李术
性 别： 女 出生年月： 1970-10-01
职 称： 教授 工作单位： 动物医学学院
招生学科1： 基础兽医学 招生学科2：
办公电话： E-mail： lishu@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
206305 动物生理学专题 硕士课 32
106312 动物生理学研究技术 博士生课程 48
106119 动物生理学与生物化学研究进展 博士生课程 48
 近五年主持科研项目概况
1. 国家自然科学基金面上项目，基于硒蛋白调控中性粒细胞外捕网形成探讨鸡缺硒性动脉炎的发生机制，2019/01-2022/12，主持。
2. 环境有害气体因子对肉鸡免疫损伤的影响及机制，国家重点研发计划，2016/07-2020/12，子课题负责人。
3. 国家自然科学基金面上项目，microRNA-155在鸡缺硒性脾淋巴细胞凋亡中的作用机制研究， 2015/01-2018/12， 主持。
4. 哈尔滨市科技创新人才研究专项资金项目， 谷氨酰胺在冷应激雏鸡肺损伤中保护作用的研究， 2010/05-2013/04，主持。
5. α-突触核蛋白在阿维菌素致鸽神经元线粒体损伤中的作用，高等学校博士学科点专项科研基金联合资助课题（博导类联合），2011/01-2013/12，主持。


 近五年项目获奖概况


 近五年代表性著作、论文
1 Zhepeng Sun, Zhe Xu, Dongxu Wang, Haidong Yao, Shu Li*,Selenium Deficiency Inhibits Dendritic Cells Differentiation and Immune Function, Imbalance the Th1/Th2 of Dendritic Cells, Metallomics, 2018, 10: 759—767
2 Tingru Pan, Xueyuan Hu, Tianqi Liu, Zhe Xu, Na Wan, Yiming Zhang, Shu Li*, miR-128-1-5p regulates tight junction induced by Se deficiency via targeting CADM1 in broilers vein endothelial cells,Journal of Cellular Physiology,DOI: 10.1002/jcp.26794
3 Tianqi Liu, Tianshu Yang, Zhe Xu, Siran Tan, Tingru Pan, Na Wan, Shu Li*,microRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1,Journal of Inorganic Biochemistry, 2018,186: 235–245
4 Qianru Chi,Xin Chi, Xueyuan Hu, Shuang Wang, Hongfu Zhang*, Shu Li*,The effects of atmospheric hydrogen sulfide on peripheral blood lymphocytes of chickens: Perspectives on inflammation, oxidative stress and energy metabolism, Environmental Research, 2018, 167 : 1–6
5 Xueyuan Hu, Qianru Chi, Dongxu Wang, Xin Chi, Xiaohua Teng*, Shu Li*, Hydrogen sulfide inhalation-induced immune damage is involved in oxidative stress, inflammation, apoptosis and the Th1/Th2 imbalance in broiler bursa of Fabricius, Ecotoxicology and Environmental Safety, 2018, 164: 201–209
6 Shuang Wang, Zhe Xu, Hang Yin, Yahong Min,Shu Li*, Protective mechanisms of selenium on cadmium-spiked chicken ovaries: Perspectives from autophagy and energy metabolism, Biological Trace Element Research. https://doi.org/10.1007/s12011-018-1341-y
7 He Huang,Yang An, Wanying Jiao,Jinghan Wang,Shu Li*, Xiaohua Teng*,CHOP/caspase-3 signal pathway involves in mitigative effect of selenium on lead-induced apoptosis via endoplasmic reticulum pathway in chicken testes, Environmental Science and Pollution Research, Environmental Science and Pollution Research, 2018, 25:18838–18845
8 Pervez Ahmed Khoso, Yiming Zhang, Hang Yin, Xiaohua Teng*, Shu Li* Selenium deficiency affects immune function by influencing selenoprotein and cytokine expression in chicken spleen, Biological Trace Element Research, DOI: 10.1007/s12011-018-1396-9
9 SiranTan, Qianru Chi, Tianqi Liu, Zhepeng Sun, Yahong Min, Ziwei Zhang, Shu Li*, Alleviation Mechanisms of Selenium on Cadmium-Spiked Neutrophil Injury to Chicken, Biol Trace Elem Res, 2017, 178:301–309
10 Jianqiao Chen, Tingru Pan, Na Wan, Zhepeng Sun, Ziwei Zhang, Shu Li*, Cadmium-Induced Endoplasmic Reticulum Stress in Chicken Neutrophils is Alleviated by Selenium, Journal of Inorganic Biochemistry. 2017, 170: 169–177
11 Ci Liu, Zhepeng Sun, Zhe Xu, Tianqi Liu, Tingru Pan, Shu Li*, Down-regulation of microRNA-155 promotes selenium deficiency-induced apoptosis by tumor necrosis factor receptor superfamily member 1B in the broiler spleen, Oncotarget. 2017,8(35): 58513–58525.
