沈雷 简介
男 出生年月：1983年2月
学位： 博士 职称： 教授，硕、博士生导师
Email：leishen@whut.edu.cn
教育经历：
2003-2008，中国科学技术大学 & University of Toronto，博士(联培)，导师：吴奇 院士 & Prof. Mitchell A. Winnik
1999-2003，中国科学技术大学，化学物理系，本科
研究经历：
2017-今，武汉理工大学，化学化工与生命科学学院，教授
2013-2016，华中科技大学，化学与化工学院，副教授
2012-2013，美国 Columbia University，化学系，助理研究员
2009-2012，美国 The University of Texas at Austin & University of Minnesota，博士后，合作导师：Prof. Xiaoyang Zhu & Prof. Timothy Lodge
2008-2009，瑞士University of Geneva，博士后，合作导师：Prof. Michal Borkovec
研究领域：
课题组面向科学前沿和热点，聚焦软物质科学基础研究，利用高分子物理化学、计算机模拟等交叉科学研究，解决软物质领域相关的重要科学问题，设计软物质功能材料。
招收研究生方向：物理化学、材料、高分子、无机、有机化学等。
近年来培养的研究生获国家一等奖学金、校一等奖学金、三好学生和优秀毕业生称号。
欢迎喜欢化学与计算机模拟的你加入课题组！
主持科研项目及获得荣誉：
1. 国家自然科学基金面上项目，糖脂双层膜界面在阿尔茨海默病Aβ肽聚集中的作用研究，2016-2019，主持；
2. 国家自然科学基金青年项目，流感病毒HA蛋白质与糖的多价相互作用研究，2015-2017，主持；
3. 武汉理工大学"15551"青年拔尖人才计划，2019-2024；
4. 湖北省人才计划，2015，高分子化学与物理；
5. 武汉理工大学第十届青年教师教学竞赛，2020，二等奖。
近年代表性论文：
在专业核心期刊上发表学术论文50余篇，包括化学领域内顶尖期刊JACS, Macromolecules, ACS Macro Lett., Langmuir等，他引1400余次，研究工作多次被审稿人和国际同行亮点评述，并多次被ACS Macro Lett., Langmuir, Soft Matter编辑邀请以封面形式发表，在国际权威胶体界面化学综述期刊Adv. Colloid Interface Sci.撰写综述评论文章。
1. X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir, 2020, 36, 15212. (Invited as Cover work)
2. M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett. 2020, 9, 1759. (Invited as Cover work)
3. M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)
4. J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.
5. J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, **.
6. S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431. (Invited as Cover work)
7. S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.
8. P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445. (Invited as Cover work)
9. J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir, 2018, 34, 8415.
10. M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408.
11. K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, Lei Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527.
12. K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238.
13. Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877.
14. Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172.
Prof. Lei Shen
Tel: +86-**
Email: leishen@whut.edu.cn
Education
2003 B.Sc. University of Science & Technology of China
2008 Ph.D. University of Science & Technology of China
Position
Since 2017 Professor, Wuhan University of Technology
2014-2016 Associate Professor, Huazhong University of Science and Technology
2012-2013 Associate Research Scientist, Columbia University, USA
2009-2012 Research Associate, The University of Texas at Austin, USA
2009-2009 Research Associate, University of Minnesota, USA
2008-2009 Research Associate, University of Geneva, Switzerland
Research Interests
Our research interests focus on soft matter, such as macromolecules at surfaces and bio-interface phenomena, including:
1. nucleation and fiber formation of neuro-degenerative diseases related proteins and peptides at surfaces;
2. molecular characteristic properties of polymers at surfaces;
3. multivalent interactions at bio-interfaces;
4. design, synthesis and modification of interfacial materials
Representative Publications
1. X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir, 2020, 36, 15212. (Invited as Cover work)
2. M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett. 2020, 9, 1759. (Invited as Cover work)
3. M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)
4. J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.
5. J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, **.
6. S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431. (Invited as Cover work)
7. S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, DOI: 10.1039/C9CC06980A.
8. P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445-4453. (Invited as Cover work)
9. J. Lin, K. Wang, X. Xia, Lei Shen*, Quantification of multivalency in protein oligomer coated nanoparticles targeting dynamic membrane glycan receptors. Langmuir, 2018, 34, 8415-8421.
10. M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408-8414.
11. K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, Lei Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527-12534.
12. K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238-8244.
13. Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877-1884.
14. Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172-14178.


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