吕银凤
性 别： 女 出生年月： 1987-12-12
职 称： 讲师 工作单位： 动物科学技术学院
招生学科1： 动物营养与饲料科学 招生学科2：
办公电话： ** E-mail： lvyinfeng2010@163.com

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
 近五年主持科研项目概况
2020.01-2022.12，国家自然科学基金青年科学基金项目-LPS靶向抗菌肽-壳聚糖纳米微粒抑制断奶仔猪肠道炎症反应研究(**)，资助金额25万元，主持人2019.07-2022.07，黑龙江省自然科学基金优秀青年项目-非完美α-螺旋结构抗菌肽的构效关系及抗菌机制研究(YQ2019C007)，资助金额10万元，主持人2019.01-2020.12，中国博士后科学基金面上资助项目-铰链影响α-螺旋抗菌肽生物学活性及抑菌机制的研究(2018M641800)，资助金额5万元，主持人2017.11-2020.10，黑龙江省普通本科高等学校青年创新人才培养计划-高效靶向抗菌肽的分子设计、生物学活性及作用机理研究(UNPYSCT-**)，资助金额10万元，主持人2019.01-2020.12，黑龙江省博士后资助项目-含铰链结构抗菌肽的构效关系及抑菌机理研究(LBH-Z18027)，资助金额7万元，主持人2018.11-2021.11，东北农业大学“东农学者计划”-“青年才俊”项目-纳米抗菌肽的构建及生物学活性研究(18QC34)，资助金额6万元，主持人2018.01-2019.12，农业部东北动物营养与饲料科学观测试验站开放课题-不同作用靶点抗菌肽的构效优化及联合应用的协同抗菌活性研究(yy-2017-08)，资助金额2万元，主持人

