沈国民，男，汉族，出生于1979年12月。2018年先后被评为校级优秀教师，洛阳市优秀教师，河南省优秀教师。1998年考入河南师范大学生科院生物教育专业学习，2002年毕业后继续在河南师范范大学徐存拴教授课题组深造，攻读细胞生物学专业的硕士研究生，主要从事肝再生相关的研究。2005年毕业后到河南科技大学医学院遗传教研室任教。2008年考入北京协和医学院基础医学研究所，在张俊武教授课题组攻读生化和分子生物学专业的博士，主要研究低氧诱到因子1(HIF1)在肝癌糖脂代谢改变中的作用机制。毕业后，2012年2月到美国南阿拉巴马大学从事博士后研究，2012年9月转入圣路易斯华盛顿大学生物物理与分子生化系从事博士后研究，主要研究华法林抑制VKOR的机制。2015年8月归国，继续在河南科技大学医学院工作。目前主要研究维生素K代谢相关酶的结构与功能以及与出凝血疾病的关系。目前主持国家自然科学基金面上项目1项，青年基金1项，参与2项；主持河南省重点科技攻关项目1项（国际科技合作项目）；并入选河南省高等学校青年骨干教师资助计划。在Nature Structural & Molecular Biology, Nature Communication ，Journal of Thrombosis & Haemostasis等SCI期刊发表论文24篇，其中第一作者7篇。其中在国际顶尖期刊Nature Structural & MolecularBiology发表题目为Warfarin traps humanvitamin K epoxide reductase in an intermediate state during electron transfer的研究论文，揭示了临床应用有60多年的抗凝血药物华法林的抑制机制，该文章作为当期的亮点文章被评论，此项研究得到国际同行的高度评价。
基金项目
1. 华法林特异性靶蛋白VKOR在维生素K循环中的催化机制研究. 国家自然科学基金面上项目（**）01/2018—12/2021，在研，55万，主持。
2. 维生素K限速酶GGCX抑制剂的筛选与抗血栓药物的开发. 河南省科技厅科技攻关项目(**9), 01/2018—12/2019, 在研，10万，主持。
3. 维生素K环氧化物还原酶催化活性的结构基础. 河南省高等学校青年骨干教师培养计划(2017GGJS069), 01/2018—12/2020,在研，主持
4. HIF1 调控SCD1 的机制及其在肝癌中的作用研究. 国家自然科学基金青年基金（No：**)， 01/2014—12/2016, 已结题，23万，主持。
5. 解整合素-金属蛋白水解酶ADAM8在肝细胞癌发生发展中的作用机制研究. 国家自然科学基金青年基金(No.**)，01/2013-12/2015,参与，已结题，23万，第3参与人。
6. 二氢黄酮柚皮苷对阿尔茨海默病突触线粒体功能障碍的作用及机制研究. 国家自然科学基金青年基金(No.**)，01/2017-12/2019,参与，22万，第2参与人。

发表文章
1. Guomin Shen,Shuang Li, Weidong Cui, Shixuan Liu, Qian Liu, Yihu Yang, Michael Gross, and Weikai Li*. Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 bya peripheral region determines their different sensitivity to warfarininhibition. Journal of Thrombosis andHaemostasis. 2018, 16(6):1164-1175. CoverStory
2. Guomin Shen,Shuang Li, Weidong Cui, Shixuan Liu, Yihu Yang, Michael Gross, and Weikai Li*. Membraneprotein structure in live cells: Methodology for studying drug interaction bymass spectrometry-based footprinting. Biochemistry.2018,23;57(3):286-294.
3. Shuang Li, Guomin Shen, Weikai Li*.Intramembrane Thiol Oxidoreductases: Evolutionary Convergence and StructuralControversy. Biochemistry. 2018 23;57(3):258-266.
4. Guomin Shen＊, Weidong Cui＊, Hao Zhang, Fengbo Zhou, Wei Huang, YihuYang, Qian Liu, Greg Bowman, Evan Sadler, Michael Gross, Weikai Li. Warfarintraps human vitamin K epoxide reductase in an intermediate state duringelectron transfer. Nature Structural & Molecular Biology,2017 Jan;24(1):69-76. （＊:Co-first author, Featured in News and Views ）
5. Tianzhen Wang, Peng Han, Yan He, Ci Zhao, Guangyu Wang, WeiweiYang, Ming Shan4, Yuanyuan Zhu, Chao Yang, Mingjiao Weng, Di Wu, Lin Gao,Xiaoming Jin, Yunwei Wei, BinBin Cui^＃, Guomin Shen^＃, Xiaobo Li^＃ Lin28A enhanceschemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in alet-7 independent manner. Tumour Biol, 2016, Jun ; 37(6) :7657-65.(^＃ Co-corresponding author)
6. GuominShen^＃, Ning Ning, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang,Ran Zhao, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, YinjiJin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li^＃. Adiposedifferentiation-related protein (ADRP) is not involved in hypoxia induciblefactor-1(HIF1) induced lipid accumulation under hypoxia. MolecularMedicine Reports. 2015, Dec;12(6):8055-61. (^＃ Co-corresponding author)
7.Guomin Shen, Xiaobo Li, Yong-feng Jia, Gary A Piazza,Yaguang Xi. Hypoxia-regulated microRNAs in humancancer. Acta Pharmacol Sin. 2013, Mar;34(3):336-341.
