陈洪，博士/副教授，三峡大学兼职硕士生导师，河南息县人，中共党员，现任食品与药品学院副院长、河南省制药工程院士工作站负责人、洛阳市有机功能分子重点实验室主任、食品与药品学院天然功能因子研发中心主任。2012年获得中山大学理学博士学位，2012.07-2012.12在康龙化成（北京）新药技术有限公司从事科研工作，任课题组长。2013.01-2014.12在广州医科大学药学院从事博士后研究工作。2018.07-2020.06在南方医科大学南方医院从事博士后研究工作。近年来在Journal of Hazardous Materials、Sensors and Actuators B: Chemical、Analytica Chimica Acta、Talanta、Dyes and Pigments、Analyst、Spectrochim. Acta A、Chinese Chemical Letters、Bioorganic & Medicinal Chemistry、Bioorganic & Medicinal Chemistry Letters、Pharmacological Reports、Steroids等期刊发表SCI文章25余篇，授权发明专利3项，主持省部级课题5项。指导、培养硕士研究生5名。
联系方式：chenwexpo@sina.com
研究领域和兴趣：

1．靶向抗肿瘤药物的设计、合成及作用机制研究
2．活性天然产物的提取、分离，合成，结构修饰和构效关系研究
3．小分子荧光探针的设计、合成及应用
教育经历：
2004.09-2006.07 河南师范大学 化学专业 学士
2006.09-2009.07 华南师范大学 有机化学专业 硕士
2009.09-2012.06 中山大学 有机化学专业 博士
工作背景：
2012.07-2012.12 康龙化成（北京）新药技术有限公司，课题组长
2013.01-2014.12 广州医科大学药物研究中心，药物化学 博士后
2015.02-2018.11 洛阳师范学院食品与药品学院，讲师
2018.07-2020.06 南方医科大学南方医院，药物化学 博士后
2018.12-至今　 洛阳师范学院食品与药品学院，副教授
主持科研项目：
1．中国第54批博士后基金（2013M542165）：基于α1A/1D-AR靶点的拮抗剂的设计、合成与构效关系研究，2013.01-2015.01，5万，主持。
2．广东省自然科学基金（S20**）：基于α1A/1D-AR靶点的拮抗剂的设计、合成与构效关系研究，2013.10-2015.10，3万，主持。
3．2016年河南省科技攻关（社会发展）项目（**7），芳基哌嗪类衍生物的合成、生物活性及调控雄激素受体（AR）的研究，2016.01-2018.12，10万元，主持。
4．2016年度河南省高等学校重点科研项目（16A350008），酰胺类芳基哌嗪衍生物的设计、合成及构效关系研究，2016.01-2017.12，3万元，主持。
5．洛阳师范学院国家级项目培育基金（2015-PYJJ-005）：酰胺类芳基哌嗪衍生物的设计、合成及构效关系研究，2016.01-2018.12，5万元，主持。
发表代表性论文：
1．Xiaojun He, Wei Xu, Chuchu Xu, Feng Ding, Hong Chen*, Jianliang Shen*. Reversible spiropyran-based chemosensor with pH-switches and application for bioimaging in living cells, Pseudomonas aeruginosa and zebrafish. Dyes and Pigments. 2020, 180(9), 108497.
2．Hong Chen, Yuna Qian,·Huixia Jia, Yuzhong Yu, Haibo Zhang, Jianliang Shen*， Shanchao Zhao*. Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety. Pharmacol Rep. 2020, https://doi.org/10.1007/s43440-019-00041-w2020.
3．Hong Chen, Xiaojun He, Yuzhong Yu, Yuna Qian, Jianliang Shen, Shanchao Zhao. Execution of aggregation-induced emission as nano-sensors for hypochlorite detection and application for bioimaging in living cells and zebrafish. Talanta 2020, 214(7), 120842.
4．Xiaojun He, Qi Xie, Jinyi Fan, Chuchu Xu, Wei Xu, Yahui Li, Feng Ding, Hui Deng*, Hong Chen*, Jianliang Shen*. Dual-functional chemosensor with colorimetric/ratiometric response to Cu(II)/Zn(II) ions and its applications in bioimaging and molecular logic gates. Dyes and Pigments 2020, 177, 108255.
