一、个人简介：
吴东栋，男，博士，副教授，硕士生导师。主持2项国家自然科学基金、2项河南省科技攻关项目、1项河南省教育厅科学技术研究重点项目、2项开封市科技发展计划项目、1项河南大学优秀青年基金培育项目，1项河南大学医学院青年人才科研培育计划项目，参与国家自然科学基金、河南省科技攻关项目等10余项，担任浙江省、河北省自然科学基金评审专家。已发表SCI论文38篇，其中第一/通讯作者SCI论文23篇，影响因子共计139，被他引500余次，EI论文2篇，中文核心期刊论文7篇，申请国家发明专利9项。获得河南省教育厅优秀科技论文一等奖4项，二等奖1项，河南省自然科学优秀学术论文二、三等奖各1项，河南大学科研优秀奖2项，河南大学优秀硕士学位论文指导教师。
二、主要研究方向：
硫化氢与核蛋白在肿瘤、脂肪肝、慢性肾衰、膈肌无力、口腔相关疾病发生发展过程中的分子机制研究。
三、承担科研项目：
1.国家自然科学基金，**，CSE/H2S促进鼻咽癌生长的作用及其分子机制，2019/01-2021/12，主持。
2.国家自然科学基金，U**，生物活性肽V3对肝癌生长的抑制作用及其分子机制，2016/01-2018/12，主持。
3.河南省科技攻关项目，0，HA-ADT抑制食管癌生长的分子机制研究，2020/01-2021/12，主持。
4.河南省科技攻关项目，**5，PCNP介导神经母细胞瘤生长的作用及分子机制，2018/01-2019/12，主持。
5.河南省教育厅科学技术研究重点项目，15A310017，生物活性肽V3对人肝癌细胞生长的抑制作用及其临床研究，2015/01-2016/12，主持。
6.河南大学优秀青年基金培育项目，yqpy**，生物活性肽V3对肝癌生长的抑制作用及其分子机制，2018/01-2019/12，主持。
7.河南大学医学院青年人才科研培育计划项目，**，HA-ADT抑制食管癌生长的作用及其分子机制，2019/06-2020/12，主持。
8.开封市科技发展计划项目，**，硫化氢通过表皮生长因子受体促进肝癌生长的机制研究，2018/01-2019/12，主持。
9.开封市科技发展计划项目，**，硫化氢提高CuZn-SOD与Mn-SOD活性的作用及其分子机制，2017/01-2018/12，主持。
四、发表论文：（注：*为通讯作者）
1.Qian Dong^#, Bo Yang^#, Ju-Guo Han, Meng-Meng Zhang, Wei Liu, Xin Zhang, Hai-Lan Yu, Zheng-Guo Liu, Shi-Hui Zhang, Tao Li,Dong-Dong Wu*, Xin-Ying Ji*, Shao-Feng Duan*. A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.Cancer Lett.2019;455:60-72.
2.Dongdong Wu, Jianmei Li, Qianqian Zhang, Wenke Tian, Peiyu Zhong, Zhengguo Liu, Huijuan Wang, Honggang Wang, Ailing Ji*, Yanzhang Li*. Exogenous hydrogen sulfide regulates the growth of human thyroid carcinoma cells.Oxid. Med. Cell. Longev.2019;2019,**.
3.Dong-Dong Wu, Da-Yong Wang, Hui-Min Li, Jian-Cheng Guo, Shao-Feng Duan*, Xin-Ying Ji*. Hydrogen sulfide as a novel regulatory factor in liver health and disease.Oxid. Med. Cell. Longev.2019;2019,**.
4.Dong-Dong Wu^#, Shi-Yu Liu^#, Ying-Ran Gao, Dan Lu, Ya Hong, Ya-Ge Chen, Peng-Zhen Dong, Da-Yong Wang, Tao Li, Hui-Min Li, Zhi-Guang Ren, Jian-Cheng Guo, Fei He, Xue-Qun Ren, Shi-Yong Sun, Shao-Feng Duan*, Xin-Ying Ji*.Tumor necrosis factor-α-induced protein 8-like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells.J. Cell. Mol. Med.2019;23:1698-1713.
