姓名

杨炳友

性别

男

出生年月

1970.07

专业职称

教授

最后学历/

学位

研究生/博士

招收学生

层次

博士/硕士

所属学院

药学院

办公电话

0451-**

从事专业

中药学

电子邮箱

ybywater@163.com

主要研究

方向

中药及复方药效物质基础研究；中药性味物质基础研究

主要社会

兼职

世界中医药学会联合会中药化学专业委员会副秘书长；

中华中医药学会中药化学分会常务委员；

黑龙江省药学会中药天然药物专业委员会委员。

目前主持

科研课题

1. 促进骨折愈合五类新药接骨木总苷片的临床前研究，国家科技部重大新药创制专项课题，2009-2012(2009ZX09103-383)；

2. 接骨木促进骨折愈合有效成分及作用机制研究(**)，国家自然科学基金面上项目，2012-2015(**)；

3. 洋金花治疗银屑病的作用机理及新药研究，高等学校全国优秀博士学位论文作者专项资金资助项目，2009-2013(200980)；

4. 洋金花治疗银屑病的作用机理研究，黑龙江省杰出青年科学基金项目，2012-2013(JC201105)；

5. 基于以微生物次生代谢产物和生物转化为药效物质基础的发酵类中药六神曲的炮制原理研究，国家自然科学基金面上项目，2011-2013(**)。

主要论著

1.《中药化学图表解》副主编，人民卫生出版社，2008；

2.全国高等中医药院校研究生规划教材《中药化学专论》编委，人民卫生出版社，2010；

3.普通高等教育“十一五”国家级规划教材《中药化学》编委，中国中医药出版社，2011；

4.全国中医药行业内高等中医药院校成人教育规划教材《中药化学》副主编，湖南科学技术出版社，2011；

5.普通高等教育“十一五”国家级规划教材《中药化学成分波谱解析》副主编，中国中医药出版社，2012。

主要科研

成果

1.《洋金花治疗银屑病有效部位的化学成分和药理作用》，全国百篇优秀博士论文,No.**；

2.《银线草抗肿瘤药理作用及有效成分研究》,黑龙江省科技（进步类）二等奖（1），No.2010-146-01；

3.《洋金花治疗银屑病的基础与应用研究》，中国中西医结合学会科学技术一等奖（2），No.2011-10-5C；

4.《东风菜根抗肿瘤作用与有效成分的研究》，黑龙江省科技（进步类）二等奖（2），No.2007-122-02；

5.《黑龙江产中草药化学成分研究》，黑龙江省科学技术(自然类)一等奖（6）；无

《银线草抗肿瘤药理作用及有效成分研究》，黑龙江省中医药科技进步一等奖（1），No.2009-01-01；

6.《黑龙江产中草药化学成分研究》，黑龙江省中医药科技进步一等奖（6），No.2009-01-06；

7.《洋金花治疗银屑病有效组分的研究》，黑龙江省中医药科技进步一等奖（2），No.2010-01-02；

8.《中药性味的可拆分性、可组合性研究》，黑龙江省中医药科技进步一等奖（4），No.2010-01-04；

主要发表

学术论文

在国内外专业期刊或国际学术会议上共发表研究论文50余篇，其中，被SCI收载30余篇。部分论文如下：

[1] Bingyou Yang, Qiuhong Wang, Yonggang Xia, Weisheng Feng, and Haixue Kuang*. Withanolide Compounds from the flower of Datura metel L. Helv Chim. Acta., 2007, 90, 1522-1528.

[2] Bingyou Yang, Qiuhong Wang, Yonggang Xia, Weisheng Feng and Haixue Kuang*. Baimantuoluolines D-F, three new withanolides from the flower of Datura metel L. Helv. Chim. Acta., 2008, 91, 964-971.

[3] Bingyou Yang, Yonggang Xia, Qiuhong Wang, Deqiang Dou and Haixue Kuang*. Baiman tuoluosides D-G, Four New Withanolide Glucosides from the Flower of Datura metel L.. Archives of Pharmacal Research, 2010, 33: 1143-1148.

