姓名： 王海磊
职称： 教授(博导)
办公电话：

电子邮箱： whl@htu.edu.cn








个人简介：
王海磊，男，1978年9月生，河南睢县人，汉族，中共党员，中国科学院生物物理学博士，河南师范大学生物化学与分子生物学学科****，河南省高校科技创新人才，新加坡南洋理工大学访问****。申请国家发明专利9项。在国内外期刊上发表文章50余篇，其中SCI论文40余篇。Environmental Science Technology、Water Research、Applied Environmental Microbiology、Biotechnology Progress、Bioresource Technology、Biochemical Engineering Journal、Enzyme and microbial technology、Desalination、Process Biochemistry、Journal of Applied Microbiology等多个国际期刊审稿专家。

研究领域：
1.微生物间相互作用机制研究；
2.创新药物、新型食品添加剂及生物农药的微生物发酵与产业化。
主要学术及社会兼职：
1.中国科学院湖北产业创新及育成中心生物技术工程化中心技术委员会委员；
2.功能微生物绿色转化河南省工程实验室、资源微生物与功能分子河南省重点实验室副主任；
3.河南省微生物学会常务理事。
主持或参加科研项目情况：
承担3项国家自然科学基金项目[丝状真菌Phanerochaete sp. HSD促进好氧活性污泥快速颗粒化的机理. 2011.1-2013.12 (No.**），20万元；一种青霉红色素的二元发酵机制研究. 2015.1-2017.12（U**）, 30万元； Phanerochaete chrysosporium 生物强化削减猪粪堆肥中四环素抗性基因的机制. 2017.01-2019.12( U)，60万元]. 此外主持河南师范大学****启动基金（2012年，30万元）、河南省高校科技创新人才支持计划项目[黄孢原毛平革菌厚垣孢子化机制研究，18HASTIT039，60万元]; 河南省科技重点攻关项目[2016.01-2018.12，一种新型天然红色素的二元发酵，成分鉴定及安全性研究(**0)]、河南省青年骨干教师项目[2015.01-2017.12, 基于基因水平的Phanerochaete chrysosporium厚垣孢子的诱导机制研究(2015GGJS-091)]；河南省教育厅自然科学基金及企业横向课题等项目多项。
学术成果：
代表性论文：
37. Xiaobing Jiang, YiminGeng, Siyu Ren, Tao Yu, Yi Li, Guosheng Liu, Hailei Wang*, Hecheng Meng, LeiShi. The VirAB-VirSR-AnrAB multi-component system involves in resistance ofListeria monocytogenes EGD-e to cephalosporins, bacitracin, nisin, benzalkoniumchloride and ethidium bromide. Applied and Environmental Microbiology 2019，DOI:10.1128/AEM.01470-19
36. LeiLiu，JieSong，YiLi，PingLi，HaileiWang*. Robust and cost-saving static solidcultivation method for lipid production using the chlamydospores of Phanerochaetechrysosporium. Biotechnology for Biofuels 2019, 12:123
35. Yi Li, Zhiyu Zhang,Yingxing Duan, Hailei Wang. The effect of recycling culture medium afterharvesting of Chlorella vulgaris biomass by flocculating bacteria on microalgalgrowth and the functionary mechanism, Bioresource Technology, 2019,280:188-198.
34. Kun Zhang，Xinxin Lu，Yi Li，Xiaobing Jiang，Lei Liu，HaileiWang. New technologies provide more metabolic engineering strategies forbioethanol production in Zymomonas mobilis.Applied Microbiology and Biotechnology, 2019,103: 2087–2099.
33. Yi Li, Yanting Xu,Ruixue Song, Congqi Tian, Lei Liu , Tianling Zheng and Hailei Wang*.Flocculation characteristics of a bioflocculant produced by the actinomyceteStreptomyces sp. hsn06 on microalgae biomass. BMC Biotechnology 2018,18:58 doi:10.1186/s12896-018-0471-9
32. Jingchao Chen, Yi Li,Kun Zhang, Hailei Wang*. Whole-Genome Sequence of Phage-Resistant StrainEscherichia coli DH5a. Genome Announcement 2018, 6: e00097-18. Doi :10.1128/genomeA.00097-18.
31. Wang Hailei, Li Yi,Zhang Kun, Ma Yingqun, Li Ping*. Feasibility and transcriptomic analysis ofbetalain production by biomembrane surface fermentation of Penicilliumnovae-zelandiae. AMB Express 2018，8:4. Doi:10.1186/s13568-017-0529-4.
