姓 名
高冠斌
性 别
男
民 族
汉
出生年月
1987-01

职 称
副教授
职 务
博导
联系电话
**

单位名称
材料复合新技术国家重点实验室
Email
gbgao@whut.edu.cn

实验室网址
http://sklwut.whut.edu.cn/rcdw/yjry/202010/t**_459276.shtml

研究方向
1. 多尺度手性纳米生物界面材料调控多肽/蛋白构象；
2. 手性纳米材料的生物医学新效应、新应用；
3. 用于阿尔兹海默病(AD)和帕金森病(PD)诊疗的手性纳米生物材料；
4. 用于重大疾病诊疗的近红外II区荧光成像材料

教育背景
2010/09–2016/06，武汉理工大学，材料物理与化学，博士(硕博)，导师：孙涛垒
2006/09–2010/06，武汉纺织大学，高分子材料与工程， 工学学士

工作经历
2019/09-至今武汉理工大学材料复合新技术国家重点实验室副研究员
2018/09-2019/09武汉理工大学材料复合新技术国家重点实验室副研究员、硕士生导师
2016/07-2018/09武汉理工大学材料复合新技术国家重点实验室助理研究员

项目情况
1.国家自然科学基金面上项目，**，智能响应性手性纳米生物界面材料调控多肽/蛋白质构象，2020.01-2023.12，65万元，在研，主持
2.国家自然科学基金青年科学基金项目，**，多尺度微纳米手性界面Aβ聚集及纤维化调控机制研究,2019.01-2021.12，26万元，在研，主持
3.湖北省自然科学基金青年项目，2018CFB348，纳米手性界面调控Aβ聚集及纤维化，2018/03-2019/12，3万元，在研，主持
4.横向科技项目（20192h0118），SA1和SA2药物疾病模型横向委托开发（2019-4201-28-000279），2019.06-2024.05，300万元，在研，主持
5.横向科技项目(20181h0232)，SA药物疾病模型横向委托开发(2018-4201-13-001190), 2018.06-2021.12，100万元，在研，主持

