姓 名：
郭海明

职 称：
博士，教授，博士生导师，科技处处长

办公电话：


电子邮箱：
ghm@htu.edu.cn


个人简介：
郭海明，博士，教授，博士生导师，科技处处长，国家中青年科技创新领军人才，百千****才工程国家级人选，国家有突出贡献中青年专家，教育部新世纪优秀人才支持计划获得者，河南省学术技术带头人，河南省杰出人才基金获得者，河南省****基金获得者，河南省青年科技奖获得者，河南创新型科技团队及高校科技创新团队带头人。曾任河南师范大学化学与环境科学学院兼职本科生辅导员，助教，副教授，硕士生导师，教授，博士生导师，副院长，期间，美国Scripps研究所，分子生物学专业，博士后；河南师范大学化学化工学院教授，博士生导师，教务处副处长，博士生导师，科技处处长。主讲课程本科生《波谱分析》，《有机化学及实验》，研究生《不对称合成》，《有机及药物化学专论》。



















研究领域：

1.不对称合成；
2.核苷合成方法学研究；
3.分子的荧光标记与荧光识别；
4.核苷类药物的设计与合成。

主要学术及社会兼职：


主持或参加科研项目情况：

1.河南省科技创新杰出人才（**8），通过环加成反应合成糖杂核苷类似物，2016.1-2017.12，项目主持人；
2.973计划前期研究专项（2014CB560713），具有抗病毒活性的手性非环核苷类药物的新合成策略研究，2014.10-2016.8，项目主持人；
3.国家自然科学基金（**），基于9-联烯嘌呤构建环状大小不同的手性碳环核苷，2015.1-2018.12，项目主持人；
4.国家自然科学基金（**），三环及多环核苷的设计、合成及在荧光标记中的应用，2013.1-2016.12，项目主持人；
5.国家自然科学基金（**），手性非环核苷类化合物的设计、合成及其药物活性研究，2011.1-2013.12，项目主持人；
6.国家自然科学基金（**）, 嘌呤类核苷新化合物的合成及方法学研究, 2009.1-2011.12，项目主持人；
7.高等学校博士学科点专项科研基金（博导类）（006），“具有荧光活性多环核苷的绿色合成研究”，2013.1-2015.12，项目主持人；
8.教育部新世纪优秀人才支持计划（NCET-09-0122），“冠醚-嘌呤核苷缀合物的合成及其药理活性研究”，2010.1-2012.12，项目主持人；
9河南****基金（1**），“新型手性非环核苷类化合物的设计及合成研究”，2011.1-2013.12，项目主持人；
10.河南省高校科技创新研究团队支持计划(2012IRTSTHN006)：“功能有机分子的设计、合成及活性研究”2012, 1-2014, 12.团队负责人；
11.河南省科技开放合作项目（**8）：“腺苷蛋氨酸的合成及产业化”，2014.1-2015.12，项目主持人；
12.河南省高等教育教学改革研究项目（2009SJGLX145）“化学类专业人才培养方案与课程体系综合改革与实践”，2009.9-2011.9，项目主持人；
13.河南省高等教育教学改革研究项目（）, “分流培养模式下教学质量保障体系的探索与实践”，2012.1-2013.12，项目主持人；
14.新乡市科技创新平台建设项目（），“新型手性非环核苷类药物的设计与合成”，2012-2014，项目主持人；
15.企业横向项目，“三种阿糖核苷的合成方法及产业化研究”，2009.8-2010.8，项目主持人。
16.河南师范大学****基金，“手性非环核苷的不对称合成”，2011.1-2013.12，项目主持人。
17.国家自然科学基金（**），5-取代嘧啶碳环核苷的合成及生物活性研究, 2008.1-2010.12，第3参加人；
18.国家自然科学基金（**），脱氧核苷的合成新方法新方法研究,2008.1-2010.12，第3参加人；
19.国家自然科学基金（**），微波技术合成核苷类化合物的新方法研究,2003.1-2006.12，第5参加人；
20.国家自然科学基金（**），手性有机小分子催化剂设计及其在不对催化反应中的应用, 2004.1-2007.12，第4参加人；
21.河南省杰出人才创新基金()，绿色合成技术在脱氧及氟代核苷的合成及产业化中的应用研究, 2008.1-2010.12，第3参加人。