5.Da-Yong Wang^#, Ya Hong^#, Ya-Ge Chen, Peng-Zhen Dong, Shi-Yu Liu, Ying-Ran Gao, Dan Lu, Hui-Min Li, Tao Li, Jian-Cheng Guo, Fei He, Xue-Qun Ren, Shi-Yong Sun,Dong-Dong Wu*, Shao-Feng Duan*, Xin-Ying Ji*. PEST- containing nuclear protein regulates cell proliferation, migration and invasion in lung adenocarcinoma.Oncogenesis2019;8:22.
6.Attia Afzal^#, Muhammad Sarfraz^#, Guang-Lei Li, Shao-Ping Ji, Shao-Feng Duan, Nazeer Hussain Khan,Dong-Dong Wu*, Xin-Ying Ji*. Taking a holistic view of PEST-containing nuclear protein (PCNP) in cancer biology.Cancer Med.2019;8(14):6335-6343.
7.Dongdong Wu^#, Peiyu Zhong^#, Jun Wang, Honggang Wang. Exogenous hydrogen sulfide mitigates LPS+ATP-induced inflammation by inhibiting NLRP3 inflammasome activation and promoting autophagy in L02 cells.Mol Cell Biochem.2019;457(1-2):145-156.
8.Dongdong Wu, Zhengguo Liu, Jianmei Li, Qianqian Zhang, Peiyu Zhong, Tieshan Teng, Mingliang Chen, Zhongwen Xie*, Ailing Ji*, Yanzhang Li*. Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/ RAF/MEK/ERK signaling pathway.Cancer Cell Int.2019;19:43.
9.Dongdong Wu, Mengling Li, Yingran Gao, Wenke Tian, Jianmei Li, Qianqian Zhang, Zhengguo Liu, Mengli Zheng, Hongju Wang, Jun Wang, Tieshan Teng, Lei Zhang, Xinying Ji, Zhongwen Xie*, Ailing Ji*, Yanzhang Li*. Peptide V3 inhibits the growth of human hepatocellular carcinoma by inhibiting the Ras/Raf/MEK/ERK signaling pathway.J. Cancer2019;10:1693-1706.
10.Dongdong Wu, Wenke Tian, Jianmei Li, Qianqian Zhang, Honggang Wang, Lei Zhang, Zhongwen Xie*, Ailing Ji*, Yanzhang Li*. Peptide P11 suppresses the growth of human thyroid carcinoma by inhibiting the PI3K/AKT/mTOR signaling pathway.Mol. Biol. Rep.2019;46(3):2665-2678.
11.Guoyu Zhang^#, Dan Lu^#, Shaofeng Duan^#, Yingran Gao, Shiyu Liu, Ya Hong, Pengzhen Dong, Yage Chen, Tao Li, Dayong Wang, Xiangshu Cheng, Fei He, Jianshe Wei, Guangyu Li, Qingyong Zhang,Dongdong Wu*, Xinying Ji*. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF- κ B Signaling Pathways.Oxid. Med. Cell. Longev.2018;2018,**.
12.Dongdong Wu, Honggang Wang, Tieshan Teng, Shaofeng Duan, Ailing Ji*, Yanzhang Li*. Hydrogen sulfide and autophagy: A double edged sword.Pharmacol. Res.2018;131:120-127.
13.Dongdong Wu^#, Yingran Gao^#, Tao Li^#, Dayong Wang, Dan Lu, Shiyu Liu, Ya Hong, Huibin Ning, Junping Liu, Jia Shang, Junfeng Shi, Jianshe Wei*, Xinying Ji*. PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.BMC Cancer2018;18(1):499.
14.Dongdong Wu, Mengling Li, Wenke Tian, Shuaiwei Wang, Longzhen Cui, Hui Li, Huijuan Wang, Ailing Ji*, Yanzhang Li*, Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways,Sci. Rep.2017;7:5134.
15.Dongdong Wu^#, Ning Luo^#, Lianqu Wang, Zhijun Zhao, Hongmin Bu, Guoliang Xu, Yongjun Yan, Xinping Che, Zhiling Jiao, Tengfu Zhao, Jingtao Chen, Ailing Ji, Yanzhang Li*, Garrick D. Lee*. Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.Sci. Rep.2017;7:455.
16.Dongdong Wu, Jun Wang, Honggang Wang, Ailing Ji*, Yanzhang Li*. Protective roles of bioactive peptides during ischemia-reperfusion injury: From bench to bedside.Life Sci.2017;180:83-92.