代表性学术
成果
1. Xintong Tang, Guanbin Gao*, Ting Zhang,Jianhang Li, Meng Yu, Meng HeandTaolei Sun*,Charge Effects at Nano-Bio interfaces: A Model of Charged Gold Nanoclusters on Amylin Fibrillation, Nanoscale, 2020,12,18834-18843.
2.Wenkang Zhang,Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He and Taolei Sun*, Au₂₃(CR)₁₄ Nanocluster Restores Fibril Aβ’s Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques, Natl. Sci. Rev., 2020,7(4), 763-774.
3. Zhuoying Luo, Guanbin Gao*,Zhongjie Ma,Qian Liu, Xiaobing Gao, Xintong Tang, Zhenxing Gao, Chaoyang Li* and Taolei Sun*,Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP, Int. J. Bio. Macromol., 2020,148, 1272-1279.
4. Wenkang Zhang, Meng Yu, Wenbo Zhu, Liang Wang, Juncheng Wang, Feifei Yang, Jing Li,Guanbin Gao*, Temperature-Controlled β-Crystal-to-α-Crystal Phase Transition of HgS Nanoparticles, J. Nanosci. Nanotech., 2020, 20(4),2567-2572;
5. Jinqi Hu, Guanbin Gao*,Meng He*,Qiang Yin, Xiaobing Gao, Haixing Xu, and Taolei Sun*,The Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’s Disease, Nanomedicine, 2020,15(6),563-580.
6. Yanping Dai, Mingxi Zhang*, Xiulei Shi, Kang Wang, Guanbin Gao, Lei Shen, Taolei Sun*, Kinetic Study of Aβ(1-42) Amyloidosis in the Presence of Ganglioside-Containing Vesicles. Colloids and Surfaces B: Biointerfaces, 2020,185, 110615.
7. Juncheng Wang, Feifei Yang, Guanbin Gao*, and Taolei Sun*,Ag doped HgS Quantum Dots: A pH-tunable Near-Infrared-Ⅱ Fluorescent Nanoprobe, J.Inorg. Mater., 2019,34(11), 1156-1160.
8. Zhongjie Ma, Guanbin Gao*, Zhuoying Luo,Xintong Tang and Taolei Sun*,Tuning Chirality Transfer and Amplification of Supraparticles via Solvent Inducing Self-aggregation of Chiral Gold Nanoclusters, J.Phys. Chem. C, 2019,123, 24973-24978.
9. Meng He, Xu-Feng Huang, Guanbin Gao, Ting Zhou, Wenting Li, Jinqi Hu, Jia Chen, Jing Li*, Taolei Sun*, Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate, Psychoneuroendocrinology, 2019,104, 286-299.
10. Jing Li, Rui Chen, Shasha Zhang, Zhongjie Ma, Zhuoying Luo,Guanbin Gao*, Chiral Effect at Nano-Bio Interface: A Model of Chiral Gold Nanoparticle on Amylin Fibrillation, Nanomaterials, 2019, 9(3),412.
11.Juncheng Wang, Guanbin Gao*, Feifei Yang, Rui Chen, Liang Wang, Wenbo Zhu, Zhongjie Ma, Zhuoying Luo and Taolei Sun*,A Fluorescent Nanoprobe Based on HgS/ZnS Core/Shell Quantum Dots for In-Situ Rapid Visual Detection of Cr³⁺, J.Nanopart. Res., 2019,21(3), 50.
12.Feifei Yang, Guanbin Gao*, JunchengWang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo and Taolei Sun*,Chiral β-HgS Quantum Dots: Aqueous Synthesis, Optical Properties and Cytocompatibility, J. Colloid. Interf. Sci., 2019,537, 422-430.
13.Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang and Taolei Sun*. Gold Nanoclusters for Parkinson’s Disease Treatment,Biomaterials, 2019, 194, 36-46.
14.Shan Wu, Guanbin Gao*, Shasha Zhang, Wenbo Zhu, Liang Wang, Rui Chen, Wenkang Zhang, Juncheng Wang, Feifei Yang; Jing Li, Lei Shen, Taolei Sun*,Mixed-solvent precipitation: a facile approach for nanoparticleself-assembled monolayers, Appl. Surf. Sci., 2019,465, 526-531.
15. Kang Liu, Guanbin Gao*, Taolei Sun*, β-HgS Quantum Dots: Preparation, Properties and Applications, Prog. Chem.,2017, 29, 776-784.
16. Xuejiao Hu, Guanbin Gao*, Mingxi Zhang*, Gold Nanorods—from Controlled Synthesis and Modification to Nano-biological and Biomedical Applications, Acta Phys. -Chim. Sin., 2017,33, 1324-1337.
17.Guanbin Gao, Mingxi Zhang, Dejun Gong, Rui Chen, Xuejiao Hu and Taolei Sun*. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. Nanoscale,2017,9, 4107-4113.
18. Xuesong Lv, Zhixiong Huang*, Mingxian Shi*, Yun Fan, Guanbin Gao*, Composition Distribution, Damping and Thermal Properties of the Thickness-Continuous Gradient Epoxy/Polyurethane Interpenetrating Polymer Networks,Appl. Sci. -Basel,2017, 7, 135.
19.Guanbin Gao, Dejun Gong, Mingxi Zhang* and Taolei Sun*. Chiral gold nanoclusters: a new near-infrared fluorescent probe. Acta Chim. Sinica, 2016, 74, 363-368.
20.Dejun Gong, Guanbin Gao,Mingxi Zhang* and Taolei Sun, Chiral Gold Nanoclusters: Synthesis, Properties and Biological Application, Prog.Chem.,2016, 28, 296-307.
21.Xuesong Lv*, Zhixiong Huang, Chi Huang, Minxian Shi,Guanbin Gao,Quanqin Gao,Damping properties and the morphology analysis of the polyurethane/epoxy continuous gradient IPN materials, Compos.Part B-Eng., 2016, 88, 139-149
22. Xuesong Lv*, Zhixiong Huang*, Minxian Shi, Yun Fan, Guanbin Gao*, Self-gradient mechanism, morphology and damping analysis of a thickness continuous gradient epoxy-polyurethane interpenetrating polymer network, RSC Adv., 2016, 6, 111688-111701.
23.Guanbin Gao, Mingxi Zhang, Pei Lu, Guanlun Guo, Dong Wang and Taolei Sun*. Chirality-assisted ring-like aggregation of Aβ(1-40) at liquid-solid interfaces: a stereoselective two-step assembly process. Angew. Chem. Int. Ed., 2015, 54, 2245-2250.



