王启明 姓 名：王启明
职 称：博士，研究员，博士生导师
邮 箱：wangqm@hbu.edu.cn
联系地址：河北省保定市五四东路180号，河北大学生命科学学院综合科研楼，邮编：071002


个人简介
科研领域
代表性论文
教育经历：
2001-2004年：理学博士，微生物学专业，中国科学院微生物研究所
1998-2001年：理学硕士，微生物学专业，华中农业大学
1994-1998年：工学学士，农产品加工与储运专业，山东农业大学
工作经历：
2020.3至今： 研究员，河北大学
2016.10-2020.3：项目研究员，中国科学院微生物研究所
2008.12-2016.9：副研究员，中国科学院微生物研究所
2013.6-2014.6： 访问****，美国威斯康辛大学-麦迪孙分校 （University of Wisconsin-Madison）
2012.3-2012.6： 访问****，荷兰艺术和科学皇家学院真菌生物多样性中心（CBS-KNAW）
2010.6-2010.11：访问****，荷兰艺术和科学皇家学院真菌生物多样性中心（CBS-KNAW）
2004.7-2008.11：助理研究员，中国科学院微生物研究所
奖励荣誉：
2009年获中国科学院“卢嘉锡青年人才奖”；
2012年“中国科学院青年创新促进会”会员；
2018年西藏自治区科学技术一等奖排名14/20；
社会服务工作：
国际真菌分类委员会异担子菌工作组委员
执教课程：课程名称（本科生/研究生）
河北大学本科生课程：基因组学
国际合作研究：
1. 国际合作：外担菌目系统发育、寄主专一性与进化研究
合作者：Prof. Dr. Dominik Begerow, Ruhr-University Nochum, Germany
2. 国际合作：4. BYE TOL: The Basidiomycetous YEasts Tree Of Life
合作者：Prof. Dr. Teun Boekhout, Westerdijk Fungal Biodiversity Institute, The Netherlands

实验室研究方向和内容
酵母菌及相关丝状真菌系统学、进化基因组学及重要经济价值酵母菌应用开发研究。
1. 酵母菌生物多样性和生态学研究：对我国及世界酵母菌物种多样性和生态功能进行调查和研究，利用分子系统学、群体遗传学、系统基因组学和生态基因组学等方法，重建酵母菌及相关丝状真菌的演化历程和探讨单细胞和丝状类群间的演化关系，揭示生态、寄主和地理隔离等因素对其遗传分化与物种形成的作用。重点对特殊环境（低温、干燥、高辐射、高压）和重要生物基质（如地衣、重要植物、海洋生物）来源的酵母菌多样性和生态功能进行研究。
2. 酵母菌遗传和进化研究：利用基因编辑等遗传手段和比较基因组学、进化基因组学，探讨特殊生态、生理及代谢功能类群的环境适应机制、遗传特性和调控机制以及其基因组进化规律，从而阐明基因组进化和环境、寄主的进化关系。
3. 酵母菌新型表达系统研究：对具有各种抗逆性和特殊代谢途径等酵母菌进行系统筛选，选择具有外源蛋白表达系统开发潜力的类群进行遗传操作及代谢途径改造，研发高效可控的适用于不同需求外源基因表达系统。重点开展重要低温酶类和高价值重组疫苗的表达系统。
4. 酵母菌产业化开发：在拓展传统酵母菌（如酿酒酵母）在食品发酵等行业应用的基础上，重点开展非传统酵母菌在生物能源、生物医药和环境保护等行业中的产业化开发。


（*通讯作者，^#共同第一作者）
1.Li AH, Yuan FX, Groenewald M, Bensch K, Yurkov AM, Li K, Han PJ, Guo LD, Aime MC, Sampaio JP, Jindamorakot S, Turchetti B, Inacio J, Fungsin B, Wang QM*, Bai FY*. 2020. Diversity and phylogeny of basidiomycetous yeasts from plant leaves and soil: Proposal of two new orders, three new families, eight new genera and one hundred and seven new species. Stud Mycol, 96: 17-140.
