1. 个人信息： 万绍贵，男，1979年8月出生，博士，教授，现任河南大学药学院生物制药学科带头人、黄河学者特聘教授Email：shaoguiwan@126.com

2. 大学开始的受教育经历
2003/09-2006/07，中国科学院昆明动物所，博士
2000/09-2003/07，江西农业大学动物科技学院，硕士
1996/09-2003/07，江西农业大学动物科技学院，学士

3. 研究工作经历
2013/09 - 至今 河南大学药学院， 教授
2013/07 - 2013/09 第四军医大学基础部教学与实验中心，合作研究
2010/07 - 2013/07 美国托马斯杰斐逊大学Kimmel癌症研究中心， 博士后
2008/08 - 2010/06 美国托马斯杰斐逊大学药理系，博士后
2006/09 - 2008/07 美国美国俄亥俄州立大学癌症癌症研究中心，博士后

4. 研究方向
1. 游离线粒体DNA作为无创分子标志物的临床应用及其免疫调节机制（Circulating mitochondrial DNA and its immune regulatory functions)
2. 免疫调节天然产物的结构与功能研究 （Purification and functional characterization of immune regulatory bioactive proteins）
3. 线粒体生物学与免疫功能 (Mitochondrial biology and its immune functions) (该方向与第四军医大学邢金良教授合作培养)

欢迎对无创分子标志物以及体外诊断行业有兴趣的广大同学加入我们的科研团队！

5. 在研的主要科研项目:
1. 河南省高校科技创新人才支持计划,计划编号：15HASTIT035；研究方向：无创分子标志物的发掘及其转化医学研究；资助经费：60万元；资助期限：2015.1-2017.12；主持人
2. 河南大学杰出青年科研人才培育计划，研究方向：无创肿瘤分子标志物；资助金额：300万元；起止时间：2014.9- 2018.8；主持人
3. 河南大学黄河学者启动基金，资助金额：50万元；起止时间：2013.11-2017.10；主持人
4. 国家自然科学基金青年项目，基金编号: **；项目名称：缺锌诱导的DNA异常甲基化在食管鳞状上皮细胞癌变过程中的机理研究；资助金额: 23万元；起止时间: 2013.1-2015.12；主持人

6．主要论著

第一作者及通讯作者SCI文章 (13篇)

[1] Wu YS, Bao DK, Dai JY, Chen C, Zhang HX, Yang YF, Xing JL, Huang XJ, Wan SG*. Polymorphisms in Genes of the De Novo Lipogenesis Pathway and Overall Survival of Hepatocellular Carcinoma Patients Undergoing Transarterial Chemoembolization. Asian Pacfic Journal of Cancer Prevention.2015 Mar 16 (3), 1051-1056. (IF=1.5）(通讯作者)
[2] Hann HW, Wan S, Lai Y, Hann RS, Myers RE, Patel F, Zhang K, Ye Z, Wang C, Yang H. AST to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic HBV infection. Journal of Gastroenterology and Hepatology. 2014 Jul 3. Doi: 10.1111/jgh.12664. (共同第一者) (IF=3.33)
[3] Du X, Wan S, Chen Y, Qu P, Huang X, Yu X, Yang H, Zhang Y, Xing J. Genetic variants in genes of tricarboxylic acid cycle key enzymes predict postsurgical overall survival of patients with hepatocellular carcinoma. Annals of Surgical Oncology. 2014 Aug 1. Doi: 10.1245/s10434-014-3876-2. (共同第一者) (IF=4.12)
[4] Yang Y, Fei F, Song Y, Li X, Zhang Z, Fei Z, Su H*, Wan S*. Polymorphisms of EpCAM Gene and Prognosis of non-small cell lung cancer in Han Chinese. Cancer Science. 2014 Jan;105:89-96. (通讯作者) (IF=3.48)
[5] Wan S, Hann HW, Myers R, Fu X, Hann H, Kim SH, Tang H, Xing J, Yang H. Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis risk: a nested case control analysis. Liver International. 2012 Sep; 32(8):1233-41. (IF=3.87)
[6] Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ, Huang K, Liu XP, Farber JL, Croce CM, Fong LY. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. International Journal of Cancer. 2011 Jul 15; 129 (2):331-45. (IF=6.20)
[7] Wan S. Lai Y, Myers RE, Li B, Palazzo JP, Burkart AL, Chen G, Xing JL, Yang H. Post-diagnosis hemoglobin change associates with the overall survival of multiple malignancies-Results from a 14-year hospital-based cohort of lung, breast, colorectal, and liver cancers. BMC Cancer. 2013 Jul 10; 13:340. (IF=3.33)
[8] Wan S, Lai Y, Myers RE, Li B, Hyslop T, London J, Chatterjee D, Palazzo JP, Burkart AL, Zhang K, Xing J, Yang H. Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients. Journal of Gastrointestinal Cancer. 2013 Apr 3.
[9] Wan S, Civan J, Rossi S, Yang H. Profiling HBV integrations in hepatocellular carcinoma. Hepatobiliary Surgery and Nutrition. 2012 Oct; 1:19. (Invited commentary)
[10] Wan SG, Jin Y, Lee WH, Zhang Y. A snake venom metalloproteinase that inhibited cell proliferation and induced morphological changes of ECV304 cells. Toxicon. 2006, 47(4):480-489. (IF=2.92)
[11] Wan SG, Jin Y, Lee WH, Zhang Y. Cloning of Two Novel P-III Class Metalloproteinases from Trimeresurus stejnegeri Venom Gland. Toxicon. 2006, 47(4):465-472. (IF=2.92)
[12] Fu X, Wan S, Hann HW, Myers R, Hann RS, Au J, Chen B, Xing J, Yang H. Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in HBV patients. European Journal of Cancer. 2012 May; 48(7):1014-22 (共同第一者). (IF=5.06)
[13] Hann HW, Wan S, Myers R, Hann RS, Xing J, Chen B, Yang H. Comprehensive analysis of common serum liver enzymes as prospective predictors of hepatocellular carcinoma in HBV patients-results of a clinic-based cohort. PLoS One. 2012; 7(10): e47687. (共同第一作者). (IF=3.73)

