李彬副研究员简介
李彬，男，1981年生，博士，副研究员，副所长，江苏省农业科学院兽医研究所，2009年毕业于华中农业大学预防兽医学专业。南京农业大学硕士生导师,江苏省双创人才，江苏省“六大人才高峰”资助对象,教育部学位论文评议专家,美国斯坦福大学访问****，美国退伍军人医院研究科学家，江苏省农科院学科带头人优秀后备人才，江苏省科协所属省级学会青年科技人才。
长期从事动物传染病防控技术研究，近5年来，主持国家重点研发计划子课题1项，国家自然科学基金2项、江苏省自然科学基金1项，江苏省双创计划1项，江苏省自主创新项目2项，以第一作者或通讯作者在PNAS、JVI、EID、Virology等杂志发表论文30余篇，其中SCI论文23篇；获国家发明专利授权5项；申报新兽药临床试验1项。培养硕士研究生5名，博士研究生1名。Sci Rep、Arch Virol、PLoS ONE、J Virol Methods、Medicine、Protein & Peptide Letters等杂志审稿人。
研究方向：
1. 猪病毒性腹泻防控技术研究：开展猪流行性腹泻病毒、猪传染性胃肠炎病毒、猪轮状病毒和猪delta冠状病毒的病原学、分子生物学、免疫学、疫苗及诊断技术相关研究；
2. 猪繁殖与呼吸综合征病毒病原学和新型疫苗研制、猪肺炎支原体与PRRSV混合感染的分子机制研究
3. 开发筛选新型的免疫佐剂和抗原递呈系统。
代表性成果：
Du L, Yu Z, Pang F, Xu X, Mao A, Yuan W, He K, Li B*. Targeted Delivery of GP5 Antigen of PRRSV to M Cells Enhances the Antigen-Specific Systemic and Mucosal Immune Responses. Front Cell Infect Microbiol. 2018, 25;8:7. doi: 10.3389/fcimb.
Bin Li, Luping Du, Zhengyu Yu, Bing Sun, Xiangwei Xu, Baochao Fan, Rongli Guo, Wanzhe Yuan, Kongwang He. Poly ( D , L -lactide-co-glycolide) nanoparticle-entrapped vaccine induces a protective immune response against porcine epidemic diarrhea virus infection in piglets. Vaccine, 2017. 10. 054.
Bin Li, Siyuan Ding, Ningguo Feng, Nancie Mooney, Yaw Shin Ooi, Lili Ren, Jonathan Diep, Marcus R. Kelly, Linda L. Yasukawa, John T. Patton, Hiroyuki Yamazaki, Tomoaki Shirao, Peter K. Jackson, and Harry B. Greenberg. Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. Proc Natl Acad Sci USA. 2017, 114(18):E3642-E3651.
Fan B, Jiao D, Zhao X, Pang F, Xiao Q, Yu Z, Mao A, Guo R, Yuan W, Zhao P, He K, Li B*. Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome. Sci Rep.2017, 7:44209.
Du L, Pang F, Yu Z, Xu X, Fan B, Huang K, He K, Li B*. Assessment of the efficacy of two novel DNA vaccine formulations against highly pathogenic Porcine Reproductive and Respiratory Syndrome Virus. Sci Rep.2017, 7: 41886;
Fan B, Yu Z, Pang F, Xu X, Zhang B, Guo R, He K, Li B*. Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China. Virology. 2017, 500, 50-61.
Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016, 5;12(10):e**.
Du L1,Bin Li (co-first author),Xu X,Sun B,Pang F,Wen L,Huang K,He K. Adsorption of a porcine reproductive and respiratory syndrome virus DNA vaccine candidate onto biodegradable nanoparticles improves immunogenicity in mice. Arch Virol.2015, 160(6):1543-7.
Bin Li, Luping Du, Xiangwei Xu, Bing Sun, Zhengyu Yu, Zhixin Feng, Maojun Liu, Yanna Wei, Haiyan Wang, Guoqing Shao, Kongwang He.Transcription analysis on response of porcine alveolar macrophages to co-infection of the highly pathogenic porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Virus research, 2015, 196,60-69.
Bin Li, Luping Du, Bing Sun, Zhengyu Yu, Maojun Liu, Zhixin Feng, Yanna Wei, Haiyan Wang,
Guoqing Shao, Kongwang He. Transcription Analysis of the Porcine Alveolar Macrophage
Response to Mycoplasma hyopneumoniae. PLoS ONE 2014, 9(8): e101968.
Luping Du, Bin Li (co-first author), Kongwang He, Haibin Zhang, Kehe Huang and Shaobo Xiao. Construction and Immunogenicity of DNA Vaccines Encoding Fusion Protein of Porcine IFN-1 and GP5 Gene of Porcine Reproductive and Respiratory Syndrome Virus. BioMed Research International, Volume 2013 (2013), Article ID 318698.
