何世斌，女，1984年7月生，博士，硕士生导师，毕业于武汉大学遗传学专业。承担遗传学实验、分子细胞遗传学等课程的教学工作，参编教材1部。主要从事植物分子细胞遗传学与表观遗传学研究，主持国家自然科学基金、河南省博士后基金、河南省青年骨干教师基金各1项，先后在Biomaterials、Lab on a chip、PloS one、Biochimie、Crop Science等国内外杂志上发表论文20余篇，申报国家发明专利 4项。

主要研究方向：
我的研究方向是将分子细胞遗传学和表观遗传学的方法相结合，包括原位杂交、免疫染色、流式细胞技术、染色质免疫共沉淀等，以及常规的分子生物学方法研究染色体的进化，植物重复序列的表观遗传修饰情况以及逆境胁迫下的表观遗传机制。

发表论文和著作：
1) Shibin He, Xu Yu, Xiangwu Wang, Junjun Tan, Shihan Yan, Pu Wang, Bi-Hai Huang, Zhi-Ling Zhang*, Lijia Li*.Fast Magnetic Isolation of Simple Sequence Repeat Markers in Microfluidic Channels. Lab on a Chip, 2014, 14, 1410-1414. (SCI一区, IF: 5.748)
2) Shibin He*, Shihan Yan, Pu Wang, Wei Zhu, Xiangwu Wang, Yao Shen, Kejia Shao,Haiping xin, Shaohua Li, Lijia Li*. Chromosome-scale epigenetic modification patterns among different maize inbred lines. PLoS One, 2014, 9 (5), e97364. (SCI三区, IF: 3.534)
3) Shihan Yan, Qi Zhang, Yingnan Li, Yan Huang, Lin Zhao, Shibin He* and Lijia Li*. Comparison of Chromatin Epigenetic Modification Patterns among Root Meristem, Elongation and Maturation Zones in Maize (Zea Mays L.). Cytogenetic and Genome Research, 2014, DOI: 10.1159/. (SCI四区, IF: 1.905)
4) Shibin He, Bi-Hai Huang, Junjun Tan, Qing-Ying Luo, Yi Lin, Jun Li, Yong Hu, Lu Zhang, Shihan Yan, Qi Zhang, Dai-Wen Pang*, Lijia Li*. One-to-one quantum dot- labeled single long DNA probes. Biomaterials, 2011, 32(23), 5471-5477. (SCI一区, IF: 8.312)
5) Shibin He, Min Huang, Jing Huang, Jun Li, Yong Hu, Lu Zhang, ChenZhen Zhang, Shuizhang Fei, LiJia Li*. Dynamics of the Evolution of the Genus of Agrostis Revealed by GISH/FISH. Crop science, 2009, 49, 2285-2290. (SCI三区, IF: 1.478)
6) Lu Ma, Shibin He (co-first author), Jing Huang, Lei Cao, Fei Yang, LiJia Li*. Maximizing Specificity and Yield of PCR by the Quantum Dot itself rather than the Property of the Quantum Dot Surface. Biochimie, 2009, 991(8), 969-973. (SCI三区, IF:3123)
7) Pu Wang, Hao Zhang, Haoli Hou, Qing Wang, Yingnan Li, Yan Huang, Liangfu Xie, Fei Gao, Shibin He, Lijia Li*. Cell cycle arrest induced by inhibitors of epigenetic modifications in maize (Zea mays) seedling leaves: characterization of the process and possible mechanisms involved. New Phytologist, 2016, 211: 646–657.
8) Junjun Tan, Shibin He, Shihan Yan, Hui Li, Fei Gao, Hao Zhang, Lijia Li*. Exogenous EDDS modifies copper-induced various toxic responses in rice. Protoplasma, 2014, DOI: 10.1159/.
9) Shihan Yan, Lin Zhao, Hui Li, Qi Zhang, Junjun Tan, Min Huang, Shibin He, Lijia Li*. Single-walled carbon nanotubes selectively influence maize root tissue development accompanied by the change in the related gene expression. Journal of Hazardous Materials. 246–247, 110–118, 2013.