Prof. Gao Guanbin
Address: No.122 Luoshi Road, Wuhan, Hubei, China
Email：gbgao@whut.edu.cn Tel: +86 **
EDUCATION
2010.09 – 2016.06
Wuhan University of Technology
Materials Physics and ChemistryPh.D.

2006.09 – 2010.06
Wuhan Textile University
Polymer Materials and EngineeringB.E.





WORK EXPERIENCE
2018.09 – present
Wuhan University of Technology
Associate Professor

2016.07 – 2018.09
Wuhan University of Technology
Assistant Professor





RESEARCH PROJECT
2020.01-2023.12.
National Natural Science Foundation of China (**)

2019.01-2021.12.
National Natural Science Foundation of China (**)

2018.01-2019.12.
Natural Science Foundation of Hubei Province (2018CFB348)

2017.01-2021.12
The Fundamental Research Funds for the Central Universities
(WUT: 2020III009GX2019IVB051, 2018III023, 2017IVA093)

SELECTED PUBLICATION
1. Xintong Tang, Guanbin Gao*, Ting Zhang,Jianhang Li, Meng Yu, Meng HeandTaolei Sun*,Charge Effects at Nano-Bio interfaces: A Model of Charged Gold Nanoclusters on Amylin Fibrillation, Nanoscale, 2020,12,18834-18843.
2.Wenkang Zhang,Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He and Taolei Sun*, Au₂₃(CR)₁₄ Nanocluster Restores Fibril Aβ’s Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques, Natl. Sci. Rev., 2020,7(4), 763-774.
3. Zhuoying Luo, Guanbin Gao*,Zhongjie Ma,Qian Liu, Xiaobing Gao, Xintong Tang, Zhenxing Gao, Chaoyang Li* and Taolei Sun*,Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP, Int. J. Bio. Macromol., 2020,148, 1272-1279.
4. Wenkang Zhang, Meng Yu, Wenbo Zhu, Liang Wang, Juncheng Wang, Feifei Yang, Jing Li,Guanbin Gao*, Temperature-Controlled β-Crystal-to-α-Crystal Phase Transition of HgS Nanoparticles, J. Nanosci. Nanotech., 2020, 20(4),2567-2572;
5. Jinqi Hu, Guanbin Gao*,Meng He*,Qiang Yin, Xiaobing Gao, Haixing Xu, and Taolei Sun*,The Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’s Disease, Nanomedicine, 2020,15(6),563-580.
6. Yanping Dai, Mingxi Zhang*, Xiulei Shi, Kang Wang, Guanbin Gao, Lei Shen, Taolei Sun*, Kinetic Study of Aβ(1-42) Amyloidosis in the Presence of Ganglioside-Containing Vesicles. Colloids and Surfaces B: Biointerfaces, 2020,185, 110615.
7. Juncheng Wang, Feifei Yang, Guanbin Gao*, and Taolei Sun*,Ag doped HgS Quantum Dots: A pH-tunable Near-Infrared-Ⅱ Fluorescent Nanoprobe, J.Inorg. Mater., 2019,34(11), 1156-1160.
8. Zhongjie Ma, Guanbin Gao*, Zhuoying Luo,Xintong Tang and Taolei Sun*,Tuning Chirality Transfer and Amplification of Supraparticles via Solvent Inducing Self-aggregation of Chiral Gold Nanoclusters, J.Phys. Chem. C, 2019,123, 24973-24978.
9. Meng He, Xu-Feng Huang, Guanbin Gao, Ting Zhou, Wenting Li, Jinqi Hu, Jia Chen, Jing Li*, Taolei Sun*, Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate, Psychoneuroendocrinology, 2019,104, 286-299.