5．Xiaojun He, Chu-Chu Xu, Wei Xiong, Yu-Na Qian, Jin-Yi Fan, Feng Ding, Hui Deng, Hong Chen*, Jian-Liang Shen. The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish. Analyst 2020, 145, 29–33.
6．Xiaojun He, Hong Chen, Chuchu Xu, Jinyi Fan, Wei Xu, Yahui Li, Hui Deng, Jianliang Shen. Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish. J. Hazard. Mater. 2020, 388(4), 122029
7．Hong Chen, PingYang, Ya-Hui Li, Li-Lei Zhang, Feng Ding, Xiao-Jun He, Jian-Liang Shen*. Insight into triphenylamine and coumarin serving as copper (II) sensorswith“OFF”strategy and for bio-imaging in living cells. Spectrochim. Acta A. 2020, 224, 117384.
8．Hong Chen, Jing-Xiao Zhang, Pei-Xin Hu, Yu-Na Qian, Jing Li, Jian-Liang Shen
Synthesis, biological evaluation and molecular docking of 4-Amino-2Hbenzo[
h]chromen-2-one (ABO) analogs containing the piperazine moiety. Bioorg. Med. Chem. 2019, 27, 115081.
9．Hong Chen, Yu-Zhong Yu, Xiu-Mei Tian, Cai-Lu Wang, Yu-Na Qian, Zai-An Deng, Jing-Xiao Zhang, Dao-Jun Lv, Hai-Bo Zhang, Jian-Liang Shen*, Mu Yuan*, Shan-Chao Zhao. Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents. Bioorg. Med. Chem. 2019, 27, 133–143.
10．Xiao-Jun He, Cheng-Lin Wu, Yu-Na Qian, Li-Lei Zhang, Feng Ding, Hong Chen*, Jian-Liang Shen. Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo. Analyst 2019, 144, 3807–3816.
11．Hong Chen, Tao Sun, Xiao-Guang Qiao, Qian-Oian Tang, Shan-Chao Zhao*, Zhan Zhou*. Red-emitting fluorescent probe for detecting hypochlorite acid in vitro and in vivo. Spectrochim. Acta A. 2018, 204, 196–202.
12．Hong Chen, Zong-Lin Yang, Tao Sun, Jiang-Xiu Niu, Xiu-Mei Tian*, Mu Yuan*. Synthesis and Biological Evaluation of Arylpiperazine Derivatives as Anticancer Agents. Lett. Org. Chem. 2018, 15, 981–989.
13．Hong Chen, Xue Liang, Tao Sun, Xiao-Guang Qiao, Zhan Zhou, Zi-Yong Li, Chao-Jun He, Hui-Yuan Ya*, Mu Yuan*. Synthesis and biological evaluation of estrone 3-O-ether derivatives containing the piperazine moiety. Steroids 2018, 134, 101–109.
14．Hong Chen, Cai-Lu Wang, Tao Sun, Zhan Zhou, Jiang-Xiu Niu, Xiu-Mei Tian*, Mu Yuan*. Synthesis, Biological Evaluation and SAR of Naftopidil-based Arylpiperazine Derivatives. Bioorg. Med. Chem. Lett. 2018, 28, 1534–1539.
15．Hong Chen, Bing-Bing Xu, Tao Sun, Zhan Zhou, Hui-Yuan Ya*, Mu Yuan*. Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety. Molecules 2017, 22, 1857.
16．Hong Chen, Fang Xu, Bing-Bing Xu, Jing-Yi Xu, Bin-Hao Shao, Bi-Yun Huang, Mu Yuan*. Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines. Chinese Chem. Lett. 2016, 27, 277–282.
发明专利：
1．陈洪，马录芳，姚景才，冯爱青，孙涛，罗光远，王豹，陈夏雨，俞佳俊。醚类芳基哌嗪衍生物及其盐、制备方法和用途，授权号：ZL 2.2。
2．陈洪，孙涛，周战，押辉远，冯爱青，许启泰。羟嗪衍生物以及制备方法，用途和制剂，授权号：ZL 2016 1 **.5。
3．陈洪，王利亚，汪彩露，孙涛，孙献仲，李自永，许启泰。 醚类芳基哌嗪衍生物及其盐、制备方法以及用于制备治疗抗肿瘤药物的用途，授权号：ZL 2017 1 **.6。
获奖情况：
1．陈洪，Design, synthesis and biological evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines，河南省第四届自然科学学术三等奖，2018年。