17.Dongdong Wu, Tao Li, Xinying Ji. Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.J. Immunol. Res.2017;2017:**.
18.Dongdong Wu^#, Biao Gao^#, Mengling Li, Ling Yao, Shuaiwei Wang, Mingliang Chen, Hui Li, Chunyan Ma, Ailing Ji*, Yanzhang Li*. Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice.Oxid. Med. Cell. Longev.2016;2016:**.
19.Dongdong Wu, Zhen Lu, Mengling Li, Zhenxian Feng, Ailian Liu, Dongzhu Jin, Ailing Ji*, Yanzhang Li*. Treadmill exercise increases cystathionine γ-lyase expression and decreases inflammation in skeletal muscles of high-fat diet-induced obese rats.Int. J. Clin. Exp. Med.2016;9(12):23119-23126.
20.Dongdong Wu, Jun Wang, Hui Li, Mengzhou Xue*, Ailing Ji*, Yanzhang Li*. Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury.Oxid. Med. Cell. Longev.2015;2015:186908.
21.Dongdong Wu, Weirong Si, Mingjie Wang, Shuangyu Lv, Ailing Ji*, Yanzhang Li*. Hydrogen sulfide in cancer: Friend or foe?.Nitric Oxide2015;50:38-45.
22.Dongdong Wu, Yanfeng Gao, Yuanming Qi*, Lixiang Chen, Yuanfang Ma, Yanzhang Li*. Peptide-based cancer therapy: Opportunity and challenge.Cancer Lett.2014;351(1):13-22.
23.Dongdong Wu, Yanfeng Gao, Lixiang Chen*, Yuanming Qi*, Qiaozhen Kang, Haili Wang, Linyu Zhu, Yong Ye, Mingxia Zhai. Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice.Peptides2010;31(5):850-864.
24.Lei Zhang,Wen Liu,Fangyan Liu,Qun Wang*,Mengjiao Song,Qi Yu,Kun Tang,Tieshan Teng,Dongdong Wu,Xijing Wang,Wuqi Han,Yanzhang Li*. IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer.Oxid. Med. Cell. Longev.2020;2020:**.
25.Qing Zhao, Yongqiang Li, Yanhong Li, Xinying Ji, Huimin Li,Dongdong Wu, Wenqiang Wei, Xinchun Wang*. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.Med. Sci. Monit.2020;26:e920594.
26.Tieshan Teng^#, Qiming Li^#, Zhengguo Liu, Xianghui Li, Zizheng Liu, Hanshu Liu, Fangyan Liu, Longxiang Xie, Huijuan Wang, Lei Zhang,Dongdong Wu, Mingliang Chen, Yanzhang Li*, Ailing Ji. Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae.Arch. Virol.2019;164 (9):2389-2393.
27.Honggang Wang^#, Jianmei Li^#, Peiyu Zhong, Shuaiwei Wang, Lei Zhang, Ruisheng Yang,Dongdong Wu, Mingliang Chen, Ailing Ji*, Yanzhang Li*, Jun Wang*. Blocking CXCR3 with AMG487 ameliorates the blood-retinal barrier disruption in diabetic mice through anti-oxidative.Life Sci.2019;228:198-207.
28.Jun Wang,Dongdong Wu, Honggang Wang*. Hydrogen sulfide plays an important protective role by influencing autophagy in diseases.Physiol. Res.2019;68:335-345.
29.Tieshan Teng, Gai Zhang, Xiangyu Fan, Zhenjiang Zhang, Lei Zhang,Dongdong Wu, Yanzhang Li*, Jing Jin*. Complete genome sequence analysis of PS2, a novel T4-like bacteriophage that infects Serratia marcescens clinical isolates.Arch. Virol.2018;163(7):1997-2000.
30.Huijuan Wang^#, Hailong Zhang^#, Ling Yao, Longzhen Cui, Lei Zhang, Biao Gao, Wen Liu,Dongdong Wu, Mingliang Chen, Xue Li, Ailing Ji*, Yanzhang Li*. Serum metabolic pro?ling of type 2 diabetes mellitus in Chinese adults using an untargeted GC/TOFMS.Clin. Chim. Acta2018;477:39-47.
