姓 名
戴红莲
性 别
女
民 族
汉
出生年月
1970.5

职 称
研究员
职 务

联系电话
**

单位名称
材料复合新技术国家重点实验室
Email
daihonglian@whut.edu.cn

实验室网址
http://sklwut.whut.edu.cn/

研究方向
1. 生物医用材料及其医疗器械的研究与开发
2. 纳米生物材料及药物缓释体系
3. 组织工程与再生医学材料
4. 材料-细胞/机体相互作用

教育背景
2002.3-2005.6 武汉理工大学，材料学专业，工学博士
1997.9-2000.6 武汉理工大学，生物医学工程专业，工学硕士
1989.9-1993.6 武汉工业大学，材料科学专业，工学学士

工作经历
2007.12-至今 武汉理工大学材料复合新技术国家重点实验室，研究员
2006.12-2007.12 荷兰格罗宁根大学访问研究员
2002.10-2007.11 武汉理工大学生物材料与工程研究中心，副研究员
2002. 3-2002. 6 香港科技大学访问****
1998.10-2002.9 武汉理工大学生物材料与工程研究中心，助理研究员
1993. 7-1998.9 武汉工业大学生物材料与工程研究中心，实习助理研究员

在研项目
情况
1. 国家自然科学基金面上项目：磁性长效多药缓释型骨修复材料的构建及其成骨机制（No. **）
2. 国家重点研发计划：诱导型纳米复合材料神经移植物研发（No.2016YFC**）
3. 国家重点研发计划：适用于增材制造的可降解医用高分子及其复合材料（No. 2018YFB**）
4. 国家自然科学基金重大项目：硬组织生物活性材料的宿主体内应答及其与宿主防御和再生体系的相互作用（No.**）
5. 国家自然科学基金面上项目：磁靶向性形状记忆复合微球的血管栓塞机制（No. **）
6. 武汉市应用基础前沿项目：药物缓释型生物活性椎体强化材料设计与制备技术研究 (No. 20**273)

代表性学术
成果
近期发表论文
1. Qian Zhou, Haifei Kang, Monika Bielec, Xiaopei Wu, Qiao Cheng, Wenying Wei, Honglian Dai*. Influence of different divalent ions cross-linking sodium alginatepolyacrylamide hydrogels on antibacterial properties and wound healing. Carbohydrate Polymers, 2018,197:292-304
2. Wei Xu, Chao Xu, Jiling Yi, Honglian Dai*. The effect of different hydroxyapatite microparticles on osteogenic differentiation of MC3T3-E1 preosteoblasts. Journal of Materials Chemistry B, 2018, DOI: 10.1039/C8TB01352G
3. Rongrong Liu，Qian Zhang，Qian Zhou， Ping Zhang， Honglian Dai*. Nondegradable magnetic poly (carbonate urethane) microspheres with good shape memory as a proposed material for vascular embolization. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 82: 9-17
4. Jiling Yi, Nan Jiang, Binbin Li, Qiongjiao Yan, Tong Qiu, Killugudi Swaminatha Iyer, Yixia Yin, Honglian Dai,* Ali K. Yetisen, and Shipu Li. Painful terminal neuroma prevention by capping PRGD/PDLLA conduit in rat sciatic nerves. Adv. Sci. 2018, **
5. Chao Xu, Suchun Yu, Langlang Liu, Xiaopei Wu and Honglian Dai*. Magnetically targeted co-delivery of hydrophilic and hydrophobic drugs with hollow Mesoporous Ferrite Nanoparticles. RSC Advances, 2018, 8, 15326 - 15335
6. Qiying Zou, Qian Zhou, Honglian Dai*. Synthesis, mechanical properties and biocompatibility of novel biodegradable Poly(amide-imide)s for spinal implant. Polymer Degradation and Stability, 2017, 135:85-98
7. Binbin Li, Qinghua Li, Jingxin Mo, Honglian Dai*. Drug-loaded polymeric nanoparticles for cancer stem cell targeting. Frontiers in Phamacology, 2017,8: 51.
8. Chao Xu, Xiaolong Lu, Honglian Dai*. The synthesis of size-adjustable superparamagnetism Fe₃O₄ hollow microspheres. Nanoscale Research Letters, 2017, 12(1): 234.
9. Rongrong Liu, Honglian Dai*, Qian Zhou, Qian Zhang and Ping Zhang. Synthesis and characterization of shape-memory poly carbonate urethane microspheres for future vascular embolization. Journal of Biomaterials Science, Polymer Edition, 2016, 27(12): 1248-1261
10. Qiying Zou, Qian Zhou, Langlang Liu and Honglian Dai*. A highly hydrophilic and biodegradable novel Poly(amide-imide) for biomedical applications. Polymers 2016, 8, 441
授权发明专利
1. 戴红莲，吴艳增，曲坤楠，康海飞.一种纳米β-磷酸三钙的制备方法. 国家发明专利，ZL2.3
2. 戴红莲，刘荣荣，张平，喻莹. 一种温敏性磁性复合微球的制备方法. 国家发明专利，ZL4.5
3. 戴红莲，杨冬，张平. 一种具有生物活性的温敏性水凝胶及其制备方法. 国家发明专利，ZL8.X
4. 戴红莲，黄岸，刘荣荣，韩颖超，李世普. 一种介孔β-磷酸三钙粉体的微乳液合成方法. 国家发明专利，ZL5.7
5. 戴红莲，黄岸，杨冬，韩颖超，陆小龙，李世普. 一种介孔羟基磷灰石粉体的制备方法, 国家发明专利，ZL4.4
6. 戴红莲，黄岸，喻莹，韩颖超，李世普. 一种介孔β-磷酸三钙粉体的制备方法, 国家发明专利，ZL4.5
7. 戴红莲. 牙根管充填用磷酸钙镁复合材料及其制备方法. 国家发明专利，ZL4.1
8. 戴红莲，毛恩亮，李世普，韩颖超，张平，雷军. 释氧型多孔无机/有机复合支架材料. 国家发明专利，ZL 2.8
9. 戴红莲，周超，李世普，韩颖超，王欣宇，李建华，贾莉. 一种核/壳型聚氨酯磁性复合微球及其制备方法和用途. 国家发明专利，ZL 6.0
10. 戴红莲，李世普，邵海成，王欣宇，韩颖超，黄福龙，黄健，王友法，江昕. 共沉淀法制备钴铁氧体的方法. 国家发明专利，ZL 2.1
主要获奖
1. 骨外科用生物降解复合材料制备关键技术及商品化开发应用，国家科技进步二等奖，2010
2. α-TCP/TTCP复合骨水泥研制及其在修复根尖周骨缺损的应用，武汉市科技进步二等奖，2010


