吕运开教授、博士生导师
一、个人简介
吕运开（Lv Yun-Kai），男，教授，硕士/博士研究生导师，生于1967年11月，河北省隆尧县人。1987年6月毕业于河北大学化学系，1999年获河北大学分析化学硕士学位，2004年获南开大学分析化学博士学位， 2005年在河北大学化学博士后流动站工作。1987年7月至今在河北大学化学与环境科学学院任教。
联系方式：E-mail：lvyunkai@hbu.edu.cn
二、主讲课程及研究方向
[1] 主讲课程：现代分离分析方法、分析化学进展、现代仪器分析、食品安全与健康、食品风味化学
[2] 专业与研究方向：分析化学；微萃取与分离技术，光电传感分析，光催化降解技术
[3] 研究领域与兴趣
（1）新型多孔材料合成及应用：金属有机骨架（MOFs）、共价有机骨架（COFs）、多孔有机聚合物（POPs）、功能化量子点和金属纳米簇、石墨烯复合材料等；
（2）色谱-质谱联用技术：分析对象主要包括环境污染物、疾病标志物、农兽药残留、中草药活性成分等；
（3）环境污染物的检测、释放规律、吸附净化与光催化降解技术；
（4）疾病标志物甄定与检测；
（5）中药分离鉴定及其活性研究。
三、主持项目
[1] 泛亚秦皇岛环保科技有限公司（合同编号: 横**）：室内环保材料的制备和性能研究，2018-2023
[2] 河北省自然科学基金资助项目（B）：金属有机骨架复合材料的合成及其在室内有害气体富集检测中应用，2016.1-2018.12
[3] 开滦集团项目（合同编号：KL煤化工[2016]282号）：复合材料分析检测技术开发及其阻燃剂研究中的应用，72016.5-2017.5
[4] 国家自然科学基金资助项目（**）：基于限进介质-分子印迹磁性微球的食品中抗生素残留选择性萃取净化体系研究，2014.1-2017.12。
[5] 河北省自然科学基金资助项目（B）：分子印迹杂化材料制备及在线SPE-HPLC分离分析新方法研究，2011.1-2013.12。
[6] 河北省应用基础研究计划重点基础研究项目（**D）：乳制品及相关食品的样品处理新技术与有毒有害物质关键检测技术研究，2010.1-2012.12。
[7] 国家自然科学基金资助项目（**）：新型分子印迹材料制备方法的研究及其在食品安全检测中的应用，2007.1-2009.12。
[8] 河北省教育厅科学计划项目（**）：基于动物源食品安全分析的新型色谱分离介质研究，2007.1-2009.12。
[9] 第三十七批中国博士后科学基金（）：溶胶－凝胶色谱固定相的制备及兽药残留分析新方法研究，2005.1-2005.12。
[10] 河北大学自然科学研究计划项目：食品中痕量有毒元素及有机污染物分离富集新技术方法研究，2005.1-2008.12。
四、研究生项目
[1] 河北省研究生创新创业计划训练项目（CXZZBS**）：基于中空MOFs复合材料的SPME-GC/MS甄别检测血样中癌症标志物，2020.1-2021.1
[2] 河北大学研究生创新创业计划训练项目（hbu2020ss017）：NH2-MIL-53/氧化石墨烯复合材料的光催化降解有机污染物性能，2020.1-2021.1
[3]河北省研究生创新资助项目（S201717）：肝癌标志物蛋白的适配体筛选优化及特异性分析，2017.03-2018.03
五、获奖情况
2007年获天津市自然科学一等奖：金属组学和环境化学中的分析新技术和新方法研究。
2014年获河北省自然科学三等奖：基于多孔功能分离材料的微型化复杂样品萃取分离技术。
2016年获河北省科学技术进步二等奖：生物分子高灵敏度质谱检测新技术研究
六、代表性论文
[46] Liang Linlin, Wang Jing*, Wu Ruifang, Li Zekai, Yan Xiaoran,Lv Yunkai*. Preparation of BiOCl_1-xI_xsolid solution and its visible light photocatalytic performance.Journal of Materials Science: Materials in Electronics,2020, 31: 2817–2825. DOI: 10.1007/s10854-019-02825-5
[45] Wang Chen-Feng⁺, Sun Xin-Yue⁺, Su Ming*, Wang Yi-Peng andLv Yun-Kai*. Electrochemical biosensors based on antibodies, nucleic acids and enzymes functionalized graphene for the detection of disease-related biomolecules. Analyst,2020, 145: 1550-1562. DOI: 10.1039/C9AN02047K
[44] Zhang Xi, Wang Jing**, Dong Xing-Xing,Lv Yun-Kai*. Functionalized metal-organic frameworks for photocatalytic degradation of organic pollutants in environment.Chemosphere,2020,242: 125144. DOI: 10.1016/j.chemosphere.2019.125144
[43] Ma Yao-Jia⁺, Jiang Xiao-Xue⁺,Lv Yun-Kai*.Research progress in the preparation and application of magnetic metal–organic framework composites.Chemistry-An Asian Journal,2019, 14, 3515 – 3530. DOI: 10.1002/asia.
