李艳飞
性 别： 女 出生年月： 1967-08-01
职 称： 教授 工作单位： 东北农业大学
招生学科1： 临床兽医学 招生学科2：
办公电话： ** E-mail： liyanfei@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
206332 兽医内科学专题 硕士研究生 64
206108 临床兽医学科前沿专题讲座 硕士研究生 48
106224 现代兽医内科临床专题 博士研究生 32
 近五年主持科研项目概况
1.主持国家自然科学基金，线粒体自噬在铝抑制骨形成中的作用及ROS/PINK1/Parkin通路的调控机制, 2019.01-2022.12，59万元2.主持黑龙江省自然基金，铝骨病大鼠骨矿化障碍的分子机制，2015.01-2017.12，6万元3.主持黑龙江省教育厅科学技术研究项目，铝骨病大鼠骨矿化抑制的分子机制, 2014.01-2016.12，2万元4.主持高等学校博士学科点专项科研基金，铝骨病大鼠骨形成调控的Wnt/β-catenin信号转导机制，2014.01-2016.12，12万元5.主持国家自然科学基金项目，铝骨病大鼠骨形成抑制的Wnt/β-catenin 信号转导机制，2014.01-2017.12，85万元6.主持“十二五”国家科技支撑计划子课题，奶牛健康养殖疾病防治关键技术研究-围产期奶牛群发性营养代谢障碍性疾病的早期监测预警和诊断关键技术研究，2012.01-2016.12，10万元7.主持黑龙江省级领军人才梯队后备人才资助资金，铝致大鼠成骨作用抑制的分子机制，2013.01-2015.12，5万元8.主持国家自然科学基金项目，铝免疫毒性的神经内分泌调控机制，2012.01-2015.12，60万元

 近五年项目获奖概况
1、铝的免疫毒性，省自然科学学术成果奖，三等奖，20152、铝毒性研究，省自然科学奖，三等奖，2018

 近五年代表性著作、论文
一、著作1.参编《兽医手册》，中国农业出版社，2013.112.主编专著《铝中毒研究》，中国农业出版社，2015.11 3.主审《西藏家畜常见普通病防治技术》，西藏人民出版社，2016.1二、通讯作者文章59.Iron dyshomeostasis participated in rat hippocampus toxicity caused by aluminum chloride,Biological Trace Element Research, 2019, doi.org/10.1007/s12011-019-02008-7（SCI，通讯作者）58.Protective effects of lycopene against AFB1-induced erythrocyte disfunction and oxidative stress in mice,Research in Veterinary Science,2020,129:103-108（SCI，通讯作者）57.Concentration distribution of heavy metals in Manila clam (Ruditapes philippinarum) and potential health risk in the coastal areas of Liaodong Bay, China, Applied ecology and environmental research,2020,18(1):77-88（DOI: http://dx.doi.org/10.15666/aeer/1801_077088）（SCI，通讯作者）56.A review of the reproductive toxicity of T-2 toxin，Journal of Agricultural and Food Chemistry，2020.1(（SCI一区，TOP期刊，通讯作者）55.Mitochondrial damage are involved in Aflatoxin B1-induced testicular damage and spermatogenesis disorder in mice。Science of the Total Environment 701 (2020) 135077，（SCI二区，TOP期刊，通讯作者）54.Aflatoxin B1 promotes autophagy associated with oxidative stress-related PI3K/AKT/mTOR signaling pathway in mice testis。Environmental Pollution，255 (2019) 113317（SCI二区，TOP期刊，通讯作者）53.T-2 toxin impairs male fertility by disrupting hypothalamic-pituitary-testis axis and declining testicular function in mice. Chemosphere. 2019; 234: 909-916. （SCI二区，TOP期刊，通讯作者）52.Spermatogenesis disorder caused by T-2 toxin is associated with germ cell apoptosis mediated by oxidative stress，Environmental Pollution，251 (2019) 372-379 (**) （SCI二区，TOP期刊，通讯作者）51.Lycopene alleviates AFB1-induced immunosuppression by inhibiting oxidative stress and apoptosis in spleen of mice，Food & Function, 2019, 10, 3868-3879（SCI一区，TOP期刊，通讯作者）50．Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat, Journal of Inorganic Biochemistry 193 (2019) 143-151 （SCI，通讯作者）49．Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway, Ecotoxicology and Environmental Safety 173 (2019) 131-14（SCI二区，TOP期刊，通讯作者）48．Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells.Chemico-Biological Interactions,2019,299:15-26（SCI，通讯作者）47．Lycopene attenuates AFB1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice.Food Funct, 2018,9, 6427-6434（SCI二区，TOP期刊，通讯作者）46. Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway. Environ Pollut. 2018;243:1689-1695.(SCI二区，TOP期刊，通讯作者)45. AlCl3 inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production through suppressing NF-kB signaling pathway in murine peritoneal macrophages. Chemosphere, 2018, 209: 972-980.