1.个人信息（Personals）：
　　男，1973年1月生，博士，硕士生导师，教授，黄河********。Drug Discoveries & Therapeutics 编委，河南省药学会药物制剂专委会副主任委员，河南省药效物质基础国际联合实验室副主任， 河南省核蛋白基因调控国际联合实验室常务副主任， 河南省开封市药学会常务理事、技术部主任，河南大学创新药物设计与评价研究所所长。Email：sduan@henu.edu.cn
2.受教育经历 (Educational Experience) ：
　　2002/09-2007/10，美国新墨西哥州立大学，化学，博士
　　1998/09-2000/12，华东理工大学，精细化工研究所，攻读博士
　　1995/09-1998/04，南京理工大学，化工学院，硕士
　　1991/09-1995/06，南京理工大学，化工学院，学士
3.工作经历(Professional Experience) ：
　　2015/09–至今，河南大学，药学院，教授；
　　2007/11–2015/08，美国堪萨斯大学，化学系/药学院，博士后/研究员；
　　2001/01–2001/05；药明康德，研发工程师
4. 研究兴趣（Research Interests）：
　　1）小分子抗癌药的设计与合成；2）纳米高分子药物载体的设计与合成；3）抗癌前药的合成及药物控释。
5. 承担项目情况(Financial Supports)
[1] 河南大学黄河****启动基金， 50万元，2015.09-2020.08，河南省博士后科研项目，主持。
6. 代表性论著 (Publications)
[1]Dong, Qian; Yang, Bo; Han, Ju-Guo; Zhang, Meng-Meng; Liu, Wei; Zhang, Xin; Yu, Hai-Lan; Liu, Zheng-Guo; Zhang, Shi-Hui; Li, Tao; Dong‐Dong Wu*; Xin-Ying Ji*；Shao-Feng Duan* A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways. Cancer Letters 2019, 455, 60-72
[2]Yan, Li-Juan; Guo, Xin-Hong; Wang, Wei-Ping; Hu, Yu-Rong*; Duan, Shao-Feng*; Liu, Ying; Sun, Zhi; Huang, Sheng-Nan; Li, Hui-li. Gene Therapy and Photothermal Therapy of Layer-by-Layer Assembled AuNCs /PEI/miRNA/ HA Nanocomplexes. Current Cancer Drug Targets 2019, 19(4), 330-337
[3]Dong-Dong Wu, Da-Yong Wang, Hui-Min Li Jian-Cheng Guo, Shao-Feng Duan*, Xin-Ying Ji*. Hydrogen sulfide as a novel regulatory factor in liver health and disease. Oxidative Medicine and Cellular Longevity 2019, 1-16
[4]Dong‐Dong Wu, Shi‐Yu Liu, Ying‐Ran Gao, Dan Lu, Ya Hong, Ya‐Ge Chen, Peng‐Zhen Dong, Da‐Yong Wang, Tao Li, Hui‐Min Li, Zhi‐Guang Ren, Jian‐Cheng Guo, Fei He, Xue‐Qun Ren, Shi-Yong Sun, Shao‐Feng Duan*, Xin‐Ying Ji*. Tumour necrosis factor‐α‐induced protein 8‐like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells. J Cell Mol Med. 2019, 23(3), 1698-1713
[5]Li, Huili; Li, Huanjie; Yu, Wei; Huang, Shengnan; Liu, Ying; Zhang, Ningxia; Yuan, Jinxiu; Xu, Xin; Duan, Shaofeng*; Hu, Yurong*. PEGylated hyaluronidase/NIR induced drug controlled release system for synergetic chemo-photothermal therapy of hepatocellular carcinoma. European Journal of Pharmaceutical Sciences 2019, 133, 127-136
[6]Cui Li, Chen Zang, Qixia Nie, Bo Yang, Baoxian Zhang, Shaofeng Duan*. Simultaneous determination of seven flavonoids, two phenolic acids and two cholesterines in Tanreqing injection by UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2019, 163, 105–112.