2.Duan SF, Han PJ, Wang QM, Liu WQ, Shi JY, Li K, Zhang XL, Bai FY. 2018. The origin and adaptive evolution of domesticated populations of yeast from Far East Asia. Nat Commun9: 690.
3.S-F Duan, J-Y Shi, Q Yin, R-P Zhang, P-J Han,Q-M Wang, F-Y Bai.2019. Reverse Evolution of a Classic Gene Network in Yeast Offers a Competitive Advantage. Curr Biol 29(7):1126-1136.e5
4.Peris D, Moriarty RV, Alexander WG, Baker E, Sylvester K, Sardi M, Langdon QK, Libkind D, Wang QM, Bai FY, Leducq JB, Charron G, Landry CR, Sampaio JP, Gonçalves P, Hyma KE, Fay JC, Sato TK, Hittinger CT. 2017. Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production. Biotechnol BiofuelseCollection 2017.
5.Alimadadi N, Soudi MR, Wang SA, Wang QM, Talebpour Z,Bai FY. Starmerella orientalisf.a., sp. nov., an ascomycetous yeast species isolated from flowers. Int J Syst Evol Microbiol66: 1476-1481.
6.Han PJ, Li AH, Wang QM^*, Bai FY. 2016. Ballistosporomyces changbaiensissp. nov. and Ballistosporomyces bomiensis sp. nov., twonovel species isolated fromshrubs plant leaves.Antonie van Leeuwenhoek109: 965-970.
7.Wang QM, Groenewald M, Takashima T, Theelen B, Han PJ, Liu XZ, Boekhout T, Bai FY. 2015. Phylogeny of yeasts and related filamentous fungi within Pucciniomycotina determined from multigene sequence analyses. Stud Mycol81: 27-54.
8.Liu XZ^#, Wang QM^#, Theelen B, Groenewald M, Bai FY, Boekhout T. Phylogeny of tremellomycetous yeasts and related dimorphic and filamentous basidiomycetes reconstructed from multiple gene sequence analyses. Stud Mycol81: 1-26
9.Wang QM, Begerow D, Groenewald M, Liu XZ, Theelen B, Bai FY, Boekhout T. 2015. Multigene phylogeny and taxonomic revision of yeastsandrelated fungiin the Ustilaginomycotina. Stud Mycol 81: 55-84
10.Wang QM, Groenewald M, Göker M, Lumbsch HT, Leavitt SD, Yurkov AM, Theelen B, Liu XZ, Bai FY, Boekhout T. Phylogenetic classification of yeasts and related taxa within Pucciniomycotina. Stud Mycol 81: 149-189
11.Liu XZ, Wang QM, Göker M, GroenewaldM, Kachalkin AV, Lumbsch HT, Millanes AM, Wedin M, Yurkov AM, Boekhout T, Bai FY. 2015. Towards an integrated phylogenetic classification of the Tremellomycetes.Stud Mycol81: 85-147
12.Wang QM, Theelen B, Groenewald M, Bai FY, Boekhout T. 2014. Moniliellomycetes and Malasseziomycetes,two new classes in Ustilaginomycotina. Persoonia33: 4147.
13.Wang QM, Liu WQ, Gianni L, Wang, SA & Bai, FY. 2012. Surprisingly diverged populations of Saccharomyces cerevisiaein natural environments remote from human activity. Molecular Ecology21: 5404-5417.
14.Wang QM, Zhang YH, Wang B & Wang L. 2016. Talaromyces neofusisporus and T. qii, two new species of section Talaromycesisolated from plant leaves in Tibet, China. Scientific Reports6: 18622.
