姓 名
王欣宇
性 别
男
民 族
汉
出生年月
1970.9

职 称
研究员
职 务
首席教授
联系电话
**

单位名称
材料复合新技术国家重点实验室
湖北省生物材料工程技术研究中心
Email
wangxinyu@whut.edu.cn

实验室网址
http://sklwut.whut.edu.cn/

研究方向
1、 生物材料/再生医学材料的仿生设计、制备和组织诱导性
2、 纳米生物材料、组织工程材料及生物复合材料研究
3、 材料的生物学评价及医疗器械的设计和开发

教育背景
本科: 武汉工业大学材料工程专业 获学士学位, 1993
硕士研究生: 武汉工业大学无机非金属材料专业 获硕士学位, 1997
博士研究生: 武汉理工大学材料学专业 获工学博士学位, 2003

工作经历
1999-2004: 武汉理工大学材料学科 助理研究员
2004-2005: 荷兰Delft理工大学生物医学工程学科 国家公派访问****
2004-2008: 武汉理工大学材料学科 副教授、硕士生导师
2008-至今: 武汉理工大学材料学科 研究员、博士生导师（2010）
2003-至今: 武汉理工大学生物材料与工程研究中心、湖北省生物材料工程技术研究中心 副主任、主任
2018-至今：武汉理工大学材料学科首席教授

项目情况
1. 新型无机非金属纳米生物材料制备工程化技术及产品研发
（国家重点研发计划重点专项2017YFC**，1190万）
2. 生物活性神经再生诱导材料关键技术合作研究
（国家港澳台科技合作专项2015DFH30180，100万）
3. 修复全层皮肤组织缺损的生物可降解活性材料关键技术研发
（湖北省技术创新专项重大项目2017ACA168，200万）
4. 新型经皮通路材料的制备、性能及其应用研究
（国家自然科学基金）
5. 仿生周围神经修复材料制备、降解特性及神经诱导作用研究
（教育部科学技术研究重大项目）
6. 纳米羟基磷灰石/PRGD/PDLLA复合材料制备、降解性能及其诱导神经再生的研究（湖北省自然科学基金****人才项目）
7. 复合型可吸收周围神经导管的中试及应用开发
（湖北省研究与开发计划项目）
8.高性能复合型髋关节股骨假体用材料制备关键技术及应用开发
（武汉市关键技术攻关计划项目）
9. 湖北省生物材料工程技术研究中心创新平台
（湖北省科技支撑计划项目）
10. 生物材料工程技术产学研基地
（洪山区校企合作产学研基地建设项目）

代表性学术
成果
1. 主要论文
(1) Zongrui Zhang, Xinyu Wang*, Binbin Li, Yuanjing Hou, Jing Yang & Li Yi. Development of a novel morphological paclitaxelloaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations. Drug Delivery, 2018, 25, 1: 166–177, DOI:10.1080/**.2017.** (SCI)
(2) Yiyu Wang, Xinyu Wang*, Jian Shi, Rong Zhu, Junhua Zhang, Zongrui Zhang, Daiwei Ma, Yuanjing Hou, Fei Lin, Jing Yang & Mamoru Mizuno.A Biomimetic Silk Fibroin/SodiumAlginate Composite Scaffold for Soft Tissue Engineering. Scientific Reports, 2016, 12 , 6:39477, DOI: 10.1038/srep39477 (SCI)
(3) Yiyu Wang, Xinyu Wang*, Jian Shi,Rong Zhu,Junhua Zhang,Zongrui Zhang. Flexible Silk Fibroin Films Modified by Genipin and Glycerol. RSC Advances, 2015, 5, 101362–101369, DOI: 10.1039/C5RA19754F (SCI)
(4) Zongrui Zhang, Xinyu Wang*, Binbin Li, Yuanjing Hou, Zhengwei Cai, Jing Yangc and Yi Li. Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate the drug delivery and antitumor efficiency. RSC Advances, 2018, 8, 3274-3285, DOI: 10.1039/c7ra12683b(SCI)
(5) Fei Lin, Xinyu Wang*, Yiyu Wang, Yushi Yang, Yi Li. Preparation and Biocompatibility of Electrospinning PDLLA/β-TCP/Collagen for Peripheral Nerve Regeneration. RSC Advances, 2017, 7, 41593-41602, DOI:10.1039/C7RA05966C(SCI)
(6) Rong Zhu, Xinyu Wang*, Jing Yang, Yiyu Wang, Zongrui Zhang, Yuanjing Houand Fei Lin. Influence of hydroxyl-terminated polydimethylsiloxane on high-strength biocompatible polycarbonate urethanes films. Biomedical Materials, 2017,1,12,015011,DOI:10.1088/1748-605X/12/1/015011 (SCI)
(7)YuanjingHou,XinyuWang*,JingYang,RongZhu,ZongruiZhang,YiLi.Developmentandbiocompatibilityevaluationofbiodegradablebacterialcelluloseasanovelperipheralnervescaffold.Journal of biomedical materials research. Part A, 2018, 106A, 5: 1288-1298, DOI:10.1002/jbm.a.36330 (SCI)
(8) Rong Zhu,Xinyu Wang*, Jing Yang, Yiyu Wang, Zongrui Zhang, Yuanjing Hou, Fei Lin and Yi Li. Influence of Hard Segments on the Thermal, Phase-Separated Morphology, Mechanical, and Biological Properties of Polycarbonate Urethanes. Appl. Sci., 2017, 7, 306, DOI:10.3390/app** (SCI)
(9) Dai-Wei MA, Rong ZHU, Yi-Yu WANG, Zong-Rui ZHANG, and Xin-Yu WANG*. Evaluation on Biocompatibility of Biomedical Polyurethanes with Different Hard Segment Contents. Front. Mater. Sci., 2015, 9(4), 397-404, DOI:10.1007/s11706-015-0316-6 (SCI)
(10) Zongrui Zhang, Xinyu Wang*, Rong Zhu, Yiyu Wang, Binbin Li, Yanxu Ma, and Yixia Yin. Synthesis and Characterization of Serial Random and Block-Copolymers Based on Lactide and Glycolide. Polymer Science, Series B, 2016, 6, 58, 720–729, DOI: 10.1134/S**60191(SCI)