[7]Wang, Weiping; Huang, Shengnan; Yuan, Jinxiu; Xu, Xin; Li, Huili; Lv, Zhanwei; Yu, Wei; Duan, Shaofeng*; Hu, Yurong*. Reverse multidrug resistance in human HepG2/ADR by anti-miR-21 combined with hyperthermia mediated by functionalized gold nanocages. Molecular Pharmaceutics 2018, 15(9), 3767-3776
[8]Yanping Cao, Zhihao Wei, Mengmeng Li, Haiyan Wang, Li Yin, Dongxiao Chen, Yanfei Wang,Yongchao Chen, Qi Yuan, Xiaohui Pu*, Lanlan Zong*, Shaofeng Duan*. Formulation, pharmacokinetic evaluation and cytotoxicity of an enhanced-penetration paclitaxel nanosuspension. Current Cancer Drug Targets 2019 19(4), 338-347
[9]Pu, Xiaohui; Li, Jia; Qiao, Peng; Li, Mengmeng; Wang, Haiyan; Zong, Lanlan; Yuan, Qi; Duan, Shaofeng*. Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications. Current Cancer Drug Targets 2019, 19(4), 285-295
[10] Wang Da-Yong; Wang Da-Yong; Hong Ya; Chen Ya-Ge; Dong Peng-Zhen; Liu Shi-Yu; Gao Ying-Ran; Lu Dan; Li Hui-Min; Li Tao; Dong‐Dong Wu*; Xin-Ying Ji*；Shao-Feng Duan*. PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma. Oncogenesis 2019, 8(3), 22
[11] Li, Changlin; He, Chenchen; Xu, Ying; Xu, Haixia; Tang, Yuzhe; Chavan, Hemantkumar; Duan, Shaofeng; Artigues, Antonio; Forrest, Marcus Laird; Krishnamurthy, Partha; et al. Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer. Prostate 2019, 79(6), 628-639
[12] Guo-Yu Zhang#, Dan Lu#, Shao-Feng Duan#, Ying-Ran Gao, Shi-Yu Liu, Ya Hong Peng-Zhen Dong, Ya-Ge Chen, Tao Li, Da-Yong Wang, Xiang-Shu Cheng, Fei He Jian-She Wei, Guang-Yu Li, Qing-Yong Zhang, Dong-Dong Wu. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity 2018, 2018, **
[13] Dongdong Wu, Honggang Wang, Tieshan Teng Shaofeng Duan, Ailing Ji, Yanzhang Li. Hydrogen sulfide and autophagy: A double edged sword. Pharmacological Research 2018, 131, 120-127
[14] Huang, Shengnan; Liu, Ying; Xu, Xin; Ji, Mengfei; Li, Yuanmin; Song, Chengjun; Duan, Shaofeng*; Hu, Yurong*. Triple therapy of hepatocellular carcinoma with microRNA-122 and doxorubicin co-loaded functionalized gold nanocages. Journal of Materials Chemistry B: Materials for Biology and Medicine 2018, 6(15), 2217-2229
[15] Mengfei Ji, Xiaojing Qiu, Lin Hou, Yuanmin Li, Shengnan Huang, Yang Liu, Shaofeng Duan*, Yurong Hu*. Construction and Application of a Liver Cancer-targeting drug Delivery System Based on Core-shell Gold Nanocages. International Journal of Nanomedicine 2018, 13, 1773-1789
[16] Shijin Bao, Shengnan Huang, Ying Liu,Yurong Hu,*Weiping Wang, Mengfei Ji, Huili Li, Ningxia Zhang, Chengzhi Song, Shaofeng Duan*. Gold nanocages with dual modality for imageguided therapeutics. Nanoscale 2017, 9, 7284-7296
[17] Li, Mengmeng; Chen, Yongchao; Yin, Li; Wang, Haiyan; Cao, Yanping; Wei, Zhihao; Wang, Yanfei; Yuan, Qi; Pu, Xiaohui; Zong, Lanlan; Duan, Shaofeng. Formulation and stability evaluation of structure-altered paclitaxel nanosuspensions stabilized by a biocompatible amino acid copolymer. Science of Advanced Materials 2017, 9(10), 1713-1723
[18] Chenchen He, Shaofeng Duan, Liang Dong,Yifen Wang,Qingting Hu, Chunjing Liu,Marcus L. Forrest,Jeffrey M. Holzbeierlein,Suxia Han, Benyi Li. Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells. Prostate 2017, 77(11):1187-1198.
