姓 名
殷义霞
性 别
女
民 族
汉
出生年月
1978年7月

职 称
副研究员
职 务
／
联系电话
**

单位名称
材料复合新技术国家重点实验室
Email
yinyixia@whut.edu.cn

实验室网址
／

研究方向
生物医用材料 生物医学工程 干细胞与组织工程

教育背景
10/2009-10/2010
联合培养博士
生物医学材料
美国得克萨斯大学医学中心

09/2007-06/2011
理学博士
生物材料学
武汉理工大学

09/2004-06/2007
医学硕士
生物医学工程
武汉理工大学

09/1996-07/1999

医学专科
武汉科技大学医学院



工作经历
2007/01-至今，美国哈佛大学医学院，访学, 合作导师：Ali Khademosseini, Joseph Bonventre
2014/07-至今，武汉理工大学，材料复合新技术国家重点实验室，副研究员
2012/02-2014/06，武汉理工大学，生物材料工程研究中心，助理研究员


项目情况
1.国家自然科学基金青年基金： PDLLA/PRGD/β-TCP神经修复材料抑制神经瘤形成的作用机制（No.**），项目起止时间：2015.01-2017.12.（主持）
2.含银藻酸盐敷料的安全性研究与评估, 企业委托项目，起止时间：2016.04-2018.04.（主持）
3.国家重点实验室基金：基于重建神经再生微环境的诱导型修复材料（No.**）(2018.3-2020.12) （主持）
4.诱导型纳米复合神经移植物研发, 国家重大发展与研究项目“135” (2016YFC**)，2016.09-2020.12.（项目骨干）
5.适用于骨与关节个性化植入假体增彩制造生物医用材料的研制，国家重大发展与研究项目“135”（2016YFC**），项目起止时间： 2016.07-2020.06. （项目骨干）


代表性学术
成果
代表性论文：
1）Jiling Yi, Nan Jiang, Binbin Li, Qiongjiao Yan, Tong Qiu, K. Swaminathan Iyer, Yixia Yin*, Honglian Dai, Ali K. Yetisen, Shipu Li. Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves. Advanced Science.2018. DOI: 10.1002/advs..
2）Nan Jiang, Yong Wang, YiXia Yin*, Ruipeng Wei, Guoliang Ying, Binbin Li, Tong Qiu, Patrick Rijn, Ge Tian, Qiongjiao Yan, Honglian Dai, Henk J Busscher, Shipu Li, Ali K Yetisen, XiaoYu Yang. bFGF and Poly-RGD Cooperatively Establish Biointerface for Stem Cell Adhesion, Proliferation and Differentiation. Advanced Materials Interfaces. 2018.Doi: DOI: 10.1002/admi..
3）Jiling Yi, Feng Xiong, Binbin Li, Heping Chen, Yixia Yin*, Honglian Dai, Shipu Li. Degradation characteristics, cell viability andhost tissue responses of PDLLA-based scaffold with PRGD and β-TCP nanoparticles incorporation. Regenerative Biomaterials, 2016:1-8.
4）Yixia Yin, Binbin Li, Qiongjiao Yan, Honglian Dai, Shipu Li*. Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/β-TCP conduit: report of two cases [J]. Regenerative Biomaterials, 2015, 2: 119-124.
5）Yixia Yin, Jiling Yi, Lijuan Xie, Qiongjiao Yan, Honglian Dai, Shipu Li*. Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold [J]. Frontiers of Materials Science. 2014, 8: 95-101.
6）Yixia Yin, Lin Qiang, Sun Haiming, Chen Dan, Wu Qingzhi, Chen Xiaohui, Li Shipu. Effects of ZnO hierarchical architectures on RSC96 Schwann cells [J]. Nanoscale Research Letters. 2012, 7:439-441.
7）Jie Zeng#, Yixia Yin#, Li Zhang, Wanghui Hu, Chaocan Zhang, Wanyu Chen. A Supramolecular Gel Approach to Minimize the Neural Cell Damage during Cryopreservation Process [J]. Macromolecular Bioscience.2015, DOI: 10.1002 /mabi. . (#: Co-first author)
8）Tong Qiu, Yixia Yin*, Binbin Li, Lijuan Xie, Qiongjiao Yan, Honglian Dai, Xinyu Wang, Shipu Li. PDLLA/PRGD/β-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration [J]. Journal of Biomedical Materials Research A. 2014, 102: 3734-3743.
9）Binbin Li, Tong Qiu, Ping Zhang, Xinyu Wang, Yixia Yin* and Shipu Li. IKVAV regulates ERK1/2 and Akt signaling pathways on BMMSCs growth and proliferation [J]. Cell Proliferation. 2014, 47:133-145.
10）Fang Liu, Haiwei Zhang, Kaiming Zhang, Yixia Yin*, Shipu Li. Rapamycin promotes Schwann cell migration and nerve growth factor secretion [J]. Neural Regeneration Research. 2014, 9(6):602-609.
(*：corresponding author )
主要获奖情况：
军队科学技术奖二等奖：诱导周围神经再生的可降解材料研制及临床应用。
授权专利情况：
一种缓释型透明质酸基可注射行水凝胶及其制备方法（专利号：5.9）。





