姓名：王江
学科：基础兽医学
系别: 动物生物技术系
电话/传真：**
电子邮件：wangjiang_hau@hotmail.com
通讯地址：郑州市郑东新区龙子湖高教园区15号 河南农业大学龙子湖校区第一实验楼动物医学院 450046

简介：
王江，男，博士，副教授，硕士研究生导师，1982年出生。
教学上承担的动物生物化学课程，获得河南农业大学2015年度校级精品资源共享课；指导本科生从事科技创新，获得河南农业大学牧医工程学院第七届“大学生科技创新”活动“优秀指导教师奖”。2016年被授予河南农业大学牧医工程学院优秀教师称号。
科研上近年来主持国家自然科学基金青年基金项目和河南省基础研究计划，参与了转基因生物新品种培育重大专项、“十二五”农村领域国家科技计划、河南省重大科技专项、霍英东教育基金会高等院校青年教师基金和国家自然科学基金青年等项目。并在Redox Biology、Plos Pathogens、Frontiers in Immunology、Journal of Virology、Molecular Immunology、Journal of Lipid Research、Cell Metabolism、Cell等国际期刊上发表多篇原创性研究论文。获得国家发明专利2项，申请国家发明专利5项。
教授课程 本科生《动物生物化学》
硕士研究生《生物化学和分子生物学研究进展》、《兽医生物技术》、《畜牧生物技术专题》、《分子种系发育与生物信息学》、《动物生物化学进展》、《基因工程原理与技术》
博士研究生《兽医生物技术》
研究领域 动物生物化学与分子生物学
学历及培训经历 2000.09-2004.06，兰州大学，生物科学专业， 学士
2004.09-2007.06，兰州大学，生物化学与分子生物学，硕士
2008.09-2013.01，中科院生化细胞所，生物化学与分子生物学，博士
工作经历 2013.01-2015.11，河南农业大学牧医工程学院，博士后
2013.09-2017.12，河南农业大学牧医工程学院，讲师
2018.01-至今， 河南农业大学牧医工程学院，副教授
学术社会兼职
承担科研项目
情况 1.国家自然科学基金青年项目：丙酮酸激酶M2对奶牛乳腺上皮细胞增殖和乳合成的影响（**）2015.01-2017.12，主持
2. 河南省基础研究计划：CRISPR-Cas新型基因敲除载体的构建及功能验证（**9）2014.02-2016.12，主持
代表论著
（*通讯作者） Lei Zeng, Meng-Di Wang, Sheng-Li Ming, Guo-Li Li, Peng-Wei Yu,Yan-Li Qia, Da-Wei Jiang, Guo-Yu Yang^*, Jiang Wang^*, Bei-Bei Chu^*.An effective inactivant based on singlet oxygen-mediated lipid oxidationimplicates a new paradigm for broad-spectrum antivirals. 2020, Redox Biology; 8;36:101601
Jiang Wang, Guo-Li Li, Sheng-Li Ming, Chun-Feng Wang, Li-Juan Shi1, Bing-Qian Su, Hong-Tao Wu, Lei Zeng, Ying-Qian Han, Zhong-Hu Liu, Da-Wei Jiang, Yong-Kun Du, Xiang-Dong Li, Gai-Ping Zhang, Guo-Yu Yang^*, Bei-Bei Chu^*. BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. 2020, Plos Pathogens; 24;16(3):e**
JiangWang, Gen Ba, Ying-Qian Han, Sheng-Li Ming, Meng-Di Wang, Peng-Fei Fu, Qing-Qing Zhao,Shuang Zhang, Ya-Nan Wu, Guo-Yu Yang^*, Bei-Bei Chu^*.Cyclic GMP-AMP Synthase Is Essential for Cytosolic Double-Stranded DNA and Fowl Adenovirus Serotype 4 Triggered Innate Immune Responses in Chickens. 2020, International Journal of Biological Macromolecules; 146:497-507
Shao-Ting Weng, Feng Gao, Juan Wang, Xing-Yu Li, Bei-Bei Chu, Jiang Wang^*, Guo-Yu Yang^*. Improvement of Muscular Atrophy by AAV-SaCas9-mediated Myostatin Gene Editing in Aged Mice. 2020, Cancer Gene Therapy; doi: 10.1038/s41417-020-0178-7
Sheng-Li Ming, Lei Zeng, Yu-Kun Guo, Shuang Zhang, Guo-Li Li, Ying-Xian Ma, Yun-Yun Zhai, Wen-Ru Chang, Le Yang, Jiang Wang, Guo-Yu Yang*, Bei-Bei Chu*. The human specific STING agonist G10 activates type I interferon and the NLRP3 inflammasome in porcine cells. 2020, Frontiers in Immunology; accepted
Jiang Wang, Jiao-Yang Liu, Ke-Yu Shao, Ying-Qian Han, Guo-Li Li, Sheng-Li Ming, Bing-Qian Su, Yong-Kun Du,Zhong-Hu Liu, Gai-Ping Zhang, Guo-Yu Yang^*, Bei-Bei Chu^*. PRRSV activates lipophagy to facilitate viral replication through down-regulation of NDRG1 expression. 2019, Journal of Virology; 13;93(17):e00526-19
Jiang Wang, Chun-Feng Wang, Sheng-Li Ming, Guo-Li Li, Lei Zeng, Meng-Di Wang, Bing-Qian Su, QiWang,Guo-Yu Yang^⁎, Bei-Bei Chu^⁎. Porcine IFITM1 is a host restriction factor that inhibits pseudorabiesvirus infection. 2019, International Journal of Biological Macromolecules; 151:1181-1193
Ying-Qian Han, Sheng-Li Ming, Hong-Tao Wu, Lei Zeng, Gen Ba, Jian Li, Wei-Fei Lu, Jie Han, Qia-Jun Du, Miao-Miao Sun, Guo-Yu Yang^*, Jiang Wang^*, Bei-Bei Chu^*.Myostatin Knockout Induces Apoptosis in Human Cervical Cancer cells via Elevated Reactive Oxygen Species Generation.2018, Redox Biology; 19:412-42