2. 主要发明专利（第一发明人）
（1）有机硅修饰的脂肪族聚氨酯生物材料及其制备方法，授权号ZL 2.3
（2）自燃烧法合成羟基磷灰石微粉, 授权号ZL **.4
（3）具有片状解理晶粒结构的β-TCP生物陶瓷粉末的制备, 授权号ZL **.5
（4）硅橡胶表面磷灰石涂层的仿生法制备, 授权号ZL 3.2
（5）常压低温烧结高性能氧化铝生物陶瓷，授权号ZL**.3
（6）有气囊式开关的经皮元件的制备方法，授权号ZL 9.7
（7）纯镁表面磷灰石涂层的仿生法制备，授权号ZL 5.X

3. 主要获奖：
（1）“骨外科用生物降解复合材料制备关键技术及商品化开发应用” 国家科技进步二等奖（2010）
（2）“诱导损伤神经再生的可降解材料设计与制备技术及临床应用” 中国建材科技技术发明一等奖（2014）
（3）“人工髋关节及骨内固定件的研究开发” 武汉市科技进步一等奖（2005）
（4）“外科植入物用高纯氧化铝陶瓷材料（主编国家标准GB/T 22750-2008）” 武汉市标准研制奖励（2009）
（5）“外科植入物用无定形聚丙交酯树脂和丙交酯-乙交酯共聚树脂（主编医药行业标准YY/T 0510-2009）” 武汉市标准研制奖励（2011）
（6）“自燃烧法制备纳米羟基磷灰石粉的机理探讨及影响因素“ 第四届中国科协期刊优秀学术论文奖（2007）