(SCI二区，TOP期刊，通讯作者)44. Aluminum trichloride-induced hippocampal inflammatory lesions are associated with IL-1 b -activated IL-1 signaling pathway in developing rats.Chemosphere, 2018, 203: 170-178.(SCI二区，TOP期刊，通讯作者)43. Bone impairment caused by AlCl3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress. Food and Chemical Toxicology, 2018, 116: 307-314. (SCI二区，TOP期刊，通讯作者)42. Cytoprotective effect of deferiprone against aluminum chloride-induced oxidative stress and apoptosis in lymphocytes. Toxicology letters, 2018, 285(3): 132-138. (SCI二区，通讯作者)41. Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzymes Activities and Gonadotropin Receptors Expression in Rats. Biol Trace Elem Res, 2018 ,183(2):1-9. (SCI，通讯作者)40. Autophagy Protects MC3T3-E1 Cells upon Aluminum-Induced Apoptosis. Biological Trace Element Research, 2018,(2):1-7. (SCI，通讯作者)39. Hyperforin attenuates aluminum-induced Aβ production and Tau phosphorylation via regulating Akt/GSK-3β signaling pathway in PC12 cells. Biomedicine & Pharmacotherapy, 2017, 96: 1-6. (SCI，通讯作者)38. Protective Effect of Selenium on Aflatoxin B1-Induced Testicular Toxicity in Mice. Biol Trace Elem Res, 2017, 180(2): 233-238. (SCI，通讯作者)37. Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation.Journal of Functional Foods, 2017, 39: 215-224. (SCI二区，通讯作者) 36. AlCl3 caused liver dysfunction and mitochondrial energy metabolism. Journal of Inorganic Biochemistry, 2017, 174(20): 55-62 (SCI，通讯作者)35. Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer's disease rats. Biomedicine & Pharmacotherapy, 2017, 91: 931-937 (SCI，通讯作者)34.Fas-and Mitochondria- mediated signaling pathway involved in osteoblasts apoptosis induced by AlCl3. Biological Trace Element Research, 2017, (Suppl 1):1-13. (SCI，通讯作者)33. Aluminum trichloride inhibited osteoblastic proliferation and downregulated the Wnt/β-catenin pathway in rat osteoblasts. Biol Trace Elem Res, 2017, 177(2): 323-330. (SCI，通讯作者)32. Inhibition of bone formation in rats by aluminum exposure via Wnt/β-catenin pathway. Chemosphere, 2017, 176: 1-7. (SCI二区，TOP期刊，通讯作者)31. A pilot study on interaction between donkey tetherin and EIAV stains with different virulent and replication characteristics. Microbial Pathogenesis, 2017,（5）106:65-68. (SCI，通讯作者)30. Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats. BioMetals, 2017, 30(1): 143-150 .(SCI，通讯作者)29. Aluminum Trichloride Inhibits the Rat Osteoblasts Mineralization in vitro. Biol Trace Elem Res, 2017, 175(1): 186-193. (SCI，通讯作者)28. The suppressive effects of aluminum chloride on the osteoblasts function.Environmental Toxicology and Pharmacology, 2016, 48: 125-129. (SCI，通讯作者)27. Suppressive effects of copper sulfate accumulati on on the spermatogenesis of rats.Biol Trace Elem Res, 2016, 174(2): 356-361. (SCI，通讯作者) 26. Inhibition of osteoblast differentiation by aluminum trichloride exposure is associated with inhibition of BMP-2/Smad pathway component expression. Food and Chemical Toxicology, 2016, 11（97）: 120-126. (SCI二区，TOP期刊，通讯作者)25. The Toxicity of Aluminum Chloride on Kidney of Rats. Biol Trace Elem Res,2016, 173(2): 339-44. (SCI，通讯作者)24. Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride. Biol Trace Elem Res,2016, 173(2): 399-404. (SCI，通讯作者) 23. Aluminum chloride induced splenic lymphocytes apoptosis through NF-κB inhibition. Chemico-Biological Interactions, 2016, 257: 94-100. (SCI，通讯作者)22. Aluminum trichloride induces bone impairment through TGF-β1/Smad signaling pathway. Toxicology,2016, 371: 49-57. (SCI二区，通讯作者)21. Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats. Biol Trace Elem Res, 2016, 171(1): 116-23. (SCI，通讯作者)20. Aluminum chloride induces neuroinflammation, loss of neuronal dendritic spine and cognition impairment in developing rat. Chemosphere, 2016, 151: 289-295. (SCI二区，TOP期刊，通讯作者)19. The immunotoxicity of aluminum trichloride on rat peritoneal macrophages via β2adrenoceptors/cAMP pathway. Chemosphere, 2016, 149: 34-40. (SCI二区，TOP期刊，通讯作者)18. AlCl3 Induces Lymphocyte Apoptosis in Rats through the Mitochondria-Caspase Dependent Pathway. Environmental Toxicology. 2016 , 31(4): 385-94. (SCI，通讯作者)17. cAMP/PKA signaling pathway induces apoptosis by inhibited NF-κB in aluminum chloride-treated lymphocytes in vitro. Biol Trace Elem Res, 2016, 170(2): 424-31. (SCI，通讯作者)16. Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts. Environmental Toxicology and Pharmacology, 2016, 42: 198-204. (SCI，通讯作者)15. Aluminium chloride induces osteoblasts apoptosis via disrupting calcium homeostasis and activating Ca2+/CaMKII signal pathway. Biol Trace Elem Res,2016, 169(2): 247-53 (SCI，通讯作者)14. Aluminum trichloride inhibits osteoblast mineralization via TGF-β1/Smad signaling pathway. Chemico-Biological Interactions, 2016, 244: 9-15 (SCI，通讯作者)13. AlCl3 Induces Lymphocyte Apoptosis in Rats through the Mitochondria-Caspase Dependent Pathway. Environmental Toxicology, 2016, 31(4): 385-394 (SCI，通讯作者)12. Effects of Aluminum Chloride on the Serum Protein, Bilirubin and Hepatic Trace Elements in the Chickens. Toxicol Ind Health, 2016, 32(9): 1693 (SCI，通讯作者)11. cAMP/PKA signaling pathway induces apoptosis by inhibited NF-κB in aluminum chloride-treated lymphocytes in vitro. Biol Trace Elem Res, 2016, 170(2): 424-431. (SCI，通讯作者)10. Aluminum trichloride disorders bile acid secretion and induces hepatocyte apoptosis in rats. Cell Biochemistry and Bbiophysics, 2015, 71(3): 1569-1577. (SCI，通讯作者)9. NE strengthens the immunosuppression induced by AlCl3 through β2-AR/cAMP pathway in cultured rat peritoneal macrophages. Biol Trace Elem Res, 2015, 164: 234-241. (SCI，通讯作者)8. Aluminium chloride induces osteoblasts apoptosis via disrupting calcium homeostasis and activating Ca2+/CaMKII signal pathway. Biol Trace Elem Res, 2015, 169(2): 247-253. (SCI，通讯作者)7. Aluminum chloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats. Biol Trace Elem Res, 2015, 171(1): 1-8. (SCI，通讯作者)6. Aluminum trichloride impairs bone and downregulates Wnt/βcatenin pathway in rats. Food and Chemical Toxicology, 2015, 86: 154-162. (SCI二区，TOP期刊，通讯作者)5. Aluminum chloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts. Environmental Toxicology and Pharmacology, 2015, 8(42): 198-204. (SCI，通讯作者) 4. Effects of Al on the splenic immune function and NE in rats. Food Chem Toxicol, 2013, 62: 194-198. (SCI，通讯作者)3. Effects of Sub-chronic Aluminum Chloride Exposure on Ovary of Rats. Life Sciences, 2014, 100: 61-66. (SCI，通讯作者)2. Effects of subchronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats. Life sciences, 2014, 102: 36-40. (SCI，通讯作者)1. Immunotoxicity of Aluminum. Chemosphere. 2014, 104(6): 1-6. (SCI，通讯作者)

 近五年授权的专利等情况
1、一种治疗奶牛附红细胞体病的重要组合物及其制备方法，ZL5.4，授权公告日：2015，第一2、治疗鸡球虫病的中药组合物及其制备方法，专利申请号ZL 2014 1 **.9授权公告日：2017，第一

 其他获奖及荣誉称号
1、东北农业大学先进女教职工20162、东北农业大学巾帼女杰称号20123、主持省级精品课程《兽医内科学》20104、主持校级精品课《兽医内科学》2009