12 Na Wan,Zhe Xu, Tianqi Liu,Yahong Min,Shu Li*,Ameliorative Effects of Selenium on Cadmium-Induced Injury in the Chicken Ovary: Mechanisms of Oxidative Stress and Endoplasmic Reticulum Stress in Cadmium-Induced Apoptosis,Biol Trace Elem Res, https://doi.org/10.1007/s12011-017-1193-x
13 Zhe Xu, Xi Jin, Tingru Pan, Tianqi Liu, Na Wan, Shu Li*, Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens , Oncotarget. 2017, 8(32): 52629–52641.
14 He Huang, Yan Wang, Yang An, Yaguang Tian, Shu Li*, Xiaohua Teng*,Selenium for the mitigation of toxicity induced by lead in chicken testes through regulating mRNA expressions of HSPs and selenoproteins, Environmental Science and Pollution Research, 2017, 24(16):14312-14321.
15 Rongkun Bao, Xinyue Wang, Shufang Zheng, Qiaojian Zhang, Hongjin Lin*, Shu Li* ,Selenium Supplementation Changes the Ion Profile in the Pancreas of Chickens Treated with Cadmium, Biol Trace Elem Res, 2018, 181:133–141
16 Kun Zhang, Yihao Zhu, Xiaoyu Wang, Xin Zhao, Shu Li*, Xiaohua Teng*, Excess Manganese-Induced Apoptosis in Chicken Cerebrums and Embryonic Neurocytes, Biol Trace Elem Res, DOI 10.1007/s12011-017-0992-4
17 Zhepeng Sun, Ci Liu, Tingru Pan, Haidong Yao, Shu Li*, Selenium Accelerates Chicken Dendritic Cells Differentiation and affects Selenoproteins Expression, Developmental and Comparative Immunology,2017, 77: 30-37
18 Tingru Pan,Tianqi Liu, Siran Tan, Na Wan, Yiming Zhang,Shu Li*,Lower Selenoprotein T Expression and Immune Response in the Immune Organs of Broilers with Exudative Diathesis Due to Selenium Deficiency,Biol Trace Elem Res, 2018, 184: 240–246
19 Tianqi Liu, Tianshu Yang, Tingru Pan, Ci Liu, Shu Li*, Effect of Low-Selenium/High-Fat Diet on Pig Peripheral Blood Lymphocytes: Perspectives from Selenoproteins, Heat Shock Proteins, and Cytokines, Biol Trace Elem Res, 2018, 183(1):102-113.
20 Qianru Chi ,Tianqi Liu, Zhepeng Sun, Siran Tan, Shiping Li, Shu Li*, Involvement of mitochondrial pathway in environmental metal pollutant lead-induced apoptosis of chicken liver: perspectives from oxidative stress and energy metabolism,Environ Sci Pollut Res. (2017) 24:28121–28131
21 Ming Li, Shuo Zhou, Xian-Song Wang, Ci Liu, Shu Li*. Effects of in vitro, and in vivo, avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons. Ecotoxicology Environmental Safety, 2017, 135: 24-31.