 近五年项目获奖概况
2018-2019年度神农中华农业科技奖优秀创新团队奖，非粮型饲料资源研究与开发创新团队

 近五年代表性著作、论文
1. Yinfeng Lyu, Tingting Chen, Lu Shang, Yang Yang, Zhongyu Li, Jiang Zhu, and Anshan Shan*. Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism. Journal of Medicinal Chemistry, 2019, 62(15): 6941-6957. (IF: 6.054 一区TOP)2. Yinfeng Lyu, Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Temilolu Idowu, Ronald Domalaon, George G. Zhanel, Anshan Shan*, Frank Schweizer*. Amphiphilic tobramycin-lysine conjugates sensitize multidrug resistant Gram-negative bacteria to rifampicin and minocycline. Journal of Medicinal Chemistry, 2017, 60(9): 3684-3702. (IF2018: 6.054 一区TOP)3. Yinfeng Lyu, Yang Yang, Xiting Lyu, Na Dong, Anshan Shan*. Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida. Scientific Reports, 2016, 6:27258. (IF: 4.011 三区)4. Yinfeng Lv, Jiajun Wang, He Gao, Zeyun Wang, Na Dong, Qingquan Ma, Anshan Shan*. Antimicrobial properties and membrane-active mechanism of a potential α-helical antimicrobial derived from cathelicidin PMAP-36. PLoS One, 2014, 9: e86364. (IF: 2.776 三区)5. Yinfeng Lyu, Ronald Domalaon, Xuan Yang, Frank Schweizer*. Amphiphilic lysine conjugated to tobramycin synergizes legacy antibiotics against wild-type and multidrug-resistant Pseudomonas aeruginosa. Biopolymers-Peptide Science, 2019, 111(1): e23091. (IF: 1.845 三区)6. Qing-Quan Ma, Yin-Feng Lv, Yao Gu, Na Dong, De-Shan Li, An-Shan Shan*. Rational design of cationic antimicrobial peptides by the tandem of leucine-rich repeat. Amino Acids, 2013, 44(4): 1215-1224. (IF: 2.520 三区)7. Xuan Yang, Ronald Domalaon, Yinfeng Lyu, George Zhanel, Frank Schweizer*. Tobramycin-linked efflux pump inhibitor conjugates synergize fluoroquinolones, rifampicin and fosfomycin against multidrug-resistant Pseudomonas aeruginosa. Journal of Clinical Medicine, 2018, 7(7): 158. (IF: 5.688 二区)8. Ronald Domalaon, Xuan Yang, Yinfeng Lyu, George G. Zhanel, Frank Schweizer*. Polymyxin B3−tobramycin hybrids with Pseudomonas aeruginosa selective antibacterial activity and strong potentiation of rifampicin, minocycline, and vancomycin. ACS Infectious Diseases, 2017, 3(12): 941-954. (IF: 4.911 二区)9. Na Dong, Xin Zhu, Yinfeng Lv, Qingquan Ma, Junguang Jiang, Anshan Shan*. Cell specificity and molecular mechanism of antibacterial and antitumor activities of carboxyl-terminal RWL-tagged antimicrobial peptides. Amino Acids, 2014, 46(9): 2137-2154. (IF: 2.520 三区)10. Qingquan Ma, Wenjing Jiao, Yinfeng Lv, Na Dong, Xin Zhu, Anshan Shan*. Structure–function relationship of Val/Arg-rich peptides: effects of net charge and Pro on activity. Chemical Biology & Drug Design, 2014, 84(3): 348-353. (IF: 2.256 三区)11. Jiajun Wang, Xiujing Dou, Jing Song, Yinfeng Lyu, Xin Zhu, Lin Xu, Weizhong Li, Anshan Shan*. Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era. Medicinal Research Reviews, 2019, 39(3): 831-859. (IF: 9.791 一区TOP)12. Ronald Domalaon, Yaroslav Sanchak, Linet Koskei, Yinfeng Lyu, Zhanel George, Gilbert Arthur, Frank Schweizer*. Short proline-rich lipopeptide potentiates minocycline and rifampicin against multidrug- and extensively drug-resistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 2018, 62(4): e02374-17. (IF: 4.715 二区TOP)13. Na Dong, Qingquan Ma, Anshan Shan*, Yinfeng Lv, Wanning Hu, Yao Gu, Yuzhi Li. Strand length-dependent antimicrobial activity and membrane-active mechanism of arginine- and valine-rich β-hairpin-like antimicrobial peptides. Antimicrobial Agents and Chemotherapy, 2012, 56(6): 2994-3003. (IF: 4.715 二区TOP)14. Na Dong, Xinran Li, Xinyao Xu, Yinfeng Lv, Zhongyu Li, Anshan Shan*, Jiali Wang. Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides. Amino Acids, 2018, 50(3-4): 453-468. (IF: 2.520 三区)15. Qing-Quan Ma, Na Dong, An-Shan Shan*, Yin-Feng Lv, Yu-Zhi Li, Zhi-Hui Chen, Bao-Jing Cheng, Zhong-Yu Li. Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units. Amino Acids, 2012, 43(6): 2527-2536. (IF: 2.520 三区)16. Na Dong, Qing-Quan Ma, An-Shan Shan*, Yin-Feng Lv, Wanning Hu, Yao Gu, Yu-Zhi Li. Novel design of short antimicrobial peptides derived from the bactericidal domain of avian β-defensin-4. Protein and peptide letters, 2012, 19: 1212-1219. (IF: 1.168 四区)17. Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Ronald Domalaon, Yinfeng Lyu, Ayush Kumar, George G. Zhanel, Frank Schweizer*. A Tobramycin vector enhances synergy and efficacy of efflux pump inhibitors against multidrug-resistant Gram-negative bacteria. Journal of Medicinal Chemistry, 2017, 60(9): 3913-3932. (IF: 6.054 一区TOP)18. Qing-Quan Ma, An-Shan Shan*, Na Dong, Yan-Ping Cao, Yin-Feng Lv, Liang Wang. The effects of Leu or Val residues on cell selectivity of ɑ-helical peptides. Protein and peptide letters, 2011, 18(11): 1112-1118. (IF: 1.168 四区)19. 单安山*，马得莹，冯兴军，马清泉，董娜，王良，吕银凤，朱鑫．抗菌肽的功能、研发与应用．中国农业科学，2012，45(11): 2249-2259. 20. 王良，马清泉，单安山*，董娜，吕银凤. 利用亮氨酸和赖氨酸设计新型α-螺旋抗菌肽. 微生物学通报，2014，41（2）：312-318.

 近五年授权的专利等情况
一种抗菌肽RW-P及其制作方法和应用；发明专利；授权号ZL0.6一种富含色氨酸抗菌肽WK12及其制备方法和应用；发明专利；授权号ZL5.2

 其他获奖及荣誉称号