姓 名
韩颖超
性 别
男
民 族
汉
出生年月
1977.4.7

职 称
研究员
职 务
无
联系电话
**

单位名称
材料复合新技术国家重点实验室
Email
hanyingchao@whut.edu.cn

实验室网址


研究方向
纳米生物材料;
有机/无机医用复合材料;
纳米药物可控释放系统;

教育背景
1996.09-2000.06，武汉理工大学，获工学学士学位；
2000.09-2002.06，武汉理工大学，获工学硕士学位；
2004.09-2007.12，武汉理工大学，获工学博士学位；

工作经历
2002.7-2004.10，武汉理工大学，生物材料与工程研究中心，研究实习员；
2004.11-2009.8，武汉理工大学，生物材料与工程研究中心，助理研究员；
2009.9-2017.8，武汉理工大学，材料复合新技术国家重点实验室/生物材料与工程研究中心，副研究员；
2010.6-2012.6，美国内布拉斯加大学医学中心，博士后。
2017.9至今，武汉理工大学，材料复合新技术国家重点实验室，研究员；

项目情况
1. 科技部国家重点研发计划项目，2016YFB**，适用于骨与关节个性化植入假体增材制造生物医用材料的研制，2016/07-2020/06；
2.国家自然科学基金面上项目，**，稀土掺杂纳米磷灰石肿瘤显影剂的荧光协同增强与体内代谢，2017/01-2020/12；
3. 科技部国际科技合作项目，KY，可降解有机－无机纳米复合医用药膜技术联合研究与示范，2016/12-2019/12；

代表性学术
成果
(1) Dong Yan, Yuxin Lou, Yingchao Han, M. Nirmali Wickramaratne, Honglian Dai, Xinyu Wang. Controllable synthesis of poly(acrylic acid)-stabilized nanohydroxyapatite suspension by an ultrasound-assisted precipitation method. Materials Letters, 2018, 227:9–12
(2) Fang Li, Qingguo Xing, Yingchao Han, Yue Li, Wei Wang, Thalagalage Shalika Harshani Perera, Honglian Dai. Ultrasonically assisted preparation of poly(acrylic acid)/calcium phosphate hybrid nanogels as pH-responsive drug carriers. Materials Science and Engineering C, 2017, 80: 688-697
(3) Wangmei He, Yunfei Xie, Qingguo Xing, Peilong Ni, Yingchao Han, Honglian Dai. Sol-gel synthesis of biocompatible Eu³⁺/Gd³⁺ co-doped calcium phosphate nanocrystals for cell bioimaging. Journal of Luminescence, 2017, 192: 902–909
(4) Jiali Guo, Yuting Mao, M. Nirmali Wickramaratne, Yingchao Han. Influence of alginate fixation on the adsorption capacity of hydroxyapatite anocrystals to Cu²⁺ ions. Colloids and Surfaces A., 2017, 529: 801-807
(5) Yunfei Xie, Wangmei He, Fang Li, Thalagalage Shalika Harshani Perera, Lin Gan, Yingchao Han*, Xinyu Wang, Shipu Li, and Honglian Dai*. Luminescence Enhanced Eu³⁺/Gd³⁺ Co-Doped Hydroxyapatite Nanocrystals as Imaging Agents In Vitro and In Vivo. ACS Applied Materials & Interfaces, 2016, 8 (16): 10212–10219.
(6) Yunfei Xie, Thalagalage Shalika Harshani Perera, Fang Li, Yingchao Han*, Meizhen Yin*. Quantitative Detection Method of Hydroxyapatite Nanoparticles Based on Eu3+ Fluorescent Labeling in Vitro and in Vivo. ACS Applied Materials & Interfaces, 2015, 7 (43): 23819-23823.
(7) Yingchao Han, Xinyu Wang, Honglian Dai, Shipu Li. Nanosize and Surface Charge Effects of Hydroxyapatite Nanoparticles on Red Blood Cell Suspensions. ACS Applied Materials & Interfaces, 2012, 4(9): 4616-4622.
(8) Yingchao Han, Shipu Li, Xianying Cao, Lin Yuan, Youfa Wang, Yixia Yin, Tong Qiu, Honglian Dai, Xinyu Wang. Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo. Scientific Reports, 2014, 4: 7134.
(9) Xiaofei Lu, Yunfei Xie, Yingchao Han*, Xinyu Wang, Honglian Dai, Shipu Li. Ultrasound-induced albumin gelation method for the preparation of nanostructured hydroxyapatite. Materials Letters, 2015, 161: 128-131.
(10) Yingchao Han, Xinyu Wang, Honglian Dai, Shipu Li. Synthesis and luminescence of Eu³⁺ doped hydroxyapatite nanocrystallines: Effects of calcinations and Eu³⁺ content. Journal of Luminescence, 2013, 135: 281-287.