31.Mengling Li, Shuaiwei Wang, Songjiang Wang, Lei Zhang,Dongdong Wu, Ruisheng Yang,Ailing Ji, Yanzhang Li*, Jun Wang*.Occludin downregulation in high glucose is regulated by SSTR2 through VEGF/NRP1/Akt signaling pathway in RF6A cells.Exp. Ther. Med.2017;14(2):1732-1738.
32.Jun Wang*, Wenke Tian, Shuaiwei Wang, Wenqiang Wei,Dongdong Wu, Honggang Wang, Li Wang, Ruisheng Yang, Ailing Ji*, Yanzhang Li*. Anti-inflammatory and retinal protective effects of capsaicin on ischemia-induced injuries through the release of endogenous somatostatin.Clin. Exp. Pharmacol. Physiol.2017;44(7):803-814.
33.Jun Wang*, Shuaiwei Wang, Mengling Li,Dongdong Wu, Fang Liu, Ruisheng Yang, Shaoping Ji, Ailing Ji*, Yanzhang Li*. The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress.PLoS One2015; 10(11): e**.
34.Jun Wang*, Ziqiang Sun, Junsheng Shen,Dongdong Wu, Fang Liu, Ruisheng Yang, Shaoping Ji, Ailing Ji*, Yanzhang Li*. Octreotide protects the mouse retina against ischemic reperfusion injury through regulation of anti-oxidation and activation of NF-κB.Oxid. Med. Cell. Longev.2015;2015:970156.
35.Yanjie Yang, Shuang-Yu Lv*, Shuang-Kun Lyu,Dongdong Wu, Qiang Chen. The protective effect of apelin on ischemia/reperfusion injury.Peptides2015;63:43-46.
36.Yu Zhou^#, Xinghui Li^#, Caicai Zhang^#, Mingjie Wang, Wenlong Xue,Dongdong Wu, Fenfen Ma, Wenwen Li, Beibei Tao, Yichun Zhu*. Hydrogen sulfide promotes angiogenesis by down-regulating miR-640 via the VEGFR2/mTOR pathway.Am. J. Physiol. Cell Physiol.2016;310(4):C305-317.
37.Min Liang, Sheng Jin,Dongdong Wu, Mingjie Wang, Yichun Zhu*. Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes.Nitric Oxide2015;46:114-122.
38.Shunna Ge, Manman Zhao,Dongdong Wu, Ying Chen, Yi Wang, Jianhua Zhu, Wenjie Cai, Yizhun Zhu, Yichun Zhu*. Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na(+)/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.Antioxid. Redox Signal.2014;21(15):2061-2082.
39.Hui Li, Guoying Wang,Dongdong Wu, Yanzhong Hu, Yanqiu Hu*. Approaches to Improve Teaching Quality of Histology and Embryology by Various Ways. Proceedings - 9th International Conference on Information Technology in Medicine and Education,ITME2018;57-60.
40.Tieshan Teng,Dongdong Wu, Guoying Wang*. Using information technology to integrate pathology course and information literacy as part of instruction. Proceedings - 8th International Conference on Information Technology in Medicine and Education.ITME2016;840-843.
41.郭矗，吴东栋*，姬新颖*，硫化氢对脊髓损伤治疗的研究进展，中国生物化学与分子生物学报，2020;36(2):159-164.
42.王红钢，程会军，吴东栋，王军，刘正国，吉爱玲*，李彦章*，外源性硫化氢减轻小鼠阻塞性肾损伤，中国病理生理杂志，2018;34(7):1277-1282.
43.陆丹，李涛，吴东栋*，段少峰，姬新颖*，硫化氢在多种生理过程中作用的研究进展，生命科学，2018;30(5):517-525.
44.王红钢*，孙伟力，钟培育，吴东栋，王军，蔡欢，王国英，乔玲，张涛，李彦章*，外源性硫化氢对肝细胞NLRP3炎症小体的影响，中国病理生理杂志，2018;34(1):118-122.
45.王红钢，张优敬，皇甫超申，陈明亮，王军，吴东栋，谢振兴，李彦章*，吉爱玲*，外源性硫化氢对小鼠原代肝细胞内脂质自噬分解的影响，中国病理生理杂志，2017;33(10):1901-1906.
46.王红钢，张优敬，皇甫超申，王军，吴东栋，钟培育，王国英，李彦章*，GYY4137对小鼠原代肝细胞胞质内脂质分解的影响，中国病理生理杂志，2017;33(8):1520-1523.
