张红蕾
一、个人简介
张红蕾，河北农业大学博士（2011-2015），河北大学博士后（2015-2018）。现为助理研究员。迄今为止，发表学术论文20余篇；获授权中国发明专利5项，承担主持横向项目1项。
联系方式：E-mail：zhl0724@126.com
二、研究方向
生物酶构建和酶催化转化及清洁生产工艺研究；靶向纳米药物创制研究。
三、代表性论文
1. Honglei Zhang, Chao Zhang, Mengnan Han, Chaohong Pei, Zhidong Xu, and Wei Li*. Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction. Green Chem. 2018, 20(6): 1224-1227.
2. Chao Zhang, Mengnan Han, Fanghua Zhang, Xueli Yang, Jie Du, Honglei Zhang*, Wei Li*, Shengxi Chen. Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle. Int J Nanomedicine. 2020, 15: 885-900.
3. Fanghua Zhang, Chao Zhang, Mengnan Han, Xuming Wang, Shuangqing Fu, Jie Du, Honglei Zhang* and Wei Li*. Affibody-Conjugated RALA Polymers Delivering Oligomeric 5-Fluorodeoxyuridine for Targeted Therapy of HER2 Overexpressing Gastric Cancer. Macromol Biosci. 2020, 20(7): e**.
4. MengNan Han, XuMing Wang, ChaoHong Pei, Chao Zhang, Zhidong Xu, HongLei Zhang*, and Wei Li*. Green and scalable synthesis of chiral aromatic alcohols through an efficient biocatalytic system. Microb Biotechnol. 2020, doi: 10.1111/1751-7915.13602.
5. Yong Huang, Xuejiao Zhang, Honglei Zhang^*, Haixia Qiao, Xiaoyun Zhang, Tianjun Jia, Shuguang Han, Yuan Gao, Hongyuan Xiao, Hejie Yang. Fabrication of silver- and strontium-doped hydroxyapatite/TiO2 nanotube bilayer coatings for enhancing bactericidal effect and osteoinductivity. Ceram Int. 2017, 43(1): 992-1007.
6. Chao Zhang, HongLei Zhang*, MengNan Han, XueLi Yang, ChaoHong Pei, ZhiDong Xu, Jie Du, Wei Li, Shengxi Chen, DNA–Affibody Nanoparticle Delivery System for Cisplatin-Based Breast Cancer Chemotherapy. RSC Advances. 2019,9,1982-1989.
7. HongLei Zhang, Chao Zhang, Chao-Hong Pei, Meng-Nan Han, Zhi-Dong Xu and Wei Li*. Enantioselective synthesis of enantiopure chiral alcohols using carbonyl reductases screened from Yarrowia lipolytica. J Appl Microbiol. 2018,126 (1): 127-137.
8. Honglei Zhang, Chao Zhang, Chaohong Pei, Mengnan Han, Zhidong Xu, Cunhui Li, Wei Li^*. Efficient production of trans-4-Hydroxy-L-proline from glucose by metabolic engineering of recombinant Escherichia Coli. Lett Appl Microbioly. 2018, 66(5): 400-408.
9. Honglei Zhang, Meng Li, Fei Yu, Bo Zhou, Qinghong Hao, Xiuling Wang*. Endophytic Bacillus strains isolated from alfalfa (Medicago sativa L.) seeds: enhancing the lifespan of Caenorhabditis elegans. Lett Appl Microbiol. 2019, 68(3):226-233.
四、科研项目
1. 姜黄素生物可降解PHA纳米微胶囊的研究（项目编号：横**），横向项目（2020-2021年，主持人）
2. 新型核苷类靶向抗肿瘤纳米药物治疗乳腺癌的研究（项目编号：0），（2019-2022年，主持人）
3. 新型靶向抗肿瘤药物研究（项目编号：B），河北省自然科学基金专项-重点项目（2015-2019年，参与人）
4. 酶催化还原合成（R）-2-羟基-4-苯基丁酸的工业研究（项目编号：A），石家庄市重点研发计划项目（2017-2019年，参与人）