[4] Bingyou Yang, Yonggang Xia, Qiuhong Wang, Deqiang Dou and Haixue Kuang*. Two new amide alkaloids from the flower of Datura metel L.. Fitoterapia, 2010, 81: 1003-1005.

[5]Bingyou Yang, Yonggang Xia, Dong Chen, Haixue Kuang. Chemical Constituents from the Flower of Datura metel L. Chinese Journal of Natural Medicines, 2010,8(6):429-432.

[6] Haixue Kuang, Bingyou Yang, Yonggang Xia and Weisheng Feng. Chemical constituents from the flower of Datura metel L. Arch. Pharm. Res., 2008, 31(9), 1094-1097.

[7] Haixue Kuang, Yonggang Xia, Bingyou Yang, Qiuhong Wang and Shaowa Lv. Sesquiterpene Glucosides from Chloranthus japonicus Sieb. Chem. Biodiv., 2008, 5(9), 1736-1742.

[8] Yonggang Xia, Bingyou Yang, Qiuhong Wang, Jun Liang, Youhe Wei, Hedan Yu, Qingbo Zhang, Haixue Kuang*. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector. Liquid Chromatography. 2009, 32:4113-4125.

[9] Haixue Kuang*, Yonggang Xia, Bingyou Yang, Qiuhong Wang and Shaowa Lv. Lignan Constituents from Chloranthus japonicus Sieb. Arch. Pharm. Res., 2009, 32(3), 329-334.

[10] Haixue Kuang*, Bingyou Yang, Ling Tang, Yonggang Xia and Deqiang Dou. Baimantuoluosides A-C, three new withanolide glucosides from the flower of Datura metel L.. Helv. Chim. Acta., 2009, 92, 1315-1323.

[11] Haixue Kuang*, Shiwei Sun, Bingyou Yang and Yonggang Xia. New megastigmane sesquiterpene and indole alkaloid glucosides from the aerial parts of Bupleurum chinense DC. Fitoterapia, 2009, 80, 35-38.

[12]Haixue Kuang, Chao Sun, Yanli Zhang, Yanlong Zhang, Dong Chen, Bingyou Yang, Yonggang Xia. Three drimane sesquiterpene glucoside from the aerial parts of Dryopteris fragrans (L.) schot. Fitoterapia, 2009, 80(2):134-137.

[13]Yingkun Liu, Deqiang Dou, Liping Cai, Haiping Jiang, Tingguo Kang, Bingyou Yang, Haixue Kuang, Michael ZC Li. Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells. Fitoterapia, 2009, 80(4):219-222.

[14] Haixue Kuang*, Yoshihito Okada, Bingyou Yang, Zhenkun Tian and Tohru Okuyama. Secocycloartane triterpenoidal saponins from the leaves of Astragalus membranaceus Bunge. Helv. Chim. Acta., 2009, 92, 950-958.

[15] Guoyu Li, Yanhai Zhang, Bingyou Yang, Yonggang Xia, Yanlong Zhang, Shaowa Lü and Haixue Kuang*. Leiyemudanosides A-C, three new bidesmosidic triterpenoid saponins from the roots of Caulophyllum robustum. Fitoterapia, 2010, 81: 200-204.

[16] Yong-Gang Xia, Hai-Xue Kuang*, Bing-You Yang, Qiu-Hong Wang, Jun Liang, Yan-Ping Sun, Yan-Hong Wang. Optimum extraction of acidic polysaccharides from the stems of Ephedra sinica Stapf by Box–Behnken statistical design and its anti-complement activity. Carbohydrate Polymers, 2011, 84, 282-291.

[17] Hai-Xue Kuang*, Yong-Gang Xia, Jun Liang, Bing-YouYang, Qiu-HongWang, Yan-Ping Sun. Fast classification and compositional analysis of polysaccharides from TCMs by ultra-performance liquid chromatography coupled with multivariate analysis. Carbohydrate Polymers, 2011, 84, 1258-1266.

[18] Hai-Xue Kuang*, Yong-Gang Xia, Bing-You Yang, Qiu-Hong Wang, Yan-Hong Wang. Screening and comparison of the immunosuppressive activities of polysaccharides from the stems of Ephedra sinica Stapf. Carbohydrate Polymers, 2011, 83, 787-795.

