武汉体育学院导师简介
姓 名
陈宁
性 别
男
出生年月
1972. 5


教研室

职 称
教 授

招生专业与研究方向
特种医学,运动康复,运动人体科学

联系
方式
电话


邮箱
nchen510@gmail.com, **@wshu.edu.cn

导


师


简


介

陈宁，生物化学博士，楚天********、二级教授，硕士、博士生导师，湖北省有突出贡献中青年专家；武汉体育学院博士后流动站博士后合作导师，运动训练监控湖北省重点实验室主任，天久运动营养食品研发中心负责人。目前主要从事运动或营养干预对慢性疾病的预防与康复机理研究、细胞自噬功能状态对于运动适应、运动机能提高、肌肉质量维持、运动创伤修复等方面的探讨以及衍生性精准靶向产品的开发，同时与国内外多所知名大学、科研院所、企业建立了密切合作关系。先后就读于湖北中医药大学获药学学士学位、武汉体育学院获运动医学硕士学位、美国乔治亚州立大学获生物化学硕士、博士学位。近年来主持国家自然科学基金、湖北省创新科技团队、国家体育总局等研究项目10多项；在Ageing Research Reviews, Trends in Endocrinology and Metabolism, Nutrients, Journal of Functional Food, Pharmcological Research, Journal of Sports Science, Journal of Cellular Physiology, Diabetes-Metabolism Research and Reviews, Oncogene, BBA-Molecular Cell Research 和 Chemistry-An European Journal 等国内外知名SCI杂志上发表高水平学术论文50多篇并获得较高的引用率，在国际学术会议上主持或进行科研成果交流40多次；成功申报并获批国际或中国发明专利7项，主持与参与开发与获批新药产品多项；现为中国生物物理学会运动科学分会副会长、中国体育科学学会运动生理与生物化学分会会员、中国老年学学会衰老与抗衰老科学委员会会员、中国体育科学学会运动医学学会运动干预与健康促进专委会常务委员；国家重点研发计划项目与国家自然科学基金项目等评审专家；Nutrients, Functional Foods, Pharmaceuticals, International Journal of Molecular Sciences, Journal of Sports Science等30多家杂志审稿专家，食品科学编委会委员, Frontiers in Bioscience 编委会委员, MDPI-Sports编委会委员, Food Science and Human Wellness副主编。
近年来在国际期刊上发表的部分学术论文(*为通讯作者)
1. Hu Zhang, Ning Chen*. Adropin as an indicator of T2DM and its complications. Food Science and Human Wellness, 2020, in press.
2. Zhengzhong Zeng, Jiling Liang, Liangwen Wu, Hu Zhang, Jun Lv and Ning Chen*. Exercise-induced autophagy suppresses sarcopenia through Akt/mTOR and Akt/FoxO3a signal pathways and AMPK-mediated mitochondrial quality control. Frontiers in Physiology, 2020, in press.
3. Hu Zhang, Jiling Liang, Ning Chen*. Do not neglect the role of circadian rhythm in muscle atrophy. Ageing Research Reviews, 2020, 63: 101115. (影响因子: 10.616)
4. Jingjing Fan, Ziyuan Feng, Ning Chen*. Spermidine as a target of cancer therapy. Pharmacological Research, 2020, 159: 104943.
5. Dandan Chen, Ying Zhang, Meng Zhang, Jingru Chang, Zhenzhong Zeng, Xianjuan Kou, Ning Chen*. Exercise attenuates brain aging by rescuing down-regulated Wnt/β-catenin signaling in aged rats. Frontiers in Aging Neuroscience, 2020, 12: 105.
6. Xianjuan Kou, Dandan Chen, Ning Chen*. The regulation of microRNAs in Alzhemier’s disease. Frontiers in Neurology, 2020, 11: 288.
7. Jiling Liang, Zhengzhong Zeng, Ying Zhang, Ning Chen*. Regulatory role of exercise-induced autophagy for sarcopenia. Experimental Gerontology, 2020, 130: 110789.
8. Klaus W. Lange, Yukiko Nakamura, Ning Chen, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Shiming Li. Diet and medical foods in Parkinson’s disease. Food Science and Human Wellness, 2019, 8: 83-95.
9. Qingxue Li, Shaohui Jia, Lei Xu, Biao Li, Ning Chen*. Metformin-induced autophagy and irisin improves INS-1 cell function and survival in high-glucose environment via AMPK/SIRT1/PGC-1a signal pathway. Food Science and Nutrition, 2019, 7: 1695-1703.
10. Jinfeng Xie, Jiling Liang, Ning Chen*. Autophagy-associated signal pathways of functional foods for chronic diseases. Food Science and Human Wellness, 2019, 8: 25-33.
11. Xianjuan Kou, Dandan Chen, Ning Chen*. Physical activity alleviates cognitive dysftunction of Alzheimer’s disease through regulating the mTOR signaling pathway. International Journal of Molecular Sciences, 2019, 20: 1591.