[42] Jia Bo, Cui Meng-Jiao, Yang Ceng-Ceng, Hu Si-Yu,Lv Yun-Kai*. Adsorption characteristics of monodisperse magnetic cation exchange microspheres prepared based on swell-penetration method.Journal of Applied Polymer Science,2019, 136, 48019. DOI: 10.1002/APP.48019
[41] Huang Li-Fei, Jia Bo, Jiang Lin, Liu Wei-Lun, Xia Li-Ya,Lv Yun-Kai*. Preparation of restricted-access material precolumns by grafting δ-gluconolactone on hybrid silica monolithic column for on-line solid-phase extraction of tetracyclines residues from milk.Journal of Separation Science,2019, 42: 843-850. DOI: 10.1002/jssc.
[40] Yu Li-Qing *, Su Fei-Hong, Ma Meng-Yuan,Lv Yun-Kai*. Metal-organic frameworks for the sorption of acetone and isopropanol in exhaled breath of diabetics prior to quantitation by gas chromatography.Microchimica Acta,2019, 186(8): 588. DOI: 10.1007/s00604-019-3713-1
[39] Liang Linlin, Wang Jing*, Song Aizhen, Wu Ruifang, Chen Danyang andLv Yunkai*. Doping effects of Nb on the dielectric properties of (Pb,La,Sr)(Zr,Sn,Ti,Nb)O3 X9R ceramic materials,Ferroelectrics,2019, 550(1): 183-189, DOI: 10.1080/**.2019.**
[38] Song Aizhen;Lv Yunkai; Liang Linlin; Wu Ruifang; Wang Jing*; Zhao Lei. Dielectric property of NBT@BT-BZN composite ceramics.Modern Physics LettersB,2019, 33(10): **. DOI: 10.1142/S02**15X
[37] Song Aizhen, Song Jianmin,Lv Yunkai, Liang Linlin, Wang Jing*, Zhao Lei. Energy storage performance in BiMnO₃-modified AgNbO₃anti-ferroelectric ceramics.Materials Letters,2019, 237, 278-281. DOI: 10.1016/j.matlet.2018.11.105
[36] Li Tianzi; Wang, Zhenguang; Jiang Dafeng; Wang Henggang; Lai Wing-Fu;Lv Yunkai; Zhai Yongqing. A FRET biosensor based on MnO₂nanosphere/copper nanocluster complex: From photoluminescence quenching to recovery and magnification.Sensors and Actuators B: Chemical,2019, 290: 535-543. DOI: 10.1016/j.snb.2019.04.033
[35] 赵娜, 梁嘉诚, 时丽艳,吕运开, 于丽青*. QuEChERS-高效液相色谱-串联质谱法同时测定有机肥料中10种氟喹诺酮类药物残留,2019, 37(3): 313-318. DOI: 10.3724/SP.J.1123.2018.11002
[34] Wang Chen-Feng, Wang Zhen-Guang, Sun Xin-Yue, Chen Meng-Jiao andLv Yun-Kai*. An ultrasensitive fluorescent aptasensor for detection of cancer marker protein based on graphene oxide-ssDNA, RSC Advances,2018, 8, 41143-41149. DOI: 10.1039/c8ra08078j.