22 Ci Liu, Ye Cao, Shuo Zhou, Pervez Ahmed Khoso, Shu Li*. Avermectin induced global dna hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon. Pesticide Biochemistry Physiology, 2017: 52-58.
23 Xian-Song Wang, Ci Liu, Pervez Ahmed Khoso1, Weijia Zheng, Ming Li*, Shu Li*. Autophagy response in the liver of pigeon exposed to avermectin.Environmental Science Pollution Research, 2016, 1-11.
24 Pervez Ahmed Khoso, Ci Liu, Chunpeng liu, Mir Hassan Khoso, Shu Li*. Selenium deficiency activates heat shock protein expression in chicken spleen and thymus.Biological Trace Element Research, 2016, 173(2), 1-9.
25 Pervez Ahmed Khoso, Tingru Pan, Na Wan, Zijiang Yang, Ci Liu, Shu Li*. Selenium deficiency induces autophagy in immune organs of chickens.Biological Trace Element Research, 2016, 1-10.
26 G.X. Sun, Y. Chen, C. P. Liu, S. Li*, J. Fu*. Effect of selenium against lead-induced damage on the gene expression of heat shock proteins and inflammatory cytokines in peripheral blood lymphocytes of chickens.Biological Trace Element Research, 2016, 172(2), 474-480.
27 Zijiang Yang, Ci Liu, Chunpeng Liu, Xiaohua Teng*, Shu Li*. Selenium deficiency mainly influences the gene expressions of antioxidative selenoproteins in broiler immune organs, Biol Trace Elem Res, 2016, 172:209–221.
28 Zijiang Yang, Ci Liu, Weijia Zheng, Xiaohua Teng*, Shu Li*. The functions of antioxidants and heat shock proteins are altered in the immune organs of selenium-deficient broiler chickens.Biological Trace Element Research, 2016, 169(2), 341-351.
29 Hao Wang, Shu Li*, Xiaohua Teng*. The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Proteins mRNA Expression in Chicken Livers. Biological Trace Element Research, 2016, 171(2):437.
30 Yihao Zhu, Shu Li*, Xiaohua Teng*. The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes. Chemosphere, 2016, 153:462.
31 Jianping Qu, Ming Li, Fuqing Zhao, Ci Liu, Ziwei Zhang, Shiwen Xu, Shu Li*. Autophagy is upregulated in brain tissues of pigeons exposed to avermectin, Ecotoxicology and Environmental Safety, 2015, 113, 159–168.
32 Liu, C. P., Fu, J., Xu, F. P., Wang, X. S., Li, S*. The role of heat shock proteins in oxidative stress damage induced by se deficiency in chicken livers. BioMetals, 2015, 28(1), 163-173.
33 Dongbo Sun, Chunqiu Li, Jing Gao, Shu Li*, Hongbin Wang*. Effects of selenium deficiency on principal indexes of chicken kidney function. Biological Trace Element Research, 2015, 164(1), 1-6.
34 Fengping Xu, Shuang Liu, Shu Li*. Effects of Selenium and Cadmium on Changes in the Gene Expression of Immune Cytokines in Chicken Splenic Lymphocytes. Biological Trace Element Research, 2015, 165(2):214-221.
35 Pervez Ahmed Khoso, Zijiang Yang, Chunpeng Liu, Shu Li*. Selenium deficiency downregulates selenoproteins and suppresses immune function in chicken thymus. Biological Trace Element Research, 2015, 167(1), 48-55.
36 Houjuan Xing, Chao Wang, Hongda Wu, Dechun Chen, Shu Li*, Shiwen Xu*. Effects of atrazine and chlorpyrifos on DNA methylation in the brain and gonad of the common carp. Comparative Biochemistry Physiology Part C Toxicology Pharmacology, 2015, 168: 11-19.
