赵宝华

博士

教授

博士研究生导师

联系电话：**

电子邮件：zhaobaohua@mail.hebtu.edu.cn

所属专业：生物化学与分子生物学、微生物学
学习经历：

2009/03– 2009/09，美国路易斯安那州立大学，兽医学院，高级访问学者；

2001/12– 2004/03，河北师范大学，生命科学学院，博士后出站；

1998/09– 2001/07，解放军军需大学，军事兽医研究所，获得农学博士学位；

1990/09– 1993/07，河北师范大学，生物系，获得理学硕士学位；

1986/09– 1990/07，河北师范大学，生物系，获得理学学士学位；



主要教学科研工作：

主要研究方向：动物病原微生物分子致病机制及其防控。采用现代微生物学、生物化学与分子生物学、分子免疫学等手段研究家畜家禽和主要水生动物等重要病原微生物的分子致病机理和基因工程疫苗。已完成国家自然科学基金项目2项；主持河北省科技厅科技支撑项目和河北省自然科学基金各1项。在Vaccine, Journal of Immunology, Anal Bioanal Chem，Hepato-Gastroenterology，Antiviral research, European journal ofphamacology, Cellular Immunology, Virus Gene, BrainResearch Bulletin，微生物学报，中国兽医学报等杂志共发表学术论文60余篇，获河北省科技进步三等奖2项。 主持河北省《微生物学》省级精品课程，作为副主编编写《微生物学教程》和《免疫学》教材两部，发表教学改革论文20余篇，指导的本科生获全国“挑战杯”大学生科技创新大赛二等奖和三等奖各1项，获河北省优秀教学成果二等奖1项。



承担的科研项目：

1、猪重要疫病诊断防控及特色养殖关键技术研究与示范，编号**D，河北省科技支撑计划，2013-2015；

2、G17-PE38KDEL胃癌靶向生物学效应研究，编号C**，河北省自然科学基金，2011-2013；

3、山区奶牛养殖主要疫病防控关键技术研究与开发，编号**D-2，河北省科技支撑计划，2011-2013；

4、绵羊肺炎支原体Y98主要外膜抗原蛋白筛选与功能鉴定，编号**，国家自然科学基金，2009-2011；

5、抗产气荚膜梭菌主要致死性毒素ScFv抗体库的构建，编号C**，河北省自然科学基金，2011-2013。



发表的论文：

[1] GuoPing Lv, BaoHong Xu , PeiNan Wei , Jie Song , HongYingZhang , Chuan Zhao, LiYun Qin, BaoHua Zhao(共责任作者). Molecularcharacterization of food borne-associated Staphylococcus aureus strains isolatedin Shijiazhuang, China, from 2010 to 2012[J].Diagnostic Microbiology and Infectious Disease, 2014, 78(4):262-268.

[2] Qiong-YingFan, Ze-Jun Dong, Zheng-Hui Li, Xia Yin, Xiao-Yan Yang, Tao Feng, Kun Wei, Ji-Kai Liu, Bao-Hua Zhao(共责任作者). Twonew ylangene-type sesquiterpenoids from cultures of the fungus Postia sp [J]. JAsian Nat Prod Res, 2014 , 16(3):254-258.

[3] ShanshanGao, Na Zhao, Said Amer, Mingming Qian, Mengxi Lv, Yuliang Zhao, Xin Su,Jieying Cao, Hongxuan He, Baohua Zhao(共责任作者). Protective efficacy of PLGA microspheres loadedwith divalent DNA vaccine encoding ompA gene of aeromonas veronii and hly geneof aeromonas hydrophila in mice [J]. Vaccine, 2013, 40(11): 1132-1139.

[4] ZhangweiXue, Yi Hu, Shujing Xu, Kouhei Ohnishi, Yanhe Ma, Jiansong Ju, Baohua Zhao(共责任作者). Characterization and preliminary mutationanalysis of a thermostable alanine racemase from Thermoanaerobactertengcongensis MB4[J]. Extremophiles,2013, 17(4):611-621.