Prof.Xinyu WANG
Address:State Key Laboratory of Advanced Technology for Materials Synthesis and Processing，Biomedical Materials and Engineering Research Center,Wuhan University of Technology（7-3，Yifu Building）
Email：wangxinyu@whut.edu.cnTel: +3，**
EDUCATION
Undergraduate: B.Sc.in Materials Engineering, Wuhan University of Technology, 1993
Graduate: M.Sc.in Inorganic Non-metallic Materials, Wuhan University of Technology, 1997
Postgraduate: Ph.D. in Materials Science, Wuhan University of Technology, 2003
WORK EXPERIENCE
1999-2004: Lecturer of Materials Science, Wuhan University of Technology, China
2004-2005: Visiting Scholar of Biomedical Engineering, Delft University of Technology, the Netherlands
2004-2008: Associate Professor and Master's Supervisor of Materials Science, Wuhan University of Technology, China
2008-present: Professor and Doctoral Supervisor of Materials Science, Wuhan University of Technology, China
2003-present: Director of Biomedical Materials and Engineering Research Center of Hubei Province,Wuhan University of Technology, China
2018-present: Chief Professor of Material Discipline,Wuhan University of Technology, China
RESEARCH PROJECT
(1)National Key R&D Program of China (No. 2017YFC**)
(2)HongKong, Macao and Taiwan Science & Technology Cooperation Program of China(No. 2015DFH30180)
(3)Major special projects of technological innovation of Hubei Province (No.2017ACA168)
(4)National Natural Science Foundation of China (No. **)
(5)Keygrant Project of Chinese Ministry of Education(No. 313041)
(6)Science and Technology Support Program of Hubei Province (No.2015BCE022)
(7)Natural Science Foundation of Hubei Province (No. 2009CDA041)
(8)Key Technologies R&D Project of Hubei Province (No. 2009BCB022)
(9)Key Technology Research Plan of Wuhan Municipality ( No. 20**120)
SELECTED PUBLICATION
(1) Zongrui Zhang, Xinyu Wang*, Binbin Li, Yuanjing Hou, Jing Yang & Li Yi. Development of a novel morphological paclitaxelloaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations. Drug Delivery, 2018, 25, 1: 166–177, DOI:10.1080/**.2017.** (SCI)
(2) Yiyu Wang, Xinyu Wang*, Jian Shi, Rong Zhu, Junhua Zhang, Zongrui Zhang, Daiwei Ma, Yuanjing Hou, Fei Lin, Jing Yang & Mamoru Mizuno.A Biomimetic Silk Fibroin/SodiumAlginate Composite Scaffold for Soft Tissue Engineering. Scientific Reports, 2016, 12 , 6:39477, DOI: 10.1038/srep39477 (SCI)
(3) Yiyu Wang, Xinyu Wang*, Jian Shi,Rong Zhu,Junhua Zhang,Zongrui Zhang. Flexible Silk Fibroin Films Modified by Genipin and Glycerol. RSC Advances, 2015, 5, 101362–101369, DOI: 10.1039/C5RA19754F (SCI)
(4) Zongrui Zhang, Xinyu Wang*, Binbin Li, Yuanjing Hou, Zhengwei Cai, Jing Yangc and Yi Li. Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate the drug delivery and antitumor efficiency. RSC Advances, 2018, 8, 3274-3285, DOI: 10.1039/c7ra12683b(SCI)
(5) Fei Lin, Xinyu Wang*, Yiyu Wang, Yushi Yang, Yi Li. Preparation and Biocompatibility of Electrospinning PDLLA/β-TCP/Collagen for Peripheral Nerve Regeneration. RSC Advances, 2017, 7, 41593-41602, DOI:10.1039/C7RA05966C(SCI)
(6) Rong Zhu, Xinyu Wang*, Jing Yang, Yiyu Wang, Zongrui Zhang, Yuanjing Houand Fei Lin. Influence of hydroxyl-terminated polydimethylsiloxane on high-strength biocompatible polycarbonate urethanes films. Biomedical Materials, 2017,1,12,015011,DOI:10.1088/1748-605X/12/1/015011 (SCI)
(7)YuanjingHou,XinyuWang*,JingYang,RongZhu,ZongruiZhang,YiLi. Developmentandbiocompatibilityevaluationofbiodegradablebacterialcelluloseasanovelperipheralnervescaffold.Journal of biomedical materials research. Part A, 2018, 106A, 5: 1288-1298, DOI:10.1002/jbm.a.36330 (SCI)
(8) Rong Zhu,Xinyu Wang*, Jing Yang, Yiyu Wang, Zongrui Zhang, Yuanjing Hou, Fei Lin and Yi Li. Influence of Hard Segments on the Thermal, Phase-Separated Morphology, Mechanical, and Biological Properties of Polycarbonate Urethanes. Appl. Sci., 2017, 7, 306, DOI:10.3390/app** (SCI)
(9) Dai-Wei MA, Rong ZHU, Yi-Yu WANG, Zong-Rui ZHANG, and Xin-Yu WANG*. Evaluation on Biocompatibility of Biomedical Polyurethanes with Different Hard Segment Contents. Front. Mater. Sci., 2015, 9(4), 397-404, DOI:10.1007/s11706-015-0316-6 (SCI)
(10) Zongrui Zhang, Xinyu Wang*, Rong Zhu, Yiyu Wang, Binbin Li, Yanxu Ma, and Yixia Yin. Synthesis and Characterization of Serial Random and Block-Copolymers Based on Lactide and Glycolide. Polymer Science, Series B, 2016, 6, 58, 720–729, DOI: 10.1134/S**60191(SCI)
PATENT
(1). Synthesis of Nanosized HAP Powder via Auto-Combustion Method, Chinese Patent ZL **.4
(2). Preparation of b-TCP Bioceramic Powder withGrain Structure of Lamellar Cleavage, Chinese Patent ZL **.5
(3). Atmospheric Low-temperature Sintering of High Performance Alumina Bioceramic, Chinese Patent ZL **.3
(4). Preparation of Apatite Coating on Silicon Rubber by Biomimetic Synthesis, Chinese Patent ZL 3.2
(5). Preparation Method of the Percutaneous Device with Ballonet Switch,Chinese Patent ZL 9.7
(6). Preparation of Apatite Coating on Magnesium by Biomimetic Synthesis, Chinese Patent ZL 5.X
(7). RGD Peptide Grafted Poly(glycolic acid-L-lysine-L-lactic acid)/β-tricalcium Phosphate Composite Material and Preparation Method thereof， US **B2、EP **B1
INTERNATIONAL CONFERENCE
1. Keynote Lecture，“R&D of Some Biomaterials and Medical Devices for Clinical Repair and Substitution”，“The 5th China-Australia Seminar on Biomaterials and Medical Device Manufacturing Technology”
2. Invited Lecture，“Biomaterials Research and Products Development for Human Health”，“Interdisciplinary Science and Technology Conference – 2016 (iSciTech-2016)“Frontiers in Nanoscience and Nanotechnology””
3. OralReport，“The flexible Silk Fibroin Films modified by Genipin and Glycerol”，“2^ndInternational Conference on Regenerative Biomedical Materials (ICRBM2015)”
4. OralReport，“Influence of Preparation Technology on the Morphology of β- tricalcium Phosphate Powders”，“The 4th Asian Biomaterials Congress（ABMC4）”


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