Prof. Dai Honglian
Address: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing， Wuhan University of Technology, 122 Luoshi Road, Hongshan, Wuhan 430070, Hubei, China
Email：daihonglian@whut.edu.cn Tel: +86-136-9733-3860
EDUCATION
2002/03-2005/06
Ph. D. in Material Science
Wuhan University of Technology

1997/09-2000/06
M.S. in Biomedical Engineering
Wuhan University of Technology

1989/09-1993/06
B.S. in Material Science
Wuhan University of Technology

WORK EXPERIENCE
2007/12 - present
Professor
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology

2006/12-2007/12
Visiting Researcher
Department of Biomedical Engineering, University of Groningen, The Netherlands

2002/08-2007/11
Associate Professor
Biomedical Materials and Engineering Center, Wuhan University of Technology

2002/03-2002/06
Visiting Scholar
Hong Kong University of Science and Technology

1993/07-2002/09
Research Associate
Biomedical Materials and Engineering Center, Wuhan University of Technology

RESEARCH PROJECT
1.
Construction and osteogenetic mechanism of the magnetic sustained multi-drug release bone repair materials, General Program of the National Natural Science Foundation of China（No. **）

2.
Research and development of nanocomposite for nerve induction graft, the National Key Research and Development Program of China（No.2016YFC**）

3.
Degradable medical polymer and composite materials for additive manufacturing, the National Key Research and Development Program of China（No. 2018YFB**）

4.
In vivo response and interactions between the immune and the regeneration system of the hard tissue bioactive materials, Major Program of the National Natural Science Foundation of China（No.**）

5.
Vascular embolic mechanism of the magnetic targeting shape memory composite microphere, General Program of the National Natural Science Foundation of China（No. **）

6.
Design and preparation technology of sustained drug release bioactive vertebral body strengthening materials, the Application Foundation and Frontier Technology Program of Wuhan (No. 20**273)