37 Shuang Liu, Fengping Xu, Jing Fu, Shu Li*. Protective roles of selenium on nitric oxide and the gene expression of inflammatory cytokines induced by cadmium in chicken splenic lymphocytes. Biological Trace Element Research, 2015, 168(1): 252.
38 Xinxing Lu, Yihao Zhu, Rensheng Bai, Shu Li*, Xiaohua Teng*. The effect of manganese-induced toxicity on the cytokine mrna expression of chicken spleen lymphocytes in vitro. Research in Veterinary Science, 2015, 101: 165-167.
39 Ye Du, Yihao Zhu, Xiaojie Teng, Kun Zhang, Xiaohua Teng*, Shu Li*. Toxicological effect of manganese on NF-κB/iNOS-COX-2 signaling pathway in chicken testes. Biological Trace Element Research, 2015, 168(1), 227.
40 Chunpeng Liu, Jing Fu, Ci Liu, Shu Li*. The role of nitric oxide and autophagy in liver injuries induced by selenium deficiency in chickens.Rsc Advances, 2015, 5(62):50549-50556.
41 Pervez Ahmed Khoso, Zijiang Yang, Chunpeng Liu, Shu Li*. Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of fabricius of chickens with selenium deficiency. Cell Stress and Chaperones, 2015, 20(6): 967.
42 Ci Liu, Yanbing Zhao, Lijie Chen, Ziwei Zhang, Ming Li, Shu Li*. Avermectin induced autophagy in pigeon spleen tissues. Chemico-biological interactions, 2015, 242:327-333.
43 Houjuan Xing, Zhilei Wang, Xuejiao Gao, Dechun Chen, Liangliang Wang, Shu Li*, Shiwen Xu*. Atrazine and chlorpyrifos exposure induces liver autophagic response in common carp. Ecotoxicology Environmental Safety, 2014, 113: 52-58.
44 Ci Liu, Ming Li, Ye Cao, Jian-Ping Qu, Zi-Wei Zhang, Shi-Wen Xu, Shu Li*. Effects of avermectin on immune function and oxidative stress in the pigeon spleen. Chemico-biological interactions, 2014, 210(1): 43-50
45 Li-Jie Chen, Bao-Hong Sun, Ye Cao, Hai-Dong Yao, Jian-Ping Qu, Ci Liu, Shi-Wen Xu, Shu Li*. The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. Pesticide Biochemistry Physiology, 2014, 110(1): 13-19
46 Houjuan Xing, Ziwei Zhang, Haidong Yao, Tao Liu, Liangliang Wang, Shiwen Xu*, Shu Li*. Effects of Atrazine and Chlorpyrifos on cytochrome P450 in common carp liver. Chemosphere, 2014, 104(3): 244.
47 Dong Yu, Zi-wei Zhang, Hai-dong Yao, Shu Li*, Shi-wen Xu*. Antioxidative role of selenoprotein W in oxidant-induced chicken splenic lymphocyte death. BioMetals, 2014, 27(2): 277-291.
48 C. P. Liu, J. Fu, S. L. Lin, X. S. Wang, S. Li*. Effects of dietary selenium deficiency on mRNA levels of twenty-one selenoprotein genes in the liver of layer chicken. Biological Trace Element Research, 2014, 159(1): 192-198.
49 Ye Cao Li-jie Chen, Zi-wei Zhang, Hai-dong Yao, Ci Liu, Shu Li*, Shi-wen Xu*. Global DNA hypomethylation: a potential mechanism in king pigeon nerve tissue damage induced by avermectin. Chemico-biological interactions, 2014, 219:113-122
50 Lu You, Ci Liu, Zi-jiang Yang, Ming Li, Shu Li*. Prediction of selenoprotein t structure and its response to selenium deficiency in chicken immune organs. Biological Trace Element Research, 2014, 160(2): 222-231.
51 Shuang Liu, Feng-ping Xu, Zi-jiang Yang, Ming Li, Ya-hong Min, Shu Li*. Cadmium-induced injury and the ameliorative effects of selenium on chicken splenic lymphocytes: mechanisms of oxidative stress and apoptosis. Biological Trace Element Research, 2014, 160(3): 340-351.