8.Guo-MinShen, Ying-Ze Zhao, Ming-Tai Chen, Feng-Lin Zhang, Xiao-Ling Liu,Yi Wang, Chang-Zheng Liu, Jia Yu, Jun-Wu Zhang. Hypoxia Inducible Facter 1(HIF1) Promotes LDL and VLDL Uptake Through Inducing VLDLR Under Hypoxia. BiochemJ, 2012, Jan; 441(2):675-683.
9. Guo-MinShen, Feng-Lin Zhang, Xiao-Ling Liu, Jun-Wu Zhang.Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogenaccumulation in human MCF-7 cells under hypoxia. FEBS Lett. 2010,584(20):4366-4372.
10.Shixuan Liu, Wei Cheng, Ronald Fowle-Grider, GuominShen, and Weikai Li. Structures of an intramembrane vitamin Kepoxide reductase homolog reveal control mechanisms for electron transfer. NatureCommunication. 2014; 5: 3110. doi: 10.1038/ncomms4110.
11. Feng-Lin Zhang, Guo-MinShen, Xiao-Ling Liu, Fang Wang, Jun-Wu Zhang. Hypoxia-inducible factor 1-mediated human GATA1 induction promoteserythroid differentiation under hypoxic conditions. J Cell Mol Med,2012, Aug; 16(8):1889-1899 .
12. Feng-LinZhang,Guo-Min Shen, Xiao-Ling Liu, FangWang, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang. HypoxicInduction of Human Erythroid-Specific Delta-Aminolevulinate Synthase Mediatedby Hypoxia-Inducible Factor 1. Biochemistry, 2011, 50 (7): 1194–1202.
13.Ying-Ze Zhao,Xiao-Ling Liu, Guo-Min Shen, Yan-Ni Ma, Feng-Lin Zhang,Ming-Tai Chen, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang. Hypoxia induces peroxisomeproliferator-activated receptor γ expression via HIF-1-dependent mechanisms inHepG2 cell line. Archives of Biochemistry and Biophysics.2014;543:40-47.
14. Pingyuan Gong,Guomin Shen, She Li, Guoping Zhang, Hongchao Fang, LinLei, Peizhe Zhang, Fuchang Zhang. Genetic Variations in COMT and DRD2 ModulateAttentional Bias for Affective Facial Expressions.PLoSOne. 2013, Dec 2;8(12):e81446.
15.Pingyuan Gong, Shoumin Xi, She Li, Guochang Cao, Peizhe Zhang, GuominShen, Fuchang Zhang, Yan Shen, and Hua Ma. Effect of Val66Metpolymorphism in BDNF on attentional bias in an extroverted Chinese Hanpopulation. Acta Neurobiol Exp (Wars). 2013;73(2):280-8.
16.Pingyuan Gong, Shoumin Xi, Guomin Shen, She Li, PeizheZhang, Guochang Cao, Fuchang Zhang, Yan Shen, Tiantian Feng, Hua Ma. Theeffects of DBH, MAOA, and MAOB on attentional biases for facial expressions. JMol Neurosci. 2013, Mar;49(3):606-131.
国际会议
1. Guomin Shen, Hao Zhang, Weidong Cui, Jian-Ke Tie, WeiHuang, Evan Sadler, Darrell Stafford, and Weikai Li. Warfarin inhibits human vitamin K epoxide reductase at apreferred conformational state.Molecular, Structural &Clinical Aspects of Vitamin K - Dependent Proteins. 2015. 特邀报告人.
2. GuominShen, HaoZhang, Weidong Cui, Evan Sadler, Michael Gross and Weikai Li. Warfarin InhibitsVitamin K Epoxide Reductase By Specifically Blocking at a Conformational andRedox State. 56^th ASH Annual Meeting and Exposition. 2014. Oral andPoster Abstracts.