基本信息
李艳飞
性 别：女出生年月：1967-08-01
职 称：教授工作单位：东北农业大学
招生学科1：临床兽医学招生学科2：兽医学
办公电话：**E-mail：liyanfei@neau.edu.cn

开设研究生课程情况
课程编号课程名称课程级别学时
6.527兽医内科学专题硕士课72
6.001现代兽医内科学进展博士课90
6.564环境公害与中毒学硕士课54
6.043动物营养代谢病与中毒病博士课64
近五年主持科研项目概况
1、主持国家自然科学基金“铝骨病大鼠骨形成抑制的Wnt/β-catenin 信号转导机制”，2014-2017,85万

2、主持国家自然科学基金“铝免疫毒性的神经内分泌调控机制”，2012-2015，60万

3、主持高等学校博士学科点专项科研基金“铝骨病大鼠骨形成调控的分子机制，2014-2016,12万

4、主持黑龙江省级领军人才梯队后备人才项目“铝致大鼠成骨作用抑制的分子机制”，2013-2015，5万

5、主持黑龙江省教育厅科学技术研究项目“铝骨病大鼠骨矿化抑制的分子机制”，2014-2016，2.5万

6、主持黑龙江省自然科学基金“铝暴露致大鼠骨损伤的分子机制”，2010-2012，5万

7、主持黑龙江省后背人才基金“铝暴露致大鼠骨丢失的分子机制”2013-2015，5万
近五年项目获奖概况
1、吉林省自然科学学术成果奖，三等奖，2013

2、吉林省自然科学学术成果奖，三等奖，2014

3、吉林省自然科学学术成果奖，三等奖，2015

4、奶牛酮病主要发病环节的分子机制及防治基础，，省科学技术进步奖，一等奖，2010



近五年代表性著作、论文
1、专著

李艳飞，李心慰，朱言柱，铝中毒研究，中国农业出版社，240千字，2015

2、通讯作者文章

1. Effects of sub-chronic aluminum exposure on serum concentrations of iron and ironassociated proteins in rats. Biological Trace Element Research. 2011, 141(1-3): 246-253. (SCI，通讯作者)

2. Effects of Aluminum Exposure on Bone Mineral Density, Mineral in Rats. Biol Trace Elem Res. 2011(143): 378-385. (SCI，通讯作者)

3. Dynamic analysis of exposure to aluminum and an acidic condition on bone formation in young growing rats. Environmental Toxicology and Pharmacology. 2011, 31(3): 295-301. (SCI，通讯作者)

4. Effects of Subchronic Aluminum Exposure on the Immune Function of Erythrocytes in Rats. Biological trace element research. 2011, 143(3): 1576-1580. (SCI，通讯作者)

5. Effects of aluminum exposure on the allergic responses and humoral immune function in rats. Biometals. 2011, 24: 973-97. (SCI，通讯作者)

6. Effects of aluminum exposure on the adherence, chemotaxis and phagocytosis capacity of peritoneal macrophages in rats. Biol Trace Elem Res. 2011, 144: 1032-1038. (SCI，通讯作者)

7. Effects of aluminum exposure on serum sex hormones and androgen receptor expression in male rats[J]. Biol Trace Elem Res. 2011, 144: 1050-1058.(SCI，通讯作者)

8. Suppressive effects of aluminum trichloride on the T lymphocyte immune function of rats. Food and Chemical Toxicology. 2012, 50: 532-535. (SCI，通讯作者)

9. Effects of Subchronic Aluminum Exposure on the Reproductive Function in Female Rats. Biol Trace Elem Res. 2012, 145: 382-385. (SCI，通讯作者)

10. Effects of Aluminum on Immune Functions of Cultured Splenic T and B Lymphocytes in Rats. Biol Trace Elem Res. 2012, 147: 246-250. (SCI，通讯作者)

11. Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats. Food and Chemical Toxicology. 2012, 50: 2911-2915. (SCI，通讯作者)

12. Aluminum Induces Osteoblast Apoptos is Through the Oxidative Stress-Media ted JNK Signaling Pathway. Biol Trace Elem Res. 2012, 150: 502-508. (SCI，通讯作者)

13. Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats. Food and Chemical Toxicology. 2013, 51: 210-214. (SCI，通讯作者)

14. Impact of aluminum exposure on the immune system: a mini review. Environmental Toxicology and Pharmacology. 2013, 82-87. (SCI，通讯作者)

15. Effects of Norepinephrine on Immune Functions of Cultured Splenic Lymphocytes Exposed to Aluminum Trichloride. Biol Trace Elem Res. 2013, 154: 275-280. (SCI，通讯作者)