15.Wang L, Wang QM*. 2015.Molecular phylogenetic analysis of ballistoconidium-forming yeasts in Trichosporonales (Tremellomycetes): A proposal for Takashimellagen. nov. and Cryptotrichosporon tibetensesp. nov.PLoS ONE10: e**.
16.Wang L, Groenewald M, Wang QM*,Boekhout T. 2015.Reclassification of Saccharomycodes sinensis, proposal of Yueomyces sinensisgen. nov., comb. nov. within Saccharomycetaceae (Saccharomycetales, Saccharomycotina). PLoS ONE10: e**.
17.Bing J, Han PJ, Liu WQ, Wang QM, Bai FY. 2014.Evidence for a Far East Asian origin of lager beer yeast.CurrentBiology24: R380-R381.
18.Sylvester K, Wang QM, James B, et al.2015. Temperature and host preferences drive the diversification of Saccharomycesand other yeasts: a survey and the discovery of eight new yeast species. FEMS Yeast Researchdoi: 10.1093/femsyr/fov002.
19.Schoch CL, Seifert KA, Huhndorf S, Seifert KA, Huhndorf S, Robert V, Spouge JL, Levesque CA, Chen W, ……,Wang QMet al. 2012. Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi. Proceedings of the National Academy of Sciences of the United States of America109: 6241-6246.
20.Liu WQ, Han PJ, Qiu JZ & Wang QM*. 2012. Naumovozyma baiisp. nov., an ascomycetous yeast species isolated from rotten wood in a tropic forest.Int J Syst Evol Microbiol62: 3096-3099.
21.Han PJ, Qiu JZ & Wang QM*, Bai FY. 2012. Udeniomyces kanasensissp. nov., a ballistoconidium-forming yeast species in the Cystofilobasidiales. Antonie van Leeuwenhoek102: 45-51.
22.Chen R, Jiang YM, Wei SC & Wang QM. 2012. Kwoniella shandongensissp. nov., a novel basidiomycetous yeast species from apple orchard. Int J Syst Evol Microbiol62: 2774-2777.
23.Wang QM, Boekhout T & BaiFY. 2012. Bensingtonia rectisporasp. nov. and Bensingtonia bomiensissp. nov., novel ballistoconidium-forming yeast species from plant leaves collected in Tibet.Int J Syst Evol Microbiol62: 2039-44.
24.Liu XZ, Wang QM, Boekhout T & BaiFY. 2012. Derxomyces amylogenessp. nov., Derxomyces bambusicolasp. nov. and Derxomyces corylopsissp. nov., three novel ballistoconidium-forming yeast species isolated from subtropical plant leaves.Int J Syst Evol Microbiol62:996-1001.
25.Wang QM*, Boekhout T & BaiFY. 2011. Cryptococcus foliicolasp. nov. and Cryptococcus taibaiensissp. nov., novel basidiomycetous yeast species from plant leaves. J Gen Appl Microbiol57: 285-291.
26.Wang QM, Bai FY, Fungsin B, Boekhout T & Nakase T. 2010. Proposal of Mingxiaeagen. nov. for the anamorphic basidiomycetous yeast species in the Bulleribasidiumclade (Tremellales) based on molecular phylogenetic analysis and description of four novel Mingxiaeaspecies. Int J Syst Evol Microbiol60: 210-219.
27.Chen R, Wei SC, Jiang YM, Wang QM & Bai FY. 2010. Kazachstania taianensissp. nov., a novel ascomycetous yeast species from orchard soil. Int J Syst Evol Microbiol60: 1473-1476.
28.Wang QM, Xu J, Wang H, Li J & Bai FY. 2009. Torulaspora quercuumsp. nov. and Candida pseudohumilissp. nov., novel yeasts from human and forest habitats. FEMS Yeast Res9: 1322-1326.
29.Wang C, Wang QM, Jia JH & Bai FY. 2009. Candida pseudocylindraceasp. nov. and Candida wuzhishanensissp. nov. from Hainan Island, southern China. Mycosystema28: 79-85.
