教育经历：

工作经历：

本科课程：有机化学，有机化学实验，精细有机合成原理 （双语）

研究生课程：当代药物开发与合成 （全英文授课）

1.有机化学方法学研究：

研究合成新型化学物质的新方法和新手段，目前实验室正在进行的方法学研究包含：

金属定向化作用诱导的阴离子重排反应的研究；

多环芳烃类化合物合成方法的研究等等。

2.新型癌症靶向性诊断试剂、治疗试剂的设计、合成及研究。

3.生物活性小分子的设计、合成及研究。

4.新型有机材料的设计/合成以及其在材料、能源等领域应用的研究。

1.Yang, J.;Hoang, T. T.; Dudley, G. B.* “Alkynogenic Fragmentation.” Submitted to OrganicChemistry Fronties. (Invited paper)

2.Yang, J*.;Sun, K.*; Dudley, G. B. “DFT study on the reaction mechanism andregioselectivity for the [1,2]-anionic rearrangement of 2-benzyloxypyridinederivatives.” Ready for submission to Tetrahedron.

3.Wu,Y.; Guan, B.; Yang, J.; Xiong, Y.; Hsien,J.; Hao, G.*; Sun, X.* “Design and Synthesis of Perfectly Paired Small-MoleculeTheranostic Agents for Prostate Cancer.” Ready for submission.

4.Yang, J.;Knueppel, D.; Cheng, B.; Mans, D.M.; Martin, S.F.* “Approaches to polycyclic1,4-dioxygenated xanthones. Application to total synthesis of the aglycone ofIB-00208.” Org. Lett. 2015, 17, 114-117.

5.Knueppel,D.; Yang, J.; Cheng, B., Mans, D.M.;Martin, S.F.* “Total synthesis of the aglycone of IB-00208.” Tetrahedron. 2015, 71, 5741-5757.

6.Yang, J.;Wangweerawong, A.; Dudley, G.B.* “[1,2]-Wittig rearrangement of aromaticheterocycles.” Heterocycles. 2012, 85, 1603-1606.

7.Yang, J.;Tummatorn, J.; Slegeris, R.; Tlais, S. F.; Dudley, G. B.* “Synthesis of thetricyclic core of aldingenin B by oxidative cyclo-ketalization of analkyne-diol.” Org. Lett. 2011, 13, 2065-2067.

8.Yang, J.;Dudley, G. B.* “Pyridine-directed organolithium addition to an enol ether.” Adv. Synth. Catal. 2010, 352, 3438-3422.

9.Yang, J.;Dudley, G. B.* “[1,2]-Anionic Rearrangement of 2-Benzyloxypyridine and RelatedPyridyl Ethers.” J. Org. Chem. 2009, 74, 7998-8000.

10. Yang,J.; Dudley, G. B.* “Conjugateaddition of organocopper reagents in dichloromethane to α, β-unsaturatedesters.” Tetrahedron Lett. 2007, 48, 7887-7889.

(1)Invited talk in 2018:

September,2018 河北欧美同学会，秦皇岛

October,2018 天津大学，天津

October,2018 河北科技大学，石家庄

(2)Development of paired small-molecule drug conjugates for prostate cancerprecision theranostics. Guan, B.; Wu, YK.; Yang, JY.; Xiong, YH.; Hsieh,JT.; Hao, GY.; Sun, XK. AACR Special Conference on Prostate Cancer - Advancesin Basic, Translational, and Clinical Research, Orland, F.L., United States,December 02^ed-05^th, 2017.

(3)Synthetic effort toward the total synthesis of IB-00208. Yang, J.;Knueppel, D.; Cheng, B.; Martin, S. F. Presented at the 245^th ACSNational Meeting, New Orleans, LA, United States, April 7^th-11^th,2013.

(4)Synthetic approach to aldingenin B using selenium-mediated ketalizationand nucleophilic addition-fragmentation reactions. Slegeris, R.; Yang, J.;Dudley, G. B. Presented at the 244^th ACS National Meeting &Exposition, Philadelphia, PA, United States, August 19^th-23^th,2012.

(5)Synthetic efforts toward the tricyclic core of roseophilin. Yang, J.;Katukojvala, S.; Dudley, G. B. Presented at the 235^th ACS NationalMeeting, New Orleans, LA, United States, April 6^th-10^th,2008.

(6)Development of a new method for glycosylation. Yang, J.; Dudley,G. B. Presented at the 235^th ACS National Meeting, New Orleans, LA,United States, April 6^th-10^th, 2008.

(7)Synthetic efforts toward the tricyclic core of roseophilin. Yang, J.;Dudley, G. B. Presented at the 58^th Southeast Regional Meeting of theAmerican Chemical Society, Augusta, GA, United States, November 1^st-4^th,2006.

Jingyue Yang

Professionals

Professor

School of Enviormentaland Chemical Engineering

Yanshan UniversityNovember 2017 – now

Sr. Research Associate

Department of Radiology,UT Southwestern Medical Center

Professor XiankaiSunDecember2016 – September 2017

Adjunct Faculty

Schoolof Mathematics, Science, & Health Professions

RichlandCollege, Dallas, TXAugust 2015 – May 2016

Postdoctoral Fellow

Department of Chemistry& Biochemistry, University of Texas at Austin

Professor Stephen. F.Martin June2011 –December 2013

Education

·Ph.D.,Organic Chemistry April 2011

Florida State University (FSU), Tallahassee, FL

Dissertation:“Anionic rearrangement of 2-benzyloxypyridines and a synthetic approach toaldingenin B.”