SELECTED PUBLICATION
1. Qian Zhou, Haifei Kang, Monika Bielec, Xiaopei Wu, Qiao Cheng, Wenying Wei, Honglian Dai*. Influence of different divalent ions cross-linking sodium alginatepolyacrylamide hydrogels on antibacterial properties and wound healing. Carbohydrate Polymers, 2018,197:292-304
2. Wei Xu, Chao Xu, Jiling Yi, Honglian Dai*. The effect of different hydroxyapatite microparticles on osteogenic differentiation of MC3T3-E1 preosteoblasts. Journal of Materials Chemistry B, 2018, DOI: 10.1039/C8TB01352G
3. Rongrong Liu，Qian Zhang，Qian Zhou， Ping Zhang， Honglian Dai*. Nondegradable magnetic poly (carbonate urethane) microspheres with good shape memory as a proposed material for vascular embolization. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 82: 9-17
4. Jiling Yi, Nan Jiang, Binbin Li, Qiongjiao Yan, Tong Qiu, Killugudi Swaminatha Iyer, Yixia Yin, Honglian Dai,* Ali K. Yetisen, and Shipu Li. Painful terminal neuroma prevention by capping PRGD/PDLLA conduit in rat sciatic nerves. Adv. Sci. 2018, **
5. Chao Xu, Suchun Yu, Langlang Liu, Xiaopei Wu and Honglian Dai*. Magnetically targeted co-delivery of hydrophilic and hydrophobic drugs with hollow Mesoporous Ferrite Nanoparticles. RSC Advances, 2018, 8, 15326 - 15335
6. Qiying Zou, Qian Zhou, Honglian Dai*. Synthesis, mechanical properties and biocompatibility of novel biodegradable Poly(amide-imide)s for spinal implant. Polymer Degradation and Stability, 2017, 135:85-98
7. Binbin Li, Qinghua Li, Jingxin Mo, Honglian Dai*. Drug-loaded polymeric nanoparticles for cancer stem cell targeting. Frontiers in Phamacology, 2017,8: 51.
8. Chao Xu, Xiaolong Lu, Honglian Dai*. The synthesis of size-adjustable superparamagnetism Fe₃O₄ hollow microspheres. Nanoscale Research Letters, 2017, 12(1): 234.
9. Rongrong Liu, Honglian Dai*, Qian Zhou, Qian Zhang and Ping Zhang. Synthesis and characterization of shape-memory poly carbonate urethane microspheres for future vascular embolization. Journal of Biomaterials Science, Polymer Edition, 2016, 27(12): 1248-1261
10. Qiying Zou, Qian Zhou, Langlang Liu and Honglian Dai*. A highly hydrophilic and biodegradable novel Poly(amide-imide) for biomedical applications. Polymers 2016, 8, 441
PATENT
1. Honglian Dai, Yanzeng Wu, Kunnan Qu, Haifei Kang. A process for preparing nano β-tricalcium phosphate. China, ZL2.3
2. Honglian Dai, Rongrong Liu, Ping Zhang, Ying Yu. A process for preparing temperature sensitive magnetic composite microsphere. China, ZL4.5
3. Honglian Dai, Dong Yang, Ping Zhang. A biologically active temperature sensitive hydrogel and its preparation method. China, ZL8.X
4. Honglian Dai, An Huang, Rongrong Liu, Yingchao Han, Shipu Li. A microemulsion synthesis method for preparing mesoporous β-tricalcium phosphate powder. China, ZL5.7
5. Honglian Dai, An Huang, Dong Yang, Yingchao Han, Xiaolong Lu, Shipu Li. A process for preparing mesoporous hydroxyapatite powder. China, ZL4.4
6. Honglian Dai, An Huang, Ying Yu, Yingchao Han, Shipu Li. A process for preparing mesoporousβ-tricalcium phosphate powder. China, ZL4.5
7. Honglian Dai. A calcium magnesium phosphate compound for root canal filling and its preparation method. China, ZL4.1
8. Honglian Dai, Enliang Mao, Shipu Li, Yingchao Han, Ping Zhang, Jun Lei. Oxygen release porous inorganic/organic composite scaffold material. China, ZL 2.8
9. Honglian Dai, Chao Zhou, Shipu Li, Yingchao Han, Xinyu Wang, Jianhua Li, Li Jia. A core-shell polyurethane magnetic composite microspheres and its preparation method and application. China, ZL 6.0
10. Honglian Dai, Shipu Li, Haicheng Shao, Xinyu Wang, Yingchao Han, Fulong Huang, Jian Huang, Youfa Wang, Xin Jiang. A coprecipitation process for preparing cobalt ferrite. China, ZL 2.1


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