郭胜海
博士、副教授、硕士生导师
联系方式：shguo@htu.cn






教育与研究经历：
2000.9-2004.7 河南师范大学，化学专业，本科
2004.9-2009.7 中国科学院上海有机化学研究所，有机化学专业，博士
2009.7-2010.8 上海美迪西生物医药有限公司，化学研发部，课题组长
2010.9-至今 河南师范大学，化学化工学院，副教授
主讲课程：
有机合成化学，有机化学实验
研究领域与兴趣：
有机合成、药物合成
近年来主持的科研项目:
1、国家自然科学基金项目(**): 5-杂芳环取代嘧啶核苷类似物的合成新方法及生物活性研究。
2、中国博士后科学基金面上资助(2014M552007): 新型5-杂芳环取代胞苷的合成及生物活性研究。
3、中国博士后科学基金特别资助(2015T80771): 基于铜催化串联反应的氮稠杂环的构筑及生物活性研究。
4、河南省科技攻关项目(**6): 含喹唑啉酮结构单元的生物碱的高效合成及生物活性研究。
5、河南省高等学校重点科研项目计划(20A150024): 三价铑催化的氧化螺环化反应研究。
代表性论文：
23. Shenghai Guo,* Yangfan Liu, Yaping Wang, Xinying Zhang,* Xuesen Fan*. Construction of Bridged Carbocycles and Heterocycles via Rh(III)-Catalyzed C-H Alkylation/Michael Addition of 2-Arylindoles with Quinone Monoacetals. J. Org. Chem., 2020, 85(14), 8910-8922.

22. Shenghai Guo,* Yangfan Liu, Xinying Zhang, Xuesen Fan*. Iridium-Catalyzed Oxidative Annulation of 2-Arylindoles with Benzoquinone Leading to Indolo[1,2-f]phenanthridin-6-ols. Adv. Synth. Catal., 2020, 362(14), 3011-3020.

21. Shenghai Guo,* Lincong Sun, Xuzhuo Li, Xinying Zhang, Xuesen Fan*. Selective Synthesis of Indazolo[2,3-a]quinolines via Rh(III)-Catalyzed Oxidant-Free [4+2] or [5+1] Annulation of 2-Aryl-2H-indazoles with α-Diazo Carbonyl Compounds. Adv. Synth. Catal., 2020, 362(4), 913-926.

20. Shenghai Guo*, Yangfan Liu, Lu Zhao, Xinying Zhang and Xuesen Fan.*Rhodium-Catalyzed Selective Oxidative (Spiro)annulation of 2-Arylindoles by Using Benzoquinone as a C2 or C1 Synthon. Org. Lett., 2019, 21(16), 6437-6441.

19. Shenghai Guo,* Lincong Sun, Yangfan Liu, Nana Ma,* Xinying Zhang, Xuesen Fan.* Rh(III)-Catalyzed Oxidative Spirocyclization of Isoquinolones with α-Diazo-1,3-indandiones. Org. Lett., 2019,21(11), 4082-4086.

18. Shenghai Guo*,Lincong Sun, Fang Wang, Xinying Zhang, and Xuesen Fan.* Rh(III)-Catalyzed Oxidative Annulation of Isoquinolones with Diazoketoesters Featuring an in SituDeacylation: Synthesis of Isoindoloisoquinolones and Their Transformation to Rosettacin Analogues. J. Org. Chem., 2018, 83(19), 12034-12043.

17. Shenghai Guo,* Fang Wang, Lincong Sun, Xinying Zhang, Xuesen Fan.* Palladium-Catalyzed Oxidative Cyclocarbonylation of Isoquinolones with CO via C-H/N-H Bond Cleavage: Easy Access to Isoindolo[2,1-b]isoquinoline-5,7-dione Derivatives. Adv. Synth. Catal., 2018, 360(13),2537-2545.

16. Shenghai Guo,* Fang Wang, Li Tao, Xinying Zhang, Xuesen Fan.*Solvent-Dependent Copper-Catalyzed Indolyl C3-Oxygenation and N1-Cyclization Reactions: Selective Synthesis of 3H-Indol-3-ones and Indolo[1,2-c]quinazolines. J. Org. Chem., 2018, 83(7), 3889-3896.

15.Shenghai Guo,* Jianhui Zhai, Fang Wang, Xuesen Fan.*One-pot three-component selective synthesis of isoindolo[2,1-a] quinazoline derivatives via a palladium-catalyzed cascade cyclocondensation/cyclocarbonylation sequence. Org. Biomol. Chem., 2017, 15(17), 3674–3680.

14. Shenghai Guo,* Jianhui Zhai, Xuesen Fan.* An I-2-mediated cascade reaction of 2'-bromoacetophenones with benzohydrazides/ benzamides leading to quinazolino[3,2-b]cinnoline or tryptanthrin derivatives. Org. Biomol. Chem., 2017, 15(6), 1521–1529.

