一、个人简介
张屹，男，博士，教授，现任河北科技大学理学院工程问题研究所所长，兼河北省数理医学会常务理事，深圳康美华大基因技术公司技术顾问，硕士研究生导师，河北省药用分子化学实验室的“生物信息学”研究室负责人，国家自然科学基金通讯评议员，美国阿拉巴马大学主办的期刊Frontiers in statistical genetics and methodology 的review editor. 是Physic A, Chem. Phys. Letter，Gigasceince等多个杂志的审稿人。2011年度河北省“三三三人才工程”第三层次人才。已经在国外杂志发表项目相关SCI论文20余篇，包括两篇Nature Communication. 其中，第一或通讯作者15篇；主持并结题：国家基金面上项目一项，教育部重点项目一项，河北省自然基金面上项目两项，中国博士后基金一项。作为第一主研人参加中科院创新项目一项。
联系方式：
电话：
Email: zhaqi1972@163.com
地址：经管楼B208
二、研究方向
1. 肿瘤精准医疗表观遗传网络构建及推理
2. 宏基因组学特征提取和高维数据处理
三、代表性科研项目
1.主持 乳腺癌多组学数据的整合分析算法研究（A），2019-2022，河北省自然基金面上项目
2.主持并结题 非编码RNA的识别方法及其在果蝇基因组中的应用(A), 2015-2018, 河北省自然基金面上项目
3.Project of State-financed students studying abroad, 2016-2017，1800 dollar/month.基于双色调控网的癌症基因发现方法的研究
4.主持并结题 基于转录组的非编码RNA分类和预测算法的研究（**），2012-2015，国家自然基金面上项目
5.主持并结题 飞蝗编码与非编码RNA的高精度识别和鉴定（212011），2012-2014，教育部科研重点项目
6.主持并结题 生物分子进化与系统发育分析算法的研究（A），2011-2013，河北省自然基金面上项目
7.主持并结题一项国家博士后基金（第46届二等）“飞蝗piRNA的识别及其功能的验证”（）.
8.主研中科院创新项目“非编码RNA和系统生物学网络分析算法研究”子课题“非编码RNA的分析鉴定以及预测算法研究”
四、代表性论文
1. Dahan Zhang, Haiyun Huang, Xiaogang Bai, Xiaodong Fang, Yi Zhang*. A high-precision hybrid algorithm for predicting eukaryotic protein subcellular localization. bioRxiv 2019, doi: https://doi.org/10.1101/620179
2. Lingjiao Meng, Fei Liu, Yingchao Ju, Pingan Ding, Sihua Liu, Sheng Chang, Shina Liu, Yi Zhang, Yishui Lian, Lina Gu, Xiaochong Zhang and Meixiang Sang. Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins. Cell Death and Disease (2018) 9:1057 2区
3. Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli , Xiaogang Li, et al. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nature Communication. . 2018. 1区
4. Jialiang Yang , Jing Qiu , Kejing Wang, Lijuan Zhu, Jingjing Fan, Deyin Zheng, Xiaodi Meng, Jiasheng Yang, Lihong Peng, Yu Fu, Dahan Zhang, Shouneng Peng, Haiyun Huang* , Yi Zhang* . Using molecular functional networks to manifest connections between obesity and obesity-related diseases. Oncotarget, 2017, 8 (49): 85136-85149.
5. Yi Zhang*, Haiyun Huang, Dahan Zhang, Jiasheng Yang, Kejing Wang, Lijuan Zhu, Xiaoqing Dong, Jialiang Yang*. A review on recent computational methods for predicting non-coding RNAs. Volume 2017, Article ID **, BioMed Research International 3区
6. Bing Chen?, Yi Zhang?, Xia Zhang, Shili Jia, Shuang Chen, Le Kang. Genome-wide identification and developmental expression profiling of long noncoding RNAs during Drosophila metamorphosis. Scientific Reports, 2016. 6:23330. DOI: 10.1038/srep23330 3区
7. Xiaoming Liu, Jiasheng Yang, Yi Zhang, Yun Fang, Fayou Wang, Jun Wang, Xiaoqi Zheng*, jialiang Yang*. A systematic study on drug response associated genes using baseline gene expressions of the Cancer Cell Line Encyclopedia. Scientific Reports, 2016. 6:22811. DOI: 10.1038/srep22811 3区
8. Yi Zhang?*, Haiyun Huang?, Xiaoqing Dong, Kejing Wang, Lijuan Zhu, Ke Wang, Tao Huang,* , Jialiang Yang*. A dynamic 3D graphical representation for RNA structure analysis and its application in non-coding RNA classification. PLos One. 2016. DOI:10.1371/journal.pone.** 3区
9. Wei Wang, Huaien Dai, Yi Zhang，Chandrasekar Raman, Lan Luo, Yasuaki Hiromasa, Changzhong Sheng, Gongxin Peng, Shaoliang Chen, et al., 2015. Armet is an effector protein mediating aphid-plant interactions. 2015. FASEB Journal. fj.14-266023, 2区
10. Yi Zhang*, Shili Jia, Haiyun Huang, Jiqing Qiu, Changjie Zhou, 2014. A Novel Algorithm for the Precise Calculation of the Maximal Information Coefficient. SCIENTIFIC REPORTS (IF=5.078), 4 : 6662. DOI: 10.1038/srep06662. 2区
11. Xianhui wang, …, Yi Zhang,….. 2014. The locust genome provides insight into swarm formation and long-distance flight, Nature communication (IF=10). 5:2957, DOI: 10.1038/ncomms3957 . 1区
12. Yi Zhang, X. H . Wang, L., Kang*, 2011. A k-mer scheme to predict piRNAs and characterize locust piRNAs. Bioinformatics . Vol. 27 no. 6 2011, pages 771–776. 2 区
13. Yi Zhang*，2010. A new model of amino acids evolution, evolution index of amino acids and its application in graphical representation of protein sequences，Chemical Physics Letters , 497: 223-228. 4区
14. Yi Zhang*，2009. Relations of Shanoon Entropy and Genome Order Index in Segmenting DNA Sequences, Physical Review E, 79，041918 . 3区
15. Yi Zhang*, Junkang Hao, Changjie Zhou, Kai Chang, 2009, Normalized Lempel-Ziv Complexity and its Application in Bio-sequence Analysis, J Math. Chem. 46:1203-1212 4区
16. Yi Zhang，Jun Wang*, 2008. Volatilities of Codons and Its Application in Similarity Analysis of Biological Sequences , J. Math. Chem., 43（2）: 864-873. 4区
17. Yi Zhang*，Jiqing Qiu, Lianqing Su, 2008. Comparing RNA secondary structures based on 2D graphical representation , Chemical Physics Letters, 458: 180-185. 4区
18. Jun Wang, Yi Zhang*, 2008. Mathematical relations between codon bias indexes and their applications, J. Math. Chem.，44 (2) : 569-575.
19. Chun Li*, Jun Wang, Yi Zhang, 2008. Similarity Analysis of Protein Sequences based on the Normalized Relative entropy, Comb. Chem. High T. Scr., 11: 477-481
20. Jun Wang, Yi Zhang*，2006. Characterization and similarity analysis of DNA sequences grounded on a 2-D graphical representation, Chemical Physics Letter, 423: 50-53.
21. Jun Wang, Yi Zhang*，2006. Characterization and similarity analysis of DNA sequences basedon mutually direct-complementary triplets, Chemical Physics Letter，425:324-328.