30. Yi Li, XuYanting,Zheng Tianling,Wang Hailei*. Amino acids in cell wall of Gram-positivebacterium Micrococcus sp. hsn08 with flocculation activity on Chlorellavulgaris biomass. Bioresource Technology 2018, 249:417-424
29. Li Ping, ChenJingchao, Li Yi, Zhang Kun, Wang Hailei*. Possible mechanisms of control ofFusarium wilt of cut chrysanthemum by Phanerochaete chrysosporium in continuouscropping fields: A case study. Scientific report 2017,7(1):15994 DOI:10.1038/s41598-017-16125-7
28. Li Ping, Zhao Guowei, ZhangKun, Wang Hailei*. Improvement of Production of Red Pigment during Biomembrane Surface Cultivation of Penicillium novae-zelandiae by Supplementing with CornStraw. Bioresources 2017，12(4):7680-7691
27.Yi Li, Xu Yanting, LeiLiu, Ping Li, Yue Yan, Tong Chen，Zheng Tianling，Wang Hailei*. Flocculationmechanism of Aspergillus niger on havesting of Chlorella vulgaris biomass. AlgalResearch 2017，25：402-412
26.Y. Li, L. Liu, Y. Xu,P. Li, K. Zhang, X. Jiang, T. Zheng , H. Wang*. Stress of algicidal substancesfrom a bacterium Exiguobacterium sp. h10 on Microcystis aeruginosa. Letters inApplied Microbiology 2017, 64(1): 57-65
25. Yi Li, Xu Yanting,Zheng Tianling, Wang Hailei*. Flocculation mechanism of the actinomycetestreptomyces, sp. hsn06 on chlorella vulgaris. Bioresource Technology 2017,239:137-143
24. Wang Hailei*, Li Ping,Wang Ying, LiuLei, Yao Jianming. Metagenomic insight into the bioaugmentationmechanism of Phanerochaete chrysosporium in an activated sludge system treatingcokingwastewater. Journal of Hazardous Materials, 2017, 321: 820-829
23. Yi Li，Lei Liu，Yanting Xu，Chengwei Guan，Xueqian Lei，Wei Zheng，Hailei Wang*. TianlingZheng. First Evidence of Altererythrobacter sp. LY02 with Indirect AlgicidalActivity on the Toxic Dinoflagellate, Alexandrium tamarense. CurrentMicrobiology.2016, 73(4): 550-560.
22. Lei Liu, Ping Li, QinGe, Yue Yan, Yi Li, Jianming Yao, Hailei Wang*. Conversion of corn stalk toethanol by one-stepprocess using an alcohol dehydrogenase mutant ofPhanerochaete chrysosporium.Bioresources,2016,11(4) 9940-9955
21. Yi Li, Yanting Xu, LeiLiu, XiaobingJiang, Kun Zhang, Tianling Zheng , Hailei Wang *. First evidence of bioflocculant from Shinella albus with flocculation activity on harvesting ofChlorella vulgaris biomass. Bioresource Technology, 2016, 218: 807-815
20. Liu Lei, Qin Yu,LiPing, Li Yi, WangYing, Wang Gang,Wang Hailei*. Improvement in continuous cropping of cut chrysanthemum by Phanerochaete chrysosporium on continuouscropping. Pakistan Journal of Botany. 2016,48(4): 1453-1457
19. Wang Hailei*, Li Ping,Qin Yu,Yang Hui.Removal of phenol in phenolic resin wastewater by a novel biomaterial: the Phanerochaete chrysosporium pellet containing chlamydospore-likecells. Applied Microbiology and Biotechnology 2016,100(11):5153-5164
18. Wang Hailei, Li Ping,Yang Yuhua, LiuYufeng. Overproduction of laccase from a newly isolated Ganoderma lucidum usingthe municipal food waste as main carbon and nitrogensupplement. Bioprocess and Biosystems Engineering 2015,38,(5):957-966
17. Hai Benzhai, Liu Lei,Qin Ge, Li Ping,Yang Qingxiang, Wang Hailei*. Simulation of aerobic granulesystem for wastewater treatment in a sequencing batch reactor based oncellularautomata. Bioprocess Biosystem Engineering 2014,37(10):2049-2059
16. Wang Hailei*, Li Ping,Jin Qianlong, Qin Ge. Specific aerobic granules can be developed in acompletely mixed tank reactor by bioaugmentation using micro-mycelial pelletsof Phanerochaete chrysosporium. Applied Microbiology and Biotechnology 2014,98:2687–2697
15. Wang Hailei*, TangChaozhi, Yu Guangli,Li Ping. A novel membrane-surface liquid co-culture toimprove the productionof laccase from Ganoderma lucidum. Biochemical EngineeringJournal 2013,80(15): 27-36
