于海宁，女，1979.1，副教授。2001.7年毕业于北京大学医学部药学专业，获得理学学士学位；2005年12月毕业于美国爱荷华大学（University of Iowa）,药学院，药物化学与天然产物学专业（College of Pharmacy, Department of Med.Chem.& Nat.Pro.），获得理学博士学位。

研究方向领域
通过蛋白质组学、基因组学结合药理学手段从我国特有产毒动物及药源性动物尤其富含活性蛋白或多肽类生物活性分子的动物类中药中识别功能分子，采用现代分子生物学技术探明其结构、功能、作用靶标及作用机制，着重筛选具有靶标心血管系统(强心, 降压, 抑制或促进血小板聚集，舒缓平滑肌等), 免疫调节系统（免疫抑制与增强），以及靶标病原性微生物、肿瘤细胞的新型活性肽；建立天然药物活性蛋白/多肽分子资源库，挖掘具有重要药用前景的活性蛋白多肽，为生物制药现代化和创新药物研制及其临床应用奠定理论基础。由于各种动物来源的活性肽，活力高，专一性强，和人的生理蛋白质、多肽具有进化上的生物关联性和变异性（序列同源－变异导致功能同源－分化），深入比较研究活性蛋白肽多基因家族分子与人内源性分子构效关系，揭示重要的活性蛋白多肽与人体内相关蛋白质相互作用的规律，发现与确立作用的新靶点；探明活性蛋白多肽的基因起源，与生物靶点的协同进化特征及在生物适应中的意义。

目前承担科研课题
国家自然科学基金,项目批准号：**, 2010.1 -2012.12
国家自然科学基金,项目批准号：**, 2009.1 -2011.12河北省自然科学基金, 批准号：08B029，2008.1-2010.12，
此外，还承担有教育部留学归国人员启动基金、河北省人事厅留学归国人员启动及择优资助，中科院昆明动物所开放课题等多项课题。2010年作为主研人之一，研发出具有自主知识产权的自由基体外高通量检测试剂盒，产品获得苏州工业园区原点创投300万投资。