12. Biao Li, Jingjing Fan, Ning Chen*. A novel regulator of type II diabetes: microRNA-143. Trends in Endocrinology and Metabolism, 2018, 29(6): 380-388. (影响因子: 10.893)
13. Ying Zhang, Ning Chen*. Autophagy is a promoter for exercise performance during high-altitude training. Oxidative Medicine and Cellular Longevity, 2018, 2018: **.
14. Xianjuan Kou, Biao Li, Julia B Olayanju, Justin M. Drake, Ning Chen*. Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients, 2018, 10(3): 343.
15. Shufang Zhang, Ning Chen*. Regulatory role of microRNAs in muscle atrophy during exercise intervention. International Journal of Molecular Sciences, 2018, 19(2): 405.
16. Shufang Zhang, Ying Zhang, Biao Li, Ning Chen*. Physical inactivity induces the atrophy of skeletal muscle of rats through activating AMPK/FoxO3a signal pathway. European Review for Medical and Pharmacological Sciences, 2018, 22(1): 199-209.
17. Jingjing Fan, Yong Sun, Xuejiao Lin, Yixin, Xu, Lei Xu, Yan Zhao, Ning Chen*. Soluble dietary fiber enhances glucose uptake and mitigates insulin resistance in human liver cancer (HepG2) cell model via AMPK/SIRT1 signal pathway. Current Topics of Nutraceutical Research, 2018, 16(1): 75-84.
18. Lingjie Wang, Junlong Du, Furong Qin, Fangyu Zhao, Zonghai Chen, Jingru Chang, Zili Wang, Fengjie Wang, Houcong Li, Xianbing Chen, Ning Chen*. Trillium tschonoskii Maxim Saponin Mitigates D-galactose-induced Brain Aging of Rats through Rheb/mTOR Signal Pathway. Biomedicine and Pharmcotherapy, 2018, 98: 516-522.
19. Xianjuan Kou, Jingjing Fan, Ning Chen*. Potential molecular targets of ampelopsin in prevention and treatment of cancers. Anti-Cancer Agents in Medicinal Chemistry, 2017, 17(12): 1610-1616.
20. Depei Yuan, Chuhua Zeng, Qianfeng Chen, Fengjie Wang, Lin Yuan, Yaoqian Zhu, Ziyang Shu, Ning Chen*. Root-securing and Brain-fortifying Liquid up-regulates caveolin-1 in cell model with Alzheimer’s disease through inhibiting Tau phosphorylation. Neurology Research International, 2017, 2017: **.
21. Xianjuan Kou, Ning Chen*. Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease. Nutrients, 2017, 9(9): 927.
22. Hua Liu, Hui Lei, Yue Shi, Jinju Wang, Ning Chen, Leilei He, Zhanghua Li, Yangfang Chen, Qifa Ye, Yi Yang. Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats. Acta Pharmacologica Sinica, 2017, 38(7): 990-997.
23. Xianjuan Kou, Jie Li, Xingran Liu, Xiaoqi Yang, Jingjing Fan, Ning Chen*. Ampelopsin attenuates the atrophy of skeletal muscle from D-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade. Biomedicine and Pharmcotherapy, 2017, 90: 311-320.
24. Jingjing Fan, Xiaoqi Yang, Jie Li, Ziyang Shu, Jun Dai, Xingran Liu, Shaohui Jia, Xianjuan Kou, Ning Chen*. Exercise coupled with spermidine intervention prevents D-gal-induced atrophy of skeletal muscle through enhanced autophagy and reduced apoptosis via the activation of AMPK-FOXO3a signal pathway. Oncotarget, 2017, 8(11): 17475-17490.
25. Xianjuan Kou, Jie Li, Xingran Liu, Jingru Chang, Qingxia Zhao, Shaohui Jia, Jingjing Fan, Ning Chen*. Swimming attenuates D-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. Journal of Applied Physiology, 2017, 122(6): 1462-1469.
26. Chunyan Li, Feihu Feng, Xiaoling Xiong, Rui Li, Ning Chen*. Exercise coupled with dietary restriction reduces oxidative stress in male adolescents with obesity. Journal of Sports Sciences, 2017, 35(7): 663-668.