13. Shenghai Guo,* Li Tao, Fang Wang, Xuesen Fan.* Pd-Catalyzed Cyclocarbonylation of 2-(2-Bromoaryl)indoles with CO as a C1 Source: Selective Access to 6H-Isoindolo[2,1-a]indol-6-ones and Indeno[1,2-b]indol-10(5H)-ones. Chem. Asian J., 2016, 11(21), 3090-3096.

12. Shenghai Guo,* Li Tao, Wenwen Zhang, Xinying Zhang, and Xuesen Fan*. Regioselective Synthesis of Indolo[1,2-c]quinazolines and 11H-Indolo[3,2-c]quinolines via Copper-Catalyzed Cascade Reactions of 2-(2-Bromoaryl)-1H-indoles with Aldehydes and Aqueous Ammonia. J. Org. Chem., 2015, 80(21), 10955?10964.

11. Shenghai Guo*, Jiliang Wang, Xinying Zhang, Sandrine Cojean, Philippe M. Loiseau, and Xuesen Fan*. Synthesis of 5-isoxazol-3-yl-pyrimidine nucleosides as potential antileishmanial agents. Bioorg. Med. Chem. Lett., 2015, 25(13), 2617–2620.

10. Shenghai Guo*,Yan Li, Li Tao, Wenwen Zhang, Xuesen Fan*, Rapid assembly of quinazolinone scaffold via copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia: application to the synthesis of the alkaloid tryptanthrin. RSC adv., 2014, 4(103), 59289-59296.

9. Shenghai Guo*,Jiliang Wang, Yan Li, Xuesen Fan*, CuCl-catalyzed one-pot synthesis of 5,6-dihydropyrazolo[1,5-c]quinazolines. Tetrahedron, 2014, 70(14), 2383-2388.

8. Shenghai Guo*, Jiliang Wang, Xuesen Fan*, Xinying Zhang, Dongqiang Guo. Synthesis of pyrazolo [1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H- pyrazoles with carbonyl compounds and aqueous ammonia. J. Org. Chem., 2013, 78(7), 3262-3270.

7. Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, Xuesen Fan*. Highly regioselective and practical synthesis of 1-acyl-5-hydroxypyrazolines and 1-acylpyrazoles from 1,2-allenic ketones and hydrazides. Tetrahedron, 2012, 68(38), 7768-7774.

6. Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, Xuesen Fan*. Synthesis of 3,5- disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2'-deoxycytidine. RSC Adv., 2012, 2(9), 3772-3777.

5. Shenghai Guo,Yuanhong Liu.* A facile Zr-mediated multicomponent approach to arylated allylic alcohols and its application to the synthesis of highly substituted indenes and spiroindenes. Org. Biomol. Chem., 2008, 6(12), 2064-2070.

4. Shenghai Guo, Hao Zhang, Feijie Song, Yuanhong Liu.*Studies on the zirconium-mediated alkyne–aldehyde coupling reactions: a facile synthesis of stereodefined allylic alcohols and (Z)-2-en-4-yn-1-ols. Tetrahedron, 2007, 63(9), 2009-2018.

3. Shenghai Guo,Feijie Song, Yuanhong Liu.*Gold-catalyzed direct amination of allylic alcohols. Synlett, 2007, (6), 964-968.

2. Yuanhong Liu,* Feijie Song, Shenghai Guo.Cleavage of a carbon-carbon triple bond via gold-catalyzed cascade cyclization/oxidative cleavage reactions of (Z)-enynols with molecular oxygen. J. Am. Chem. Soc., 2006, 128(35), 11332-11333.

1. Yuanhong Liu,*Meina Liu, Shenghai Guo,Huamin Tu, Yebing Zhou, Hongjun Gao. Gold-catalyzed highly efficient access to 3(2H)-furanones from 2-oxo-3-butynoates and related compounds.Org. Lett. 2006, 8(16), 3445-3448.
授权发明专利：
(1)郭胜海，王芳，范学森，一锅三组分合成异吲哚[2,1-b]异喹啉-5,7-二酮类化合物的方法，2020.6.2，中国，ZL8.5。
(2)郭胜海，翟剑辉，陶丽，范学森，一种常压合成6H-异吲哚[2,1-a]吲哚-6-酮类化合物的方法，2019.1.1，中国，ZL6.5。
(3)郭胜海，王芳，陶丽，范学森，一种茚[1,2-b]吲哚-10(5H)-酮类化合物的合成方法，2018.12.28，中国，ZL4.8。
(4)郭胜海，王芳，翟剑辉，范学森，5H-喹唑啉[3,2-b]噌啉-7,13-二酮类化合物及其制备方法，2018.9.18，中国，ZL7.X。
(5)郭胜海，翟剑辉，王芳，范学森，一种合成6,6a-二氢异吲哚[2,1-a]喹唑啉-5,11-二酮类化合物的方法，2018.11.27，中国，ZL5.9。
(6)郭胜海，陶丽，范学森，张新迎，一种11H-吲哚并[3,2-c]喹啉类化合物的合成方法，2017.3.22，中国，ZL8.0。