[19] Yong-Gang Xia, Qiu-Hong Wang, Jun Liang, Bing-You Yang, Guo-Yu Li and Hai-Xue Kuang*. Development and application of a rapid and efficient CZE method coupled with correction factors for determination of monosaccharide composition of acidic hetero-polysaccharides from Ephedra sinica. Phytochemical Analysis, 2011, 22, 103-111.

[20] Qiu-Hong Wang, Hai-Xue Kuang, Bing-You Yang, Yong-Gang Xia, Jun-Song Wang, and Ling-Yi Kong*. Sesquiterpenes from Chloranthus japonicus. Journal of Natural Products, 2011, 74:16-20.

[21] Yong-Gang Xia, Jun Liang, Bing-You Yang, Qiu-Hong Wang and Hai-Xue Kuang*. A new method for quantitative determination of two uronic acids by CZE with direct UV detection. Biomedical chromagraphy, 2011, .

[22] Zhenyue Wang, Hua Han, Bingyou Yang, Yonggang Xia and Hai-Xue Kuang*. Two New Iridoid Glycosides from the Root Barks of Sambucus williamsii Hance. Molecules, 2011, 16(5):3869-3874.

[23] Hai-Xue Kuang*, Hongwei Li, Qiuhong Wang, Bingyou Yang, Zhibin Wang and Yonggang Xia. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba. Molecules, 2011, 16(6):4642-4651.

[24] Hai-Xue Kuang*, Yang Su, Bingyou Yang, Yonggang Xia, Qiuhong Wang, Zhibin Wang and Zhengfan Yu. Three New Cycloartenol Triterpenoid Saponins from the Roots of Cimicifuga simplex Wormsk. Molecules, 2011, 16(6):4348-4357.

[25] Hai-Xue Kuang*, Yong-Gang Xia, Jun Liang, Bing-You Yang and Qiu-Hong Wang. Lianqiaoxinoside B, a Novel Caffeoyl Phenylethanoid Glycoside from Forsythia suspense. Molecules, 2011, 16(7):5674-5681.

[26] Hai-Xue Kuang*, Bing-You Yang, Yong-Gang Xia and Qiu-Hong Wang. Two New Withanolide Lactones from Flos Datura. Molecules, 2011, 16(7):5833-5839.

[27] Qiu-Hong Wang, Liu Yang, Hai Jiang, Zhi-Bin Wang, Bing-You Yang and Hai-Xue Kuang*. Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl. Molecules, 2011, 16(7):5989-5997.

[28] Hai-xue Kuang*, Qiu-hong Wang, Bing-you Yang, Zhibin Wang, Yoshihito Okada, and Tohru Okuyama. Huangqiyenins G-J, Four New 9,10-secocycloartane (=9,19-cyclo-9,10-secolanostane) Triterpenoidal Saponins form Astragalus Membranaceus Bunge Leaves. Helvetica Chimica Acta, 2011, 94(12), 2239-2247.

[29] Hai-xue Kuang*, Hua Han, Bing-you Yang, Liu Yang, Hai Jiang, Qiu-hong Wang. Two New Iridoid Glycosides from the Root Barks of Sambucus williamsii Hance. Molecules, 2012, 17(2), 1830-1836

[30] Haixue Kuang*, Yang Su, Qiuhong Wang, Lun Wu, Bing-You Yang, Zhibin Wang, Yonggang Xia. Three New Cycloar tenol Glycosides from the Roots of Cimicifuga simplex. Planta Medica, 2012,78(6):622-625.

[31]haixue kuang, yonggang xia, bingyou yang, jun liang, qingbo zhang, guoyu li. A new caffeoyl phenylethanoid glycoside from the unripe fruits of Forsythia suspense. Chinese Journal of Natural Medicines, 2009, 7(4):278-282.

[32]Qiuhong Wang, Jian Zhang, Xu Ma, Xuyan Ye, Bingyou Yang, Yonggang Xia, Haixue Kuang. A New Triterpenoid Saponin from Leaves of Aralia elata. Chinese Journal of Natural Medicines, 2011, 9(1):17-21.