姓名：吴建平
性别：男
出生年月：1968年11月
学位：博士
职称：武汉理工大学化学化工与生命科学学院，教授
联系电话：**Email：biojpwu@whut.edu.cn 或 biojpwu@qq.com
教育经历：
1994/09 – 1997/07武汉同济医科大学，预防医学，博士
　 1991/09 – 1994/07武汉同济医科大学，预防医学，硕士
1986/09 – 1991/07武汉同济医科大学，环境医学，学士
研究经历：
2018/03至今 武汉理工大学，化学化工与生命科学学院，教授
2012/03- 2018/03Virginia Tech Carilion School of Medicine, Assistant Professor
2009/10–2012/03Washington University in St. Louis, Sr. Scientist
2003/07–2009/10University of Alabama at Birmingham, Research Associate
1999/07–2003/07Georgia State University, Post-Doc Research Associate
研究领域：
1) 脑血管病：侧重于脑功能保护基础研究及药物研发；
2) 中枢神经网络的代谢性调控与癫痫：难治性癫痫发病机制、抗癫痫药物筛选。
主要科研项目：
1) “ITPKA/IP4与PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”， 主持， 国家自然科学基金(**) 2019～2023；
2) “神经药理基础与创新”，主持，武汉理工大学，2018年～2023。
代表性论文与专利：
1) Martinez Pedro*, Wu J*, Yang CT, Liang HW, Xia XM, Lingle CJ. Genetic deletion of SLO2.2 enhances itch sensing, abolishes Na+ activated K+ current, and increases action potential firing frequency in DRG neurons. Elife. 2015 Nov 11;4. pii: e10013. doi: 10.7554/eLife.10013 (*contributed equally)
2) Thornell IM, Wu J, Liu XF, Bevensee MO. PIP2 hydrolysis stimulates electrogenic Na/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes. J Physiol. 2013 Dec 1;590(Pt 23):5993-6011
3) Wang W, Wu J, Bernard K, Bevensee MO and Kirk K. CFTR channel activation: constitutive mutants and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3888-93. Epub 2010 Feb 3.
4) Wu J, McNicholas CM, Bevensee MO. PIP2 modulation electrogenic Na/bicarbonate cotransporter (NBCe1). Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14150-5. Epub 2009 Aug 10.
5) Rojas A*, Wu J*, Wang R, Jiang C.Gating of the ATP-sensitive K(+) channel by a pore-lining phenylalanine residue. Biochim Biophys Acta- Biomembranes. 2007 Jan: 1768 (1): 39-51
6) Wu J, Hablitz JJ. Cooperative activation of D₁ and D₂ dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci. 2005 Jul 6;25(27):6322-8.
7) Wu J*, Wang R*, Rojas A*, Piao H, Adams CY, Xu H, Shi Y, Wang Y, Jiang C. Determinant role of membrane helices in K_ATP channel gating. J Membr Biol. 2005 Mar;204(1):1-10. (* contributed equally).
8) Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F and Jiang C. Critical membrane helical domains and amino acid residues in gating Kir6.2 channels by intracellular ATP. J Cell Physiol. 2004 Jan;198(1):73-81
9) Wu J, Xu H, Shen W and Jiang C. Expression and co-expression of CO2- sensitive Kir Channels in brainstem neuron of rats. J Membr Biol. 2004 Feb 1;197(3):179-91
10) Li L, Wu J and Jiang C. Differential expression of Kir6.1 and SUR2B mRNA in Vasculatures of various tissues in rats. J Membr Biol. 2003 Nov 1;196(1):61-9
11) Wang X, Wu J, Li L, Chen F, Wang R and Jiang C. Hypercapnic acidosis activates KATP channels in vascular smooth muscles. Circ Res. 2003 Jun 13;92(11):1225-32
12) Cui N*, Wu J*, Xu H*, Wang R, Rojas A, Piao H, Mao J, Abdulkadir L, Li L, Jiang C. Threonine residue (Thr71) plays a critical role in the gating of Kir6.2 channel by intracellular ATP and pH. J Membr Biol. 2003 Mar 15;192(2):111-22.
13) Mao J, Wu J, Fuxue Chen, Xueren Wang and Chun Jiang. Inhibition of G-protein Coupled Inward Rectifying K+ Channels by Intracellular Acidosis. J Biol Chem. 2003 Feb 28;278(9):7091-8. Epub 2002 Dec 25.
14) Wu J, Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J. and Jiang, C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H⁺ and ATP. J Physiol. 2002 Sep 1;543(Pt 2):495-504
15) Wu J, Xu H., Yang Z., Wang Y, MaoJ and Jiang C. Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. J Membr Biol. 2002 Nov 15;190(2):105-16.
16) Xu H, Wu J, Cu, N, Abdulkadir L, Wang R, Mao J, Giwa LR, Chanchevalap S and Jiang C. Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. J Biol Chem. 2001 Oct 19;276(42):38690-6. Epub 2001 Aug 20
学术奖励及荣誉：
“National Alliance for Research on Schizophrenia and Depression” Young Investigator Award (NARSD, 2006)

附件下载: