柳峰松 姓 名：柳峰松
职 称：教授
邮 箱：liufengsong@hbu.edu.cn
联系地址：河北省保定市五四东路180号，河北大学动物科学楼105实验室，邮编：07100





个人简介
科研领域
代表性论文
个人简介：
教育经历：（自大学起，时间为倒叙）
2002/9 - 2005/6，中科院海洋所，海洋生物学，博士
1999/9 - 2002/6，河北大学，水生生物学，硕士
1995/9 - 1999/6，河北大学，生物学，学士
工作经历：
2011/12 - 至今，河北大学生命科学学院，教授
2006/12 - 2011/11，河北大学生命科学学院，副教授
2002/07 - 2006/11，河北大学生命科学学院，助教
执教课程：课程名称（本科生/研究生）
“分子生物学”（本科生）、“分子免疫学原理与技术”（硕士生）、“生命科学前沿”（博士生）

科研领域：
1. 分子免疫学研究：以家蝇和沼虾等为实验材料，研究动物先天免疫应答过程，包括免疫识别、免疫信号的调理和转导、转录激活及效应分子合成等。
2. 环境毒理学研究：以大型溞和家蝇等为模式动物，研究机体对环境胁迫和典型污染物响应的分子机制，重点关注线粒体在生物适应中的作用。


