基金2项、新加坡国家医学基金1项、河南省科技攻关项目1项、河南省教育厅重点科研项目1项。在J Biol Chem、J Cell Sci、Sci Rep、Frontiers Neurosci、Biochemistry等SCI期刊发表学术论文50余篇，被引近千次。
联系方式：
E-mail: hjyang_wmd@hotmail.com
专业研究方向:
低温应激与神经保护
主要科研工作简介:
1. 具体研究领域
哺乳动物细胞对低温的感知内涵、冷休克蛋白基因表达调控机制、神经保护
2. 课题资助
1）国家自然科学基金：冷休克蛋白RBM3基因的低温诱导机制及其模拟亚低温用于脊髓损伤治疗（2018-2021）
2）国家自然科学基金：NCAM调节间充质干细胞分泌组促进成骨分化的机制及其对骨损伤修复的影响（2018-2020）
3）河南省科技攻关项目：阿尔茨海默病（老年痴呆症）新型免疫诊断试剂盒的研制（2016-2017）
4）河南省教育厅重点项目：神经细胞粘附分子对骨髓间充质干细胞成骨分化的调控机制及其在干细胞归巢中的作用（2016-2017）
5）河南省儿童神经发育工程研究中心开放课题：神经细胞对亚低温的感知及冷休克蛋白的神经保护机制（2020-2021）
3. 近期代表性论文
[1] Chen S, Guo D, Lei B, Bi J, Yang H* (2020) Biglycan protects human neuroblastoma cells from nitric oxide-induced death by inhibiting AMPK-mTOR mediated autophagy and intracellular ROS level. Biotechnol Lett, 42(4):657-68.
[2] Gao SS, Yao YL, Yuan X, Lei BB, Cheng BF, Wang M, Wang L*, Yang HJ* (2020) Identification and characterization of a novel mannose-binding C-type lectin (PjLec2) in shrimp Penaeus japonicus. Aquaculture, 518:734836.
[3] Wang M, Xue H, Gao M, Wang Q, Yang H* (2019) Synthetic fluorinated polyamides as efficient gene vectors. J Biomed Mater Res B Appl Biomater, 107(6):2132-9.
[4] Lei BB, Ju F, Fu QR, Yuan X, Song WX, Ji GQ, Lei KY, Wang L, Cheng BF, Wang M, Yang HJ* (2019) Mild hypothermia prevents NO-induced cytotoxicity in human neuroblastoma cells via induction of COX-2. J Mol Neurosci, 67(2):173-80.
[5] Yang HJ, Zhuang RJ, Li YB, Li T, Yuan X, Lei BB, Xie YF, Wang M* (2019) Cold-inducible protein RBM3 mediates hypothermic neuroprotection against neurotoxin rotenone via inhibition on MAPK signalling. J Cell Mol Med, 23(10):7010-20.
[6] Yang HJ, Shi X, Ju F, Hao BN, Ma SP, Wang L, Cheng BF, Wang M* (2018) Cold shock induced protein RBM3 but not mild hypothermia protects human SH-SY5Y neuroblastoma cells from MPP⁺-induced neurotoxicity. Front Neurosci, 12:298.
[7] Zhuang RJ, Ma J, Shi X, Ju F, Ma SP, Wang L, Cheng BF, Ma YW, Wang M, Li T, Feng ZW*, Yang HJ* (2017) Cold-inducible protein RBM3 protects UV irradiation-induced apoptosis in neuroblastoma cells by affecting p38 and JNK pathways and Bcl2 family proteins. J Mol Neurosci, 63:142-51.
[8] Ma SP, Ju F, Zhang YP, Shi X, Zhuang RJ, Xue H, Ma J, Wang L, Cheng BF, Cao H, Feng ZW, Wang M*, Yang HJ* (2017) Cold-inducible protein RBM3 protects neuroblastoma cells from retinoic acid-induced apoptosis via AMPK, p38 and JNK signaling. J Funct Food, 35:175-84.
[9] Wang M, Xue H, Ju F, Yang H* (2017) Acceleration of Batch-type Heterogeneous Ligand-free Suzuki-Miyaura Reactions with Polymer Composite Supported Pd Catalyst. Sci Rep, 7(1):7006.
[10] Wang M, Xue H, Feng Z, Cheng B, Yang H* (2017) Increase of tensile strength and toughness of bio-based diglycidyl ether of bisphenol A with chitin nanowhiskers. PLoS One, 12(6):e**.
[11] Yang HJ, Ju F, Guo XX, Ma SP, Wang L, Cheng BF, Zhuang RJ, Zhang BB, Shi X, Feng ZW*, Wang M (2017) RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Sci Rep, 7:41738.
[12] Zheng Q, Yang HJ, Yuan YA (2017) Autoantigen La Regulates MicroRNA Processing from Stem–Loop Precursors by Association with DGCR8. Biochemistry, 56: 6098–110.
[13] Yang HJ, Ma SP, Ju F, Zhang YP, Li ZC, Zhang BB, Lian JJ, Wang L, Cheng BF, Wang M*, Feng ZW (2016) Thrombospondin-4 promotes neuronal differentiation of NG2 Cells via the ERK/MAPK pathway. J Mol Neurosci, 60:517-24.
[14] Yang HJ, Wang M, Wang L, Cheng BF, Lin XY, Feng ZW* (2015) NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. PLoS One, 10:e**.
[15] Yang HJ, Wang L, Wang M, Ma SP, Cheng BF, Li ZC, Feng ZW* (2015) Serine/Threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway. J Mol Neurosci, 55:977-84.
[16] Yang HJ, Feng P, Wang L, Li ZC, Ma SP, Wang M*, Feng ZW (2015) Caveolin-1 mediates gene transfer and cytotoxicity of polyethyleneimine in mammalian cell lines. Mol CelBiochem, 402:203-11.
[17] Yang H, Wang L, Chen S, Wang M*, Feng Z* (2015) Effect of a double-structured microporous polymer support on the catalytic activity, stability and aggregation behavior of immobilized enzymes. Polymer Int, 64(7):915-23.
[18] 雷冰冰，袁昕，马周聪，宋炯，庄雪珂，吕辰飞，杨海杰 (2019) 冷休克蛋白3对细胞总蛋白质合成的影响及其靶基因的鉴定. 中国生物化学和分子生物学学报, 35(9): 968-74.
[19] 马建，王磊，杨海杰 (2019). 阿尔茨海默病血液生物标志物研究进展. 新乡医学院学报, 36:92-5.
[20] 杨海杰，付启冉，雷冰冰，袁昕，尚思楠，冯志伟 (2019) THBS4上调转录因子Ngn1影响NG2细胞的体外神经元分化. 中国细胞生物学学报, 41(9): 1747-55.
[21] 杨海杰，李志超，王勉，王磊，程彬峰，冯培，冯志伟 (2015) IL-6通过MAPK/ERK信号通路调节BMSCs软骨定向分化. 中国生物化学和分子生物学学报, 31:153-60.
[22] 杨海杰，冯培，王勉，冯志伟 (2015) SPIO和19F探针在MRI活体示踪免疫细胞中的应用. 磁共振成像, 6:239-43.