16. Effects of Al on the splenic immune function and NE in rats. Food Chem Toxicol. 2013, 62: 194-198. (SCI，通讯作者)

17. Effects of Sub-chronic Aluminum Chloride Exposure on Ovary of Rats. Life Sciences. 2014, (100):61-66. (SCI，通讯作者)

18. Effects of subchronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats. Life sciences. 2014, 102: 36-40. (SCI，通讯作者)

19. Immunotoxicity of Aluminum. Chemosphere. 2014, 104(6): 1-6. (SCI，通讯作者)

20. Aluminum chloride and norepinephrine induced immunotoxicity on splenic lymphocytes by activating β2-AR /cAMP/PKA/NF-κB signal pathway in rats. Biol Trace Elem Res. 2014, 162: 168-174. (SCI，通讯作者)

21. AlCl3 Induces Lymphocyte Apoptosis in Rats through the Mitochondria-Caspase Dependent Pathway. Environmental Toxicology.2015. DOI: 10.1002/tox.22051. (SCI，通讯作者)

22. Aluminum trichloride disorders bile acid secretion and induces hepatocyte apoptosis in rats. Cell Biochemistry and Bbiophysics. 2015. DOI: 10.1007/s12013-014-0380-z. (SCI，通讯作者)

23. NE strengthens the immunosuppression induced by AlCl3 through β2-AR/cAMP pathway in cultured rat peritoneal macrophages. Biol Trace Elem Res. 2015, 164: 234-241. (SCI，通讯作者)

24. Effects of Aluminum Chloride on the Serum Protein, Bilirubin and Hepatic Trace Elements in the Chickens. Toxicol Ind Health. 2015, DOI: 10.1177/**8035. (SCI，通讯作者)

25. Aluminium chloride induces osteoblasts apoptosis via disrupting calcium homeostasis and activating Ca2+/CaMKII signal pathway. Biol Trace Elem Res. 2015, 169(2): 247-253. (SCI，通讯作者)

26. cAMP/PKA signaling pathway induces apoptosis by inhibited NF-κB in aluminum chloride-treated lymphocytes in vitro. Biol Trace Elem Res. 2015. DOI 10.1007/s12011-015-0461-x. (SCI，通讯作者)

27. Aluminum chloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats. Biol Trace Elem Res. 2015 DOI 10.1007/s12011-015-0504-3. (SCI，通讯作者)

28. Aluminum trichloride impairs bone and downregulates Wnt/βcatenin pathway in rats. Food and Chemical Toxicology. 2015, 86: 154-162. (SCI，通讯作者)

29. Aluminum chloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts. Environmental Toxicology and Pharmacology. 2015, 8(42): 198-204. (SCI，通讯作者)

30. Aluminum trichloride inhibits osteoblast mineralization via TGF-β1/Smad signaling pathway. Chemico-Biological Interactions. 2016, 244: 9-15. (SCI，通讯作者)

31. The immunotoxicity of aluminum trichloride on rat peritoneal macrophages via β2adrenoceptors/cAMP pathway. Chemosphere. 2016, 149: 34-40.(SCI，通讯作者)

32. Aluminum chloride induces neuroinflammation, loss of neuronal dendritic spine and cognition impairment in developing rat. Chemosphere. 2016. DOI: org/10.1016/j.Chemosphere.2016.02.092. (SCI，通讯作者)

33. The Toxicity of Aluminum Chloride on Kidney of Rats. Biol Trace Elem Res.2016. DOI 10.1007/s12011-016-064-9. (SCI，通讯作者)

近五年授权的专利等情况
1、一种治疗牛瓣胃阻塞的组合物及其制备方法，专利号 ZL**7.9 ,2011.5，第一

2、一种治疗犬瘟热的中药的组合物及其制备方法 专利号ZL**3.9,2012.3， 第一

3、一种治疗羊腹泻的组合物及其制备方法 专利号ZL**4.1 ,2012.5，第一

4、一种治疗奶牛附红细胞体病的重要组合物及其制备方法 专利号ZL**5 2013.1，第一

5、兽医冷冻式运输箱，申请号 **0.2第三

6、兽医冷藏式储运箱，申请号 **2.8第四
其他获奖及荣誉称号
1、“亚慢性铝中毒对雏鸡免疫器官生长发育和形态结构的影响”，获哈尔滨市自然科学技术学术成果奖优秀奖，2010

2、东北农业大学巾帼女杰称号，2012

3、主持校级精品课《兽医内科学》，2009

4、主持省级精品课程《兽医内科学》，2010

5、东北农业大学先进女教职工，2016