10) Yong Hu, Lu Zhang, Shibin He, Min Huang, Junjun Tan, Lin Zhao, Shihan Yan, Hui Li, Kun Zhou, Yanan Liang, Lijia Li*. Cold stress selectively unsilences tandem repeats in heterochromatin associated with accumulation of H3K9ac. Plant, Cell & Environment, 2012, 35(12), 2130–2142.
11) Jun Li, Shibin He, Lu Zhang, Yong Hu, Fei Yang, Lu Ma, Jing Huang, Lijia Li*. Telomere and 45S rDNA sequences are structurally linked on the chromosomes in Chrysanthemum segetum L. Protoplasma, 2012, 249:207–2152.
12) Min Huang, Hui Li, Lu Zhang, Fei Gao, Pu Wang, Yong Hu, Shihan Yan, Lin Zhao, Qi Zhang, Junjun Tan, Xincheng Liu, Shibin He, Lijia Li*. Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterations. PLoS ONE, 2012 7(4): e35139.
13) Lu Zhang, Yong Hu, Shihan Yan, Hui Li, Shibin He, Min Huang, Lijia Li*. ABA-mediated inhibition of seed germination is associated with ribosomal DNA chromatin condensation, decreased transcription, and ribosomal RNA gene hypoacetylation. Plant Molecular Biology, 2012, 79, 285–293.
14) Yong Hu, Lu Zhang, Lin Zhao, Jun Li, Shibin He, Kun Zhou, Fei Yang, Min Huang, Li Jiang, Lijia Li*. Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. PLoS ONE, 2011, 6(7), e22132.
15) Lu Zhang, Zhengming Qiu, Yong Hu, Fei Yang, Shihan Yan, Zhao Lin, Bo Li, Shibin He, Min Huang, Jun Li, Lijia Li*. ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. Physiologia plantarum, 2011, 143(3):287-296
16) Yong Hu, Jun Li, Lu Ma, Qionglin Peng, Wei Feng, Lu Zhang, Shibin He, Fei Yang, Jing Huang, Lijia Li*. High efficiency transport of quantum dots into plant roots with the aid of silwet L-77. Plant Physiology and Biochemistry, 2010, 48, 703-709.
17) Jun Li, Fei Yang, Jia Zhu, Shibin He, Lijia Li*. Characterization of a tandemly repeated subtelomeric sequence with inverted telomere repeats in maize. Genome, 2009, 52:286-293.
18) Ya-Hua Chen*, Ying Mao, Shibin He, Peng Guo, Ke Xu. Heat stress increases the efficiency of EDTA in phytoextraction of heavy metals. Chemosphere, 2007, 67:1511-1517.
19) 何世斌*，柴连琴，谭珺隽，沈尧，周萍，马云峰，李立家。荧光原位杂交技术的研究进展。植物科学学报，2014，32，199-204。
20) 柴连琴，何世斌，王摇楠，孟景会，苗迎春，于威。棉铃虫C型凝集素抑制多角体病毒体内增殖。植物保护学报，2014，41(4):468-473。
21) 李立家*，何世斌，张璐。遗传，2012, 34(12):1624-1627。
22) 王子成，董美芳，许守明，李忠爱，孙立荣，何艳霞，何世斌，王棚涛，艾鹏慧，大学生物学综合实验指导书，河南大学出版社，2013。


主持项目：
1) 玉米异染色质纽(Knob)形成的表观遗传制及进化分析，批准号：**，2015-2017，国家自然科学基金，主持人。
2) 玉米及其野生近缘种的表观基因组比较分析与进化关系，批准号：**，2012-2014，河南省博士后基金，主持人。
3) 棉花重金属胁迫下的表观遗传机制，2014-2019，河南大学青年科研人才种子基金，主持人。
4) 硅增强棉花抗重金属镍胁迫的表观调控机制，批准号：2016GGJS-024，2017-2019，主持人。


专利：
(1)李立家，庞代文，何世斌，黄碧海，一种植物单拷贝基因的检测方法，2013.1，中国，专利号：9.6。(已授权)
(2)李立家，何世斌，李慧，谭珺隽，张琦，一种诱导玉米小孢子形成胚状体的方法，2012.1，中国，专利号：0.9。(已授权)
(3)李立家，马璐，何世斌，使用量子点改进聚合酶链式反应的方法，2012.6，中国，专利号：2.0。(已授权)
(4)李立家，庞代文，何世斌，黄碧海，单个量子点偶联单个长链DNA分子的方法，2012.9，中国，专利号：7.8。(已授权)



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