姓名：王海磊

职称：教授（博导）

办公电话：

电子邮箱：whl@htu.edu.cn









个人简介：
王海磊，男，1978年9月生，河南睢县人，汉族，中共党员，中国科学院生物物理学博士，河南师范大学****，河南省高校科技创新人才，新加坡南洋理工大学访问****。申请国家发明专利13项。在国内外期刊上发表文章SCI论文50余篇。Environmental Science Technology、Water Research、Applied and Environmental Microbiology、Biotechnology Progress、Bioresource Technology、Biochemical Engineering Journal、Enzyme and microbial technology、Desalination、Process Biochemistry、Journal of Applied Microbiology等多个国际期刊审稿专家。

研究领域：
1.微生物间相互作用机制研究；
2.创新药物、新型食品添加剂及生物农药的微生物发酵与产业化;
3.噬菌体宿主相互作用机制。
主要学术及社会兼职：
1. 中国科学院湖北产业创新及育成中心生物技术工程化中心技术委员会委员；
2. 功能微生物绿色转化河南省工程实验室、资源微生物与功能分子河南省重点实验室副主任；
3. 河南省微生物学会常务理事。

主持或参加科研项目情况：
承担3项国家自然科学基金项目[丝状真菌Phanerochaete sp. HSD促进好氧活性污泥快速颗粒化的机理. 2011.1-2013.12 (**)；一种青霉红色素的二元发酵机制研究. 2015.1-2017.12（**）； Phanerochaete chrysosporium 生物强化削减猪粪堆肥中四环素抗性基因的机制. 2017.01-2019.12 (U)]. 此外主持河南师范大学****启动基金（2012年）；河南省高校科技创新人才支持计划项目[黄孢原毛平革菌厚垣孢子化机制研究，18HASTIT039]；河南省科技重点攻关项目[2016.01-2018.12，一种新型天然红色素的二元发酵，成分鉴定及安全性研究(**0)]；河南省青年骨干教师项目[2015.01-2017.12,基于基因水平的Phanerochaete chrysosporium厚垣孢子的诱导机制研究(2015GGJS-091)]；河南省教育厅自然科学基金及企业横向课题等项目多项。
学术成果：
代表性论文：
20. Xiaobing Jiang, YiminGeng, Siyu Ren, Tao Yu, Yi Li, Guosheng Liu, Hailei Wang*, Hecheng Meng, LeiShi. The VirAB-VirSR-AnrAB multi-component system involves in resistance ofListeria monocytogenes EGD-e to cephalosporins, bacitracin, nisin, benzalkoniumchloride and ethidium bromide. Applied and Environmental Microbiology 2019，DOI:10.1128/AEM.01470-19
19. LeiLiu，JieSong，YiLi，PingLi，HaileiWang*. Robust and cost-saving static solidcultivation method for lipid production using the chlamydospores of Phanerochaetechrysosporium. Biotechnology for Biofuels 2019, 12:123
18. Yi Li, Zhiyu Zhang, Yingxing Duan, Hailei Wang*. Theeffect of recycling culture medium after harvesting of Chlorella vulgaris biomassby flocculating bacteria on microalgal growth and the functionary mechanism,Bioresource Technology, 2019, 280:188-198.
17. KunZhang，XinxinLu，YiLi，XiaobingJiang，LeiLiu， Hailei Wang*. New technologies provide more metabolic engineeringstrategies for bioethanol production in Zymomonas mobilis.
Applied Microbiology and Biotechnology, 2019,103: 2087–2099.
16. Yi Li, Yanting Xu, Ruixue Song, Congqi Tian, Lei Liu, Tianling Zheng and Hailei Wang*. Flocculation characteristics of abioflocculant produced by the actinomycete Streptomyces sp. hsn06 on microalgaebiomass. BMC Biotechnology 2018,18:58 doi: 10.1186/s12896-018-0471-9
15. Wang Hailei, Li Yi, Zhang Kun, Ma Yingqun, Li Ping*.Feasibility and transcriptomic analysis of betalain production by biomembranesurface fermentation of Penicillium novae-zelandiae. AMB Express 2018，8:4. Doi:10.1186/s13568-017-0529-4.
14. Yi Li, Xu Yanting,Zheng Tianling,Wang Hailei*. Aminoacids in cell wall of Gram-positive bacterium Micrococcus sp. hsn08 withflocculation activity on Chlorella vulgaris biomass. Bioresource Technology2018, 249:417-424
13. Li Ping, Chen Jingchao, Li Yi, Zhang Kun, WangHailei*. Possible mechanisms of control of Fusarium wilt of cut chrysanthemum byPhanerochaete chrysosporium in continuous cropping fields: A case study.Scientific report 2017,7(1):15994 DOI: 10.1038/s41598-017-16125-7
12. Li Ping, Zhao Guowei, Zhang Kun, Wang Hailei*.Improvement of Production of Red Pigment during Biomembrane Surface Cultivationof Penicillium novae-zelandiae by Supplementing with Corn Straw. Bioresources2017，12(4):7680-7691