27. Xing Wan, Zonghai Chen, Xianbing Chen, Ning Chen*. Lunasin: promising polypeptide for cancer prevention and treatment. Oncology Letters, 2017, 13: 3997-4001.
28. Xianjuan Kou, Xingran Liu, Jie Li, Xianbing Chen, Xiaoqi Yang, Jingjing Fan, Yi Yang, Ning Chen*. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway. Oncotarget, 2016, 7(46): 74485-74495.
29. Hao Wu, Yong Qiu, Ziyang Shu, Xu Zhang, Renpeng Li, Su Liu, Longquan Chen, Hong Liu, Ning Chen*. Protective effect of Trillium tschonoskii Maxim saponin on CCl₄-induced acute liver injury of rats through apoptosis inhibition. Canadian Journal of Physiology and Pharmacology, 2016, 94(12): 1291-1297.
30. Jingjing Fan, Xianjuan Kou, Yi Yang, Ning Chen*. MicroRNA-regulated pro-inflammatory cytokines in sarcopenia. Mediators of Inflammation, 2016, 2016:**.
31. Yi Yang, Xi Yang, Yuchen Dong, Ning Chen, Xiang Xiao, Hua Liu, Zhanghua Li, Yanfang Chen. Transcutaneous electrical acupoint stimulation alleviates adverse cardiac remodeling induced by overload training in rats. Journal of Applied Physiology, 2016, 120(11): 1269-1276.
32. Xiaoqi Yang, Hong Yuan, Jie Li, Jingjing Fan, Shaohui Jia, Xianjuan Kou, Ning Chen*. Swimming intervention mitigates HFD-induced obesity of rats through PGC-1a-irisin pathways. European Review for Medical and Pharmacological Sciences, 2016, 20(10): 2123-2130.
33. Xianjuan Kou, Ning Chen*. Autophagy as the modulator of neuronal homeostasis and neurological disorders. Journal of Neurological Disorders and Stroke, 2016, 2(1): 1005.
34. Fan Pu, Ning Chen*, Shenghui Xue. Calcium intake, calcium homeostasis and health. Food Science and Human Wellness, 2016, 5(1): 8-16.
35. Jingjing Fan, Xianjuan Kou, Shaohui Jia, Xiaoqi Yang, Yi Yang, Ning Chen*. Autophagy as a potential target for sarcopenia. Journal of Cellular Physiology, 2016, 231(7): 1450-1459.
36. Ning Chen*, Qingxue Li, Jun Liu, Shaohui Jia. Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review. Diabetes-Metabolism Research and Reviews, 2016, 32(1): 51-59.
37. Xianjuan Kou, Jie Li, Jing Bian, Yi Yang, Xiaoqi Yang, Jingjing Fan, Shaohui Jia, Ning Chen*. Ampelopsin attenuates 6-OHDA-induced neurotoxicity by regulating GSK-3β/NRF2/ARE signaling. Journal of Functional Foods, 2015, 19: 765-774.
38. Shaohui Jia, Zhongxia Du, Hua Jiang, Xingyuan Huang, Zhengwang Chen, Ning Chen*. Daintain/AIF-1 accelerates the activation of insulin-like growth factor-1 receptor signaling pathway in HepG2 cells. Oncology Reports, 2015, 34(1): 511-517.
39. Xianbing Chen, Hong Yuan, Hong Liu, Fengjie Wang, Zhixin Tan, Ning Chen*. Protective role of selenium-enriched supplement on spinal cord injury through the up-regulation of CNTF and CNTF-Ra. European Review for Medical and Pharmacological Sciences, 2015, 19(22): 4434-4442.
40. Shaohui Jia, Shufang Zhang, Hong Yuan, Ning Chen*. Lunasin inhibits cell proliferation via apoptosis and reduces the production of pro-inflammatory cytokines in cultured rheumatoid arthritis synovial fibroblasts. BioMed Research International, 2015, 346839.
41. Shufang Zhang, Xiaolu Wang, Xiaoqi Yang, Ning Chen*. Autophagy-associated targeting pathways of natural products during cancer treatments. Asian Pacific Journal of Cancer Prevention, 2014, 15(24): 10557-10563.