专利

1.于海宁；路则宽；王义鹏；孙文敬；迟连利

一种抗微生物肽Ea-CATH1及其基因和应用，中国 申请号：**7. 7

2.于海宁；王义鹏
一种广谱抗微生物肽Pc-CATH1及其基因、化学合成和应用，中国
申请号：**6.3

论文与著作（第一与通讯作者共18篇）

FengF, Chen C, Zhu W, He W, Guang H, Li Z,Wang D, Liu J, Chen M, Wang Y, HainingYu (通讯). Gene cloning, expression, and characterization ofavian cathelicidin orthologue, Cc-CATHs, from Coturnix coturnix. FEBSJournal. Accepted. IF 3.421 WangY, Lu Z, Feng F, Zhu W, Guang H, Liu J, He W, Chi L, Haining Yu (通讯). Molecular cloning and characterization of novel cathelicidin-derivedmyeloid antimicrobial peptide from Phasianus colchicus. Dev Comp Immunol. 2011 Mar;35(3):314-22. IF 3.290Zheng R, Yao B, Haining Yu (通讯), Wang H, Bian J, Feng F. Novel family of antimicrobial peptidesfrom the skin of Rana shuchinae. Peptides. 2010 Sep;31(9):1674-7. IF 2.705 Lu, Z, Wang Y, Zhai L, Wang H, Che Q, Du S, Wang D, Feng F, LaiR, Haining Yu (通讯). Novel cathelicidin-derived antimicrobial peptides from Equus asinus. FEBS Journal. 2010 May;277(10):2329-39. IF 3.421 Wu J, Wang Y, Liu H, Yang H, Ma D, Li J, Li D, Lai R, HainingYu (通讯). Two immunoregulatory peptides withantioxidant activity from tick salivary glands. J Biol Chem. 2010 May 28; 285(22):16606-13. IF 5.581Lu Z, Zhai L, Wang H, Che Q, Wang D, Feng F, Zhao Z, HainingYu (通讯). Novel families of antimicrobialpeptides with multiple functions from skin of Xizangplateau frog, Nanorana parkeri. Biochimie. 2010 May;92(5):475-81. IF 3.897 Lu X, Che Q, Lv Y, Wang M, Lu Z, Feng F, Liu J, Haining Yu (通讯). A novel defensin-likepeptide from salivary glands of the hard tick, Haemaphysalis longicornis.Prot. Sci.2010Mar;19(3):392-7.IF 3.484Mi X, Haining Yu (并一作者), Jia P, Zhang Z, Zhang L, Liu J. Twotachykinin-like peptides from skin secretions of Danio rerio. J.Pep. Sci.2010 Feb;16(2):81-4. IF1.807 Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, HainingYu (通讯), Lai R. Peptidomics andgenomics analysis of novel antimicrobial peptides from the frog, Rananigrovittata. Genomics. 2010Jan;95(1):66-71. IF 3.613 Peng K, Kong Y, Zhai L, Wu X,Jia P, Liu J, Haining Yu (通讯). Two novelantimicrobial peptides from centipede venoms. Toxicon. 2010 Feb-Mar;55(2-3):274-9. IF2.713 Wang H, Yan X, Haining Yu, Hu Y, Chen Z, Zhang Z, Liu J.Isolation, characterization and molecular cloning of new antimicrobial peptidesbelonging to the brevinin-1 and temporin families from the skin of Hylaranalatouchii (Anura: Ranidae). Biochimie. 91(4):540-7(2009). IF3.897You D, Hong J, Rong M, Haining Yu, Liang S, Ma Y, Yang H, WuJ, Lin D, Lai R. The first gene-encoded amphibian neurotoxin. J Biol Chem. 2009 Aug14;284(33):22079-86 IF5.581 Zhao R, Yu X, Haining Yu, Han W, Zhai L, Han J, Liu J.Immunoregulatory peptides from salivary glands of the horsefly, Tabanuspleskei. CompBiochem Physiol B Biochem Mol Biol.2009 Sep;154(1):1-5. IF1.771Yang X, Wang Y, Lu Z, Zhai L, Jiang J, Liu J, HainingYu (通讯). A novel serineprotease inhibitor from the venom of Vespa bicolor Fabricius. Comp Biochem Physiol BBiochem Mol Biol. 2009 May;153(1):116-20 IF1.771Wang H, Lu Y, Zhang X, Hu Y, Haining Yu, Liu J, Sun J. The novel antimicrobial peptides fromskin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae). Peptides. 2009 Feb;30(2):273-82.IF 2.705Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, HainingYu (通讯). Antimicrobial peptides from the venomsof Vespa bicolor Fabricius. Peptides. 2008 Nov;29(11):1887-92. IF 2.705 Yan X, Feng H, Haining Yu, Yang X, Liu J, Lai R. Animmunoregulatory peptide from salivary glands of the horsefly, Hybomitraatriperoides. DevComp Immunol. 32(10):1242-7 (2008). IF3.290 Han Y, Haining Yu (并一作者),Yang X, Rees HH, Liu J, Lai R. A serine proteinase inhibitor from frog eggswith bacteriostatic activity. CompBiochem Physiol B Biochem Mol Biol. 149(1):58-62 (2008). IF1.771Lu J, Haining Yu, Gao W, Lai R, Liu J, Liang X. A novelserine protease inhibitor from Bungarus fasciatus venom. Peptides. 29(3):369-74 (2008). IF 2.705Hainig Yu, Wang X, Liu J, Lai R. Anovel algesic peptide derived from skin secretions of the frog Amolopsloloensis. J Pept Sci. 13(12):798-802 (2007). IF 1.807 HainingYu, Yang H,Ma D, Lv Y, Liu T, Zhang K, Lai R, Liu J. Vespid chemotactic peptide precursorfrom the wasp, Vespa magnifica (Smith).Toxicon. 50(3):377-82(2007). IF2.713 Li J, Zhang C, Xu X, Wang J, Haining Yu, Lai R, Gong W. Trypsininhibitory loop is an excellent lead structure to design serine proteaseinhibitors and antimicrobial peptides. FASEB J. 21(10):2466-73 (2007). IF7.128 Xu C, Ma D, Haining Yu, Li Z, Liang J, Lin G, Zhang Y, Lai R.A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom. Peptides. 28(5):969-73 (2007). IF 2. 705Li J, Xu X, Xu C, Zhou W, Zhang K, Haining Yu, Zhang Y, Zheng Y, Rees HH,Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 6(5):882-94 (2007). IF9.425Li J, Haining Yu (并一作者), Xu X, Wang X, Liu D, Lai R.Multiple bombesin-like peptides with opposite functions from skin of Odorranagrahami. Genomics. 89(3):413-8 (2007). IF 3.613Lu Y, Li J, Haining Yu, Xu X, Liang J, Tian Y, Ma D, Lin G,Huang G, Lai R. Two families of antimicrobial peptides with multiple functionsfrom skin of rufous-spotted torrent frog, Amolops loloensis. Peptides. 27(12):3085-91 (2006). IF2.705 Xu X, Yang H, Haining Yu, Li J, Lai R. The mastoparanogen fromwasp. Peptides. 27(12):3053-7 (2006). IF2.705D. Yu, J. Liang, Haining Yu, H. Wu, C Xu, J Liu, R. Lai. A tickB-cell inhibitory protein from salivary glands of the hard tick, Hyalommaasiaticum asiaticum. BiochemBiophys Res Commun. 343(2):585-90 (2006). IF 2.823 J. Li, X. Xu, Haining Yu, H. Yang, Z. Huang, R. Lai. Directantimicrobial activities of PR-bombesin. Life Science. 78(17):1953-6 (2006). IF2.616HainingYu, E. M.Muoz, F. Zhang, R. E. Edens, and R. J. Linhardt. Kinetic studies on the interaction of heparinand complement proteins using surface plasmon resonance. Bioch. Biophy. Acta.1726(2): 168-176 (2005). IF3.64 E. M. Muoz, Hainig Yu, J. Hallock, R. E. Edens, and R.J. Linhardt. Poly(ethylene glycol)-based biosensor chipto study heparin protein interactions. Analytical Biochmesitry, 343(1): 176-178 (2005). IF 3.145 HainingYu, F.Zhang, R. E. Edens and R. J. Linhardt.Studies of the interaction between proteoglycan and proteins of biologicalimportance, 226th National Meeting of the American Chemical Society,September 7-11, 2003, New York, NY. Haining Yu, R. E. Edens and R. J. Linhardt. Regulation activity of heparin in complementsystem, in Chemistry and Biology of Heparin and Heparan Sulfate”, ElsevierLtd., Oxford, H. G. Garg, R. J. Linhardt, and C. A. Hales (Eds.), Chapter 11, 313-343,2005. 学术兼职及所做工作
英文SCI杂志《Peptides》（IF2.705）、《ChemBioChem》（IF 3.474）《Biochimie》（3.897）
《Comp Biochem Physiol BBiochem Mol Biol.》（IF 1.771）审稿人

American ChemicalSociety美国化学学会会员
AmericanAssociation of Pharmaceutical Scientists美国药物科学家协会会员
ChineseAssociation of Pharmaceutical Scientists中国药学会会员
The Chinese Society of Biochemistry and Molecular Biology中国生物化学与分子生物会