30.Wang QM& Bai FY. 2008. Molecular phylogeny of basidiomycetous yeasts in the Cryptococcus luteoluslineage (Tremellales) based on nuclear rRNA and mitochondrial cytochrome b gene sequence analyses: proposal of Derxomycesgen. nov. and Hannaellagen. nov., and description of eight novel Derxomycesspecies. FEMS Yeast Research8: 799-814.
31.Wang QM, Li J, Wang SA & Bai FY. 2008. Rapid Differentiation of Phenotypically Similar Yeast Species by Single-Strand Conformation Polymorphism Analysis of Ribosomal DNA. Applied and Environmental Microbiology74: 2604-2611.
32.Wang QM, Jia JH & Bai FY. 2008. Diversity of basidiomycetous phylloplane yeasts belonging to the genusDioszegia(Tremellales) and description of Dioszegia athyriumsp. nov., Dioszegia creamsp. nov and Dioszegia xingshanensissp. nov. Antonie van Leeuwenhoek93: 391-399.
33.Wang QM, Wang SA, Jia JH & Bai FY. 2007. Cryptococcus tibetensissp. nov., a novel basidiomycetous anamorphic yeast species isolated from plant leaves. J Gen Appl Microbiol53: 281-285.
34.Wang QM, Jia JH & Bai FY. 2006. Pseudozyma hubeiensissp. nov. and Pseudozyma shanxiensissp. nov., novel ustilaginomycetous anamorphic yeast species from plant leaves. Int J Syst Evol Microbiol 56: 289-293.
35.Wang QM, Jia JH & Bai FY. 2006. Bensingtonia pseudonaganoensissp. nov., a novel ballistoconidium-forming yeast species isolated from plant leaves. Antonie van Leeuwenhoek 89: 261-266.
36.Wang QM, Bai FY, Lu HZ, Jia JH & M Takashima. 2004. Bullera cylindrica, Bullera hubeiensisand Bullera nakasei, novel ballistoconidium-forming yeast species isolated from plant leaves.Int J Syst Evol Microbiol54: 1877-1822.
37.Wang QM& Bai FY. 2004. Four new yeast species of the genus Sporobolomycesfrom plant leaves. FEMS Yeast Research4: 579-586.
38.Wang QM, Bai FY, Zhao JH & Jia JH. 2003. Bensingtonia changbaiensissp. nov. and Bensingtonia sorbisp. nov., novel ballistoconidium- forming yeast species isolated from plant leaves. Int J Syst Evol Microbiol53: 2085-2089.
39.Wang QM, Bai FY, Zhao JH & Jia JH. 2003. Dioszegia changbaiensissp. nov., a basidiomycetous yeast species isolated from northeast China. J Gen Appl Microbiol 49: 295-299.
40.ML Xue, LQ Zhang,QM Wang, JS Zhang & FY Bai. 2006. Metschnikowia sinensissp. nov., Metschnikowia zizyphicolasp. nov. and Metschnikowia shanxiensissp. nov., three novel yeast species from jujube fruit. Int J Syst Evol Microbiol 56: 2245-2250.
41.Lu HZ, Jia JH, Wang QM& Bai FY. 2004. Candida asparagisp. nov., Candida diospyrisp. nov. and Candida qinlingensissp. nov., novel anamorphic ascomycetous yeast species.Int J Syst Evol Microbiol54: 1409-1414.
42.Bai FY, Cai Y, Wang QM& Ohkubo H. 2004. Rhodotorula oryzaesp. nov., a novel basidiomycetous yeast species isolated from paddy rice.Antonie van Leeuwenhoek86: 295-299.
43.Zhao JH, Bai FY, Wang QM& Jia JH. 2003. Sporobolomyces bannaensis, a new ballistoconidium-forming yeast species in the Sporidioboluslineage. Int J Syst Evol Microbiol53: 2091-2093.