[19] Shengnan Huang, Chunming Li, Weiping Wang, Huanjie Li, Zhi Sun, Chengzhi Song, Shaofeng Duan*, Yurong Hu*, Benyi Li. A54 peptide-mediated functionalized gold nanocages for targeted delivery of DOX as acombinational chemo-photothermal therapy for hepatocellular carcinoma. International Journal of Nanomedicine 2017, 12, 5163-5176
[20] Shengnan Huang#, Shaofeng Duan#, Jing Wang, Shijin Bao, Xiaojing Qiu, Chunming Li, Ying Liu, Lijuan Yan, Zhenzhong Zhang,Yurong Hu. Folic Acid Mediated Functionalized Gold Nanocages for Targeted Delivery of Anti-miR-181b in Combination of Gene Therapy and Photothermal Therapy against Hepatocellular Carcinoma. Advanced Functional Materials 2016, 26(15), 2532-2544 (first co-author)
[21] Solomon Z Okbazghi, Apurva S More, Derek R White, Shaofeng Duan, Ishan S Shah, Sangeeta B Joshi, C Russell Middaugh, David B Volkin, Thomas J Tolbert. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. J Pharm Sci 2016, 105(2), 559-74.
[22] Yunqi Zhao, Ti Zhang#, Shaofeng Duan#, Neal M Davies, M Laird Forrest. CD44-tropic polymeric nanocarrier for breast cancer targeted rapamycin chemotherapy. Nanomedicine 2014, 10(6), 1221-30.
[23] Lohrman, Jessica; Liu, Yueying; Duan, Shaofeng; Zhao, Xiaoyong; Wuttig, Manfred; Ren, Shenqiang; All Conjugated Copolymer Excitonic Multiferroics. Advanced Materials 2013, 25 (5), 783-787.
[24] Ndolo, Rosemary A.; Luan, Yepeng; Duan, Shaofeng; Forrest, M. Laird; Krise, Jeffrey P. Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro. PLoS One 2012, 7(11), e49366.
[25] SM Cohen, R Mukerji, S Duan, S Cai, ML Forrest, MS CohenM. Laird Forrest. A Novel Nanocarrier Delivery System for Doxorubicin with Improved Tumor Response and Reduced Systemic Toxicity in Advanced Pediatric Non-Hodgkin Lymphoma. Journal of Surgical Research. 2012, 172 (2), 317.
[26] Yunqi Zhao#, Shaofeng Duan#, Xing Zeng, Chunjing Liu, Benyi Li, Neal M. Davies, M Laird Forrest. Prodrug Strategy for PSMA-targetted Delivery of TGX-221 to Prostate Cancer Cells. Molecular Pharmaceutics 2012, 9, 1705 1716 (first co-author).
[27] Taryn R. Bagby#, Shaofeng Duan#, Shuang Cai, Laird Forrest. Functional lymphatic imaging using negatively charged star polymer architectures grafted with near-infrared dye. European Journal of Pharmaceutical Sciences 2012, 47(1), 287-294 (first co-author)
[28] Taryn R. Bagby, Shuang Cai, Shaofeng Duan, Sharadvi Thati, Aires, Daniel J., Laird Forrest. Impact of molecular weight on lymphatic drainage of a biopolymer-based imaging agent. Pharmaceutics 2012, 4(2), 276-295.
[29] Shaofeng Duan, Shuang Cai, Yumei Xie, M. Laird Forrest. Ester star polymers as controlled drug release carriers for cisplatin and nitric oxide. Journal of Polymer Science Part A: Polymer Chemistry 2012, 50, 2715–2724.
[30] Shaofeng Duan, Shuang Cai, Qiuhong Yang, M. Laird Forrest. Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma. Biomaterials 2012, 33, 3243-3253.