代表性论文：
1. Li J, Lin DD, Li MY, Wang QS, Xie S, Zhang YM*, LiuFS*. Effectsof Butyl benzyl phthalate exposure on Daphnia magna growth,reproduction, embryonic development and transcriptomic responses. Journal ofHazardous Materials, 2020, published online. doi: 10.1016/j.jhazmat.2020.124030
2.Qin N, Sun HH, Lu MK, Wang JH, Tang T*, LiuFS*. A single von Willebrand factorC-domain protein acts as an extracellular pattern-recognition receptor in theriver prawn Macrobrachium nipponense. Journal of Biological Chemistry, 2020, 295(30): 10468-10477.doi:10.1074/jbc.RA120.013270
3. Cao XR, Li YB, Li SS, Tang T*, LiuFS*. Two ferritin genes (MdFerH and MdFerL) are involved in ironhomeostasis, antioxidation and immune defense in housefly Musca domestica. Journal of Insect Physiology, 2020, 124: 104073doi: 10.1016/j.jinsphys.2020.104073
4. Feng Q, Shao MH, Han JJ, Tang T, ZhangYM*, Liu FS*. TFAM, a potentialoxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol,2020, 155: 524-534. doi: 10.1016/j.ijbiomac.2020.03.208.
5.Qin N, Wu MJ, Tang T*, Liu FS*. Afibrinogen-related protein (Mnfico3) acts as a novel pattern recognitionreceptor in Macrobrachium nipponense.Fish & Shellfish Immunology, 2020, 100: 272-282. doi:10.1016/j.fsi.2020.02.066.
6. Zhang YM, Li YJ, Feng Q, Shao MH, YuanFY, Liu FS*. Polydatin attenuates cadmium-induced oxidative stress viastimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere,2020, 248: 126009. doi: 10.1016/j.chemosphere.2020.126009.
7.Tang T, Liu JL, Li SS, Li HQ, Liu FS*.Recombinant expression of an oriental river prawn anti-lipopolysaccharidefactor gene in Pichia pastoris andits characteristic analysis. Fish & Shellfish Immunology, 2020, 98:414-419. doi: 10.1016/j.fsi.2020.01.030.
8.Wang XF, Gao S, Hao ZX, Tang T*, LiuFS*. Involvement of TRAF6 in regulating immune defense and ovariandevelopment in Musca domestica. Int JBiol Macromol, 2020, 153: 1262-1271. doi: 10.1016/j.ijbiomac.2019.10.259.
9.Yuan FY, Yang ZL, Tang T, Xie S*, LiuFS*. A 28.6-kD small heat shock protein (MnHSP28.6) protects Macrobrachium nipponense against heavymetal toxicity and oxidative stress by virtue of its anti-aggregation activity.Fish & Shellfish Immunology, 2019, 95: 635-643. doi:10.1016/j.fsi.2019.10.053.
10.SunJS, Shi JH, Wang YH, Wu SJ, Zhao LP, Li YC, Wang H, Chang L, Lyu ZT, Wu JZ, Liu FS*, Li WJ*, He FC*, Zhang Y*, Xu P*.Open-pFind enhances the identification of missing proteins from human testistissue. J. Proteome Res. 2019,18:4189-4196. doi: 10.1021/acs.jproteome.9b00376.
11.QinN, Tang T, Liu X, Xie S*, Liu FS*.Involvement of a TNF homologue in balancing the host immune system of Macrobrachium nipponense. Int J BiolMacromol, 2019, 134: 73-79. doi: 10.1016/j.ijbiomac.2019.05.045.
12.TangT, Yang ZL, Li J, Yuan FY, Xie S*, LiuFS*. Identification of multiple ferritin genes in Macrobrachium nipponense and their involvement in redox homeostasisand innate immunity. Fish & Shellfish Immunology, 2019, 89: 701-709. doi:10.1016/j.fsi.2019.04.050.
13.TangT, Sun HH, Li YB, Chen PR, Liu FS*. MdRDH1, a HSP67B2-like rhodanesehomologue plays a positive role in maintaining redox balance in Musca domestica. Molecular Immunology,2019, 107:115-122. doi: 10.1016/j.molimm.2019.01.016.
14.ZhangYM, Wang F, Feng Q, Wang HX, Tang T, Huang DW, Liu FS*. Involvement oftrehalose-6-phosphate synthase in innate immunity of Musca domestica. Developmental & Comparative Immunology, 2019,91: 85-92. doi: 10.1016/j.dci.2018.10.010.
15.TangT, Li WQ, Wang XF, Wu YJ, Liu FS*. A house fly TNF ortholog Eigerregulates immune defense via cooperating with Toll and Imd pathways.Developmental & Comparative Immunology, 2019, 90: 21-28. doi:10.1016/j.dci.2018.08.016.
16. TangT, Li X, Liu X, Wang YL, Ji CC, Wang Y, Wang XC, Xie S, Liu FS*, WangJH*. A single-domain rhodanese homologue MnRDH1 helps to maintain redox balance in Macrobrachiumnipponense. Developmental & Comparative Immunology, 2018, 78: 160-168.doi: 10.1016/j.dci.2017.09.022.
17.TangT, Ji CC, Yang ZL, Liu FS*, Xie S*. Involvement of the Macrobrachium nipponense rhodanesehomologue 2, MnRDH2 in innate immunity and antioxidant defense. Fish& Shellfish Immunology, 2017, 70: 327-334. doi: 10.1016/j.fsi.2017.09.010.
18. MaXY, Wang JH, Ma CX, Wang JL, Wang XC, Liu FS*. Malat1 as anevolutionarily conserved lncRNA, plays a positive role in regulatingproliferation and maintaining undifferentiated status of early-stagehematopoietic cells. BMC Genomics, 2015, 16(1):676. doi:10.1186/s12864-015-1881-x.
19.GaoYF, Tang T, Gu JH, Sun LL, Gao XB, Ma XY, Wang XC, Liu FS*, Wang JH*.Down regulation of the Musca domestica peptidoglycan recognition proteinSC (PGRP-SC) leads to over expression of antimicrobial peptides and tardypupation. Molecular Immunology, 2015, 67(2 Pt B): 465-474.doi:10.1016/j.molimm.2015.08.007.
20.WangYL, Tang T, Gu JH, Li X, Yang X, Gao XB, Liu FS*, Wang JH*.Identification of five anti-lipopolysaccharide factors in oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology, 2015,46(2):252-260. doi: 10.1016/j.fsi.2015.07.003.
21.ChenHJ, Yang X, Tang T, Li J, Liu BZ, Liu FS*, Xie S*. The involvement ofcysteine-rich intestinal protein in early development and innate immunity ofAsiatic hard clam, Meretrix meretrix. Fish & Shellfish Immunology,2014, 40(2): 435-440. doi:10.1016/j.fsi.2014.07.027.
22.TangT, Li X, Yang X, Yu X, Wang JH, Liu FS*, Huang DW*. Transcriptionalresponse of Musca domestica larvae to bacterial infection. PLoS One.2014, 9(8): e104867. doi:10.1371/journal.pone.**.
23.Tang T, Li LX, Sun LL, Bu JC, Xie S, Liu FS*. Functionalanalysis of Fenneropenaeus chinensis anti-lipopolysaccharide factorpromoter regulated by lipopolysaccharide and (1, 3)--D-glucan. Fish &Shellfish Immunology, 2014, 38(2):348-353. doi:10.1016/j.fsi.2014.03.026.
24.TangT, Wu C, Li JG, Ren GD, Huang DW*, LiuFS*. Stress-induced HSP70 from Muscadomestica plays a functionally significant role in the immune system.Journal of Insect Physiology, 2012, 58: 1226-1234. doi:10.1016/j.jinsphys.2012.06.007.
25.TangT, Huang DW*, Zhou CQ, Li X, Xie QJ, LiuFS*. Molecular cloning andexpression patterns of copper/zinc superoxide dismutase and manganesesuperoxide dismutase in Musca domestica.Gene, 2012, 505: 211-220.doi: 10.1016/j.gene.2012.06.025.
26.Liu FS*, Tang T, Sun LL, Priya TA. Transcriptomicanalysis of the housefly (Musca domestica)larva using massively parallel pyrosequencing.Molecular Biology Reports, 2012, 39(2):1927-1934. DOI: 10.1007/s11033-011-0939-3.
27.DongXY, Liu FS*, Zhang D, Tang T, Ge XD.Identification and characterization of cysteine protease inhibitor gene MdCPIfrom Musca domestica. InsectMolecular Biology, 2011, 20(5), 577-586. doi:10.1111/j.1365-2583.2011.01088.x.
28.Tang T, Huang DW, Zhang D, Wu YJ, MurphyRW, Liu FS*. Identification of twometallothionein genes and their roles in stress responses of Musca domestica toward hyperthermy andcadmium tolerance. Comparative Biochemistry andPhysiology, Part B, 2011, 160 (2-3): 81-88. doi:10.1016/j.cbpb.2011.06.008.
29.Liu FS,Li FH, Dong B, Wang XM, Xiang JH. Molecular cloning and characterisation of apattern recognition protein, lipopolysaccharide and beta-1, 3-glucan bindingprotein (LGBP) from Chinese shrimp Fenneropenaeus chinensis. MolecularBiology Reports, 2009, 36(3): 471-477.
30.XieS, Sun LN, Liu FS*, Dong B.Molecular characterization and mRNA transcript profile of vitellogenin inChinese shrimp, Fenneropenaeus chinensis.Molecular Biology Reports, 2009,36(2):389-397.
31.Liu FS,Li FH, Xiang JH, Dong Bo, Liu YC, Zhang XJ, Zhang LS. Molecular cloning andexpression analysis of crustin-like gene from Chinese shrimp Fenneropenaeus chinensis. ActaOceanologica Sinica, 2008, 27(2): 81-92.
32.LiuFS, Liu YC, Li FH, Dong B, Xiang JH. Molecularcloning and expression profile of putative anti-lipopolysaccharide factor (ALF)in Chinese shrimp Fenneropenaeus chinensis. MarineBiotechnology, 2005, 7(6):600-608.