陈兵 姓名：陈兵
职称：研究员，教授
邮箱：chenbing@hbu.edu.cn
电话：
联系地址：河北省保定市五四东路180号河北大学综合科研楼727室，邮编：071002
Webpage in English:https://orcid.org/0000-0002-1238-3948



个人简介
科研领域
代表性论文
【个人简介】
教育经历：
2005.01-2006.12，博士后，芝加哥大学(The University of Chicago)
2000 –2003年，博士，中国科学院动物研究所
1997 –2000年，硕士，华中农业大学植物保护系
1993 –1997年，学士，长江大学农学院
工作经历：
2018年至今，教授，研究员，博士生导师，河北大学
2008–2010年，访问****，瑞士苏黎世大学（University of Zürich）/瑞士生物信息研究所（Swiss Institute of Bioinformatics）
2006–2018年，副研究员，中国科学院动物研究所，农业虫害鼠害综合治理研究国家重点实验室
2003–2005，助理研究员，中国科学院动物研究所，农业虫害鼠害综合治理研究国家重点实验室
社会服务工作：
中国昆虫学会昆虫生理生化与分子生物学专业委员会委员（2018-）
中国昆虫学会直翅类昆虫专业委员会委员（2018-）
《环境昆虫学报》编委（2015-）
项目评阅专家：国家自然科学基金委评阅专家；浙江省自然科学基金委同行评议专家；科技部科技评估中心项目评估专家
国际杂志审稿人，包括Ecology Letters,Molecular Ecology,Insect Molecular Biology,Development Genes and Evolution,Journal of Insect Physiology,Insect Science,Archives of Insect Biochemistry & Physiology,Entomological Research,European Journal of Entomology,Florida Entomology,Gene,Journal of Insect Behavior,Journal of Integrative Agriculture，Scientific Reports,PLoS ONE，Genomics等
执教课程：
《遗传学》（本科生）
《生命科学导论》（本科生）
《生命科学研究进展》（本科生）
《动物学研究进展》（研究生）
研究生招生：
硕士研究生招生专业：071010生物化学与分子生物学，04生态基因组学
博士研究生招生专业：071000生物学，04生物化学与分子生物学
欢迎有兴趣的考生咨询和报考！


研究方向：
环境基因组学与逆境适应。研究动物对环境压力的生理和行为响应及其分子和遗传适应调节机制。目前聚焦于组织缺氧、重金属污染、极端温度等环境效应，开展生理和行为学、分子遗传学、生态和进化基因组学等前沿交叉学科研究，其中特别关注热激蛋白、表观遗传（修饰）和长非编码RNA等相关的分子机制。
主持国家级科研项目
1.国家自然科学基金委面上项目（No: **），“转座因子通过介导长非编码RNA的表达调控飞蝗行为可塑性”，2019-2022年，62万
2.国家自然科学基金委国际（中国-以色列）合作和交流项目（No：），“高原低氧环境下昆虫呼吸系统的适应性进化及其遗传机制研究”，2017-2019年，167万
3.国家自然科学基金委面上项目（No：**），“飞蝗型变可塑性的父性遗传及其表观遗传机制研究”，2015-2018年，84万
4.国家自然科学基金委重大研究计划培育项目(No：**），“飞蝗对青藏高原低氧极端环境遗传适应的多基因互作机”，2014-2016年，100万
5.国家自然科学基金委面上项目（No：**），“分子伴侣蛋白Hsp90 对飞蝗滞育特征进化的调控”，2012-2015年，62万
6.国家自然科学基金委面上项目（No：**），“斑潜蝇生态适应与热激蛋白基因表达的进化”，2010-2012年，29万
7.国家自然科学基金委面上项目（No：**），“温室对斑潜蝇温度胁迫耐受性地理分化的调节及其生态学机制”，2005-2007年，20万
8.科技部“973”项目子课题（No：2012CB114103），“飞蝗对温度等环境因子变化的适应机制”，2012 - 2016年，250万
9.科技部“973”项目子课题（No：2006CB102002），“斑潜蝇对环境胁迫的适应机制”，2006 - 2011年，126万
其他项目
1.河北省高校百名优秀创新人才支持计划（no. SLRC**），省级，2019-2021年，20万
2.国家重点实验室开放课题，农业虫害鼠害综合治理研究国家重点实验室，2019-2021年，8万
国际合作研究：
1.西藏飞蝗高原低氧适应的基因组学机制研究
合作者：Dr. Eran Gefen, University of Haifa, Israel
2.生物对重金属响应的进化生态毒理学
合作者：Prof. Dr. JohnColbourne, The University of Birmingham, UK
3.热激蛋白表达在适应全球环境变化中的作用
合作者：Prof. Dr. Martin Feder, The University of Chicago, USA
4.飞蝗适应环境干旱的分子机制研究
合作者：Prof. Dr. Amir Ayali, Tel Aviv University, Israel


【代表性论文】
(*通讯作者，#共同贡献作者)
1.XiaZhang, Yanan Xu,Bing Chen*, Le Kang*. 2020. Long noncoding RNAPAHALmodulates locust behavioural plasticity through the feedback regulation of dopamine biosynthesis.PLoS Genetics, 16(4): e**. doi: 10.1371/journal.pgen.**.
2.Ting Li,Bing Chen, Pengcheng Yang, Depin Wang, Baozhen Du, Le Kang. 2020. Long Noncoding RNA Derived from LncRNA–mRNA co-expression networks modulates the locust Phase change.Genomics, Proteomics & Bioinformatics:inpress;bioRxivdoi: 10.1101/2020.04.11.036848.
3.Lin Hu, Wanying Gui,Bing Chen*, Li Chen*. 2019. Transcriptome profiling of maternal stress-induced wing dimorphism in pea aphids.Ecology and Evolution9: 11848–11862.
4.Xinyue Gu, Yan Zhao, Yun Su, Jiajiao Wu, Ziya Wang, Juntao Hu, Lijun Liu, Zihua Zhao, Ary A.Hoffmann*,Bing Chen*, Zhihong Li*.2019. A transcriptional and functional analysis of heat hardening in two invasive fruit fly species,Bactrocera dorsalisandBactrocera correcta.Evolutionary Applications,12(6): 1147-1163
5.Bing Chen*, Martin E. Feder, Le Kang*. 2018. Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress.Molecular Ecology, 27(15): 3040-3054
6.Ding Ding, Guangjian Liu, Li Hou, Wanying Gui,Bing Chen*,Le Kang*.2018. Genetic variation inPTPN1contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts.Nature Communications,9(1): 4991
7.Bing Chen*,Bo Zhang, Lingling Xu, Qing Li, Feng Jiang, PengchenYang, Yanan Xu, and Le Kang*. 2017. Transposable element-mediated balancing selection atHsp90underlies embryo developmentalvariation.Molecular Biology and Evolution,1.34,1127-1139
8.Bing Chen#, Ronghui Ma#, and Le Kang. 2017. Aerobic respiration by hemocyanin in the embryo of the migratory locust.Insect Molecular Biology, 26(4): 461-468.
9.Bing Chen#,Yi Zhang#,Xia Zhang, Shili Jia, Shuang Chen, Le Kang. 2016. Genome-wide identification and developmental expression profiling of long noncoding RNAs duringDrosophilametamorphosis.Scientific Reports6, 23330
10.Bing Chen#, Shaoqin Li#, Qiang Ren, Xiwen Tong, Xia Zhang, Le Kang. 2015. Paternal epigenetic effects of population density on locust phase-related characteristics associated with heat-shock protein expression.Molecular Ecology, 24:851-62
11.Bing Chen#, Ronghui Ma#, Guolan Ma#, Xiaojiao Guo, Xiwen Tong, Guowen Tang, Le Kang. 2015. Haemocyanin is essential for embryonic development and survival in the migratory locust.Insect Molecular Biology, 24(5): 517-527
12.Xiwen Tong#,Bing Chen#,Li-Hua Huang, Qi-Li Feng, Le Kang. 2015.Proteomic analysis reveals that COP9 signalosome complex subunit7A (CSN7A) is essential for the phase transition of migratory locust.Scientific Reports,5：12542
13.Juntao Hu,Bing Chen*,Zhihong Li*. 2014. Thermal plasticity isrelated to the hardening response of heat shock protein expression in two Bactrocera fruit flies.Journal of Insect Physiology,67:105-113
14.Xianhui Wang, Xiaodong Fang, Pengcheng Yang, ...Bing Chen(19),etal. 2014.The locust genome provides insight into swarm formationand long-distance flight.Nature Communications,5:2957
15.Zhengyu Zhang,Bing Chen,Dejian Zhao, Le Kang. 2013. Functionalmodulation of mitochondrial cytochrome c oxidase underliesadaptation to high-altitude hypoxia in Tibetan migratory locust.Proceedings of the Royal Society B: Biological Sciences,1.280:**
16.Bing Chen, Andreas Wagner. 2012. Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.BMC Evolutionary Biology, 12:25
17.Bing Chen#, Tieliu Jia#, Ronghui Ma, Bo Zhang, Le Kang. 2011. Evolution of Hsp70 gene expression: A role of changes in AT-richness within promoters.PLoS One6(5): e20308
18.Le Kang,Bing Chen, Jianing Wei, and Tong-Xian Liu. 2009. Roles of Thermal Adaptation and Chemical Ecology inLiriomyzaDistribution and Control.Annual Review of Entomology, 54: 127-45
19.Bing Chen,Victoria Shilova, Olga Zatsepina, Michael Evgenev, Martin E. Feder. 2008. Location ofPelement insertions in the proximal promoter region ofHsp70Ais consequential for gene expression and correlated with fecundity inDrosophila melanogaster.Cell Stress & Chaperones, 13(1): 11-17
20.Li-Hua Huang#,Bing Chen#and Le Kang. 2007. Impact of mild temperature hardening on thermotolerance, fecundity, and Hsp gene expression inLiriomyza huidobrensis.Journal of Insect Physiology, 53：1199-1205
21.Bing Chen, Jean-Claude Walser, Teresa Rodgers, Rafal Sobota, Molly Burke, Michael Rose, and Martin Feder. 2007. Abundant, diverse, and consequentialPelement segregate in promoters of small heat-shock genes inDrosophilapopulations.Journal of Evolutionary Biology, 20(5): 2056-2066