Prof.Yixia Yin
Address: 7^thYifu building, 122 Luoshi Road, Wuhan University of Technology, 430070
Email： yinyixia@gmail.com Tel: +86-**
EDUCATION
10/2009-10/2010
Joint Ph.D.
Biomedical
Materials
University of Texas Health Science Center
at San Antonio, U.S.
Advisor: Xiaodong Chen Ph.D.


09/2007-06/2011
Ph.D.
Biomedical
Materials

Wuhan University of Technology, Wuhan,
China
Advisor: Shipu Li Professor


09/2004-06/2007
Master
BiomedicalEngineering

Wuhan University of Technology, Wuhan,
China
Advisor: Shipu Li Professor

09/1996-07/1999
Medical academy
Medicine
Wuhan University of Science and Technology,
Wuhan, China
Advisor: Houzhi Wang Professor









WORK EXPERIENCE
01/2017-
Visiting scholar

Department of Medicine
Brigham and Woman’s Hospital
Harvard Medical School
Advisor: Joseph Bonventre, MD, PhD


07/2014-present
Associate
Professor

State Key Laboratory of Advanced Technology
for Materials Synthesis and Processing,
Wuhan University of Technology, China
01/2017-
Visiting scholar
BiomedicalEngineering
Department of Medicine
Brigham and Woman’s Hospital
Harvard Medical School
Advisor: Joseph Bonventre, MD, PhD







02/2012-07/2014
Assistant
Professor

State Key Laboratory of Advanced Technology for
Materials Synthesis and Processing,
Wuhan University of Technology, China






RESEARCH PROJECT
12/2017-12/2019 Inducing nerve regeneration system building based on
microenvironment of nerve and regeneration materials
State Key Laboratorysupport grant (＃**)
PI, China

01/2015-12/2017
Mechanism of inhibition neuroma formation with PDLLA/
PRGD/β-TCPnerve repairing composite


Natural Science Foundation of China(#**)


PI, China


01/2014-12/2015
Mechanism of composite peripheral nerve repair materials promote
nerve
regeneration
Natural Science Foundation of Hubei Province(#2013CFB354)


PI, China




01/2013-12/2014
Improving nerve repairing with β-TCP/PDLLA/CHS conduits
Fundamental Research Funds for the Central Universities(#2013-IV-099)


PI, China




01/2015-12/2020
Biological Safety Evaluationof New Spunlace Silver-Containing Alginate
Dressings
Cooperation between WHUTand enterprise(#20161h0072)
PI, China




01/2016-12/2019
Study on a three-dimensional gradient β-TCP composite nerve conduit with electrical stimulation
Natural Science Foundation of China(#**)
Co-PI, China




01/2015-12/2018
Construction of magnetically driven swimmers based on flexible photonic
nanochains for sensing, controlled loading and releasing cargoes
Natural Science Foundation of China(#**)
Co-PI, China




01/2011-12/2015
Mechanism of material induced tissue formation
National Key Basic Research Program of China(#2011CB606205)
Co-PI, China