Prof. Yingchao Han
Address: 7th floor, YIFU Building, Wuhan University of Technology
Email：hanyingchao@whut.edu.cn Tel: **
RESEARCH AREA AND INTERESTS
1. Bioceramic and biomedical inorganic nanomaterials
1.1 Fabrication of hydroxyapatite (HAP) powders and bioceramics;
1.2 Adsorption properties of HAP nanoparticles to biomolecules (such as serum albumin, heparin and salic acid) and the interaction of HAP nanoparticles with cells;
1.3 Preparation and application of rare earth doped HAP nanoparticles as bioimaging agent.
1.4 Application of HAP nanoparticles as drug or gene carriers
2. Organic/inorganic nanocomposite for biomedical application
2.1 Fabrication of nanocomposites of polymers and nano calcium phosphate.
2.2 Application of biomedical composites for tissue regeneration
3. Drug delivery nano-carrier system and drug formulation
3.1 Preparation of anti-cancer drug loading amphiphilic block micelles formulation;
3.2 Synergistic effects study between multiple anti-cancer drugs
EDUCATION
1996.09-2000.06, Bachelor Degree, Wuhan University of Technology, China
2000.09-2002.06, Master Degree, Wuhan University of Technology, China
2004.09-2007.12, Doctor Degree, Wuhan University of Technology, China
WORK EXPERIENCE
2002.07-2004.10, Researcher Assistant, Wuhan University of Technology, China
2004.11-2009.08, Assistant Researcher, Wuhan University of Technology, China
2009.09-2017.08, Associate Researcher, Wuhan University of Technology, China
2010.06-2012.06, Postdoctoral Researcher, University of Nebraska Medical Center, USA
2017.09-present, Researcher, Wuhan University of Technology, China
RESEARCH PROJECT
(1) National Key R & D Projects, Ministry of Science and Technology: Study of biomedical materials for additive manufacturing of bone and joint personalized prosthesis, 2016YFB**, 2016/07-2020/06;
(2) National Natural Science Foundation of China, General Program: Luminescence synergistic enhancement and in vivo metabolism of rare earth doped nano apatite as tumor imaging agent, **, 2017/01-2020/12；
(3) Science and Technology Partnership Program, Ministry of Science and Technology of China: Collaborative technology research and demonstration of biodegradable organic-inorganic nanocomposite biomedical membrane, KY, 2016/12-2019/12；
SELECTED PUBLICATION
(1) Dong Yan, Yuxin Lou, Yingchao Han, M. Nirmali Wickramaratne, Honglian Dai, Xinyu Wang. Controllable synthesis of poly(acrylic acid)-stabilized nanohydroxyapatite suspension by an ultrasound-assisted precipitation method. Materials Letters, 2018, 227:9–12
(2) Fang Li, Qingguo Xing, Yingchao Han, Yue Li, Wei Wang, Thalagalage Shalika Harshani Perera, Honglian Dai. Ultrasonically assisted preparation of poly(acrylic acid)/calcium phosphate hybrid nanogels as pH-responsive drug carriers. Materials Science and Engineering C, 2017, 80: 688-697
(3) Wangmei He, Yunfei Xie, Qingguo Xing, Peilong Ni, Yingchao Han, Honglian Dai. Sol-gel synthesis of biocompatible Eu³⁺/Gd³⁺ co-doped calcium phosphate nanocrystals for cell bioimaging. Journal of Luminescence, 2017, 192: 902–909
(4) Jiali Guo, Yuting Mao, M. Nirmali Wickramaratne, Yingchao Han. Influence of alginate fixation on the adsorption capacity of hydroxyapatite anocrystals to Cu²⁺ ions. Colloids and Surfaces A., 2017, 529: 801-807
(5) Yunfei Xie, Wangmei He, Fang Li, Thalagalage Shalika Harshani Perera, Lin Gan, Yingchao Han*, Xinyu Wang, Shipu Li, and Honglian Dai*. Luminescence Enhanced Eu³⁺/Gd³⁺ Co-Doped Hydroxyapatite Nanocrystals as Imaging Agents In Vitro and In Vivo. ACS Applied Materials & Interfaces, 2016, 8 (16): 10212–10219.
(6) Yunfei Xie, Thalagalage Shalika Harshani Perera, Fang Li, Yingchao Han*, Meizhen Yin*. Quantitative Detection Method of Hydroxyapatite Nanoparticles Based on Eu3+ Fluorescent Labeling in Vitro and in Vivo. ACS Applied Materials & Interfaces, 2015, 7 (43): 23819-23823.
(7) Yingchao Han, Xinyu Wang, Honglian Dai, Shipu Li. Nanosize and Surface Charge Effects of Hydroxyapatite Nanoparticles on Red Blood Cell Suspensions. ACS Applied Materials & Interfaces, 2012, 4(9): 4616-4622.
(8) Yingchao Han, Shipu Li, Xianying Cao, Lin Yuan, Youfa Wang, Yixia Yin, Tong Qiu, Honglian Dai, Xinyu Wang. Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo. Scientific Reports, 2014, 4: 7134.
(9) Xiaofei Lu, Yunfei Xie, Yingchao Han*, Xinyu Wang, Honglian Dai, Shipu Li. Ultrasound-induced albumin gelation method for the preparation of nanostructured hydroxyapatite. Materials Letters, 2015, 161: 128-131.
(10) Yingchao Han, Xinyu Wang, Honglian Dai, Shipu Li. Synthesis and luminescence of Eu³⁺ doped hydroxyapatite nanocrystallines: Effects of calcinations and Eu³⁺ content. Journal of Luminescence, 2013, 135: 281-287.



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