47.郑乃汭，张优敬，吴东栋，刘彬，吉爱玲，李彦章，皇甫超申*，硫化氢对肥胖小鼠肝脂质蓄积的影响，中国药理学通报，2015;31(7):945-951.
五、发明专利：
1.吴东栋，任志广，李涛，卫文强，沈永红，陆丹，刘诗语，高荧苒，洪亚，潘韦彤，郭建成，姬新颖，硫化氢作用脂多糖诱导L6细胞在膈肌功能障碍中的应用，国家发明专利，申请号：CN1.3，已公开。
2.吴东栋，田文柯，李见梅，张倩倩，李彦章，陈明亮，王红钢，王慧娟，张磊，一种生物活性肽P11在治疗甲状腺癌的药物中效果分析方法，国家发明专利，申请号：CN5.0，已公开。
3.吴东栋，李涛，高荧苒，王大勇，陆丹，刘诗语，洪亚，魏建设，姬新颖，一种过表达PCNP基因的药物的制备及用途，国家发明专利，申请号：CN3.1，已公开。
4.王红钢，吴东栋，葛振英，陈明亮，吕双瑜，聂小博，刘峰涛，王怡禛，5,6-吲哚并二恶烷类衍生物及其制备方法和应用，国家发明专利，申请号：CN7.1，已公开。
5.段少峰，吴东栋，董茜，韩举国，杨波，余海兰，姬新颖，胡玉荣，张梦梦，张欣，刘玮，张师慧，一种硫化氢释放剂HA-ADT、其制备方法及应用，国家发明专利，申请号：CN3.9，已公开。
6.段少峰，吴东栋，余海兰，韩举国，杨波，董茜，李翠，刘玮，胡玉荣，姬新颖，王新春，一种芦丁螯合物及其制备方法和应用，国家发明专利，申请号：CN4.0，已公开。
7.张国瑜，李涛，吴东栋，赵琼，滕铁山，段少峰，姬新颖，一种基于干细胞源外泌体的组合物及其在制备治疗心肌梗死的药物中的应用，国家发明专利，申请号：CN1.3，已公开。
8.贺飞，李涛，张凡，李振华，杨乐，吴东栋，滕铁山，姬新颖，外泌体、其制备方法及其在制备治疗肺癌的药物中的应用，国家发明专利，申请号：ZL5.0，已授权。
9.张磊，刘稳，黄永伟，李彦章，王慧娟，陈明亮，王群，刘芳艳，吴东栋，IMCA在制备抗结直肠癌药物中的应用，国家发明专利，申请号ZL8.X，已授权。
六、获奖情况：
1.吴东栋，河南大学2017-2018年度科研优秀奖，河南大学，2019.9
2.吴东栋，吉爱玲，李彦章等，Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice，河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2019.5
3.吴东栋，吉爱玲，李彦章等，Treadmill exercise increases cystathionine γ-lyase expression and decreases inflammation in skeletal muscles of high-fat diet-induced obese rats，河南省教育厅优秀科技论文奖二等奖，河南省教育厅，2019.5
4.吴东栋，2018年河南大学优秀硕士学位论文指导教师，河南大学，2018.11
5.吴东栋，王军，李慧等，Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury，河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2018.5
6.吴东栋，司伟荣，吕双瑜等，Hydrogen sulfide in cancer: Friend or foe?河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2018.5
7.吴东栋，高艳锋，祁元明等，Peptide-based cancer therapy opportunity and challenge,河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2018.5
8.吴东栋，高标，李孟玲等，Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice,河南省自然科学优秀学术论文三等奖，河南省人力资源和社会保障厅，河南省科学技术协会，2017.12
9.吴东栋，2017年河南大学优秀硕士学位论文指导教师，河南大学，2017.11
10.吴东栋，河南大学2015-2016年度科研优秀奖，河南大学，2017.9
11.吴东栋，高艳锋，祁元明等，Peptide-based cancer therapy: Opportunity and challenge,河南省自然科学优秀学术论文二等奖，河南省人力资源和社会保障厅，河南省科学技术协会，2015.12
七、出版著作：医学生理学实验（副主编）
八、讲授课程：生理学（本科生）、实验动物学（研究生）
九、联系方式（邮箱等）：ddwubiomed2010@163.com