52 Zi-wei Zhang, Ming-yu Bi, Hai-dong Yao, Jing Fu, Shu Li*, Shi-wen Xu*. Effect of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation genes. Avian Diseases, 2014, 58(3):415-26.
53 Ming Li, Xian-Song Wang, Feng-Ping Xu, Shuang Liu, Shi-Wen Xu, Shu Li*. The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. Ecotoxicology Environmental Safety, 2014, 110:95-102.
54 Wen-Jun Zhu, Zi-Wei Zhang, Xian-Song Wang, Shi-Wen Xu ,Ming Li*, Shu Li*. Effects of avermectin on microsomal cytochrome P450 enzymes in the liver and kidneys of pigeons. Environ Toxicol Pharmacol, 2014, 38(2):562-569.
55 Ci Liu, Xian-Song Wang, Zhe Xu, Ming Li, Zi-Wei Zhang, Ya-Hong Min, Pervez Ahmed Khoso, Li Shu*. Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. Chemico-biological interactions, 2014, 224:176.
56 Houjuan Xing, Hongda Wu, Gang Sun, Ziwei Zhang, Shiwen Xu*, Shu Li*. Alterations in activity and mRNA expression of acetylcholinesterase in the liver, kidney and gill of common carp exposed to atrazine and chlorpyrifos. Environmental Toxicology and Pharmacology, 2013, 35:47-54.
57 Fu-qing Zhao, Zi-wei Zhang, Hai-dong Yao, Liang-liang Wang, Tao Liu, Xian-yi Yu, Shu Li*, Shi-wen Xu*. Effects of cold stress on mRNA expression of immunoglobulin and cytokine in the small intestine of broilers. Research in Veterinary Science, 2013(95):146-155.
58 Fu-Qing Zhao, Zi-Wei Zhang, Chao Wang, Bo Zhang, Hai-Dong Yao, Shu Li*, Shi-Wen Xu*. The role of heat shock proteins in inflammatory injury induced by cold stress in chicken hearts. Cell Stress and Chaperones, 2013, 18(6):773-783.
59 Yao Fu, Ming Li, Ci Liu, Jian-Ping Qu, Wen-Jun Zhu, Hou-Juan Xing, Shi-Wen Xu, Shu Li*. Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills. Ecotoxicology & Environmental Safety, 2013, 94(1):28.
60 Shu Li*, Ming Li, Yali Cui, Xiansong Wang. Avermectin exposure induces apoptosis in King pigeon brain neurons. Pesticide Biochemistry & Physiology, 2013, 107(2):177-187.
61 Ming Li, Tian-Zi You, Wen-Jun Zhu, Jian-Ping Qu, Ci Liu, Bing Zhao, Shi-Wen Xu, Shu Li*. Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin.. Ecotoxicology, 2013, 22(8):1241.
62 Li-Jie Chen, Bao-Hong Sun, Jian ping Qu, Shiwen Xu, Shu Li*. Avermectin induced inflammation damage in king pigeon brain. Chemosphere, 2013, 93(10):2528.
63 Wen-Jun Zhu, Ming Li, Ci Liu, Jian-Ping Qu, Ya-Hong Min, Shi-Wen Xu, Shu Li*. Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. Ecotoxicology & Environmental Safety, 2013, 98(12):74-81.

 近五年授权的专利等情况
1.发明专利，治疗犬皮肤真菌病的药物组合及其制备方法，第1完成人，国家知识产权局，专利号：ZL5.1，2012年5月。
2.实用新型专利，奶牛酮病快速诊断板，第1完成人，国家知识产权局，专利号：ZL2.2，2010年9月。
3.实用新型专利，细胞爬片培养板，第1完成人，国家知识产权局，专利号：ZL1.8，2010年9月。


 其他获奖及荣誉称号