Research Advisor: Professor Gregory B. Dudley

·B.S.,Pharmaceutical Sciences June2005

Tianjin University, Tianjin, China

Thesis: “Methodology to prepare N-heterocycles from N, O-heterocycles.”

Research Advisor: Professor John Reiner

Courses

Undergraduate: Organic Chemistry,Organic Chemistry Labs, Fine Organic Synthesis and Technology (Bilingual)

Graduate: Contemporary Drug Development and Synthesis (English Only)

Research Interest

The group focuses in the area of organic / medicinal chemistry, and aimsto use organic / synthetic chemistry as a tool to solve the problems in drugdevelopment, material and energy field. Current on-going projects in the groupinclude:

1.Methodology development

Inonic rearrangement reaction

The synthesis of polycyclic aromatics,etc.

2.Design, synthesis and study of novel targeting reagents for cancer

3.Design, synthesis and study of small bioactive molecules

4.Design and synthesis of novel organic compounds and their application inmaterial and energy field.

Publications

1.Yang, J.; Hoang, T. T.; Dudley, G. B.*“Alkynogenic Fragmentation.” Submitted to Organic Chemistry Fronties. (Invitedpaper).

2.Yang, J*.; Sun, K.*; Dudley, G.B. “DFT study on the reaction mechanism and regioselectivity for the[1,2]-anionic rearrangement of 2-benzyloxypyridine derivatives.” Ready forsubmission to Tetrahedron.

3.Wu,Y.; Guan, B.; Yang, J.; Xiong, Y.; Hsien,J.; Hao, G.*; Sun, X.* “Design and Synthesis of Perfectly Paired Small-MoleculeTheranostic Agents for Prostate Cancer.” Ready for submission.

4.Yang, J.; Knueppel, D.; Cheng,B.; Mans, D.M.; Martin, S.F.* “Approaches to polycyclic 1,4-dioxygenatedxanthones. Application to total synthesis of the aglycone of IB-00208.” Org. Lett. 2015, 17, 114-117.

5.Knueppel,D.; Yang, J.; Cheng, B., Mans, D.M.;Martin, S.F.* “Total synthesis of the aglycone of IB-00208.” Tetrahedron. 2015, 71, 5741-5757.

6.Yang, J.; Wangweerawong, A.;Dudley, G.B.* “[1,2]-Wittig rearrangement of aromatic heterocycles.” Heterocycles. 2012, 85, 1603-1606.

7.Yang, J.; Tummatorn, J.;Slegeris, R.; Tlais, S. F.; Dudley, G. B.* “Synthesis of the tricyclic core ofaldingenin B by oxidative cyclo-ketalization of an alkyne-diol.” Org. Lett. 2011, 13, 2065-2067.

8.Yang, J.; Dudley, G. B.*“Pyridine-directed organolithium addition to an enol ether.” Adv. Synth. Catal. 2010, 352, 3438-3422.

9.Yang, J.; Dudley, G. B.*“[1,2]-Anionic Rearrangement of 2-Benzyloxypyridine and Related PyridylEthers.” J. Org. Chem. 2009, 74, 7998-8000.

10. Yang,J.;Dudley, G. B.* “Conjugate addition of organocopper reagents in dichloromethaneto α, β-unsaturated esters.” Tetrahedron Lett. 2007, 48, 7887-7889.

Presentations/Posters

1. Invited talk in2018:

September, 2018 The 2^edConference of Western Returned Scholars Association·Overseas-educated Scholars Association of Hebei Province，Qinhuangdao,Hebei

October, 2018 Tianjin University, Tianjin

October, 2018 Hebei University of Science &Technology，Shijiazhuang,Hebei

2.Development of paired small-molecule drug conjugates for prostate cancerprecision theranostics. Guan, B.; Wu, YK.; Yang, JY.; Xiong, YH.; Hsieh,JT.; Hao, GY.; Sun, XK. AACR Special Conference on Prostate Cancer - Advances inBasic, Translational, and Clinical Research, Orland, F.L., United States,December 02^ed-05^th, 2017.

3.Synthetic effort toward the total synthesis of IB-00208. Yang, J.;Knueppel, D.; Cheng, B.; Martin, S. F. Presented at the 245^th ACSNational Meeting, New Orleans, LA, United States, April 7^th-11^th,2013.

4.Synthetic approach to aldingenin B using selenium-mediated ketalizationand nucleophilic addition-fragmentation reactions. Slegeris, R.; Yang, J.;Dudley, G. B. Presented at the 244^th ACS National Meeting &Exposition, Philadelphia, PA, United States, August 19^th-23^th,2012.

5.Synthetic efforts toward the tricyclic core of roseophilin. Yang, J.;Katukojvala, S.; Dudley, G. B. Presented at the 235^th ACS NationalMeeting, New Orleans, LA, United States, April 6^th-10^th,2008.

6.Development of a new method for glycosylation. Yang, J.; Dudley,G. B. Presented at the 235^th ACS National Meeting, New Orleans, LA,United States, April 6^th-10^th, 2008.

7.Synthetic efforts toward the tricyclic core of roseophilin. Yang, J.;Dudley, G. B. Presented at the 58^th Southeast Regional Meeting ofthe American Chemical Society, Augusta, GA, United States, November 1^st-4^th,2006.