[33] Duan Ruijie, Wang Jing*, Jiang Shenglin,Lv Yunkai, Li Jiali, Song Aizhen, Liang Linlin. Sr²⁺doping to Enhanced energy-storage properties of (Na_0.5Bi_0.5)_0.94Ba_0.06TiO₃lead-free ferroelectric ceramics. Journal of Materials Science:Materials in Electronics,2018, 29:13952–13956, 23. DOI: 10.1007/s10854-018-9528-8
[32] 马瑶佳, 张茜, 贾博,吕运开*. 功能化磁性纳米粒子在污水处理中的应用进展. 中国给水排水,2018, 34(22): 31-36
[31] Zhao Ya-Ting, Yu Li-Qing, Xia Xin, Yang Xin-Yu, Hu Wei,Lv Yun-Kai*. Evaluation of adsorption and desorption properties of zeolitic imidazolate framework-7 for volatile organic compounds through thermal desorption-gas chromatography.Analytical Methods,2018, 10(40) 4894-4901. DOI: 10.1039/C8AY01856A
[30] 张茜, 刘炜伦, 路亚楠,吕运开*. 顶空气相色谱-质谱联用技术的应用进展. 色谱,2018, 36(10): 962-971. DOI: 10.3724/SP.J.1123.2018.05013
[29] Wang Si-Ying, Wang Chen-Feng,Lv Yun-Kai*, Shen Shi-Gang. Fabrication of fluorescent biosensing platform based on graphene oxide-dna and their application in biomolecule detection.Trends in Analytical Chemistry,2018, 106: 53-61. DOI: https://doi.org/10.1016/j.trac.2018.07.004
[28] Zhang Qi, Wang Chen-Feng,Lv Yun-Kai*. Luminescent switch sensors for the detection of biomolecules based on metal-organic frameworks.Analyst,2018, 143(18): 4221-4229. DOI: 10.1039/C8AN00816G
[27] Liu Chang, Yu Li-Qing, Zhao Ya-Ting,Lv Yun-Kai*. Recent advances in metal-organic frameworks for adsorption of common aromatic pollutants.Microchim Acta,2018, 185(7): 342. DOI：https://doi.org/10.1007/s00604-018-2879-2
[26] Yu Li-Qing, Wang Li-Ya, Su Fei-Hong, Hao Ping-Yu, Wang Huan,Lv Yun-Kai*. A gate-opening controlled metal-organic framework for selective solid-phase microextraction of aldehydes from exhaled breath of lung cancer patients.Microchim Acta,2018, 185(6): 307. DOI: https://doi.org/10.1007/s00604-018-2843-1
[25] 周少丹，唐嘉琦，贾博，吕运开*. 表面接枝亲水性聚合物刷磁性微球的制备及其对蜂蜜中四环素类抗生素残留的磁分散固相萃取,色谱,2018, 38(2): 85-93. DOI: 10.3724/SP.J.1123.2017.10026
[24] 马俊琴, 于小慧, 贾翠玲,吕运开*. 分子印迹杂化介孔硅胶材料的制备及固相萃取-高效液相色谱法测定鳕鱼中氟喹诺酮类兽药残留.食品安全质量检测学报,2018, 9(3): 540-546
[23] 张琪，马瑶佳，艾连峰，吕运开*. 基于轻质萃取剂的涡旋辅助分散液液微萃取-气相色谱法测定瓶装水中塑化剂.河北大学学报(自然科学版).2018, 1(38): 33-40. DOI: 10.3969/j.issn.**.2018.01.006
[22] 董焕新, 吕二盼, 詹磊,吕运开*. 食品中动物源性成分的多重PCR快速检测.食品安全质量检测学报,2018, 9(17): 4595-4600.
[21]Lv Yun-Kai*, Xiong Xue, Zhao Fang-Fang, Li Meng-Zhe, Wang Mian and Li Xiao-Yang. Preparation of magnetic surface-imprinted polymer microspheres with hydrophilic external layers for selective extraction of fluoroquinolones from eggs. Australian Journal of Chemistry, 2017, 70(3): 237-244.
[20]Lv Yun-Kai*, Zhang Jing, Li Meng-Zhe, Zhou Shao-Dan, Ren Xing-Hui and Wang Jing. Fast clean-up and selective enrichment of florfenicol in milk by restricted access media molecularly imprinted magnetic microspheres based on surface-initiated photoiniferter-mediated polymerization. Analytical Methods, 2016, 8(19): 3982-3989.
[19]Lv Yun-Kai*, Zhang Jing-Qi, Guo Zhi-Yong, Zhang Wei, Sun Han-Wen. Determination of tetracyclines residues in egg, milk, and milk powder by online coupling of a precolumn packed with molecular imprinted hybrid composite materials to RP-HPLC-UV. Journal of Liquid Chromatography & Related Technologies, 2015, 38 (1): 1-7.
[18]Lv Yun-Kai*, Guo Zhi-Yong, Wang Jin-Zhi, Guo Meng-Meng, Yu Lin-Kang, Fang Hui. Preparation of a restricted access material–macroporous hybrid monolithic column – for on-line solid-phase extraction of the sulfonamides residues from honey. Analytical Methods, 2015, 7(4), 1563-1571
[17]Lv Yun-Kai*, He Yan-Dong, Xiong Xue, Wang Jin-Zhi, Wang Hai-Yan, Han Ya-Meng. Layer-by-layer fabrication of restricted access media-molecularly imprinted magnetic microspheres for magnetic dispersion microextraction of bisphenol A from milk samples. New Journal of Chemistry, 2015, 39(3), 1792-1799
[16]Lv Yun-Kai*, Zhang Wei, Guo Meng-Meng, Zhao Fang-Fang, Du Xiao-Xue. Centrifugal microextraction tube - cloud point extraction coupled with gas chromatography for simultaneous determination of six phthalate esters in mineral water. Analytical Methods, 2015, 7(2): 560-565.