11.Yi Li, Xu Yanting, Lei Liu, Ping Li, Yue Yan, TongChen，ZhengTianling，Wang Hailei*. Flocculation mechanism of Aspergillus nigeron havesting of Chlorella vulgaris biomass. Algal Research 2017，25：402-412
10.Y. Li, L. Liu, Y. Xu, P. Li, K. Zhang, X. Jiang, T.Zheng, H. Wang*. Stress of algicidal substances from a bacteriumExiguobacterium sp. h10 on Microcystis aeruginosa. Letters in Applied Microbiology2017, 64(1): 57-65
9. Yi Li, Xu Yanting, Zheng Tianling, Wang Hailei*.Flocculation mechanism of the actinomycete streptomyces, sp. hsn06 on chlorellavulgaris. Bioresource Technology 2017,239: 137-143
8. Wang Hailei*, Li Ping, Wang Ying, LiuLei, YaoJianming. Metagenomic insight into the bioaugmentation mechanism of Phanerochaetechrysosporium in an activated sludge system treating cokingwastewater. Journalof Hazardous Materials, 2017, 321: 820-829
7. Yi Li，Lei Liu，Yanting Xu，Chengwei Guan，Xueqian Lei，Wei Zheng，Hailei Wang*. Tianling Zheng. First Evidence ofAltererythrobacter sp. LY02 with Indirect Algicidal Activity on the ToxicDinoflagellate, Alexandrium tamarense. Current Microbiology.2016, 73(4): 550-560.
6. Lei Liu, Ping Li, Qin Ge, Yue Yan, Yi Li, JianmingYao, Hailei Wang*. Conversion of corn stalk to ethanol by one-stepprocess usingan alcohol dehydrogenase mutant of Phanerochaete chrysosporium. Bioresources,2016,11(4)9940-9955
5. Yi Li, Yanting Xu, Lei Liu, XiaobingJiang, Kun Zhang,Tianling Zheng , Hailei Wang *. First evidence ofbioflocculant from Shinellaalbus with flocculation activity on harvesting of Chlorella vulgaris biomass.Bioresource Technology, 2016, 218: 807-815
4. Wang Hailei*, Li Ping, Qin Yu,Yang Hui.Removal ofphenol in phenolic resin wastewater by a novel biomaterial: the Phanerochaetechrysosporium pellet containing chlamydospore-like cells. Applied Microbiologyand Biotechnology 2016,100(11): 5153-5164
3. Wang Hailei, Li Ping, Yang Yuhua, LiuYufeng.Overproduction of laccase from a newly isolated Ganoderma lucidum usingthemunicipal food waste as main carbon and nitrogen supplement. Bioprocess andBiosystems Engineering 2015,38(5):957-966
2. Hai Benzhai, Liu Lei, Qin Ge, Li Ping,Yang Qingxiang, WangHailei*. Simulation of aerobic granule system for wastewater treatment in asequencing batch reactor based on cellularautomata. Bioprocess Biosystem Engineering2014,37(10):2049-2059
1. Wang Hailei*, Li Ping, Jin Qianlong, Qin Ge. Specificaerobic granules can be developed in a completely mixed tank reactor bybioaugmentation using micro-mycelial pellets of Phanerochaete chrysosporium.Applied Microbiology and Biotechnology 2014, 98:2687–2697
专利成果：
1. 王海磊，王刚，刘宇峰，彭玉婉。一种适于切花菊连作障碍消除的土壤修复剂及其使用方法（ZL4.2)，已授权
2. 王海磊，李平，刘国生。一种黄孢原毛平革菌厚垣孢子的培养方法(ZL8.4) ，已授权
3. 曹媛媛 姚建铭 李俊 王冬梅 翟志军 王海磊 王姗姗 严守保。一种利用餐厨废弃物生产微生物油脂的方法( ZL3) ，已授权
4. 王海磊，刘宇峰，杨玉华，李平。一种利用废纸粉碎物提高灵芝漆酶产量的方法(ZL8.3) ，已授权
5. 王海磊，王莹，李平，李祎，刘磊。一种利用黄孢原毛平革菌固体发酵玉米秸秆生产厚垣孢子样细胞的方法(CN3.8)
6. 王海磊，秦雨，李祎，李平。一种用于处理高浓度苯酚废水的微生物固化床反应器（ZL0.5) ，已授权
7. 王海磊。一种天然红色素的生产方法（CN7.x）
8. 王海磊，李平，张永梅。一株篮状菌及利用该篮状菌液体菌膜发酵生产甜菜苷的方法（3.0）
9. 王海磊，闫越，宋洁，李平。利用黄孢原毛平革菌静止固体发酵农业废弃物产生厚垣孢子并积累油脂的方法（8.X）
10. 邵云, 王海磊, 张黛静, 胡永娟, 马建辉,姜丽娜. 一种用于修复麦田重金属铬污染土壤的复合菌剂（CN 20**.A）
11.王海磊，赵国威，鲁欣欣。利用食烷菌发酵降解石蜡生产2-氧代己二酸的方法（3.7）
12. 李祎，王海磊，张志宇，刘磊，姜晓冰，张昆。一种高效收集微藻生物质的絮凝物质的提取方法及其应用（CN4.7）
13. 李祎，王海磊，张志宇，刘磊，姜晓冰，张昆。一种强效抑藻活性物质的提取方法及其应用（CN4.7）