基本信息
张继
性 别：男出生年月：1983-03-01
职 称：副教授工作单位：东北农业大学生命科学学院
招生学科1：微生物学招生学科2：
办公电话：E-mail：lumenzi@163.com

开设研究生课程情况
课程编号课程名称课程级别学时
209103现代微生物学生物技术必修课32
近五年主持科研项目概况

国家自然科学基金面上项目，大豆疫霉苏氨酰tRNA合成酶结构与Borrelidin结合位点解析 国家自然科学基金青年项目，含氯化酶基因放线菌的筛选和农用新活性化合物的研究 国家基础科学人才培养基金子项目，基于PCR技术的杂合型类异戊二烯次级代谢物的发现及生物合成的研究 黑龙江省自然科学基金面上项目，松嫩平原盐碱地稀有放线菌及其活性代谢产物的挖掘 黑龙江普通高等学校“青年学术骨干”支持计划项目，松嫩平原盐碱地中可培养耐（嗜）盐放线菌的多样性及其农用活性代谢产物的研究 中国博士后基金，基于卤化酶基因为探针的基因组扫描技术在新型农用活性代谢物及其产生菌筛选中的应用 黑龙江省博士后基金，作物内生菌中卤化物产生菌的筛选及其活性代谢物的研究 东北农业大学博士科研启动金，基因组扫描技术在特殊结构新农药发现中的应用 东北农业大学“东农学者—学术骨干”项目，大豆疫霉苏氨酰tRNA合成酶与Borrelidin复合物晶体结构的制备与解析

近五年项目获奖概况

向文胜，王相晶，王继栋、陈正杰、白骅、张继. 农用抗生素高效发现新技术及系列新产品产业化，国家科技发明二等奖，2015年12月 向文胜，王相晶，白骅、王继栋、陈正杰、张继、刘重喜、李艳华、徐美冬、李继昌、王晴。高效筛选农用抗生素体系构建及产多拉菌素新菌株发现与产业化。黑龙江省科技发明一等奖，2014年8月 向文胜，王相晶，白骅，王继栋，李继昌，陈正杰，赵长山，陶波，张继，颜一军，高爱丽。农用抗生素米尔贝霉素、米尔贝霉素肟原料药研制及产业化。黑龙江省科技发明一等奖，2011年12月

近五年代表性著作、论文
近5年，在Bioresource Technology、Microbial Cell Factories、Applied Microbiology Biotechnoogy和Journal of Agricultural and Food Chemistry等杂志上发表SCI学术论文30余篇，其中第一作者SCI论文最高影响因子5.039，单篇论文最高它引35次。

[1] Ji Zhang, Xiang-Jing Wang, Yi-Jun Yan, et al. Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp. HBDN08 with antifungal activity. Bioresource Technology 2010, 101: 8383-8388. (SCI一区，影响因子5.039)

[2] Ji Zhang, Yi-Jun Yan, Jing An, Sheng-Xiong Huang, Xiang-Jing Wang, Wen-Sheng Xiang. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microbial Cell Factories. 2015, 14: 152 (SCI一区，影响因子4.22)

[3] Ji Zhang, Jing An, Ji-Jia Wang, et al. Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin. Appl Microbiol Biotechnol 2013, 97, 10091-10101 (SCI二区，影响因子3.811)

[4] Ji Zhang, Xiang-Jing Wang, Yi-Jun Yan, Wen-Sheng Xiang. Comparative studies on the interaction of genistein, 8-chlorogenistein and 3',8-dichlorogenistein with bovine serum albumin. Journal of Agricultural and Food Chemistry 2011, 59(13): 7506-7513 (SCI一区，影响因子3.107)

[5] Ji Zhang, Xiangjing Wang, Jinnao Diao, et al. Streptomycin resistance-aided genome shuffling to improve doramectin productivity of Streptomyces avermitilis NEAU1069. Journal of Industrial Microbiology and Biotechnology 2013, 40:877-889 (SCI二区，影响因子2.505)

[6] Ming Li*, Ji Zhang*, Chongxi Liu, Baozhu Fang, Wensheng Xiang, Xiangjing Wang. Identification of borrelidin binding site on threonyl-tRNA synthetase. Biochemical and Biophysical Research Communications 2014, 451(4): 485-490 (SCI，影响因子2.281)

[7] Ji Zhang, Ji-Dong Wang, Chong-Xi Liu, et al. A new prenylated indole derivative from endophytic actinobacteria Streptomyces sp. neau-D50. Nat Prod Res 2014, 28(7): 431-7 (SCI，影响因子1.088)

[8] Tong Pan, Hairong He, Chuang Li, Junwei Zhao, Yuejing Zhang, Jiansong Li, Xiangjing Wang, Chongxi Liu, Ji Zhang(通讯作者), Wensheng Xiang. Streptomyces daqingensis sp. nov., isolated from saline-alkaline soil. Int J Syst Evol Microbiol 2016 doi: 10.1099/ijsem.0.000887 (SCI，影响因子2.511)

[9] Hai-Yan Wang, Ji Zhang, Yue-Jing Zhang, et al. Combined application of plasmas mutagensis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis. Applied Microbiology and Biotechnology. 2014, 98, 9703-9712 (SCI二区，影响因子3.811)

[10] Xiang-Jing Wang, Ji Zhang, Ping-Ting Qian, et al. Three new cyclopentenone derivatives from Actinoalloteichus nanshanensis sp. nov. NEAU 119. J Asian Nat Prod Res 2014, 16: 587-592 (SCI，影响因子1.130)

[11] Xiang-Jing Wang, Ji Zhang, Ji-Dong Wang, et al. Novel cyclopentenone derivatives produced by a rare actinobacterial strain Actinoalloteichus nanshanensis sp. nov. NEAU 119. Natural Product Research. 2013, 27(20), 1863-1869 (SCI，影响因子1.088)

[12] Gao Ya-mei, Wang Xiangjing, Zhang Ji, et al. Borrelidin, a Potent Antifungal Agent: Insight into the Antifungal Mechanism against Phytophthora sojae. Journal of Agricultural and Food Chemistry 2012, 60: 9874-9881 (SCI一区，影响因子3.107)

[13] Chong-Xi Liu, Ji Zhang, Xiang-Jing Wang, et al. Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean. Journal of Agricultural and Food Chemistry 2012, 60: 1251-1257 (SCI一区，影响因子3.107)

[14] Xiang-Jing Wang, Ji Zhang, Ji-Dong Wang, et al. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chemistry Biodiversity 2011, 8, 2117-2125 (SCI，影响因子1.802)

[15] Xiang-Jing Wang, Ji Zhang, Chong-Xi Liu, et al. A novel macrocyclic lactone with bioactivity from Streptomyces microflavus neau3. Bioorganic Medicinal Chemistry Letters 2011, 21, 5145-5148 (SCI，影响因子2.331)
近五年授权的专利等情况
[1] 向文胜，张继，王相晶，姜玲. 氯化染料木素及其生物转化制备和应用方法，中国发明专利，ZL**1.1

[2] 向文胜，张继，王相晶，安静. 一种冰城链霉菌的基因阻断突变菌及其制备方法和应用，中国发明专利，ZL**0.2


其他获奖及荣誉称号
“东农学者—学术骨干”、省“青年学术骨干”