共同作者的SCI文章（13篇）

[14] Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM and Fong LYY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009, 136 (3):953-66. (IF=12.82)
[15] Xing J, Wan S, Zhou F, Qu F, Li B, Myers RE, Fu X, Palazzo JP, He X, Chen Z, Yang H. Genetic Polymorphisms in Pre-microRNA Genes as Prognostic Markers of Colorectal Cancer. Cancer Epidemiology, Biomarkers & Prevention. 2012 Jan; 21(1):217-27. (IF=4.56)
[16] Dai J, Wan S, Zhou F, Myers R, Guo X, Fu X, Palazzo J, Dou K, Yang H, Xing J. Genetic polymorphism in a VEGF-independent angiogenisis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection. PLoS One. 2012;7(4):e34758. (IF=3.73)
[17] Zhang J, Zhang Y, Wan SG, Wei SS, Lee WH, Zhang Y.Bm-TFF2, a trefoil factor protein with platelet activation activity from frog Bombina maxima skin secretions. Biochemical and Biophysical Research Communications. 2005, 330: 1027–1033. (IF=2.41)
[18] Dong G, Guo X, Fu X, Wan S, Zhou F, Myers R, Bao G, Burkart A, Yang H, Xing J. Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer. Cancer Science. 2012 Mar;103(3):561-8. (IF=3.48)
[19] Hann HW, Fu X, Myers RE, Hann RS, Wan S, Kim SH, Au N, Xing J, Yang H. Predictive value of alpha fetoprotein in the long-term risk of developing hepatocellular carcinoma in patients with hepatitis B virus infection- results from a clinic-based longitudinal cohort. European Journal of Cancer. 2012 Mar 19. (IF=5.06)
[20] Yuan P, Wang S, Zhou F, Wan S, Yang Y, Huang X, Zhang Z, Zhu Y, Zhang H, Xing J. Functional polymorphisms in NPAS2 gene are associated with overall survival in TACE-treated hepatocellular carcinoma patients. Cancer Sci. 2014 Apr 23. doi: 10.1111/cas.12428.(IF=3.48)
[21] Chen Y, Qu F, He X, Bao X, Liu X, Wan S, Xing J. Short leukocyte telomere length predicts poor prognosis and indicates altered immune functions in colorectal cancer patients. Annals of Oncology, 2014 Apr. 25 (4): 869-876. (IF=7.38)
[22] Yu X, Ge N, Guo X, Shen S, Liang J, Huang X, Wan S, Xing J, Huang Q, Yang Y. Genetic Variants in the EPCAM Gene Is Associated with the Prognosis of Transarterial Chemoembolization Treated Hepatocellular Carcinoma with Portal Vein Tumor Thrombus. PLoS One. 2014 Apr 9;9(4):e93416. (IF=3.73)
[23] Lei W, Huang Y, Zhang Y, Yu G, Wan S, Lee W, Zhang Y. The frog trefoil factor Bm-TFF2 activates human platelets via Gq and G12/13 signaling pathway. Toxicon. 2012 Jan; 59(1):104-9. (IF=2.92)
[24] Liu B, Liu Q, Song Y, Li X, Wang Y, Wan S, Zhang Z, Su H. Polymorphisms of HIF1A gene are associated with prognosis of early stage non-small-cell lung cancer patients after surgery. Medical Oncology. 2014 Apr;31(4):877. (IF=2.15)
[25] Wang S, Chen Y, Qu F, He S, Huang X, Jiang H, Jin T, Wan S, Xing J. Association between leukocyte telomere length and glioma risk: a case-control study. Neuro Oncology. 2013 Dec 22. [Epub ahead of print] (IF=6.18)
[26] Xing J, Myers RE, He X, Qu F, Zhou F, Ma X, Hyslop T, Bao G, Wan S, Yang H, Chen Z. GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis. European Journal of Cancer. 2011 Jul 47(11):1699-707. (IF=5.06)