学术成果：

代表性论文：
[1] Dong-ChaoWang, Ming-Sheng Xie, Hai-Ming Guo*, Gui-Rong Qu, Meng-Cheng Zhang, Shu-Li You*, Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles, Angew. Chem. Int. Ed.2016, in press.
[2] Dan-Jie Zhang, Ming-Sheng Xie*, Gui-Rong Qu, Yao-Wei Gao, and Hai-Ming Guo*, Synthesis of Azacyclic Nucleoside Analogues via Asymmetric [3 + 2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines, Org. Lett., 2016, 18(4), 820–823.
[3] Dong-Chao Wang, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu*and Hai-Ming Guo*, Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via?Domino Heck–Sonogashira Reaction in Water,Adv. Synth. Catal., 2016, 358: 494–499.（as a VIP paper. see Inside cover）
[4] Hua Zhang*, Kui Wang, Xiao-peng Xuan, Qing-zhang Lv, Ya-min Nie, Hai-ming Guo*, Cancer Cells-Targeted Two-Photon Fluorescence Probe for the Real-time Ratiometric Imaging of DNA Damage, Chem. Commun., 2016,52, 6308-6311.
[5]Dong-chao Wang, Ran Xia, Ming-sheng Xie, Gui-rong Qu*, Hai-ming Guo*, Synthesis of Cycloalkyl Substituted Purine Nucleosides via a Metal-Free Radical Route, Org. Biomol. Chem., 2016, 14, 4189-4193. (Invited paper )
[6] Huan-Li Sun, Fei Chen, Ming-Sheng Xie, Hai-Ming Guo*, Gui-Rong Qu, Yan-Mei He, Qing-Hua Fan*, Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues, Org. Lett., 2016, 18 (9), 2260–2263.
[7] ????Jianping Li, Yanyan Zhang, Hua Zhang*, Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu, Haiming Guo??*, ??Nucleoside-based Ultrasensitive FluorescentProbe for the Dual-mode Imaging of Microviscosity in Living Cells, Anal.Chem.,2016, 88(10), 5554–5560.
[8] Hai-Xia Wang, Dan-Dan Xi, Ming-Sheng Xie*, Hui-Xuan Wang, Gui-Rong Qu, Haiming Guo*Nucleoside-Based Diarylethene Photoswitches: Synthesis and Photochromic Properties, ChemBioChem, 2016, 17(13), 1216–1220.
[9] Ming-Sheng Xie, Peng Zhou, Hong-Ying Niu, Gui-Rong Qu*, Hai-Ming Guo*, Enantioselective Intermolecular Cyclopropanations for the Synthesis of Chiral Pyrimidine Carbocyclic Nucleosides, Org. Lett., 2016, 18(17), 4344–4347. (highlighted by Synfacts)
?
?
[10] Peng Zhou, Ming-Sheng Xie, Gui-Rong Qu*, Ren-Long Li, Hai-Ming Guo*, Synthesis of Acyclic Nucleoside Analogues via the Insertion of Carbenoids into N-H Bond of Nucleobases, Asion J. Org. Chem.2016, 5, 1100–1106.

[11]Hui-Li Liu, Ming-Sheng Xie*, Gui-Rong Qu, and Hai-Ming Guo*, Organocatalytic Enantioselective Allylic Etherification of Morita–Baylis–Hillman Carbonates and Silanols, J. Org. Chem., 2016, DOI: 10.1021/acs.joc.6b01931.
[12]Ming-Sheng Xie, Yong Wang, Jian-Ping Li,* Cong Du, Yan-Yan Zhang, Er-Jun Hao, Yi-Ming Zhang, Gui-Rong Qu, Hai-Ming Guo*A Straightforward Entry to Chiral Carbocyclic Nucleoside Analogues via Enantioselective [3+2] Cycloaddition of -Nucleobase Substituted Acrylates, Chem. Commun.,2015,51, 12451 - 12454.
[13]Hua Zhang*, Caixia Wang, Tao Jiang, Haiming Guo*, Ge Wang, Xinhua Cai, Lin Yang, Yi Zhang, Haichuan Yu, Hui Wang, and Kai Jiang, Microtubule-Targetable Fluorescent Probe: Site-Specific Detection and Super-Resolution Imaging of Ultratrace Tubulin in Microtubules of Living Cancer Cells, Anal. Chem.,2015，87 (10), 5216–5222.
[14]Hong-Ying Niu*,Cong Du, Ming-Sheng Xie, Yong Wang, Qian Zhang,Gui-Rong Qu, and Hai-Ming Guo*,Diversity-Oriented Synthesis of Acyclic Nucleosides via Ring-Opening of Vinyl Cyclopropanes with Purines, Chem. Commun.,2015, 15, 3328-3331.
[15]Ming-Sheng Xie, Hong-Ying Niu*, Gui-Rong Qu, and Hai-Ming Guo*，The development for the synthesis of chiral acyclic nucleosides and their phosphonates,Tetrahedron Letters 55 (2014), pp. 7156-7166.（Invited Digest Paper）
[16]Qi-Liang Yang, Ming-Sheng Xie, Chao Xia, Huan-Li Sun, Dan-Jie Zhang, Ke-Xin Huang, Zhen Guo, Gui-Rong Qu*, and Hai-Ming Guo*，A rapid and divergent access to chiral azacyclic nucleoside analogues via highly enantioselective 1,3-dipolar cycloaddition of β-nucleobase substituted acrylates,Chem. Commun., 2014,50, 14809-14812.
[17]Shao-Hua Gao,Ming-Sheng Xie, Hai-Xia Wang, Hong-Ying Niu, Gui-Rong Qu,*and Hai-Ming Guo*,Highly Selective Detection of Hg2+ion by Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensor, Tetrahedron, 2014, 70, 4929-4933.
[18]Qian Zhang*, Bai-Wei Ma, Qian-Qian Wang, Xing-Xing Wang, Xia Hu, Ming-Sheng Xie, Gui-Rong Qu, andHai-Ming Guo*, The Synthesis of Tenofovir and its Analoguesvia Asymmetric Transfer Hydrogenation,Org. Lett.2014,16, 2014-2017.