SELECTED PUBLICATION
1）Jiling Yi, Nan Jiang, Binbin Li, Qiongjiao Yan, Tong Qiu, K. Swaminathan Iyer, Yixia Yin*, Honglian Dai, Ali K. Yetisen, Shipu Li. Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves. Advanced Science.2018. DOI: 10.1002/advs..
2）Nan Jiang, Yong Wang, YiXia Yin*, Ruipeng Wei, Guoliang Ying, Binbin Li, Tong Qiu, Patrick Rijn, Ge Tian, Qiongjiao Yan, Honglian Dai, Henk J Busscher, Shipu Li, Ali K Yetisen, XiaoYu Yang. bFGF and Poly-RGD Cooperatively Establish Biointerface for Stem Cell Adhesion, Proliferation and Differentiation. Advanced Materials Interfaces. 2018.Doi: DOI: 10.1002/admi..
3）Jiling Yi, Feng Xiong, Binbin Li, Heping Chen, Yixia Yin*, Honglian Dai, Shipu Li. Degradation characteristics, cell viability andhost tissue responses of PDLLA-based scaffold with PRGD and β-TCP nanoparticles incorporation. Regenerative Biomaterials, 2016:1-8.
4）Yixia Yin, Binbin Li, Qiongjiao Yan, Honglian Dai, Shipu Li*. Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/β-TCP conduit: report of two cases [J]. Regenerative Biomaterials, 2015, 2: 119-124.
5）Yixia Yin, Jiling Yi, Lijuan Xie, Qiongjiao Yan, Honglian Dai, Shipu Li*. Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold [J]. Frontiers of Materials Science. 2014, 8: 95-101.
6）Yixia Yin, Lin Qiang, Sun Haiming, Chen Dan, Wu Qingzhi, Chen Xiaohui, Li Shipu. Effects of ZnO hierarchical architectures on RSC96 Schwann cells [J]. Nanoscale Research Letters. 2012, 7:439-441.
7）Jie Zeng#, Yixia Yin#, Li Zhang, Wanghui Hu, Chaocan Zhang, Wanyu Chen. A Supramolecular Gel Approach to Minimize the Neural Cell Damage during Cryopreservation Process [J]. Macromolecular Bioscience.2015, DOI: 10.1002 /mabi. . (#: Co-first author)
8）Tong Qiu, Yixia Yin*, Binbin Li, Lijuan Xie, Qiongjiao Yan, Honglian Dai, Xinyu Wang, Shipu Li. PDLLA/PRGD/β-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration [J]. Journal of Biomedical Materials Research A. 2014, 102: 3734-3743.
9）Binbin Li, Tong Qiu, Ping Zhang, Xinyu Wang, Yixia Yin* and Shipu Li. IKVAV regulates ERK1/2 and Akt signaling pathways on BMMSCs growth and proliferation [J]. Cell Proliferation. 2014, 47:133-145.
10）Fang Liu, Haiwei Zhang, Kaiming Zhang, Yixia Yin*, Shipu Li. Rapamycin promotes Schwann cell migration and nerve growth factor secretion [J]. Neural Regeneration Research. 2014, 9(6):602-609.
(*：corresponding author )

PATENT
The preparation and property of hyaluronic acid based drug controlled-release injectable hydrogel (No. 5.9)
INTERNATIONAL CONFERENCE
1.Yixia Yin, “The Survival of Neural Stem Cells within Hydrogels Grafted with IKVAV PLEOF” 2015 International conference on regenerative biomedical materials, 10-min presentation, Nanjing, China, June 2015.
2.Yixia Yin, “Mechanism of Inducing nerve regeneration and inhibiting neuroma formation with PRGD/PDLLA/β-TCP conduit” Joint symposium of 4th International Neural Regeneration Symposium, 15-min oral presentation, Nanjing, China, June 2015.
3.Yixia Yin, “Improving nerve regeneration with bioabsorbable conduit” The 4th Asian Biomaterials Congress, 10-min oral presentation, Hongkong, June 2013.
4.Yixia Yin, “Improving nerve regeneration and neuroma inhibition with PRGD/PDLLA/β-TCP conduit.” Tissue Engineering and Regenerative Medicine International Society–Asia Pacific Chapter (TERMIS-AP) 2013 annual conference, 15-min oral presentation, Shanghai-Wuzhen, October 2013.
5.Yixia Yin, “Improving regeneration of nerves with absorbable PRGD/PDLLA/β-TCP conduits” 2nd international neural regeneration symposium, 15-min oral presentation, Shenyang China, September 2012.


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