Bin Li*, Du L, Sun B, Yu Z, Wen L, Zhang X, Guo R, Ni Y, Hu Y, Zhou J, Zhu H, Lv L, Yu Y, Wang X, He K*. Monoclonal antibodies against Nsp2 protein of the highly pathogenic porcine reproductive and respiratory syndrome virus. Monoclon Antib Immunodiagn Immunother. 2013, 32(5): 362-365.
Bin Li*, Bing Sun, Lu-ping Du, Ai-hua Mao, Li-bin Wen, Yan-xiu Ni, Xue-han Zhang, Kong-wang He*. Development of a loop-mediated isothermal amplification assay for the detection of porcine hokovirus. J Virol Methods. 2013, 193: 415-418.
Bin Li*, Haofei Liu, Kongwang He, Rongli Guo, Yanxiu Ni, Luping Du, Libin Wen, Xuehan Zhang, Zhengyu Yu, Junming Zhou, Aihua Mao, Lixin Lv, Yiyi Hu, Yang Yu, Haodan Zhu, Xiaomin Wang. Complete genome sequence of a recombinant porcine epidemic diarrhea virus strain from eastern China. Genome Announc. 2013, 18;1(2): e00105-13.
Jianbo Cao, Bin Li (co-first author), Liurong Fang, Huanchun Chen, Shaobo Xiao. Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus. J Vet Diagn Invest. 2012, 24(4):767-71.
Bin Li*, Ma Junjie, Liu Yanling, Wen Libin, Yu Zhengyu, Ni Yanxiu, Zhang Xuehan, Zhou Junming, Guo Rongli, Wang Xiaomin, Feng Zhixin, Hu Yiyi, Lv Lixin, He Kongwang. Complete genome sequence of a highly prevalent porcine circovirus 2 isolated from piglet stool samples in China，J. Virol, 2012, 86(8), 4716.
Bin Li, Ma JJ, Xiao SB, Fang LR, Zeng SL, Wen LB, Zhang XH, Ni YX, Guo RL, Yu ZY, Zhou JM, Mao AH, Lv LX, Wang XM, He KW. Complete genome sequence of a novel species of porcine bocavirus, PBoV5. J. Virol. 2012, 86:1286–1287.
Bin Li, Ma JJ, Xiao SB, Wen LB, Ni YX, Zhang XH, Fang LR, He KW. Genome sequence of a highly prevalent porcine partetravirus in mainland China. J. Virol. 2012, 86:1899.
Bin Li, Ma JJ, Xiao SB, Zhang XH, Wen LB, Mao L, Ni YX, Guo RL, Zhou JM, Lv LX, He KW. Development of a loop-mediated isothermal amplification method for rapid detection of porcine boca-like virus. J. Virol. Methods. 2012, 179:390-395.
Bin Li, Liurong Fang, Xueliang Guo, Janfeng Gao, Tao Song, Jing Bi, Kongwang He, Huanchun, Chen, Shaobo Xiao. Epidemiology and Evolutionary Characteristics of the Porcine Reproductive and Respiratory Syndrome Virus in China between 2006 and 2010. J Clin Microbiol. 2011, 49 (9): 3175-3183.
Bin Li, Xiao SB, Ma JJ, Liu YL, Mao L, Wen LB, Mao AH, Zhang XH, Ni YX, Guo RL, Zhou JM, Yu ZY, Lv LX, Wang XM, Fang LR, Chen HC, He KW. Development of a novel TaqMan-based real-time PCR assay for the detection of porcine boca-like virus (Pbo-likeV). Virol. J. 2011, 8:357.
Bin Li, Liurong Fang, Suyan Liu, Fuwei Zhao, Yunbo Jiang, Kongwang He, Huanchun Chen, Shaobo Xiao The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009. Vet Microbiol. 2010, 146: 226-237.
Bin Li, Liurong Fang, Zuofei Xu, Suyan Liu, Jianfeng Gao, Yunbo Jiang, Huanchun Chen, Shaobo Xiao. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome virus. Emerg Infect Dis. 2009, 15 (12): 2032-2035.
Bin Li, Shaobo Xiao, Yanwei Wang, Shanshan Xu, Yunbo Jiang, Huanchun Chen, Liurong Fang. Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine. 2009, 27: 1957-1963.
授权专利：
2011年，人工合成的修饰型高致病性猪繁殖与呼吸综合征病毒ORF5基因及应用，专利号：ZL8.0，第2完成人。
2012年，一种用于检测猪博卡病毒核苷酸片段的引物和探针序列，专利号：ZL7.9，第1完成人。
2013年，一种检测猪Hokovirus的PCR方法，专利号：ZL5.1，第1完成人。
2013年，一种用于检测猪Hokovirus核苷酸片段的引物和探针序列，专利号：ZL4.7，第1完成人。
2014年，一种猪瘟病毒重组E2 蛋白及其IgM 抗体ELISA 检测试剂盒，专利号：ZL 2.6，第4完成人。
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