[5] YanqingBian, Xiujun Zhao, Menghu Li , Shaohua Zeng, Baohua Zhao(责任作者). Various roles of astrocytes during recovery from repeated exposure todifferent doses of lipopolysaccharide[J]. Behav Brain Res, 2013, 253:253-61.

[6] Li Gao , Yongqing Shen, Jing Zhang, Chunyun Li, Liang Li, Baoen Shan , Baohua Zhao(责任作者). Effect of spider venom on inhibitionproliferation of TE13 cells in vivo and in vitro[J]. Thoracic Cancer, 2013, 4(3):306-311.

[7] 胡奕, 刘朋朋, 张志明, 卢鹤真, 罗静, 王承民, 刘军须, 赵宝华(共责任作者), 何宏轩.格尔德霉素抑制高致病性禽流感病毒增殖及其所介导炎性反应研究[J]. 生物化学与生物物理进展, 2013, 40(11): 1132-1139.

[8] YanqingBian, Zhuo Pan, Ziyuan Hou, Cui Huang, Wei Li, Baohua Zhao(责任作者). Learning, memory, and glial cell changes following recovery fromchronic unpredictable stress [J]. Brain Research Bulletin, 2012, 88(5): 471-476.

[9] Fengyang Lei, Baohua Zhao(共第一作者), Rizwanul Haque, Xiaofang Xiong, Lynn Budgeon,Neil D. Christensen, Yuzhang Wu, Jianxun Song. In vivo programming of tumor antigen-specificT lymphocytes from pluripotent stem cells to promote cancer immunosurveillance [J]. Cancer Research, 2011, 71(14): 4742-4747.

[10] Zhi-Hui Zheng, Yi Yang , Xin-Hua Lu, Hua Zhang, Xiao-Xi Shui , Chen Liu,Xiao-Bo He, Qin Jiang, Bao-Hua Zhao(共责任作者), Shu-Yi Si. Mycophenolic acid induces adipocyte-like differentiation and reversal ofmalignancy of breast cancer cells partly through PPARγ[J]. Europeanjournal of pharmacology, 2011, 658(1):1-8.

[11] Xiaoxi Shui, Xinhua Lu,Yan Gao, Chen Liu, Fengzhi Ren, Qin Jiang, Hua Zhang, Baohua Zhao(共责任作者), Zhihui Zheng. A mammalian two-hybrid system-based assay forsmall-molecular HIV fusion inhibitors targeting gp41[J]. Antiviralresearch, 2011, 90(1): 54-63.

[12] Xin Guo, Bao-Hua Zhao(责任作者), Mu-Xia Zhang. Risk factors of Helicobacter pylori infection among adults in northernChina[J]. Hepato-Gastroenterology, 2011, 58(106): 306-310.

[13] Zhi-Hui Zheng, Xin-Hua Lu,Hua Zhang, Guo-Ping Lv, Jian-Gong He, Bao-HuaZhao(共责任作者), Shu-YiSi. Impacts of different promoters on the mammalian one-hybrid assay for detectingnuclear receptor agonists[J]. Anal Bioanal Chem, 2010, 396(5):1721–1730 .

[14] Jie Song, Di Shen, Jie Cui, Baohua Zhao(责任作者). Acceleratedevolution of PRRSV during recent outbreaks inChina[J]. Virus Gene, 2010, 41(2):241–245.

[15] Baohua Zhao(第一作者), Aihua Song, Rizwanul Haque, Fengyang Lei, Lauren Weiler, Xiaofang Xiong,Yuzhang Wu, Michael Croft, Jianxun Song. Cooperation between molecular targetsof costimulation in promoting T cell persistence and tumor regression[J]. Journal of Immunology, 2009, 182(11): 6744-6752.



教学、科研获奖（含各种荣誉称号）：

1.仔猪腹泻基因工程菌株的构建及其免疫原性研究，赵宝华、边艳青、杨英伟、田莉瑛、柏佳宁、宋杰、胡奕，河北省科技进步奖，三等奖，2011；

2. 海水工厂化养殖推广，申红旗、赵宝华、李全振、曹杰英、杨振才，河北省科技进步奖，三等奖，2008。