[19]Ren-Long Li, Lei Liang, Ming-Sheng Xie, Gui-Rong Qu,* Hong-Ying Niu, Hai-Ming Guo,*Copper-Catalyzed Intramolecular Cyclization of N-Propargyl-Adenine: Synthesis of Purine-Fused PolycyclicsJ. Org. Chem.2014,79, 3665-3670.

[20]Jian-Ping Li, Hui-Xuan Wang, Hai-Xia Wang,* Ming-Sheng Xie, Gui-Rong Qu, Hong-Ying Niu, Hai-Ming Guo,*Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensors for the Selective Detection of Pd2+in Aqueous Buffer,Eur. J. Org. Chem.2014, 2225-2230.
[21]Qian Zhang,* Yong-Zhen Huang, Jun-Hui Yang, Bai-Wei Ma, Gui-Rong Qu,Hai-Ming Guo,* Synthesis of 9-oxiranyl-9H-purine derivatives in β-cyclodextrin cavity, Tetrahedron Letters2014, 55, 1203-1206.
[22]Ming-Sheng Xie; Zhi-Liang, Chu, Hong-Ying Niu, Gui-Rong Qu,* Hai-Ming Guo*, A Copper-Catalyzed Domino Route toward Purine-Fused Tricyclic Derivatives, J. Org. Chem.2014, 79, 1093-1099.
[23] Tao Wei, Ming-Sheng Xie, Gui-Rong Qu,* Hong-Ying Niu, and Hai-Ming Guo*, A New Strategy to Construct Acyclic Nucleosides via Ag(I)-Catalyzed Addition of Pronucleophiles to 9-Allenyl-9H-Purines,Org. Lett.2014, 16, 900-903.
[24]Ran Xia, Ming-Sheng Xie, Hong-Ying Niu, Gui-Rong Qu,* and Hai-Ming Guo*, Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4in water,Green Chem.2014, 16, 1077-1081.
[25]Ran Xia, Ming-Sheng Xie, Hong-Ying Niu, Gui-Rong Qu,* and Hai-Ming Guo,* Radical Route for the Alkylation of Purine Nucleosides at C6 via Minisci Reaction,Org. Lett.2014, 16, 444-447.
[26] Dong-Chao Wang, Hong-Ying Niu, Ming-Sheng Xie, Gui-Rong Qu,* Hui-Xuan Wang, and Hai-Ming Guo,*Highly Regioselective Three-Component Domino Heck?Negishi Coupling Reaction for the Functionalization of Purines at C6,Org. Lett.2014, 16, 262-265.
[27].Jian-Ping Li, Yu Huang, Ming-Sheng Xie,Gui-Rong Qu, Hong-Ying Niu,* Hai-Xia Wang, Bo-Wen Qin, and Hai-Ming Guo,* One-Pot Synthesis of 7,9-Dialkyl-Purin-8-One Analogues: Broad Substrate Scope, J. Org. Chem.2013, 78, 12629-12636.(Highlighted by JOC Homepage)

[28]Hai-Ming Guo,*Run-Ze Mao, Qiao-Tian Wang, Hong-Ying Niu,Ming-Sheng Xie,and Gui-Rong Qu* , Pd(II)-Catalyzed One-Pot, Three-Step route for the Synthesis of Unsymmetrical Acridines, Org. Lett.2013, 15, 5460-5463.

[29].Qian Zhang,* Bai-Wei Ma, Yong-Zhen Huang, Qian-Qian Wang, Xing-Xing Wang, Gui-Rong Qu, and Hai-Ming Guo*Efficient Synthesis of Purine Derivatives by one-pot three-component mannich type reaction,Heterocyclics, 2013, 87, 2081-2091.