10. Jing Li, Rui Chen, Shasha Zhang, Zhongjie Ma, Zhuoying Luo,Guanbin Gao*, Chiral Effect at Nano-Bio Interface: A Model of Chiral Gold Nanoparticle on Amylin Fibrillation, Nanomaterials, 2019, 9(3),412.
11.Juncheng Wang, Guanbin Gao*, Feifei Yang, Rui Chen, Liang Wang, Wenbo Zhu, Zhongjie Ma, Zhuoying Luo and Taolei Sun*,A Fluorescent Nanoprobe Based on HgS/ZnS Core/Shell Quantum Dots for In-Situ Rapid Visual Detection of Cr³⁺, J.Nanopart. Res., 2019,21(3), 50.
12.Feifei Yang, Guanbin Gao*, JunchengWang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo and Taolei Sun*,Chiral β-HgS Quantum Dots: Aqueous Synthesis, Optical Properties and Cytocompatibility, J. Colloid. Interf. Sci., 2019,537, 422-430.
13.Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang and Taolei Sun*. Gold Nanoclusters for Parkinson’s Disease Treatment,Biomaterials, 2019, 194, 36-46.
14.Shan Wu, Guanbin Gao*, Shasha Zhang, Wenbo Zhu, Liang Wang, Rui Chen, Wenkang Zhang, Juncheng Wang, Feifei Yang; Jing Li, Lei Shen, Taolei Sun*,Mixed-solvent precipitation: a facile approach for nanoparticleself-assembled monolayers, Appl. Surf. Sci., 2019,465, 526-531.
15. Kang Liu, Guanbin Gao*, Taolei Sun*, β-HgS Quantum Dots: Preparation, Properties and Applications, Prog. Chem.,2017, 29, 776-784.
16. Xuejiao Hu, Guanbin Gao*, Mingxi Zhang*, Gold Nanorods—from Controlled Synthesis and Modification to Nano-biological and Biomedical Applications, Acta Phys. -Chim. Sin., 2017,33, 1324-1337.
17.Guanbin Gao, Mingxi Zhang, Dejun Gong, Rui Chen, Xuejiao Hu and Taolei Sun*. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. Nanoscale,2017,9, 4107-4113.
18. Xuesong Lv, Zhixiong Huang*, Mingxian Shi*, Yun Fan, Guanbin Gao*, Composition Distribution, Damping and Thermal Properties of the Thickness-Continuous Gradient Epoxy/Polyurethane Interpenetrating Polymer Networks,Appl. Sci. -Basel,2017, 7, 135.
19.Guanbin Gao, Dejun Gong, Mingxi Zhang* and Taolei Sun*. Chiral gold nanoclusters: a new near-infrared fluorescent probe. Acta Chim. Sinica, 2016, 74, 363-368.
20.Dejun Gong, Guanbin Gao,Mingxi Zhang* and Taolei Sun, Chiral Gold Nanoclusters: Synthesis, Properties and Biological Application, Prog.Chem.,2016, 28, 296-307.
21.Xuesong Lv*, Zhixiong Huang, Chi Huang, Minxian Shi,Guanbin Gao,Quanqin Gao,Damping properties and the morphology analysis of the polyurethane/epoxy continuous gradient IPN materials, Compos.Part B-Eng., 2016, 88, 139-149
22. Xuesong Lv*, Zhixiong Huang*, Minxian Shi, Yun Fan, Guanbin Gao*, Self-gradient mechanism, morphology and damping analysis of a thickness continuous gradient epoxy-polyurethane interpenetrating polymer network, RSC Adv., 2016, 6, 111688-111701.
23.Guanbin Gao, Mingxi Zhang, Pei Lu, Guanlun Guo, Dong Wang and Taolei Sun*. Chirality-assisted ring-like aggregation of Aβ(1-40) at liquid-solid interfaces: a stereoselective two-step assembly process. Angew. Chem. Int. Ed., 2015, 54, 2245-2250.

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