22.Walser JC,Bing Chen, and Martin E. Feder. 2006. Heat-shock promoters: Targets for evolution byPtransposable elements inDrosophila.PLoS Genetics, 2: e165
23.Bing Chenand Le Kang. 2005. Can greenhouses eliminate the development of cold resistance of the leafminers?Oecologia, 144: 187-195
24.Bing Chenand Le Kang. 2005. Implication of pupal cold tolerance for the northern over-wintering range limit of the leafminerLiriomyza sativae(Dipera: Agromyzidae) in China.Applied Entomology and Zoology, 40(3): 437-446
25.Bing Chenand Le Kang. 2005. Insect population differentiation in response to environmental thermal stress.Science China-Life Sciences, 15(4): 289-296
26.BingChenand Le Kang. 2004. Variation in cold hardiness ofLiriomyza huidobrensis(Dipera: Agromyzidae) along latitudinal gradients.Environmental Entomology, 33(2): 155-164
27.BingChenand Le Kang. 2002. Cold hardiness and supercooling capacity in the pea leafminerLiriomyza huidobrensis.Cryoletters, 23(3): 173-182
28.芦超,丁玎，陈兵.2020.昆虫对环境低氧的适应：生理和分子机制研究进展.环境昆虫学报, 42(1): 82-93
29.陈兵. 2019. 环境胁迫适应的生态基因组学. 见：生态基因组学, 康乐主编. 北京: 科学出版社, 付印中
30.陈兵, 康乐. 2016. 生态基因组学与分子适应. 见：生态学的现状与发展趋势, 于振良主编. 北京: 科学出版社, p42-53
31.陈兵，康乐. 2013. 表型可塑性研究. 见：新生物学年鉴2013, 新生物学年鉴编委会主编. 北京：科学出版社, p128-155

国际性学术会议报告或特邀报告
2019.07 The 2nd International Conference on Insect Pest Management, Guiyang, China
Report: Targeting Heat-shock protein genes to promote pest management: an evolutionary perspective
2019.07 The 4th International Conference of Insect Genomics and the 7th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Chongqing, China
Report：Genetic Adaptation of Insects to High Altitude in Tibetan Plateau Revealed by Ecological Functional Genomics
2018.07 The annual meeting of the Society for Molecular Biology and Evolution in 2018 (SMBE 2018),Yokohama, Japan
Report：Whole Genome Sequencing Reveals Metabolic Adaptation to High-Altitude Hypoxia in a Tibetan Locust
2017.07 The 3rd International Conference of Insect Genomics & the 6th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Hangzhou, China
Report: Transposable Element-Mediated Natural Mutagenesis of Heat-Shock Proteins underlying Environmental Stress Adaptation
2016.11 The XXV International Congress of Entomology, Orlando, USA
Report: Transgenerational Inheritance of Population Crowding and the Underlying Epigenetic Mechanisms in the Migratory Locust
2015.06 The 5th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Guangzhou, China
Report: Epigenetic Inheritance of Population Density Effects Associated with Heat-shock Protein Expression in the Migratory Locusts
2013.11 Seminar at the College of Agriculture and Natural Sciences, Lincoln University, Jefferson City, USA
Report: Thermal Stress Adaptation in Two Leafminer Species
2013.06 The 4th International Symposium on Insect Physiology, Biochemistry and Molecular Biology,Nanjing, China
Report: Transgenerational Inheritance of Density-Dependent Phase Change Plasticity in the migratory locust
2013.08 The Eleventh International Conference of Orthopterology, Kunming, China
Report：Transgenerational Epigenetic Inheritance of Population Density-dependent Phase Change Plasticity in the Migratory Locust
2012.08 The XXIV International Conference of Entomology, Daegu, Korea
Report：Identification and Characterization of Long Non-coding RNAs in Two Phases of the Migratory Locust
2011.7 The 3rdInternational Symposium on Insect Physiology, Biochemistry and Molecular Biology, Shanghai, China
Report：Balancing selection for heterozygote advantage associated with a highly repetitive transposon- mediated Hsp90 mutation inLocusta migratoria
2010.04 Swiss Drosophila meeting 2010, Fribourg, Switzerland
Report：The Hsp90 capacitor androbustness to developmental stress inDrosophila melanogaster
2007.6 The 1st International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Jinan, China
Report: Thermal stress adaptation and distribution in the two leafminers
2006.10 Midwest Stress Response and Molecular Chaperone Meeting, Chicago, USA
Report:Pelements: A common mechanism of evolution ofHspgenes inDrosophila melanogaster
大会特邀报告：中国昆虫学会2019年学术年会，时间：2019年8月27-30日；地点：南宁，广西
题目：昆虫适应青藏高原极端环境的生理生化和遗传机制研究
承办学术会议：中国昆虫学2019雄安高峰论坛暨中国昆虫学会三个专业委员会学术年会；时间：2019年12月13-15日；地点：河北保定（河北大学）