[15]Lv Yun-Kai*, Zhang Jing-Qi, He Yan-Dong, Zhang Jing, Sun Han-Wen. Adsorption-controlled preparation of molecularly imprinted hybrid composites for selective extraction of tetracyclines residues from honey and milk. New Journal of Chemistry, 2014, 38 (2): 802–808.
[14] Sun Yue-Na, Qin Xin-Ying,Lv Yun-Kai*, Li Shan-Ze, Wei Chen. Simultaneous Determination of Five Phytohormones in Mungbean Sprouts of China by Micellar Electrokinetic Chromatography. Journal of Chromatographic Science, 2014, 52 (7), 725-729.
[13]Lv Yun-Kai*, Li Pan, Jiao Miao-Lun, Liu Bao-Sheng, Yang Chao. Fluorescence quenching study of moxifloxacin interaction with calf thymus DNA. Turkish Journal of Chemistry, 2014, 38(2): 202-209.
[12]Lv Yun-Kai*, Yang Lei, Liu Xiao-Hui, Guo Zhi-Yong, Sun Han-Wen. Preparation and evaluation of a novel molecularly imprinted hybrid composite monolithic column for online solid-phase extraction coupled with HPLC to detect trace fluoroquinolone residues in milk. Analytical Methods, 2013, 5(7): 1848–1855.
[11]Lv Yun-Kai*, Liu Xiao-Hui, Yan Shuai-Lei, Zhang Yan, Sun Han-Wen, Synthesis and characterization of the molecularly imprinted mesoporous silica based on the self-assembly technique for selective recognition of lomefloxacin in aqueous solution. Journal of Porous Materials, 2013, 20(5): 1345-1352.
[10]Lv Yun-Kai*, Zhao Chen-Xi, Li Pan, He Yan-Dong, Yang Zhong-Rui, Sun Han-Wen. Preparation of doxycycline - imprinted magnetic microspheres by inverse-emulsion suspension polymerization for magnetic dispersion extraction of tetracyclines from milk samples. Journal of Separation Science, 2013, 36(16): 2656-2663.
[9]Lv Yun-Kai*, Wang Li-Min, Yang Lei, Zhao Chen-Xi, Sun Han-Wen, Synthesis and application of molecularly imprinted poly(methacrylic acid)-silica hybrid composite material for selective solid-phase extraction and high-performance liquid chromatography determination of oxytetracycline residues in milk. Journal of Chromatography A, 2012, 1227: 48-53.
[8]Lv Yun-Kai*, Ma Yong, Zhao Xiao-Bo, Jia Cui-Ling, Sun Han-Wen, Grafting of norfloxacin imprinted polymeric membranes on silica surface for the selective solid-phase extraction of fluoroquinolones in fish samples. Talanta, 2012, 89: 270-275.
[7]Lv Yun-Kai*, Sun Yue-Na, Wang Li-Min, Jia Cui-Ling, Sun Han-Wen, A simple and high-throughput method of ultrasonic extraction-capillary electrophoresis for determination of melamine in milk. Analytical Methods, 2011, 3 (11), 2557-2561.
[6]Lu Yun-kai, Yan Xiu-Ping. An Imprinted Organic-Inorganic Hybrid Sorbent for Selective Separation of Cadmium from Aqueous Solution. Analytical Chemistry, 2004, 76(2): 453-457.
[5]Lu Yun-kai, Sun Han-Wen, Yuan Chun-Gang, and Yan Xiu-Ping. Simultaneous Determination of Trace Cadmium and Arsenic in Biological Samples by Hydride Generation-Double Channel Atomic Fluorescence Spectrometry. Analytical Chemistry, 2002, 74(7): 1525-1529.
[4]吕运开*, 郭志勇, 王金治, 赵文革, 秦新英. 一种外表面亲水性大孔有机-无机杂化整体柱的制备方法. 中国发明专利：ZL0.9，2015-10-28.
[3]吕运开*, 何艳冬, 熊雪, 秦新英, 孙汉文. 一种外表面亲水的分子印迹磁性硅胶微球的制备方法. 中国发明专利：ZL3.6，2015-12-02.
[2]吕运开*, 张婧琦, 魏海英, 秦新英, 孙汉文. 一种外表面亲水性杂化复合固相萃取吸附剂的制备方法. 中国发明专利：ZL5.5，2015-12-30.
[1] 秦新英，吕运开*，杨磊. 一种恩诺沙星分子印迹整体柱的制备方法. 中国发明专利：ZL8.3，2015-04-08.