[30]Jia-jia Jin, Dong-chao Wang, Hong-ying Niu*, Shan Wu, Gui-rong Qu, Zhong-bo Zhang and Hai-Ming Guo*,Br?nsted Acid Catalyzed Synthesis of 1,3-Di(2-quinolyl)propane Derivatives via Tandem C(sp3)-H Functionalization, Tetrahedron, 2013, 69, 6579-6584.
[31] Qian Zhang*, Gang Cheng, Yong-Zhen Huang, Gui-Rong Qu, Hong-Ying Niu, Hai-Ming Guo*, Regioselective N9 alkylation of purine rings assisted by b-cyclodextrin, Tetrahedron, 2012, 68, 7822-7826.
[32] Ran Xia, Hong-Ying Niu, Gui-Rong Qu,* Hai-Ming Guo*, CuI Controlled C-C and C-N Bond Formation of Heteroaromatics through C(sp3)-H Activation, Org. Lett.,2012, 14, 5546–5549.(Highlighted by SYNFACTS, 2013, 2(9), 0197.and Org. Chem. Portal.)
[33] Hong-Ying Niu, Shi-Xia Bai, Shan Wu, Gui-Rong Qu,* Hai-Ming Guo*, Synthesis of Chiral N-(Purin-6-yl)amino Acids Derivatives: Using Natural Amino Acids as Starting Materials, Asian J. Org. Chem., 2012, 1, 238–244.
[34] Gui-Rong Qu, Lei Liang, Hong-Ying Niu, Wei-Hao Rao, Hai-Ming Guo,*John S. Fossey,* Copper-Catalysed Synthesis of Purine-Fused Polycyclics, Org. Lett.,2012,14(17),4494–4497.
[35]. Jin-Ying Liu,Hong-Ying Niu,Shan Wu, Gui-Rong Qu,* Hai-Ming Guo,*Metal Catalyzed C(sp3)-H Bond Amination of 2-Alkyl Azaarenes with Diethyl Azodicarboxylate, Chem. Commun.,2012, 48 (78), 9723-9725.(Top ten most accessed articles in August)
[36]Ge Meng, Hong-Ying Niu, Gui-Rong Qu, John S. Fossey, Jian-Ping Li,* Hai-Ming Guo,* 'Synthesis of Fused N-Heterocycles via Tandem C-H Activation' Chem. Commun.,2012, 48, 9601-9603. (Top ten most accessed articles in July)
[37] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization, Chem. Commun.,2012, 48, 6717-6719. (Highlighted by SYNFACTS, 2012, 8(8), 0901.)
[38] Jia-Jia Jin, Hong-Ying Niu, Gui-Rong Qu, Hai-Ming Guo,* John S. Fossey*, Copper-catalysed addition of a-alkyl azaarenes to ethyl glyoxylate via direct C(sp3)-H activation, RSC Adv., 2012, 2, 5968-5971 .
[39] Gui-Rong Qu,* Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo,* John S. Fossey,Cu(OTf)2-catalyzed Ritter reaction: Efficient synthesis of amides from nitriles and halohydrocarbons in water, RSC Adv., 2012, 2, 6161-6163 . (Highlightedby Chemistry in Water of Organic & Biomolecular Chemistry Blog,2014-3-20至2014-4-21)
[40]. Gui-Rong Qu,* Hong-Liang Zhang, Hong-Ying Niu, Zai-Kun Xue, Xin-Xin Lv, Hai-Ming Guo*, Synthesis of C6-Azolyl Purine Nucleosides via C-N Coupling Reaction of Unprotected 6-Chloropurine Nucleosides and N-Heterocycles under Catalyst- and Solvent-Free Conditions, Green Chem.,2012, 14, 1877-1879 .
[41] Hong-Ying Niu, Chao Xia, Gui-Rong Qu*, Shan Wu, Yi Jiang, Xin Jin, Hai-Ming Guo*Microwave Promoted One-Pot Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor, Chemistry - An Asian Journal, 2012, 7(1), 45-49.

专利成果：
1.化学合成法生产腺苷的工艺，(ZL**.1)，授权时间2005.1.26；(第6完成人)
2.化学合成法生产2,6-二氯嘌呤核苷的工艺，(ZL9.7)，授权时间2009.1.26；(第3完成人)
3.化学合成法生产胞苷的工艺，(ZL3.1)，授权时间2009.5.3。(第5完成人)
4.具有抗癌活性的6-位被单氮杂冠醚修饰的嘌呤核苷类新化合物及制备方法，（ZL 2009 1 **.6），授权时间2010.12.9，(第1完成人)
5.5-环己基阿糖尿苷、制备方法及其应用，（ZL4.7），授权时间2015.05.27，(第2完成人)
6.8-环己基-2-氟阿糖腺苷、制备方法及其应用,（ZL1.X），授权时间2015.05.27，(第1完成人)