性 别: 女 出生年月: 1979-09-20
职 称: 教授 工作单位: 东北农业大学动物科学技术学院
招生学科1: 动物营养与饲料科学 招生学科2:
办公电话: E-mail: ndong@neau.edu.cn
开设研究生课程情况
课程编号 课程名称 课程级别 学时
近五年主持科研项目概况
- 国家自然科学基金面上项目,基于TLR4/NF-κB信号通路研究齐墩果酸调控仔猪肠道黏膜免疫的分子机制(**),课题主持人,2020.01-2023.12,在研
- 黑龙江省自然科学基金联合引导项目,基于TLR4/MAPK途径研究丙酮酸乙酯对猪肠道免疫应激的保护作用机理(LH2019C023),课题主持人,2019.07-2022.07,在研
- 国家自然科学基金青年基金项目,枯草芽孢杆菌细胞壁组分调控IPEC-J2细胞抗菌肽表达及其信号转导机理(**),课题主持人,2016.01-2018.12,已结题
- 中国博士后特别资助,丁酸钠调控猪肠膜IPEC-J2细胞抗菌肽表达及其分子机制(2016T90267),课题主持人,2016.1-2018.12,已结题
- 中国博士后科学基金面上项目,益生菌细胞壁组分调控猪肠膜细胞抗菌肽表达的机理研究,(2015M571385),课题主持人,2016.1-2017.12,已结题
- 黑龙江省自然科学青年基金项目,全新β-折叠型抗菌肽的分子设计及稳定性研究(QC201518),课题主持人,2015.01-2017.12,已结题
- 黑龙江省博士后科学基金面上项目,猪肠源PR-39抗酶分子设计及抑菌机理研究, (LBH-Z14026), 课题主持人,2015.1-2017.12,已结题
- 东北农业大学"学术骨干"项目,丁酸钠调控猪肠膜细胞抗菌肽表达及其分子机制(16XG14),课题主持人,2016.1-2017.12,已结题
近五年项目获奖概况
- 2019. 黑龙江省科技进步奖二等奖,高效无抗动物饲料生产关键技术的开发利用,(排名第6)
- 2019. 神农中华农业科技奖优秀创新团队,非粮型饲料资源研究与开发创新团队,(排名第11)
- 2015. 黑龙江省科技进步奖一等奖,猪鸡肉质营养调控技术的研究与开发,(排名第10)
近五年代表性著作、论文
- Na Dong, Xinran Li, Chenyu Xue, Lei Zhang, Chensi Wang, Xinyao Xu, Anshan Shan. Astragalus polysaccharides alleviates LPS-induced inflammation via the NF-κB/MAPK signaling pathway. Journal of Cellular physiology 2020, (doi: 10.1002/jcp.29452)
- Na Dong, Chenyu Xue, Lei Zhang, Tingting Zhang, Chensi Wang, Chongpeng Bi, Anshan Shan. Oleanolic acid ameliorates intestinal barrier defects and inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB/MAPK pathway. Food & Function 2020,11:1122-1132
- Na Dong, Xinyao Xu, Chenyu Xue, Chensi Wang, Xinran Li, Chongpeng Bi, Anshan Shan, Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways. Cell Cycle 2019, 18(20):1-15
- Na Dong, Xinyao Xu, Chenyu Xue, Chensi Wang, Xinran Li, Anshan Shan, Li Xu, Deshan Li, Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathway. International Immunopharmacology 2019, 71: 155-163
- Na Dong, Xinran Li, Chenyu Xue, Chensi Wang, Xinyao Xu, Chongpeng Bi, Anshan Shan, Deshan Li. Astragalus polysaccharides attenuated inflammation and balanced the gut microflora in mice challenged with Salmonella typhimurium. International Immunopharmacology 2019, 74: 105681
- Na Dong, Chensi Wang, Tingting Zhang, Lei Zhang, Chenyu Xue, Xinjun Feng, Chongpeng Bi and Anshan Shan. Bioactivity and bactericidal mechanism of histidine-rich beta-hairpin peptide against Gram-negative bacteria. International Journal of Molecular Sciences 2019, 20(16):3954
- Na Dong, Shuli Chou, Jiawei Li, Chenyu Xue, Xinran Li, Baojing Cheng, Anshan Shan and Li Xu. Short symmetric-end antimicrobial peptides centered on β-turn amino acids unit improve selectivity and stability. Frontiers in Microbiology 2018, 9:2832
- Na Dong, Xinrang Li, Xinyao Xu, Yinfeng Lv, Zhongyu Li, Anshan Shan, Jiali Wang. Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides. Amino Acids 2018, 50(3-4): 453-468
- Na Dong, Zhihua Wang, Shuli Chou, Licong Zhang, Anshan Shan, Junguang Jiang, Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematodeantimicrobial peptide CP-1. Chemical Biology & Drug Design 2018; 91(5): 1017-1029
- Na Dong, Xin Zhu, Shuli Chou, Anshan Shan, Weizhong Li, Junguang Jiang. Antimicrobial potency and selectivity of simplified symmetric-end peptides. Biomaterials 2014, 35(27): 8028-8039
近五年授权的专利等情况
- 董娜等. 专利名:高细胞选择性的环形抗菌肽OIR3及其制备方法和应用.证书号:ZL0.1.
- 董娜等. 专利名:一种高效α-螺旋抗菌肽GV及其制备方法和应用.证书号:ZL9.1.
- 董娜等. 专利名:一种高效杂交抗菌肽LI及其制备方法和应用.证书号:ZL9.9.
- 董娜等. 专利名:一种鸡源抗菌肽的衍生肽及其制备方法和应用.证书号:ZL6.8.
其他获奖及荣誉称号