42. Jun Liu, Shaohui Jia, Micheal Kiberger, Ning Chen*. Lunasin as a promising health-beneficial peptide. European Review for Medical and Pharmacological Sciences, 2014, 18(14): 2070-2075.
43. Lisa Wong^#, Ning Chen^#, Vassiliki Karantza, Audrey Minden. The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells. Oncogenesis, 2013, 2(6): e50 (^# is the co-first author).
44. Xianjuan Kou, Mike Kirberger, Yi Yang, Ning Chen*. Natural products for cancer prevention associated with Nrf2-ARE pathway. Food Science and Human Wellness, 2013, 2(1): 22-28.
45. Xianjuan Kou, Ning Chen, Zhiyong Feng, Xiuqin Kong, Lan Luo, Zhimin Yin. GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling. Oncology Letters, 2013, 5(3): 1053-1057.
46. Xianjuan Kou, Ning Chen*. Pharmacological potential of ampelopsin in Rattan tea. Food Science and Human Wellness, 2012, 1(1): 14-18.
47. Ning Chen, Shen Tang, Shenghui Xue, Jenny J. Yang. Enzyme sensors for living cells. Methods in Cell Biology, 2012, 12: 421-437.
48. Tao Li, Zhiguo Feng, Shaohui Jia, Wei Wang, Zhongxia Du, Ning Chen, Zhengwang Chen. Daintain/AIF-1 promotes breast cancer cell migration by up-regulated TNF-α via activating p38 MAPK signaling pathway. Breast Cancer Research and Treatment, 2012, 131(3), 891-9.
49. Ning Chen, Vassiliki Karantza. Autophagy as a therapeutic target in cancer. Cancer Biology and Therapy. 2011, 11(2): 157-168.
50. Yingying Liu^#, Ning Chen^#, Sandy Price, Li Deng, Vassiliki Karantza, Audrey Minden. The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene, 2010, 29(44): 5883-5894 (^# is the co-first author).
51. Ning Chen, Yun Huang, Lily Yang, Rihe Liu, Jenny J. Yang. Designing sensitive EGFP-based caspase-3 sensors for imaging apoptosis in living cells. Chemistry-A European Journal, 2009, 15(37): 9311-9314.
52. Ning Chen, Yiming Ye, Jin Zou, Shunyi Li, Siming Wang, Amy Martin, Robert Wohlhueter, Jenny J. Yang. Fluorescence complementation via EF-hand interactions. Journal of Biotechnology, 2009, 142(3-4): 205-213.
53. Angela N. Holder, April L. Ellis, Ning Chen, Jin Zou, Jenny J. Yang. Facilitating chromophore formation of engineered calcium-binding green fluorescent proteins. Archives of Biochemistry and Biophysics, 2009, 486(1): 27-34.
54. Ning Chen, Jin Zou, Yiming Ye, Siming Wang, Giovanni Gadda, Jenny J. Yang. Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells. Biochemistry, 2009, 48(15): 3519-26.
55. Ning Chen, Vassiliki Karantza-Wadsworth. Role and regulation of autophagy in cancer. BBA-Molecular Cell Research, 2009, 1793(9): 1516-1523.
主要研究方向：特种医学，运动康复，运动人体科学
1. 运动或营养干预对慢性疾病预防与治疗的作用机制研究与靶向性的产品开发
2. 运动适应与机能提高、运动损伤修复的分子生物学基础与靶向性的产品开发
3. 运动营养补剂对体能康复的机理研究与产品开发
近年来主持的省部级以上科研项目
1. 运动干预通过miR-34a-Sirt1-FoxO信号轴调控细胞自噬改善衰老性肌萎缩的作用机制，国家自然科学基金面上项目，编号：**，主持，2021/01—2024/12.
2. 运动干预对II型糖尿病的预防与治疗：运动诱导的Irisin对miR-143介导的细胞自噬功能状态在II型糖尿病中的调控作用与机制，国家自然科学基金面上项目，编号：**，主持，2018/01－2021/12.
3. 运动干预对衰老性肌萎缩的预防与康复：细胞自噬功能状态的关键作用与调节机制研究, 国家自然科学基金面上项目，编号：**，主持, 2016/01－2019/12；
4. “运动干预对慢性疾病预防与康复”湖北省优秀中青年科技创新团队，项目编号：T201624，湖北省教育厅高等院校创新团队项目，主持，2017/01－2019/12；
5. “体育教育与健康促进学科群—体育健身生物学基础”，湖北省教育厅体育教育与健康促进学科群项目，主持，2016/01– 2020/12；
6. 细胞自噬功能状态对运动干预衰老性肌肉萎缩的关键作用与机制，国家体育总局研究项目，编号：2014B093, 主持，2014/09－2016/08；
7. 细胞自噬对肌肉运动适应与运动能力提高的研究与机制，湖北省教育厅规划项目，编号：B**, 主持，2014/01－2015/12；
8. 细胞自噬是肌肉运动适应与运动能力提高的促进剂，国家体育总局重点研究领域项目，编号：2012B024，主持，2012/09－2014/08；
9. 运动协同亚精胺通过自噬功能调控对衰老性肌萎缩的预防，中国博士后基金，项目编号：2015M582292, 博士后指导老师。