Jiang Wang, Shao-Fang Lu, Bo Wan, Sheng-Li Ming, Guo-Li Li, Bing-Qian Su, Jiao-Yang Liu,Yu-Shuang Wei, Guo-Yu Yang^⁎, Bei-Bei Chu^⁎. Maintenance of cyclic GMP–AMP homeostasis by ENPP1 is involved in pseudorabies virus infection.2018, Molecular Immunology; 95:56-63
Ying-Qian Han, Wan-Ying Guo, Bing-Qian Su, Yu-Jie Guo, Jiang Wang, Bei-Bei Chu, Guo-Yu Yang^*.High-level expression of soluble recombinant proteins in Escherichia coli using an HE-maltotriose-binding protein fusion tag. 2018, Protein Expression and Purification; 142:25-31
Jiang-Nan kong, Chao Zhang, Yan-Ce Zhu, Kai Zhong, Jiang Wang, Bei-Bei Chu, Guo-Yu Yang^*. Identification and characterization of G-quadruplex formation within the EP0 promoter of pseudorabies virus.2018, Scientific Reports; 8:14029
Shao-Fang Lu, Ying-Qian Han, Zhen-Zhen Guo, Shuang-Shuang Fan, Li-Qiang Han, Bo Wan, Bei-Bei Chu, Guo-Yu Yang, Jiang Wang^*. PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells. 2018, Biotechnology Letters; 40(4):641-648
Jiang Wang, Lei Zeng, Li Zhang, Zhen-Zhen Guo, Shao-Fang Lu, Sheng-Li Ming, Guo-Li Li, Bo Wan, Ke-Gong Tian, Guo-Yu Yang^*, Bei-Bei Chu^*. Cholesterol 25-Hydroxylase Acts as a Host Restriction Factor on Pseudorabies Virus Replication. 2017, Journal of General Virology; 98(6): 1467-1476
Hong-Bing Yao, Chuan-Chao Wang, Jiang Wang, Xiaolan Tao, Lei Shang, Shao-Qing Wen, Qiajun Du, Qiongying Deng, Bingying Xu, Ying Huang, Hong-Dan Wang, Shujin Li, Bin Cong, Liying Ma, Li Jin, Johannes Krause, Hui Li^*. Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci. 2017, Scientific Reports; 7:41195
Xin-Jiang Wang, Jiang Wang, Yue-Ying Wang, Yu-Jie Guo, Bei-Bei Chu, Guo-Yu Yang^*. Sus scrofa matrix attachment region enhances expression of the PiggyBac system transfected into HEK293T cells. 2016, Biotechnology Letters; 38(6): 949-58
Xue-Mei Zhang, Guang-Ming Zha, Jiang Wang, Xin-Jian Wang, Shuang Song, Jing-Chao Shu, Bei-Bei Chu, Guo-Yu Yang^*. Comparation of the effects of different 5’-untranslated regions (UTRs) on gene expression in HEK293 cells. 2016, Biotechnology Letters; 38(12):2051-2057
Bei-Bei Chu, Ya-Cheng Liao, Wei Qi, Chang Xie, Xi-Ming Du, Jiang Wang, Hong-Yuan Yang, Hong-Hua Miao, Bo-Liang Li, Bao-Liang Song^*. Cholesterol transport through lysosome-peroxisome membrane contacts. 2015, Cell; 161(2): 291-306
Jiang Wang, Bei-Bei Chu^*, Li-Li Du, Ying-Qian Han, Xue-Mei Zhang, Shuang-Shuang Fan, Yue-Ying Wang, Guo-Yu Yang^*. Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase. 2015, Molecular Immunology; 65 (2): 436-445
Bei-Bei Chu^#, Jiang Wang^#, Yue-Ying Wang^*, Guo-Yu Yang^*. Knockdown of PKM2 induces apoptosis and autophagy in human alveolar adenocarcinoma A549 cells. 2015, Molecular Medicine Reports;12(3): 4358-4363
Jiang Wang, Bei-Bei Chu, Liang Ge, Bo-Liang Li, Yan Yan^*, Bao-Liang Song^*. Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. 2009; Journal of Lipid Research; 50(8):1653-62
Jian Cao,Jiang Wang, Wei Qi, Hong-Hua Miao, Jing Wang, Liang Ge, Russell A. DeBose-Boyd,Jing-Jie Tang, Bo-Liang Li^*,Bao-Liang Song^*. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. 2007, Cell Metabolism; 6:115-128

成果奖励
荣誉称号 1. 河南农业大学牧医工程学院第二届青年教师英语演讲赛一等奖(2014.05)
2. 河南农业大学牧医工程学院第七届“大学生科技创新”活动“优秀指导教师奖” (2015.06)
3. 河南农业大学2015年度校级精品资源共享课(2015.12)
4. 河南农业大学牧医工程学院2016年度优秀教师(2016.06)
寄语动医学子 国恩深沐自要强，谨慎言行勉作纲。德厚品高缘脉广，鹏程万里任翱翔。