14.Qingxiang Yang, HaoZhang Xueling Li,Zhe Wang, Ying Xu, Siwei Ren, Xuanyu Chen,Yuanyuan Xu, HongxinHao, HaileiWang. Extracellular enzyme production and phylogenetic distributionof yeasts in wastewater treatment systems. Bioresource Technology 2013, 129:264–273
13.Wang Hailei, ZhouZhenzhen, Wang Gang,Liu Yufeng, Li Hui, Li Ping. The glucose metabolic frame ofconditions inducethe overproduction of a co-culture pigment: inductionmechanism of the pigmentand development of a specific eutrophic–oligotrophictransition cultivation system.Bioprocess Biosystem Engineering 2013, 36 (7):947-957
12. Wang Hailei*, Li Ping,Liu Yufeng, RenZhifang, Wang Gang. Overproduction of a potential red pigment bya specificself-immobilization biomembrane-surface liquid culture of Penicilliumnovae-zeelandiae.Bioprocess Biosystem Engineering 2012, 35(8):1407-1416
11. Zhai Zhijun, WangHailei, Yan shoubao,Yao, Jianming. Biodegradation of phenol at highconcentration by a novelbacterium: Gulosibacter sp. YZ4. Journal of ChemicalTechnology & Biotechnology 2012, 87(1):105-111
10. Li Ping, Wang Hailei*,Liu Guosheng, LiXin, Yao Jianming.The effect of carbon source succession onlaccase activity in the co-culture process of Ganoderma lucidum and a yeast.Enzyme and Microbial Technology 2011, 48(1):1-6
9. Wang Hailei*, Li Li, LiPing, Li Hui,Liu Guosheng, Yao Jianming. The acceleration of sludge granulationusing thechlamydospores of Phanerochaete sp. HSD. Journal of HazardousMaterials 2011,192 (3):963-969
8. Wang Hailei*, RenZhifang, LiPing, GuYangchang, Liu Guosheng, YaoJianming. Improvement of theproduction of a redpigment in Penicillium sp. HSD07B synthesized duringco-culture with Candidatropicalis. Bioresource Technology 2011,102(10):6082-6087
7. Wang Hailei*, Li Ping,Liu Guosheng, LiXin, Yao Jianming. Rapid biodecolourization of eriochrome blackT wastewater bybioaugmented aerobic granules cultivated through a specificmethod. Enzyme and Microbial Technology 2010, 47:37-43
6. Wang Hailei, YuGuangli, Li Ping, GuYanchang, Li Jun, Liu Guosheng, Yao Jianming.Overproduction of Trametesversicolor laccase by making glucosestarvation usingyeast. Enzyme and Microbial Technology 2009,45:46-49
5. Wang Hailei, Li Ping,Pang Min, ZhaiZhijun, Yu Guangli, Liu Guosheng, Yao Jianming. Rapiddecolorization of azodyes by a new isolated higher manganese peroxidaseproducer: Phanerochaete sp.HSD. Biochemical engineering journal 2009, 28:99-103
4. 冉治霖，刘国生，王海磊，刘义，沈萍，卢雁．硝酸镧引起Escherichia coli B代谢过程热爆发及其机理研究.化学学报. 200765(10):917-922
3. Wang Hailei*, YuGuangli, Liu Guosheng, Pan Feng. A new way to cultivate aerobic granules in theprocess of papermaking wastewater treatment. Biochemical Engineering Journal.2006, 28: 99-103
2. Wang Hailei*, LiuGuosheng, Li Ping, PanFeng. The effect of bioaugmentation on the performance ofsequencing batch reactor and sludge characteristics in the treatment process ofpapermakingwastewater. Bioprocess Biosystem engineering.2006, 29:283-289
1. Wang Hailei*, LiZongyi, Guo Weiyun,Wang Zhenyu, Pan feng. Study on the cooperationbetweenligninolytic enzymes produced by superiormixed flora. Journal ofEnvironmental Sciences 2005,17(4):421-423
专利成果：
1. 王海磊，王刚，刘宇峰，彭玉婉。一种适于切花菊连作障碍消除的土壤修复剂及其使用方法（ZL4.2)，已授权
2. 王海磊，李平，刘国生。一种黄孢原毛平革菌厚垣孢子的培养方法(ZL8.4) ，已授权
3. 曹媛媛姚建铭李俊王冬梅翟志军王海磊王姗姗严守保。一种利用餐厨废弃物生产微生物油脂的方法( ZL3),已授权
4. 王海磊，刘宇峰，杨玉华，李平。一种利用废纸粉碎物提高灵芝漆酶产量的方法(ZL8.3),已授权
5. 王海磊，王莹，李平，李祎，刘磊。一种利用黄孢原毛平革菌固体发酵玉米秸秆生产厚垣孢子样细胞的方法(3.8)
6. 王海磊，秦雨，李祎，李平。一种用于处理高浓度苯酚废水的微生物固化床反应器（CN0.5)
7. 王海磊。一种天然红色素的生产方法（CN7.x）
8. 王海磊，李平，张永梅。一株篮状菌及利用该篮状菌液体菌膜发酵生产甜菜苷的方法（3.0）
9. 王海磊，闫越，宋洁，李平。利用黄孢原毛平革菌静止固体发酵农业废弃物产生厚垣孢子并积累油脂的方法（8.X）
10. 邵云, 王海磊, 张黛静, 胡永娟, 马建辉,姜丽娜. 一种用于修复麦田重金属铬污染土壤的复合菌剂（CN 20**.A）
11.王海磊，赵国威，鲁欣欣。利用食烷菌发酵降解石蜡生产2-氧代己二酸的方法（3.7）