[31] Yepeng Luan, Qiuhong Yang, Yumei Xie, Shaofeng Duan, M.L Forrest. A Sensitive Near-Infrared Fluorescent Probe for Caspase-mediated Apoptosis: Synthesis and Application in Cell Imaging. Drug Discoveries & Therapeutics 2011, 5(5), 220-226.
[32] Rajesh Kumar Patti, Shaofeng Duan, Zhipeng Wang, James W. Herndon. Preparation of phenalenes and hydronaphthacenes through tandem alkyne Fischer–carbene complex coupling and inter- or intra-molecular Diels–Alder reactions. Tetrahedron Lett. 2011, 52(32), 4182-4185.
[33] Rajesh Kumar-Patti, Shaofeng Duan, Alejandro Camacho-Davila, Kris Waynant, Kenneth A Dunn, James W Herndon. Synthesis of hydronaphthalenes through coupling of enyne carbonyl compounds that contain pendant alkene groups with Fischer carbene complexes. Tetrahedron Lett. 2010, 51(28), 3682-3684.
[34] Xie, Yumei; Duan, Shaofeng; Forrest, M. Laird. Alkyne- and 1, 6-elimination-succinimidyl carbonate-terminated heterobifunctional poly (ethylene glycol) for reversible "click" PEGylation. Drug Discoveries & Therapeutics 2010, 4(4), 240-245.
[35] Sandipan Sinha, Lei Zhang, Shaofeng Duan, Todd Williams, Josef Vlasak, Roxana Lonescu, Elizabeth Topp. Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody. Protein Science 2009, 18(8), 1573-1584.
[36] Shaofeng Duan, Ranjan Jana, Jon Tunge. “Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters” J. Org. Chem. 2009, 74, 4612–4614.
[37]Shaofeng Duan, Dilip K. Sinha-Mahapatra, James W. Herndon. “Synthesis of Nanphthalenes through three-component coupling of alkynes, Fischer carbene complexes and Benzaldehyde Hydrozones via Isoindole intermediates” Org. Lett. 2008, 10, 1541-1544.
[38] Shaofeng Duan, Karen Cress, Kris Waynant, Elias Ramos-Miranda, James W. Herndon. “Synthesis of alkylidenephthalans through fluoride-induced cyclization of electron-deficient 2-siloxymethylphenylacetylene derivatives” Tetrahedron 2007, 63, 2959-2965.
[39]Binay K.Ghorai, Shaofeng Duan, Delu jiang, James W. Herndon. “Coupling of β-Cyanocarbene-Chromium Complexes with 2-Alkynylbenzoyl Derivatives: A (5+5)-Cycloaddition Approach to Phenanthridines” Synthesis 2006, 21, 3661-3669.
7. 专利（Patents）：
[1]Hu, Yurong; Ji, Mengfei; Li, Huili; Yuan, Jinxiu; Duan, Shaofeng; Xu, Xin; Huang, Shengnan Test kit detection method and application for early diagnosis of tumor diseases. CN A **）
[2]张国瑜，李涛，吴东栋，赵琼，腾铁山，段少峰，姬新颖. 一种基于干细胞源外泌体的组合物及其在制备治疗心肌梗死的药物中的应用. (1.3- 2017-06-05)
[3]Hu, Yurong; Niu, Zhenxi; Chen, Jie; Zhang, Ningxia; Yao, Xing; Duan, Shaofeng; Huang, Shengnan; Zhang, Junxia; Wang, Weiping; Liu, Ying et al From Faming Zhuanli Shenqing. A method for preparing amphiphilic polymer and application thereof. (CN A- 2017-02-22)
[4]Forrest, Marcus Laird, Zhang, Ti, Senadheera, S. P. Sanjeewa N., Aires, Daniel, Zhao, Yunqi, Duan, Shaofeng, Groer, Chad. TARGETED MTOR INHIBITOR (US (A1) - 2016-09-29)
[5]M. Laird Forrest*, Shaofeng Duan, Shuang, Cai, Ti Zhang, Qiuhong Yang. Drug and imaging agent delivery compositions and methods. (WO (A1) -2013-07-25)